23 Postdoctoral Fellowship at King’s College London, United Kingdom

This post is for an experienced post-doctoral Researcher in the Green Tribology Lab at King’s College London. The successful candidate will deliver multiple experimental research streams over the course of nine months, as part of a King’s Climate and Sustainability Project on the topic of ‘Developing alternative fats for healthier, more sustainable food products’.

King’s College is uniquely positioned to become a major contributor to tackling food security and establish its leadership in plant/fermented food research. Through our Green Tribology Lab, recently built on the Strand campus (central London), we have acquired first-of-its kind testing equipment to investigate food ingredient performance during oral processing, which will enable rapid screening of new foods prior to more cumbersome sensory panels.

The proposed work streams include characterising the mechanisms of saliva-fat lubrication during oral processing (using a state-of-the-art Bruker TriboLab tribometer and employing methods such as optical microscopy, laser-induced florescence and infrared thermal imaging), as well as determining correlations between lab measurements and taste assessments from a trained human panel using machine learning.

We are looking to appoint a Post-doctoral Research Associate to work on a project exploring military veterans’ physical and mental health needs using the  Clinical Practice Research Datalink (CPRD). This is an exciting chance to join the first ever study that will use CPRD to identify veterans and be able to understand how primary care needs may differ between veterans and non-veterans who access primary care. The post holder will lead on data analyses and write up of findings for scientific publications and a funder report. This role is well suited to a person who is not daunted by large-scale complex dataset and to those keen to expand their analytical skills and publication record.

The postdoc will be based in the Department of Philosophy King’s College, London and funded by the AHRC/DFG project ‘Positing or Predicating? Existence after Kant’ directed by Dolf Rami (Bochum) and Mark Textor (London).

Kant’s take on existence is generally seen as a paradigm change in the history of thinking about this concept. The discussion of Kant’s innovation focused so far almost exclusively on Frege, Russell, Quine and their followers and ignored 19th century contributions that worked out Kant’s thought in radically different and fruitful ways. The project intends to change this situation. We will explore the most important 19th century constructive responses to Kant’s view of existence and thereby provide a better understanding of the Kantian paradigm change as well as gain new insights into existence. The project will assess further what the 19th century engagement with Kant adds to contemporary work on existence.

Candidates must have a PhD degree in philosophy, be able to read German, and have a background in either history of philosophy, metaphysics, philosophy of logic and language or philosophy of mind. The postdoc will work with Mark Textor in London. They are expected to pursue their own research within the theme of the project and to help in organising workshops and seminars. The main selection criteria are fit with project theme and academic excellence.

This is an exciting opportunity to join an enthusiastic team investigating white matter damage occurring during low blood flow, which leads to dementia.   

You will use ex vivo and in vivo electrophysiological and imaging techniques, to investigate white matter function changes that occur during decreased brain blood flow, oxygenation and metabolism. 

You will work with mice, design and conduct your own experiments and analyses, and present your work in a variety of formats, including writing up your results for publication in peer-reviewed journals. 

You will be educated to doctoral level in neuroscience or a closely related discipline, with relevant experience in some aspects of the project. 

This 18 month postdoctoral position will spearhead laboratory and statistical genetics analyses, developing new hypotheses concerning the origins and treatment of eating disorders. The postholder will collaborate extensively with partners and consortia, particularly those focused on eating disorder genomics. The ideal candidate will have a background in lab science, psychiatric, behavioural genetics, and a strong interest in mental health or behavioural science.

Candidates should possess a relevant PhD in statistical, lab, or bioinformatic genetics or bioinformatics, with experience in high-throughput genetic/genomic data analysis and bioinformatics. Experience in genome-wide association studies, exome or whole genome sequencing analysis, chemoinformatics, or biomarker informatics is beneficial. Proficiency in statistical analysis, particularly with R and/or python, and LINUX/bash, is expected. Independent working skills, maintaining strong collaborative relationships, and excellent written and verbal communication abilities are essential.

