08 Postdoctoral Fellowship at National Jewish Health, Denver, United States

The Postdoctoral Research Associate will:

• Work on an individualized project in the field of COPD and the effects of sphingolipids in the development of lung disease in vivo and also using ex vivo tissue culture using lung cells derived from patient donors. 
• Generate data on Sphingosine Kinase and Sphingosine-1 Phosphate models as they pertain to the development of emphysema, and to generate figures for presentation and publication at national and international meetings. 
• Spearhead their own project and work to produce a post-doctoral research grant
• Contribute to our team, working towards a better understanding of the role of sphingolipids, in particular Sphingosine-1 Phosphase, in lung disease as well as how they are influenced by cigarette smoking.

To perform, on a very independent basis, all phases of experimental investigations and to collaborate with Principal Investigators and senior researchers in the progress of major research projects.  To act as technical advisor to laboratory technical, support and auxiliary staff.

To perform, on a very independent basis, all phases of experimental investigations and to collaborate with Principal Investigators and senior researchers in the progress of major research projects.  To act as technical advisor to laboratory technical, support and auxiliary staff.

The Seibold Laboratory is a cutting-edge, NIH funded, laboratory focused on elucidating the pathobiological basis of asthma and other complex lung and allergic diseases. Our goal is to discover pathobiological subgroups of disease (termed disease endotypes) and the genetic, environmental, and immune factors driving their development. We are accomplishing these goals through the integration of genomic endotyping studies of large patient cohorts with in vitro mechanistic studies of human organoid culture models. Ultimately, we will leverage the information gained from our research to develop precision medicine approaches for the diagnosis, management, and treatment of these diseases. The Seibold Laboratory is composed of a multi-disciplinary team of “wet lab” cell, airway, and molecular biologists integrated with “dry lab” computational biologists, bioinformaticians, and statistical geneticists.

1. Performs, on a very independent basis, all phases of experimental investigations, to include being responsible to the Principal Investigator in the planning, developing, operating, recording, collaborating and reporting of major projects.
2. Collaborates with Principal Investigators and senior researchers in the progress of major research projects.
3. Provides guidance to laboratory staff in one or more laboratory areas, including technicians, support and auxiliary staff.  Performs as the technical advisor on techniques involving complex analyses utilizing highly sophisticated techniques.  Serves as primary contact with researcher staff for technical services on major techniques, recording devices and statistical procedures relative to the specifically assigned field.
4. Reviews quality control of new or modified laboratory techniques which affect any part of major projects.
5. Performs routine and non-routine tests leading to the successful completion of developed experiments.  Knows and follows age-specific guidelines.

A Postdoctoral Research Associate position in immunology is available in the laboratory of Dr. Magdalena Gorska ([email protected]) in the Department of Medicine, Division of Allergy and Clinical Immunology at National Jewish Health in Denver, Colorado.

The lab studies maternal effects on the immune system and development of allergic diseases, with a major focus on asthma (http://www.njhealth.org/gorska-lab). A proportion of patients with asthma develop symptoms of their disease very early in life, sometimes in the 1st year. Genetic factors are contributory, but fail to fully explain why. It is therefore increasingly recognized that development of early-life asthma is dependent in substantial part on environmental exposures that are encountered by infants after birth and exposures and health status of their mothers during pregnancy and breastfeeding. Dr. Gorska’s lab is focused on maternal factors, trying to delineate the mechanisms underlying their effects in offspring.

The Dooms laboratory in the Department of Immunology and Genomic Medicine at National Jewish Health, Denver, Colorado is seeking to recruit a highly motivated and skilled Postdoctoral Research Fellow to study the role of T cells in autoimmune diseases.

Our laboratory is interested in understanding how T cells become dysregulated and cause autoimmunity. We are specifically investigating how T cell exhaustion, caused by chronic antigen exposure, may play protective or pathogenic roles in autoimmune diseases, and how this mechanism can be exploited for therapeutic intervention. We are currently using samples from Systemic Sclerosis patients and the NOD mouse model of Type 1 Diabetes to answer these questions.