08 Postdoctoral Fellowship at Saint Louis University, Missouri, USA

The NIH funded Postdoctoral Associate position is opened in the laboratory of Dr. Sergey Korolev at the Edward A. Doisy Department of Biochemistry and Molecular Biology at Saint Louis University School of Medicine to study structural basis and molecular mechanisms of DNA repair and recombination. The main project is focused on the novel mechanism of nucleic acid strand exchange and phase separation by the intrinsically disordered tumor suppressor PALB2 (Partner and Localizer of BRCA2) (eLife, 2019,8:e44063; BioRxiv, 2023.06.01.543259v4).  The Department hosts numerous state-of-the-art facilities from X-ray crystallography and EPR spectroscopy to single molecule microscopes microTIME200 (Picoquant) and C-Trap (Lumicks) with an access to the Center for Cellular Imaging and cryo-EM facilities at Washington University in St. Louis. The Korolev Laboratory is a member of the Alvin J. Siteman Cancer Center with an outstanding network of research expertise and facilities. Additional collaborative projects are focused on cryo-EM and X-ray structural analysis of macromolecular complexes. We are seeking highly motivated individuals with a Ph.D. degree in biochemistry, chemistry, or molecular biology. Experience in one of the fields including structural biology, biophysics, single molecule spectroscopy, molecular biology, or biochemistry is required.

The postdoctoral fellow at the Department of Psychiatry and Behavioral Neuroscience at Saint Louis University School of Medicine will collaborate closely with a multidisciplinary research team focused on investigating the epidemiology of suicide/self-harm, suicide prevention, intervention, and other pertinent mental health issues. The successful candidate will contribute to ongoing research projects while also pursuing their own research agenda in line with the department’s objectives.

Navia Lab invites applications for a postdoctoral position to join our vibrant research group dedicated to unraveling the complexities of chronic pain development and differential susceptibility.

Navia Lab is committed to fostering a diverse and inclusive environment where every member feels valued and contributes to our collective success. Our research focuses on understanding the intricate mechanisms underlying chronic pain, with an emphasis on neuro-immune interactions, metabolism, and gene regulation. We strive to identify novel targets for the development of safe and effective treatments for chronic pain, aiming to make a tangible impact on patient care and well-being.

The laboratory of Dr. Salvemini in the Department of Pharmacology and Physiology at Saint Louis University, School of Medicine is looking for a highly motivated postdoctoral fellow to join a vibrant highly collaborative and dynamic NIH-funded laboratory that performs cutting edge pain research. The lab interfaces with many of the basic science labs and clinical programs at Saint Louis University to provide a rich experience in the context of translational pain research.

The laboratory integrates behavioral pharmacology, molecular genetics, biochemistry and drug discovery measures to understand molecular pathways involved in the development of neuropathic pain. We are also interested in investigating the interactions between chronic neuropathic pain states and comorbidities, such as cognitive dysfunction, depression and anxiety. The lab has access to the many core facilities at Saint Louis University (www.slu.edu/medicine/research/cores-labs) and to cutting edge medical and biotechnology throughout the St. Louis region. Our basic-science driven approach has led to the identification of several pathways and novel targets that are enabling the development of new pharmacological strategies for therapeutic intervention. Translating our discoveries to the clinic is a key mission of our work.

NIH-funded postdoctoral positions are available for highly motivated postdoctoral fellows to join the laboratory of Dr. Aubin Moutal, in the Department of Pharmacology and Physiology at St Louis university to study novel proteins involved in chronic pain in the context of autoimmunity. Our work focuses on first identifying determinants of the transition from acute to chronic pain by reverse translating clinical findings to then perform a complete mechanistic characterization of how these new factors influence chronic vs physiological pain. The PI has a strong record of high impact papers with multiple recent publications in Science Translational Medicine, Pain, and PNAS. Through the active external collaborations with the New York University (Dr. Rajesh Khanna), the University of Arizona (Dr. Frank Porreca) and with the Institut neuromyogene in France the candidate will also grow an interest in ion channel regulation, central mechanisms of pain and paraneoplastic syndromes, respectively.

Major techniques include immunohistochemistry, protein-protein interactions and protein biochemistry are employed to support findings from our behavioral and electrophysiological experiments. Applicants should have a strong background in molecular biology, IF, IHC, Western analysis, and enzyme assays; experience with phosphorylation, ubiquitination, and/or a mouse colony are pluses. Successful applicants will be highly motivated individuals with good communication skills, will have a proven publication record, and the ability to work independently. The applicants must currently have a Ph.D. in Biochemistry, Neuroscience or a related field. The appointment will be for 2 years with renewal up to 5 years and a competitive salary following NIH guidelines. Email a single PDF containing a CV, 1-2 pages summary of past research accomplishments, and contact information for three references to: [email protected]. All questions are welcome!

Saint Louis University, a Catholic, Jesuit institution dedicated to student learning, research, health care, and service is seeking applicants for a postdoctoral fellow position in the Department of Pediatrics, Division of Medical Genetics.  

The candidate will join a dynamic, interdisciplinary team that uses cell biology, protein engineering, biochemistry, human immunology and molecular biology techniques to understand lysosomal dysfunction in rare genetic disorders. The successful candidate must be highly motivated with extensive experience within one or more of the following areas: single cell sequencing, cell culture, pharmacokinetics, pharmacodynamics, organelle, and cell/molecular biology, while experience with advanced imaging techniques is advantageous. We are particularly interested in candidates with experience in lysosomal biology.  The candidate is expected to conduct independent lab work and have a strong record of scientific productivity.   He or she should be able to think critically about complex problems and contribute to a team-working environment to advance research projects.

As a postdoctoral research fellow in the Laryngeal Biology Laboratory at Saint Louis University, the successful candidate will be expected to contribute to research experimentation under the general direction of the principal investigator (PI), Dean Bernard Rousseau. The responsibilities of the position will include, but are not limited to: 

A postdoctoral position is available immediately in the lab of Gucan “Gabriel” Dai at the Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine. Candidates with a strong publication record in biophysics and biochemistry in ion channels or membrane proteins are encouraged to apply. Past experiences in patch-clamp electrophysiology or fluorescence cell imaging using advanced microscopy are preferred but not required. The Dai lab combines structural biology, chemical biology, genetics, fluorescence microscopy and electrophysiological methods to understand the fundamental mechanisms underlying ion channels of excitable membranes. The candidate is expected to publish high-impact papers as a lead author and apply for academic faculty positions or leadership positions in industry after receiving this training. The research directions in the lab are summarized in below. Applicants who are interested in this position should contact: [email protected]