17 Postdoctoral Fellowship at University of Manchester, England

We are looking to appoint a lab-based postdoctoral research associate to undertake a programme of work funded by The Medical Research Council. The study will evaluate repurposing of commonly used drugs as antiarrhythmic agents. The post holder will be responsible for overseeing and conducting a range of in vivo and in vitro experiments including in vivo electrophysiology, single cell patch clamping, telemetry, dosing studies and whole heart optical voltage and calcium imaging.

The University of Manchester is seeking a talented and ambitious bioinformatician to play a key role within the bioinformatics team in the Next Generation Phenotyping and Diagnostics (NGPD) theme of the Manchester Biomedical Research Centre.

The aim of this National Institute for Health and Care Research (NIHR) funded project is to accelerate the adoption of high throughput diagnostic techniques through improving our understanding of disease complexity and multimorbidity in the context of high deprivation, social and ethnic diversity.

At the core of the NGPD theme we have created a bioinformatics team of 4 researchers, under the supervision of Prof David Wedge. Collectively, this team has expertise in the analysis of multilevel omic and imaging data; data integration and machine learning; risk prediction.

The Coyte Lab group within the Division of Evolution, Infection and Genomics wishes to appoint a Research Associate to an exciting project exploring the interplay between the mammalian immune system and gut microbiome, funded by an 8-year Wellcome CDA in collaboration with Prof. Matthew Hepworth.

During this position, the post-holder will design and lead bioinformatic analyses of large-scale longitudinal datasets charting microbiome and immune dynamics already gathered by the research team. There will be considerable flexibility in research direction.

The postholder will join a dynamic lab group with access to state-of-the-art lab and computational facilities and be a member of the MERMan research cluster of more than 100 researchers working in microbial ecology and evolution.

As an equal opportunities employer we welcome applicants from all sections of the community regardless of age, sex, gender (or gender identity), ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.

We have a vacancy for an experienced Research Associate to join our team working full-time on a research project funded by the National Institute for Health and Care Research (NIHR). The project aims to evaluate ‘Empowered Together’ – a social care coordination intervention in prison. This includes coordinating the complex physical and mental health needs of individuals living in prison using a trauma informed and person centred approach.

The Research Associate will support the Principal Investigators (Dr Louise Robinson and Dr Katrina Forsyth). Your role will include acting as a Junior Trial Project Manager under the supervision of the Senior Project Trial Manager. You will also be conducting interviews with key stakeholders including individuals living in prison; as well as staff working in the prison.

Applications are invited for a Research Associate in Radiotherapy-Induced Cardiovascular Toxicity to join the CRUK Manchester Radiation Research Centre of Excellence (CRUK RadNet Manchester) team to drive forward a collaborative programme of research between the Divisions of Pharmacy and Optometry, Cardiovascular Sciences and Cancer Sciences. The post will be tenable on a fixed term basis until the 31st October 2026 in the first instance, commencing 1st October 2025.

This is an exciting opportunity for a Post-Doctoral Research Associate to initiate research aimed at providing mechanistic understanding of cardiovascular toxicity induced by radiotherapy. We have previously shown that in lung cancer patients, the extent of radiation dose to specific heart regions is associated with worse survival and morbidity. Using preclinical models, the post holder will investigate whether heart tolerance is influenced by predisposition to cardiovascular disease and/or pre-existing cardiovascular pathology. Understanding what governs risk of early morbidity gives the opportunity for interventions to ameliorate cardiac toxicity. This project aims to investigate the mechanistic impact of radiotherapy on cardiovascular function using a combination of in vitro and in vivo studies, using cellular and mouse models of hypertension and/or diabetes. A combination of clinically relevant non-invasive imaging approaches to monitor myocardial function and pathology will be implemented alongside ex vivo tissue analyses to decipher potential mechanisms impacting heart tolerance and potential intervention strategies.

We are looking for an enthusiastic and motivated individual from a biological or medical sciences background with experience of preclinical cardiovascular research. The post holder will have the ability to work both independently and collaboratively, will have excellent communication and organisational skills and a proven track record of delivering impactful research. A publication record in peer-reviewed journals would be advantageous.

Applications are invited for the position of ‘Freddy Carboni Neuro-Oncology Non-Clinical Research fellow’ in the Division of Neuroscience, at The University of Manchester. This 2-year post is generously funded through a donation by the Carboni Family.

