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26 Postdoctoral Fellowship at Karolinska Institute, Sweden

Karolinska Institute, Sweden invites online Application for various Postdoctoral Fellowship in their different Departments. We are providing a list of Postdoc Fellowship positions available at Karolinska Institute, Sweden.

Eligible candidate may Apply as soon as possible.

 

(01) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoctoral studies on beta-cell regeneration in zebrafish (scholarship)

The present project will span from pharmacology to genetics in zebrafish, as well as translational studies in the mouse and human cell cultures. The studies will include assessing beta-cell neogenesis, proliferation and transdifferentiation, and how such cellular changes affect glycemia.

The zebrafish are amenable to efficient transgenesis and high-resolution imaging. We will make use of these properties to generate transgenic, knock-in and mutant zebrafish for single-cell analysis of phenotypes and lineage tracing

Deadline : 05.Jun.2022

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(02) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoctoral studies in Cancer Research (scholarship) – for Ukranian researcher

There are two available positions:

(1) Characterisation of genomic, transcriptomic or methylation aberrations in cancer or lymphoma using gene panels or whole genome sequencing and/or analysis of cell-free DNA using droplet digital PCR, targeted gene panels or whole genome sequencing. Prior knowledge and practical experience in cancer genetics and molecular genetic techniques or in bioinformatics is a merit.

or

(2) Study of risk factors and preventive factors in oesophageal and gastric cancer using large cohort data from registries in the five Nordic countries. And/or study of factors that influence the recovery after surgery for oesophageal cancer based on patient-reported outcomes from 420 patients. Knowledge in medicine, healthcare, modern epidemiology and biostatistics is meriting.

Deadline : 20.May.2022 

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(03) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoctoral Researcher in disabling occupational injuries – rehabilitation

We are looking for two postdocs who will work in one or more research projects in disabling
occupational injuries (accident, illness or disability/discomfort caused by the work). The positions are advertised and appointed centrally, which means that the successful candidate together with Karolinska Institutet will find a suitable department and research group to work with. The work will be planned together with a research group leader. The first two years are fully funded, with a possible extension within consultation with research group leaders and the department.

Deadline : 16.May.2022 

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(04) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoctoral Researcher in disabling occupational injuries – prevention

We are looking for two postdocs who will work in one or more research projects in disabling
occupational injuries (accident, illness or disability/discomfort caused by the work). The positions are advertised and appointed centrally, which means that the successful candidate together with Karolinska Institutet will find a suitable department and research group to work with. The work will be planned together with a research group leader. The first two years are fully funded, with a possible extension within consultation with research group leaders and the department.

Deadline : 16.May.2022

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(05) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoctoral researcher in stem cells and erythropoiesis in MDS

The MDS research group conducts translational research on myelodysplastic syndromes, with a particular focus on cellular and molecular pathways underlying aberrant stem cell function and ineffective erythropoiesis. The basis for most studies is molecularly annotated primary patient samples from our large MDS biobank from the MDS Clinic and clinical trials within the Nordic MDS Group. Recent studies from our group encompass Rasmussen, et al., Leukemia 2022, Bernard, et al, Nature Medicine, 2020, Elvarsdottir, et al., Leukemia 2020, Shiozawa, et al., Blood 2017, Mortera Blanco, et al., Blood 2017, Dimitriou, et al., Oncotarget 2016, Malcovati, et al, Blood 2015, Woll, et al., Cancer Cell 2014, Nikpour, et al. Leukemia 2013.  Projects are pursued within the frame of a major collaborative research grant from the Wallenberg Foundation and a large international network

Deadline : 15.May.2022

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(06) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoctoral Researcher in dementia epidemiology

You will join a multidisciplinary research team of doctors, epidemiologists, statisticians, machine learning researchers and engineers working to explore dementia and COVID-19, detect factors to prevent dementia, slow cognitive decline in patients with dementia, ensure high quality and equal access to dementia care throughout Sweden. We work in the SveDem group at the  Department of Neurobiology, Care Sciences and Society (Professor Eriksdotter’s group) and collaborate with the Department of Medical Epidemiology and Biostatistics (MEB, Campus Solna, Karolinska Institutet (Professor Johnell´s group)).

Deadline : 13.May.2022

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(07) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoctoral studies in developing novel spatial multi-omics techniques

The overall goal of the new project is to gain an increased understanding of the tumor microenvironment and the factors that affect how the patient responds to the (cytotoxic/x) treatment. In the long run, this can contribute to the development of individualized treatment protocols, based on spatial multi-omics analysis. In addition to these project-specific clinical goals, the study is an important piece of the puzzle in the long-term goal of demonstrating the benefits of multiplex immunofluorescence in tissue diagnostics in clinics and future precision medicine. Your role is to establish and validate the use of novel spatial multi-omics techniques in biopsies and cell lines from the pediatric tumour neuroblastoma. 

