15 Postdoctoral Fellowship at Queen Mary University of London, United Kingdom

We have an opportunity for a Postdoctoral Research Assistant to join the Centre for Multi-omics. We are one of the world leaders in the genetic discovery of molecular traits, such as metabolites and proteins, which we use to identify shared genetic regulation with common, complex diseases to discover new drug targets, indications and disease mechanisms. We have a keen interest in training the next generation of scientists that can translate (genomic) data into clinically actionable insights.

We have unique multi-omic biosample repositories containing over 500,000 human tissue samples for research from consented patients, and available for longitudinal follow-up, from our culturally-diverse local East London population.

Applications are invited for the above role in Dr Suchita Nadkarni’s lab . The role will be a 2-year full-time-fixed term position to investigate the role of the maternal immune system and how it may contribute to the development of fetal congenital heart diseases in human pregnancies that are ultimately diagnosed with a fetal CHD. Specifically, the project will involve obtaining maternal blood samples for in-depth immune cell phenotyping and plasma samples from pregnancies that have been diagnosed with a fetal CHD at the 20-week scan. Additionally, at the time of delivery of the baby and placenta, placenta samples will be collected and processed for RNA-sequencing and histological analyses 

Applications are invited for a 24-month post-doctoral position to study the immunological landscape of sarcoidosis. The successful candidate will lead a project to better understand the mechanistic underpinning of the immunobiology of sarcoidosis, using the various and extensive sarcoidosis patient cohorts at Bart’s Hospital. The work will involve state of the art immunological assays, such as spectral flow cytometry, single-cell RNA-sequencing, and TCR repertoire analysis

The post holder will be joining the Centre for Preventive Neurology at the Wolfson Institute of Population Health, Queen Mary University of London. They will work within the Parkinson`s disease (PD) group, whose studies focus on the clinical, genetic and biomarker aspects in people with PD and at risk of PD.

The post holder will work on the Parkinson`s Progression Markers Initiative (PPMI study), funded by the Michael J Fox Foundation. PPMI is a large-scale study creating an open-access data set and biosample library to accelerate scientific breakthroughs and treatments in PD.

We are seeking a computational postdoctoral research assistant to join the group of Dr Mirjana Efremova in the Centre for Genomics and Computational Biology, to work on a CRUK funded project to investigate the role of cell plasticity in metastasis in colorectal cancer. Our lab is focused on understanding the cellular and molecular mechanisms underlying cell plasticity in metastasis and therapy resistance. We use single-cell multiomics and spatial transcriptomics data from patient samples and patient-derived organoids (Efremova et al. Nature; Efremova et al., Cell Reports) and develop computational methods (Efremova et al. Nature Protocols, 2020; Jain et al., Genome Biology).

Applications are invited for a motivated and committed Postdoctoral Research Associate (PDRA) with rich experience/knowledge. The position is funded by a research project grant from the British Heart Foundation (BHF) within Professor Xiao’s group. The successful candidate will undertake research investigations in collaboration with and under the supervision of the line manager in order to realise the objectives and development of the research projects/programme.

Applications are invited for the role of Postdoctoral Research Associate in the Centre for Cancer Screening, Prevention and Early Diagnosis (CCSPED) to contribute to a new multi-institution collaboration. Our aim is to develop innovative prediction models, which will be integrated with information collected by a ‘virtual human’ prior to GP-consultations, to help identify individuals with cancer early. The successful candidate will use large longitudinal routinely collected healthcare datasets (comprising information from millions of patients) to develop and validate dynamic / machine learning based diagnostic prediction models for cancer. They will be supported by a multidisciplinary team with expertise in general practice, health data science and machine learning.

Applicants are invited to apply for the above post within the Translational Cardiovascular Therapeutic group (Ken Suzuki laboratory) within the Centre for Microvascular Research, Faculty of Medicine, Queen Mary University of London (QMUL). Prof Suzuki’s interdisciplinary laboratory conducts a range of translational research to develop advanced stem cell therapy for heart failure, studies of reparative macrophages, post-operative adhesions, etc. The project, in which you will be engaged, is exciting cutting-edge translational research in tissue-repairing macrophages. You are expected to have sufficient experience and knowledge in in vivo models. You will be able to enjoy this challenging project and accumulate precious experience and skill/knowledge in this area in the internationally competitive laboratory. The work will be based in the William Harvey Research Institute (Charterhouse Square Campus, London). This Institute has a strong record in preclinical and clinical therapeutic development and has recently made a large expansion forward in cardiovascular research with several large grants.

The School of EECS at Queen Mary University of London seeks to appoint a Research Assistant or Postdoctoral Research Assistant for the Innovate UK project “Maestro – AI Musical Analysis Platform”, in collaboration with Algorivm Ltd. The responsibilities of the role are to investigate, implement, and evaluate machine learning technologies for audio and music performance analysis; lead and co-author publications; and collaborate with project partners.                                                                                                              

Applications are invited for a Research Fellow in Health Data Science to conduct high-quality research and develop methodologies to gain insight into health disparities throughout the life course using electronic health records. The candidate will lead or contribute to developing statistical or machine learning based methods to quantify the health inequalities at both individual- and system-level. The candidate will use routinely collected national and regional data from sources such as The Clinical Practice Research Datalink (CPRD) and Hospital Episode Statistics. They will also assist researchers in managing and accessing CPRD data through a multi study license.

Applicants are invited to join an exciting inter-disciplinary team of clinicians and scientists working together at Queen Mary across the Centre for Bioengineering, Blizard Institute, and in Zimbabwe at the Zvitambo Institute for Maternal and Child Health Research.

 This project is funded by Medical Research Council and led by Prof Andrew Prendergast who is the Director of the Zvitambo Institute for Maternal and Child Health Research in Zimbabwe and has established clinical trials to improve healthy birth and growth. You will work under the supervision of Dr Tina Chowdhury at the School of Engineering and Materials Science, who has developed 3D models to target inflammatory pathways that are common in preterm birth

A Postdoctoral Research Assistant position is available at Queen Mary University of London (QMUL) to work with Dr Alex de Mendoza. The post-holder will be funded by the ERC Starting Grant on a project entitled “Deciphering the Evolution and Roles of cytosine DNA methylation across eukaryotes”.

This research position will work on a project aimed at understanding the role of DNA methylation in various unicellular and multicellular eukaryotic species. These species hold key phylogenetic positions aimed at maximizing our taxon sampling, allowing ancestral reconstruction of DNA methylation functions across the tree of life of eukaryotes. We use a combination of functional genomics approaches to rigorously test the roles of DNA methylation in some of these species. Additionally, in vitro methods will be used to understand the role of DNA methylation “readers” in these species. This project will investigate comparative epigenomics of early animal evolution, and the impact of viral endogenization in epigenome evolution. The findings from the project will address long-standing questions in epigenetics research, providing mechanistic insights into how one of the most studied base modifications arose. The post holder will join a multidisciplinary, diverse, inclusive team with frequent meetings, interactions, and high-quality mentoring.

Applications are invited for a post of Post-Doctoral Research Assistant (PDRA) within William Harvey Research Institute, Queen Mary University of London (QMUL)

The candidate will be highly motivated and self-driven with interest in cancer and-or developmental biology to study the molecular mechanisms underlying craniopharyngiomas, a paediatric Wnt-driven hypothalamic-pituitary tumour. This project lies at the boundary between tumour and developmental biology and aims to establish how oncogenic b-catenin bearing stem cells initiate tumour formation. The lab employs transgenic models, developmental biology and bioinformatics techniques to understand early stages of tumour formation.