You will join highly applied interdisciplinary project at the intersection of synthetic biology, AI, and biotechnology. We aim to explore the potential of non-conventional yeasts to develop novel cell factories for producing food proteins. With a team of experts from diverse fields, we are on a mission to revolutionise food production in an eco-friendly way. The project has the real potential to go far beyond fundamental research and has the potential to evolve into a real enterprise in the near future.

We are looking for a passionate and skilled Molecular Biologist with a specialisation in yeast synthetic biology research. The candidate will play a crucial role in developing yeast-based systems to produce high-quality, sustainable food proteins. This position offers the unique opportunity to be part of a pioneering team working on a highly applied research project with significant environmental and social impact. You will have an opportunity to work together within a team of bioinformaticians, ML engineers and experimental biologists to develop novel systems for protein production and explore untapped biology of diverse yeasts.

We are seeking a Research Associate who will become an integral member of Dr. Youn-Bok Lee’s dynamic research team, which is at the forefront of a gene therapy initiative. This program is dedicated to combating C9orf72-linked amyotrophic lateral sclerosis (ALS) and fronto-temporal dementia (FTD) and is supported by the My Name’5 Doddie Foundation.

The mission of the research program is to develop novel vector and refine the dosage of both gene augmentation and silencing vectors within cellular and animal models of these diseases. This is to establish a solid foundation of proof for their efficacy and potential application in clinical settings.

You will collaborate with a dedicated group of Post-doctoral Scientists, Technicians, and PhD students who together will perform analyses on cells and tissues that have been treated with various plasmid and vector constructs, aiming to quantify the impact on the expression of the targeted gene. The role involves spearheading the assessment of innovative plasmid and Adeno Associated Viral (AAV) vectors, as well as confirming their effectiveness in both cellular and animal disease models.

We are seeking to employ an experienced Research Associate for 24-months to join the Shawcross Laboratory to lead on the mechanistic analyses for the NIHR EME-funded PROMISE Trial [A PROspective randomised double-blind parallel group placebo-controlled multicentre trial of faecal MIcrobiota tranSplantation to improve the primary outcomE (first hospitalisation due to infection) in patients with cirrhosis over 24 months].    

Chronic liver disease is increasing on a global scale and patients are vulnerable to developing infections and death. The main aim of the research group is to characterise the immune-gut-liver-axis in patients and to develop interventions which normalise the abnormal gut microbiome reducing the development of complications and liver failure. Gut microbiome perturbations are prevalent in chronic liver disease resulting in overgrowth of pathobionts damaging the intestinal barrier. Manipulating the gut microbiome in chronic liver disease could have significant benefits reducing bacterial translocation across the gut barrier resulting in systemic inflammation and infections, antibiotic usage and reducing antimicrobial resistance.

We are seeking to recruit a talented and enthusiastic expert with experience in next-generation sequencing data, particularly in single-cell transcriptomics. This is an exciting opportunity to join an interdisciplinary team of scientists working on a Wellcome Trust funded programme of research. The post holder will work on projects combining cutting-edge cellular / molecular models, computational approaches and clinical data. The postholder will be part of an interdisciplinary cross-cutting network, working together with research staff / academics, clinicians, and embryologists to support and undertake ground-breaking research involving big data.

The post-holder will play a key role in setting up innovative inter-disciplinary strategies to analyse and integrate different -omics data sets, further amalgamating these with phenotypic data. The project will employ state of the art genomics, bioinformatics and applied statistical approaches in discovery research and the identification of functional pathways relevant to reproductive medicine and embryonic development.

This post is funded by the Leo Foundation to study the developmental basis for anatomical variations in wound repair and skin disease susceptibility. This collaborative and interdisciplinary project brings together three research groups and combines developmental biology, genetics and epigenetics, and cell biology. The successful candidate will study tissue and cells, make use of in vitro and in vivo models of wound repair and scarring in order to answer our research questions.