Deadline :  12.May.2022

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(08) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoctoral Researcher in neurological epidemiology

The position focuses on a research project on Parkinson’s disease (PD), which is the second most common neurodegenerative disease, with a prevalence in the population at about 2%. Much remains to be understood about its causes and underlying molecular pathology. Moreover, at present, therapeutics available for PD patients only offer symptomatic relief, and there are no known medications to prevent the disease’s onset, or slow or halt its progression. We are conducting a research program with three major aims:

1) to clarify what environmental exposures cause PD

2) to examine molecular pathways underlying PD development

3) to validate promising new therapeutic candidates for use in PD prevention and/or treatment

Your role includes participating in all parts of the scientific process; perform literature searches, plan studies, manage data, perform statistical analyses, and write manuscripts.

Deadline : 08.May.2022

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(09) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoctor in microbiome research with bioinformatics experience

As a postdoc in microbiome research, you will focus on analysis work concerning the role of the microbiome in several different projects all focusing on studying the microbiome and its interaction with the human host. A central component of the role is to assume responsibility for bioinformatics analysis work in assigned studies, e.g. establish analysis plans combining microbiome data with additional metadata such as omics-data, questionnaires, etc. in order to perform the analysis work in collaboration with other colleagues at CTMR and external research partners with the ambition to generate scientific publications. The successful candidate will be working in close collaboration with several different teams within CTMR such as clinical epidemiology, bioinformatics, wet lab, as well as external collaborators outside of CTMR. The working language is English.

Deadline : 06.May.2022

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(10) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Principal Researcher in cancer-related chromosome biology

The successful candidate is expected to establish and lead a research team towards novel discoveries within the subject area, and to disseminate these findings at the international arena in the form of scientific publications and presentations at national and international research conferences and seminars. Other included tasks are research development, recruitment, and management of personnel within the team, and fund raising. He/she should also teach and supervise graduate and undergraduate students, and actively participate in other departmental activities when called upon.

Deadline :  06.May.2022

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(11) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoctoral Researcher in Neuroscience

The project aims to define the role of neurons subtypes in the mouse striatum in emotion and cognition, including how disease progression in mouse models of Parkinson’s disease affect the function of circuits and neurons, using optogenetics and in vivo imaging of neuronal activity.

Deadline : 05.May.2022

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(12) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoctoral studies in systems biology of mRNA translation (scholarship)

This project is focused on understanding how mRNA translation is altered in cancer. Initially, multimodal data sets from large-scale studies will be used to delineate how mRNA translation is organized and how it interacts with other steps in the gene-expression pathway to control proteome composition. In the second step, the focus will be to identify mechanisms underlying this organization of mRNA translation and how these are altered in cancer. To this end, data sets from both in-vitro models and patient samples will be used.

Deadline : 05.May.2022

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(13) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoctoral studies of mRNA translation in cancer (scholarship)

This project is focused on understanding how mRNA translation is altered in cancer. Studies will include both in-vitro models and patient samples with the overarching goal of understanding mechanisms coordinating changes in mRNA translation, identification of drug targets for anti-cancer therapy and characterization of subsets of patients who may benefit from such therapy.

Deadline : 05.May.2022

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(14) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: ONE Postdoctoral Researcher in chemical and genetic screens

We are currently looking for a postdoctoral scientist to join our team with a Ph.D. in Cell Biology, Molecular Biology, Biochemistry, or other relevant fields. We are specifically looking for a highly motivated scientist that is looking to complement his/her skills with experience in large chemical and genetic screens, and that has the capacity to independently develop a scientific research project that relies mostly on cell and molecular biology technologies. In addition, it is expected that the candidate will help in the training of junior group members. Other valuable skills such as writing or presenting capacities or social skills will also be appreciated.

Deadline : 04.May.2022

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(15) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoctoral Researcher in human virology research

Our mission is to generate a better understanding of the details of pathogenesis and immunological events during tick-borne encephalitis infection, to aid in the development of specific treatment of patients. In particular, the postdoc will continue the line of investigations analyzing how tick-borne encephalitis virus impact immune cells, utilizing both in vitro experiments in BSL3-laboratory and multicolor flow cytometry of patient material.
The postdoc will be a part of the Center for Infectious Medicine (CIM), Karolinska Institutet, which is a nationally leading and internationally competitive center for human translational immunology and infectious diseases research. The center consists of approximately 25 graduate students and 25 postdocs organized around 15 independent research groups.

Deadline : 03.May.2022 

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(16) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Research specialist

As a Research Specialist, you will be overseeing NGS-based research projects that seek to understand how chromatin is spatially organized in the nucleus and how genome fragility underlies structural genomic variation.

