18 Postdoctoral Fellowship at Masaryk University, Czech Republic

Do you have a passion for understanding the details of virus replication cycles? Join our team! Our research projects focus on determining particle structures and infection mechanisms of human picornaviruses and flaviviruses, as well as bacteriophages infecting pathogenic bacteria.

The Plevka Lab has access to cutting-edge cryo-EM equipment at our in-house core facility. Our work is supported by significant third-party funding, including an ERC Consolidator grant, ensuring freedom in pursuing our research endeavors.

We are seeking creative, independent, and motivated colleagues with proven research experience relevant to this position. Candidates with expertise in virology or structural biology are particularly encouraged to apply. 

We are looking for a colleague to join the Centre for the Digital Research of Religion at the Department for the Study of Religions in the position of a postdoctoral researcher focusing on mathematical modelling of data and statistics within the Czech Science Foundation Junior Star project Socio-Spatial Situatedness of Roman Professions and its Impact on Religion in the Roman Empire: A Formal Modeling Approach (SIPROME).

The SIPROME project investigates how professions and the socio-environmental and geographical situatedness of work environments in the ancient Roman Empire contributed to the spatial spread of ancient cults. Using computational methods, the project examines how the occupational risks faced by inhabitants of the Roman Empire influenced their choice of preferred cults. The main methods used in the project include spatial analysis, predictive modelling, statistics, and the analysis of geocoded data, especially of epigraphic and archaeological origin.

• Independent and team scientific work in the field of parasitology
• Participation in the preparation and implementation of research projects and publications
• Collection and analysis of biological samples using modern laboratory methods
• Analysis of biological data
• Independent presentation of research results at conferences and other professional meetings
• Participation in domestic and international business trips as instructed by the director of the institute
• Cooperation with domestic and international partners
• Active guidance of students and provision of professional teaching

The research group of prof. Michal Masařík is a biomedical laboratory dedicated to exploring the molecular mechanisms that drive cancer progression, with a particular emphasis on the tumour microenvironment (TME). The team focuses on the communication networks between cancer cells and stromal components, aiming to uncover how these interactions contribute to therapy resistance, metabolic adaptation, and cancer cell aggressiveness. Our team is actively engaged in the broader EV research community—we are members of the International Society for Extracellular Vesicles (ISEV) and co-founders of the Czech Society for Extracellular Vesicles (CzeSEV).

A key theme of our research is the study of extracellular vesicles (EVs) released by cancer-associated fibroblasts (CAFs) and cancer cells under both physiological and stress conditions, such as lysosomal dysfunction or nutrient deprivation. Our studies aim to elucidate how the protein and RNA cargo of these EVs changes in response to cellular stress and how such alterations affect the biological behaviour of recipient cells, including their metabolism, migratory capacity, and sensitivity to cell death. Through this work, we strive to clarify the role of EVs in the TME and to identify novel EV-based biomarkers reflecting key processes of tumour progression. Beyond their diagnostic value, EVs hold immense therapeutic potential. Their natural ability to deliver molecular cargo in a targeted and biocompatible manner makes them promising vehicles for drug delivery, immune modulation, and precision oncology.

We are seeking a talented and motivated candidate to join a research team headed by Dr. Tomas Barta at Masaryk University, Faculty of Medicine (https://histology.med.muni.cz/bartalab).

Our lab focuses on understanding the molecular mechanisms behind retinal development and disease using human pluripotent stem cells. We specialize in creating retinal organoids, “eye-like” organoids, and other retinal cell types to model eye development and associated disorders, with a particular interest in photoreceptor biology.

Our laboratory studies neurological disorders with a current emphasis on Alzheimer’s disease (AD) and glioblastoma by dissecting the underlying cellular and molecular mechanisms. Using a suite of human stem-cell-based models (iPSC-derived neurons, astrocytes, cerebral organoids, neuron/astrocyte co-cultures and patient-derived glioblastoma samples and tumoroids), we investigate pathways and signaling that drive pathology across AD, glioblastoma, and other neurological conditions (e.g., stroke, schizophrenia).

We are recruiting an experienced postdoc with several years of hands-on expertise in differentiating and characterizing iPSC-derived microglia to lead our microglia-focused programs in AD and other neurodegenerative/neurological models. The role will drive studies in advanced co-cultures and organoids, deploy CRISPR perturbations and functional assays to map disease pathways, and help establish reproducible 3D testing platforms to evaluate candidate therapeutics across AD, glioblastoma, or additional indications.

Team currently consists of 10 Postdoctoral Researchers (including 2 bioinformaticians), and 9 undergraduate and graduate students, all proficient in their respective fields.

(09) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: POSTDOC POSITION in the field of Computational Neuroscience

Deadline : 31 Jan 2026

View details & Apply

Cancer Mechanobiology section of Michal Masarik Laboratory, Faculty of Medicine, Masaryk University (Brno, Czech Republic) investigates how cytoskeletal organization and cellular mechanics influence cancer cell metabolism, invasiveness, and adaptation to the microenvironment. Our research combines experimental mechanobiology, advanced light microscopy, and computational modeling to understand the physical and molecular principles underlying cancer cell plasticity.

To complement our expertise in biophysics, imaging, and modeling, we seek a molecular biologist who will conceptually lead and experimentally manage the biological component of the project.