The successful candidate will have a PhD in a relevant subject (e.g. cell/molecular/developmental biology, biochemistry, genetics). Experience in microscopy and image analysis, bioinformatics, in vivo models and/or stem cell biology would be advantageous. The candidate should be able to work independently and as part of a team.

We are seeking to appoint a cell/molecular biologist with a PhD in Cell/Molecular Biology, Chemistry, Biochemistry or related disciplines. The candidate will be hardworking with a proven scientific track record and will have a strong background in molecular biology, cell biology and microscopy.

You will be in a supportive and nurturing environment where we want you to succeed and will work with members of Dr Agromayor’s and Professor Juan Martin-Serrano’s Groups.

The nucleus is a dynamic organelle capable of sensing multiple environmental inputs. Importantly, whilst mechanical forces can impact nuclear shape, nuclear morphology also contributes to cellular function. Thus, deformations of the nuclear envelope (NE) can be sensed either as physiological signals that will modulate tissue homeostasis or as detrimental perturbations that can lead to disease development. You will be responsible for the delivery of BBSRC-funded research aiming to investigate how signalling from NE deformations is regulated and to identify the molecular mechanisms that differentiate physiological and pathological NE deformations.

We are seeking a highly motivated candidate to lead on EEG biomarker discovery and validation. As part of an international multidisciplinary team, you’ll be amongst world-leading public and industry scientists, working together on translational research at the cutting edge of precision medicine. You’ll gain experience on biomarker discovery and validation, advanced EEG analysis techniques and with the regulatory environment around biomarker approval. You’ll work with the largest deeply-phenotyped autism dataset in the world.

Drawing on data from longitudinal observational studies of infants, children and adults, clinical trials and drug challenge studies, the successful candidate will perform existing and develop new analysis techniques, and write up findings for publication in peer reviewed journals. There will be opportunities to collaborate with colleagues working in animal EEG, as well as with domain experts in other modalities such as s/fMRI, DTi, eye tracking, clinical characterisation and genetics.

Applications are invited for the position of Post-Doctoral Research Associate in the Department of Diabetes at King’s College London, working in the laboratories of Dr. Gavin Bewick. This is an MRC funded project entitled Decoding the Obese Duodenum. Its goal is to understand how the duodenum, changes in response to obesity and how these changes may exacerbate metabolic diseases. We will do this by multiomics mapping the human obese duodenum, establish how key pathological pathways disturb gut function and whole-body physiology using organoid technology and animal models and determine the therapeutic potential of restoring duodenal function. The successful candidate will work as part of team and be responsible for carrying out the multiomic mapping and gut organoid work. They will have a PhD in a relevant biomedical sciences subject and have expertise in in vitro assessment of cell function and single cell transcriptomics. Prior experience of gut stem cell biology and gut organoid culture would be a distinct advantage. 

We would like to invite applications for a Qualitative post-doctoral Research Associate to work on a National Institute of Health Research funded qualitative study to investigate the barriers and facilitators to accessing sexual health care for people with severe mental illness. The study has two parts: interviews with people with severe mental illness will explore the barriers and facilitators to accessing sexual health care in people with SMI from a service user perspective; and focus groups with sexual health clinicians will explore staff views and experiences of providing sexual health care to people with severe mental illness. The postholder will be responsible for conducting all interviews and focus groups under the supervision of Dr Margaret Heslin.

The post provides an exciting opportunity for a Research Associate to be part of a thriving centre for qualitative research that uses rigorous and innovative methods to understand and improve the experiences of people with mental health problems.  The successful candidate will join the King’s Health Economics Research Group in the Health Services & Population Research Department, Institute of Psychiatry, Psychology & Neuroscience, and be affiliated with the Qualitative Applied Health Research Centre (QUAHRC) at King’s.

(18) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title:  Postdoctoral Research Associate in Quantum Emergent Hydrodynamics of many-body systems

Deadline : 25 February 2024.