This fellowship offers a unique opportunity for a highly motivated non-clinical scientist to lead on research in the field of peripheral biomarkers in patients affected by low-grade and high-grade gliomas. Candidates are required to demonstrate a track record relevant to Neuro-Oncology research and to have previous research background in the field of peripheral biomarkers with experience covering pre-clinical models and translational and clinical projects.

The post-holder will work closely with clinical teams and translational scientists andwill be integrated within the Neuro-Oncology research portfolio. They will be expected to lead innovative research in the field of peripheral biomarker discovery along with developing and strengthening collaborations at national and international levels.

The successful candidate will join a division renowned for its excellence in neuroscience research, offering the opportunity to access to human tissue via the Manchester Brain Bank and leverage on established relationships with the Geoffrey Jefferson Brain Research Centre, the Manchester Centre for Cancer Research and teams within the Division of Cancer Sciences at The University of Manchester.

We are looking for a mass spectrometrist and/or analytical chemist who is self-motivated, highly organised and works as part of a team. The project involves the development of HDX-MS strategies to study the structure and dynamics of bacterial secretesome. In particular, the project will develop the hydrogen deuterium exchange mass spectrometry (HDX-MS) technology to interrogate the conformational dynamics of multi-proteins complexes involved in bacterial translocation and within their native environment.

Palimpsests have yielded spectacular new discoveries in the area of ancient texts: hitherto lost works are recovered and can be read again. The PI and his team recently identified a set of five palimpsests which will radically change the way in which we view the history of medicine in late antique Alexandria and the transmission of medical knowledge from Greek via Syriac into Arabic. These palimpsests contain Commentaries by Gesius (ca. 450–530s) in Syriac translation on two works by the famous Greek physician Galen (ca. 129–216), namely Mixtures and Natural Faculties. Gesius emerged as the most prominent of the iatrosophists or professors of medicine in late antique Alexandria, a period that had a tremendous impact on the subsequent tradition, both east and west. Mixtures and Natural Faculties belong to the so-called Sixteen Books of Galen, which formed part of the core curriculum in the amphitheatres of the iatrosophists. Moreover, the palimpsests also contain the Syriac version of Galen’s texts.

By using a mixed method approach, we propose to make the erased texts readable again, and then edit, translate and study them. Combining multispectral image capture and analysis with machine learning techniques, we will be able to transcribe these lost texts in full and, in the process, reconstruct the original manuscript. We shall study Gesius’ works in the context of medicine in late antique Alexandria and place it in a tradition where commentaries, abrigments, branch diagrams and encyclopaedias were all employed to impart medical knowledge. Finally, these Syriac translations offer us an opportunity to study how the Sixteen Books of Galen were transmitted into Syriac, and what role they played in Graeco-Arabic translations. We will thus study Gesius’ role as the chief medical authority in Alexandria and his subsequent influence, in order to judge his place in history on the basis of his own writings for the very first time.

Two postdoctoral positions, each for 3 years, are available through UKRI funding underwriting a European Research Council (ERC) Advanced Grant. This position is open to outstanding and ambitious computational scientists to work in molecular simulation progressing the in-house machine-learnt potential called FFLUX. One post (A) will focus on considerably speeding up the in-house code DL_FFLUX, written in FORTRAN90, and will carry out the simulations. The second post (B) will advance the machine learning behind the FFLUX potentials. By its novel architecture, the locally developed force field FFLUX aims to make a step change in the reliability of modelling of peptides/proteins in aqueous solution. The machine learning method Gaussian Process Regression is used to create knowledgeable quantum atoms that accurately predict atomic energies and multipole moments. It is vital that the two naturally complementary postdocs collaborate.

The post is working as a Research Associate at the Manchester Centre for Audiology and Deafness (ManCAD). You will work full-time on a research study funded by the William Demant Foundation examining listening intentions in everyday life and how they shape hearing aid outcomes with the ultimate aim of using the information to personalise hearing aid settings and thus improve hearing aid outcomes. We plan to use machine-learning to identify markers of listening intentions from data collected via sound recordings, photographs, ecological momentary assessments (EMA), and passively monitored behavioural, physiological, and environmental acoustic variables.

This post would suit someone with a PhD in biomedical engineering, data science, machine learning, experimental psychology, audiology, cognitive science, computational neuroscience, computer vision, or other relevant discipline.