Our ultimate mission is to understand how the complex higher-order structure of chromatin in mammalian cells is established during the cell cycle, how it is dynamically reshaped during cell differentiation, and how it is rewired during carcinogenesis.

Deadline :  03.May.2022

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(17) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Research Specialist in Biomaterials and Regenerative Medicine

The successful candidate will be involved in developing and contributing to translational projects at the interface between materials science, chemistry and biology. The candidate will work on the design and characterization of composite materials with controlled architecture, composition and biological activity of a range of healthcare applications and lead related small angle scattering research projects. The research specialist must be an expert in the design and characterization of a range of soft nanoparticle formulations, in particular lipid formulations, for diagnostic and drug delivery applications. The candidate will be offered extensive opportunities for collaborative work, both within KI and external to the group of Molly Stevens at Imperial College in London and other groups. 

Deadline :02.May.2022

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(18) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoctoral Researcher/The Strategic Research Programme for Diabetes (5)

We recently demonstrated that glutamine levels are lower in white adipocytes from obese compared to lean subjects and that this leads to white adipose tissue (WAT) inflammation (Petrus, Lecoutre et al, Cell Metabolism, 2020). Our new preliminary data in human and murine WAT, reveal that these changes are associated with decreased expression of Glutamine Synthase (GS, encoded by GLUL) and increased expression of glutaminase (GLS, encoded by GLS), the two enzymes governing glutamine metabolism. This suggests that glutamine turnover is a major determinant of adipocyte function. To further dissect the pathophysiological role of our observations in vivo, we have generated adipocyte-specific Gls and Glul knockout mice where we will study the effects of different perturbations on WAT and whole body metabolism. These analyses will be complemented by state-of-the-art mechanistic studies in human adipocytes in which we for instance will perform metabolic flux analyses following CRISPR/Cas9-mediated engineering of the glutamine pathway. Our project will allow the applicant to work with an array of methods in clinical translational research and provide unprecedented insights into the immunometabolic role of adipocyte glutamine turnover.

Deadline : 30.Apr.2022

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(19) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Research Specialist in suicide prevention

You will be working at the National Centre for Suicide Research and Prevention (NASP) as part of an international team that is focused on research in the field of mental health and suicide prevention. As Research specialist in the field of suicide prevention, you will:

  • Collaborate in several of our research projects, which involve the design, evaluation and implementation of suicide preventive interventions
  • Take coordination responsibility in specific projects
  •  Perform research support activities, such as writing ethical committee applications and drafting research reports to Swedish and International stakeholders
  • Contribute to the analysis and reporting of suicide statistics, in Sweden and internationally
  • Perform evidence reviews to provide evidence based answers to questions about suicide by policy makers and the general public
  • Draft and disseminate evidence based recommendations for suicide prevention

Deadline :  30.Apr.2022

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(20) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoctoral Researcher in Metabolic Engineering in RNA virus infection

The Systems Virology lab aims to identify the molecular mechanism of host-viral response against RNA viruses using multi-omics technologies and experimental assays. We aim to identify the components of the immune response that are required for natural immune protection and linked with disease severity that can be translated into the future development of vaccine and antiviral strategies against emerging and re-emerging viruses. The research team has both bioinformatics and experimental teams and works in an interdisciplinary research environment. The present postdoctoral position is towards understanding the host-viral interactions in RNA virus targeting HIV-1 and SARS-CoV-2 and developing antiviral strategies through metabolic engineering. The potential candidate is encouraged to look into the group website https://ki.se/en/labmed/the-systems-virology-lab

Deadline : 30.Apr.2022 

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(21) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoctoral Researcher/The Strategic Research Programme for Diabetes (4)

The postdoctoral project will focus on pharmacoepidemiological research and causal inference methods using data from national health, population and quality registers. The aim is to investigate the impact of socioeconomic factors on antidiabetic medications (ADM) use, discontinuation and type 2 diabetes (T2D) consequences such as cardiovascular diseases, kidney failure and retinopathy. The overarching purpose of the project is to identify differences in patterns of ADM use across socioeconomic groups, which will ultimately provide evidence for the development of targeted interventions for treatment management and guidelines increasing awareness about high-risk groups among the vulnerable population of T2D patients. The postdoctoral fellow will be supervised by the principal investigator Dr. Laura Pazzagli, supported by all members of the research team (including international collaborators) and other members of staff at the Centre for Pharmacoepidemiology (CPE) where the project will be conducted. CPE was established in 2005 and has become a dynamic research environment at the intersection of academia, healthcare, regulatory authorities and the pharmaceutical industry. CPE is one of the largest academic pharmacoepidemiology centres in Europe, with active Nordic, European and international collaborations.