View details & Apply

The purpose of this post is to develop and expedite projects aimed at characterizing DDR response, replication stress and epigenetic networks in leukemia using newly developed disease models in the lab. Transcription factors and their associated epigenetic modifying enzymes are frequently deregulated or even mutated in human acute myeloid leukemia (Zeisig et al., 2012, Cancer Cell). Over the years, our lab has focused on characterization of key transcriptional/epigenetic networks and their emerging crosstalk with DNA damage repair (DDR) mechanisms critical for leukemia development (Kwok et al., 2006, Cancer Cell; Zeisig et al., 2007, Cancer Cell; Cheung et al., 2007, Nat Cell Biology; Arteaga et al., 2013, Cancer Cell; Esposito et al., 2015, Nature Medicine; Cheung et al., 2016, Cancer Cell; Luo et al., 2019, Cancer Cell; Zeisig et al., 2021 Science Translational Medicine, Luo et al., 2022, Molecular Cell). Details about the lab can be found at https://www.kcl.ac.uk/research/leukaemia-and-stem-cell-biology. The candidate will lead projects aiming to characterize novel crosstalk between DDR, replication stress, transcription-replication conflicts, and epigenetic mechanisms in establishment and treatment of leukemia. The initial contract is for 3 years but is renewable subject to the progress of the projects. Candidates are expected to have a strong background and relevant publications in areas of DDR, DNA replication, epigenetic gene regulation and/or cancer biology.

The department of Informatics is looking to appoint a motivated candidate to fill a postdoctoral research fellow position in Multi-agent Reinforcement Learning and Foundation Models. This position will be hosted and located in the Cooperative AI Lab (https://coopai.kcl.ac.uk/) headed by Dr. Yali Du in the Department of Informatics, King’s College London, United Kingdom. The researcher will be supervised jointly by Dr. Yali Du (University of Edinburgh) and Dr. Biwei Huang (University of California San Diego).

The candidate will be a conscientious, innovative scientist who has completed a Ph.D. (or equivalent) in computer science, engineering (including electrical/electronic engineering), or a similar field. Candidates with strong backgrounds in reinforcement learning, multi-agent learning, language model agents and causal learning are encouraged to apply.  Inter-disciplinary research experience and project management experience are preferred. You will join a team, with an opportunity to collaborate with researchers at Google DeepMind, University of Cambridge and the Turing Institute.

A vacancy for a Postdoctoral Research Assistant to work within the T2K, Hyper-Kamiokande, and Super-Kamiokande experiments has arisen at the Experimental Particle and Astroparticle Physics (EPAP) Group, Department of Physics, King’s College London.   

We will welcome the successful candidate into the diverse Experimental Particle and Astroparticle Physics (EPAP) Group, to undertake research investigations in collaboration with the members of the EPAP group and the T2K, Hyper-Kamiokande, and Super-Kamiokande collaborations. We especially encourage applications from female and minority ethnic candidates and other groups who are under-represented in physics. 

The postholder is expected to take a leading role in the DAQ system for the Hyper-Kamiokande experiment towards the start of data taking in 2027. There is also the possibility to provide some contributions to T2K/Super-Kamiokande data analysis. 

This is an exciting opportunity to gain and develop clinical research skills. The successful candidate will play a key role in innovative clinical studies investigating better ways to treat schizophrenia with the potential to change clinical practice.  

They will be based at the Institute of Psychiatry, one of the leading clinical research centres in the world, and the South London and Maudsley NHS Foundation Trust. The post also involves some travel to other sites in London.

The main study involves testing whether the early use of clozapine improves outcomes compared to current practice. The post holder has the opportunity to get involved in all aspects of the study, including subject recruitment and collection of clinical and other data in patients.

They will also have opportunities to develop their research interests within the projects; for example to test the mechanism of action of clozapine using state-of-the-art neuroimaging techniques. Training in research methods will be provided, and the post-holder will develop skills in using gold-standard diagnostic and clinical ratings, which will provide a strong foundation for future research and clinical practice. They will also gain unique experience in the assessment and management of antipsychotic resistant schizophrenia.