Applications are invited for a Research Associate in Oligonucleotide Disposition at the Centre for Applied Pharmacokinetic Research (CAPKR) within the Division of Pharmacy and Optometry. The post will be tenable on a fixed term basis of 24 months. The post-doctoral research associate will establish novel in vitro assays to quantify in vitro siRNA uptake, intracellular distribution, and effect in primary cultured hepatocytes. These in vitro data will be subsequently used to inform mechanistic physiologically-based pharmacokinetic and pharmacodynamic (PBPK-PD) models, enabling bottom-up predictions of in vivo oligonucleotide disposition and effect. The research will involve the development and exploration of in vitro methods to assess siRNA cellular kinetics using cellular and molecular techniques, including subcellular fractionation, live-cell imaging, RT-PCR and ELISA techniques.

Successful candidate will become a member of the CAPKR research team and be fully involved in a project entitled “Improving a priori PBPK modelling for translation of oligonucleotide disposition, tissue clearance, and durability of effect”. The applicants should hold a PhD in a biomedical or pharmaceutical research area and have experience with establishing cell-based assays for measuring biological or pharmacological processes. In addition, experience in relevant molecular techniques (e.g., RT-PCR, ELISA), proteomic analyses or mathematical modelling using relevant software packages and models, as well as experience in working in multi-disciplinary teams, would be desirable.

Applications are invited for a Postdoctoral Research Associate (PDRA) to conduct research in fundamental robust feedback control theory via input-output methods under the supervision of Prof. Alexander Lanzon, Chair in Control Engineering at the University of Manchester and Head of Department of Electrical and Electronic Engineering. This PDRA post will deliver the objectives of a research grant awarded by the Engineering and Physical Sciences Research Council (EPSRC) entitled “Input-restricted robust feedback control of nonlinear dynamical systems”.

The research involves developing fundamental robust feedback control theory for nonlinear dynamical systems using input-output operator theory and graph separation theory. Excellent knowledge of input-output dissipativity theory, input-output passivity theory, IQC theory, graph separation theory, and/or operator theory (e.g. manipulation of norms and inner-products) will be a strong asset. The recruited PDRA will have a solid understanding of feedback stability analysis and control theory using input-output approaches with strong functional analysis abilities and/or mathematical systems theory skills. You will also have demonstrable potential for performing leading-edge control theory research at an international level.

The input-output approach in control theory describes (linear and nonlinear) dynamical systems as operators mapping an input to an output. Feedback stability in this input-output framework means that endogenous signals around the feedback loop are well-behaved for all exogenous inputs – in an input space – injected into the feedback loop. Influential input-output feedback stability results which can be applied to nonlinear systems to guarantee robust feedback stability include the classical small-gain, input-output passivity, input-output dissipativity, and absolute stability criteria, as well as more modern input-output stability approaches such as the Integral Quadratic Constraint framework and dynamic dissipativity. In this project, you will create fundamental analysis and control theory for input-restricted feedback stability.

Are you a highly motivated researcher with an interest in understanding and shaping effective transformative policy for sustainability? The world-renowned Alliance Manchester Business School is seeking a Post-Doctoral Research Associate to join a team working on Mission-Oriented Innovation Policies for Sustainability.

This is an exciting opportunity to contribute to an ESRC/Trans-Atlantic Platform (TAP) international project that is exploring “Policy Failures in the design and implementation of Mission-Oriented Innovation Policies (MOIPs) for Sustainability. Working collaboratively with partners in Canada and Poland, the successful candidate will analyse why MOIPs for sustainability sometimes fall short of their goals and contribute to the identification of strategies to mitigate these policy failures. The project aims at answering the following overarching research questions: (a) what are the main policy failures in in the design and implementation of MOIPs for sustainability? (b) What configurations of factors (causes) lead to specific failures? (c) Which governance and policy strategies are suitable to address these failures? The research employs in-depth qualitative analysis, including case studies, questionnaires, interviews, and workshops with policymakers and relevant stakeholders.

We are specifically looking for someone with research experience in sustainability and transformative policy, committed to impactful research and publication, and with strong qualitative research skills. We particularly welcome candidates who can demonstrate excellent qualitative research skills and the ability to interact with a diversity of stakeholders (including policy makers) and communicate research findings to both academic and non-academic audiences. The position is open to applicants with diverse educational backgrounds including innovation policy, sustainability transitions, public policy, or management studies.