The postdoctoral fellow will establish and maintain genetically and fluorescently modified cancer cell models suitable for live-cell mechanobiology, such as reporter systems for cytoskeletal dynamics, and focal-adhesion turnover, and design molecular interventions probing the synthesis, organization, and anchoring of cytoskeletal and adhesion complexes. The successful candidate will contribute to defining mechanistically testable biological hypotheses within 2D and 3D mechanobiological systems.

We offer a postdoctoral position with a topic focused on understanding key mechanisms of developmental biology. More precisely the applicant will have the opportunity to study molecular and cellular aspects responsible for tissue micro and macropatterning, soft and hard-tissue regeneration and repair from a comprehensive point of view using state-of-the-art approaches. Our research group reveals various processes involved in maintaining stem cell niche homeostasis, their phenotypical changes after injury, the control of growth dynamics, mechanobiology and development, regeneration and micropatterning of hard tissues (teeth and bones). To achieve our scientific objectives, we use comprehensive methodological approaches including single-cell RNA-sequencing, spatial transcriptomics, genetically modified organisms (lineage tracing, conditional knockouts, engineering of new genetically modified strains etc.), advanced imaging techniques including confocal, light sheet or super-resolution microscopy, scanning and transmission electron microscopy, nano/micro-CT, mathematical modelling and many others. All of our projects are based on large network of local and international collaborators. This offers multiple opportunities of traveling, networking and gaining experience also outside our lab.

Our research group offers vibrant environment full of enthusiastic people helping each other with a common aim to produce highly-visible publications in high-impact journals. We regularly organize lab retreats or having other team-building activities. We are currently looking for a new member of our team with previous experience in developmental biology, mouse genetics, evo˗devo field, or dental-oriented research.

The position is advertised for the Research Group of Karla Plevova – Genomics of Immune Cells, an interdisciplinary team of biologists and bioinformaticians exploring the complexity of the human genome, with a special focus on immune cells and hematological malignancies. We aim to understand how changes in genome structure and regulation contribute to the development and progression of leukemia. Our new teammate will be involved in exploring genomic data generated on primary leukemic samples, using computational methods. We are interested in specific features resulting from chromosome (re)organization and their functional impact. The selected candidate will work mainly with sequencing results, including data from long-read sequencing, chromatin conformation, and accessibility, toward data integration and interpretation.

Hematological malignancies are closely related to various types of somatic mutations in blood cells, which often accumulate during the course of the disease. Recent findings point to the increasing importance of inherited genetic predispositions that influence the development of lymphoid and myeloid leukemias and other neoplasms. They could play a causal role in the development of the disease and be related to its early onset, patient prognosis and the effect of therapy. The description of novel germline mutations as risk factors for disease progression therefore has clear clinical implications and benefits for patients and their families. The underlying biological mechanisms leading to leukemic transformation are specific for each genetic variant and should be further investigated. The most frequent and severe genetic variants predisposing to hematological malignancies will be selected from a novel genome-wide analysis of the Czech/European population analyzed within the Genome of Europe project, which is currently underway in our laboratory.

The Stjepan Uldrijan Research Group at the Faculty of Medicine, Masaryk University, invites applications for a postdoctoral researcher to join our team studying the molecular mechanisms underlying cancer progression.

Our research focuses on understanding how hyperactivation of growth-controlling signalling pathways reshapes cellular signalling networks and influences the response of malignant melanoma to immunotherapy and targeted therapy with BRAF and MEK inhibitors. The project will also investigate the regulatory roles of individual dual-specificity phosphatases (DUSPs) in the negative modulation of the MAPK/ERK pathway activity in tumour cells. This project builds directly upon our recent discovery of translational control of the ERK signalling pathway in malignant melanoma (Valcikova et al., Proc. Natl. Acad. Sci. U.S.A., 2024, 121(44):e2321305121), opening new perspectives for identifying more effective therapeutic strategies for this aggressive cancer.

This position offers a unique opportunity to collaborate with experts from Masaryk University and other partner institutions on research related to tourism, mobility, and labour market aspects/or regional peripheries, with the possibility of participating in ongoing research projects. These projects explore a wide range of research topics, including environmental issues, energy issues, mobility, tourism, accessibility of work, retail, and public services.  

A successful candidate is expected to work on one of the following topics:

• The interplay between magnetic phase diagrams and crystal structures in perovskite oxides
• Linear magneto-optical effects in altermagnets and non-collinear magnetic structures
• Circular dichroism in RIXS

We’re excited to announce an open post-doctoral position in Robert Vacha’s Research Group!

With nearly 10 million lives claimed annually, cancer remains one of the leading causes of mortality worldwide, highlighting the urgent need for more effective treatments. One promising strategy involves mRNA-based cancer immunotherapy vaccines, which require a drug delivery system capable of reliably reaching the cytosol. Developing such delivery systems is challenging: they must ensure cytosolic delivery and therapeutic efficacy while maintaining safety, long-term stability, and compliance with scalable manufacturing standards—including high mRNA loading efficiency and uniform particle size. Current lipid- and polymer-based systems offer distinct advantages, but integrating lessons from both may help develop more effective next-generation carriers. A major limitation remains the incomplete understanding of nanoparticle assembly and disassembly under diverse physiological conditions (e.g., extracellular fluids, endosomal compartments, cytosol).

This project will use coarse-grained molecular simulations, complemented by in-house experimental validation, to gain molecular insights in the controlled system assembly and disassembly. Our goal is to guide the rational design of improved mRNA delivery systems to advance the efficacy of cancer immunotherapy.