10 Postdoctoral Fellowship at Cleveland Clinic, Ohio, USA

The Messer laboratory works at the interface between the microbiota and host tissues to understand how healthy host-microbe relationships develop and how they break down in disease. We study infectious and inflammatory diseases at the gut and lung mucosal barriers and investigate how disease that starts at the barrier radiates throughout the body. Our philosophy is that people perform their best work in a supportive environment that challenges them to grow while they are interested and engaged by their work. We strive to provide this environment.

The ideal candidate for this position will have completed, or be close to completing, a Ph.D. degree (or clinical equivalent (M.D., D.V.M, D.D.S., etc.) with at least one year of research experience). Additionally, competitive candidates will have experience in animal and cellular models of infectious or inflammatory disease and microbiology. Experience in flow cytometry, immunofluorescence microscopy, molecular biology, techniques to interrogate complex microbiota, and protein-protein interaction assays is desirable, but not required.

The Stolley Lab, located in the department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute, seeks a motivated postdoctoral scientist to conduct research at the confluence of immunology and oral biology. The mouth encompasses a truly unique constellation of barrier, absorptive, secretory, and chemosensory tissues, and is continuously bombarded by myriad environmental, chemical, mechanical, and pathogenic insults. However, in contrast to other mucosal locations (e.g., the gut), the immunobiology of the oral mucosa remains comparatively underexplored.

The Stolley Lab is broadly interested in understanding how immune cells integrate within the distinctive environment of the mouth to mediate local immunosurveillance and tissue homeostasis. Specifically, we seek to characterize how T cell responses in the oral mucosa impact periodontal health, saliva production/composition, chemoreception (taste and smell), and the oral microbiota. Furthermore, we are interested in co-opting the inflammatory functions of mouth-resident T cells against oral cancer.

The Louveau lab is looking for motivated postdoctoral fellows for NIH funded projects. Candidate with a strong background in Neurosciences, Immunology or vascular biology are preferred. The Louveau lab research program aims at understanding how the immune system, the vasculature and the cells of the central nervous system interacts at the brain borders (meninges, choroid plexus and blood brain barrier) to influence brain function.

Our funded research focuses particularly in neurodevelopmental (Autism Spectrum Disorders) and neurodegenerative diseases (Alzheimer’s Disease and Parkinson Disease). We strongly encourage women, underrepresented minorities and members of the LGBTQIA+ community to apply.

We have an immediate opening for a Postdoctoral Fellow position in the Dr. Andrei Ivanov Laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with experience and interests in studying epithelial barriers, intercellular junctions, cell migration, actomyosin cytoskeleton and gut inflammation are encouraged to apply. A highly motivated candidate will join a productive research team to participate in NIH funded projects focusing on the roles of the actin cytoskeleton, myosin motors, and upstream cytoskeleton-targeting signaling cascades in disassembly and reformation of tight and adherens junctions and wound healing in the intestinal epithelium during mucosal inflammation and repair.

The Ivanov lab uses large variety of experimental systems including model intestinal epithelial cell monolayers, knockout and transgenic animal models and tissue samples from human patients with inflammatory bowel diseases. Ph.D. degree or equivalent with relevant laboratory experience is required. The candidates should have a publication record demonstrating on-hand molecular biology and cell biology expertise. Familiarity with epithelial cell culture, Western blotting, immunofluorescence labeling/ microscopy, and basic RNA based methods (quantitative PCR and FISH), is essential. Preference will be given to candidates with previous experience in CRISPR/Cas9-dependent gene editing, lenti- retro- or adenoviral systems for cDNA and shRNA delivery or working with human and mouse intestinal organoids. Dedication, critical thinking, and ability to work independently are very important. The appointees will be expected to take advantage of this career opportunity to develop skills in manuscript writing and grantsmanship.

Seeking a talented postdoc with focus on EITHER or BOTH of computational or wet lab in a growing translational neuro-oncology laboratory. We focus on bringing imaging biomarkers/therapeutics targeting ncRNA to the clinic.