Deadline : 30.Apr.2022

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(22) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoctoral Researcher in NK cell biology

The Malmberg Lab is located in Stockholm/Sweden and Oslo/Norway and currently consists of 24 people. We are now looking for a highly motivated post-doc with an interest in molecular immunology and experimental immunotherapy. The project concerns the spatiotemporal regulation of NK cell education with a particular focus on the cellular and molecular mechanisms that allow NK cells to translate receptor input into a “molecular memory” and how this is affected in the tumor microenvironment.  The studies involve basic molecular immunology with a strong translational component and is carried out in close collaboration with our industrial partner Merck and the Malmberg Lab at Oslo University Hospital. One goal is to develop in vitro assays to study NK cell tuning and use a variety of single-cell assays, including high-dimensional immune profiling by flow cytometry, single-cell indexed FACS-sorting and RNA Seq. The project also involves molecular biology/cloning, transient transfection / overexpression, retroviral and lentiviral transduction in mammalian cells. Additional tasks include gene-editing of primary NK cells / NK cell lines by CRISPR/Cas9, cytotoxicity assays, and qPCR. The postdoctoral fellow is expected to plan, execute, and analyze experiments in an independent manner and contribute scientifically to the group.

Deadline :  30.Apr.2022

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(23) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoctoral studies in Central Nervous System Regeneration after Spinal Cord Injury (scholarship)

Our lab investigates stromal scar formation and its impact on axonal regeneration and functional recovery following spinal cord injury. We discovered a new population of perivascular cells, called type A pericytes, as the source of fibrotic scar tissue (Göritz et al., Science, 2011) and identified pericyte-derived scar formation as a therapeutic target to achieve axonal regeneration and functional recovery following spinal cord injury (Dias et al., Cell, 2018). Recently, we showed that fibrotic scarring by perivascular cells is a conserved mechanism in the adult mammalian CNS (Dias et al., Nature Com., 2021). The intended project will test different strategies to interfere with fibrotic scarring to enhance axonal regeneration and functional recovery following spinal cord injury.

Deadline : 30.Apr.2022

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(25) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoctoral Researcher/The Strategic Research Programme for Diabetes (3)

Comorbidities of type II diabetes (T2D) are major health concerns worldwide, including peripheral artery disease (PAD). PAD lowers blood flow to the lower limb, causing muscle ischemia and dysfunction and reduced exercise tolerance. Functionality of limb skeletal muscle is a key component for determining morbidity and mortality risk in patients with PAD. Interventions that improve distal arterial pressures (ie. bypass surgery) generally fail to normalize the structural and functional abnormalities of muscles, which point towards pathophysiological mechanisms inside the skeletal myofibers that reduce overall muscle function. Despite serious muscle abnormalities, the field is lacking molecular understanding of PAD-induced muscle dysfunction. Here we aim to use a translational approach involving PAD patients and mouse models and state-of-the-art methods going from functional analyses to single cell profiling to illuminate molecular mechanisms underlying PAD-induced muscle pathophysiology. In the project, human skeletal muscle biopsies, as well as muscle from preclinical model, will undergo multiple assessments e.g., global transcriptomic analyses and single-cell profiling, histopathological analysis (electron microscopy, immunofluorescence), mitochondrial respiration, and contractility (force) measurements. Muscle cultures, isolated muscle fibers and in vivo models will be used for gain- or loss-of-function experiments to assess selected molecular candidates from the transcriptional analyses.  The expected outcome of this curiosity-driven project is detailed molecular understanding of intramuscular signaling and contractile function, which will yield substantial novel insights into PAD muscle pathology and identify targets for future therapeutic development. 

Deadline : 30.Apr.2022 

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(26) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoctoral Researcher in experimental psychology

You will be working at the National Centre for Suicide Research and Prevention (NASP) as part of an international team that is focused on research in the field of mental health and suicide prevention. As a postdoc you will design the protocols of the studies required by these projects, supervise their implementation, analyse quantitative data and lead the preparation of manuscripts reporting the findings. You will also offer scientific support and collaborate in work related to these projects such as participation and presentations in the technical project meetings, writing reports on the progress of the ongoing projects to the research Consortium, as well as assisting in project and financial management. 

Deadline : 30.Apr.2022

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About The Karolinska Institute, Sweden – Official Website

The Karolinska Institute sometimes known as the (Royal) Caroline Institute in English is a research-led medical university in Solna within the Stockholm urban area of Sweden. The Nobel Assembly at the Karolinska Institute awards the Nobel Prize in Physiology or Medicine. The assembly consists of fifty professors from various medical disciplines at the university. The current rector of Karolinska Institute is Ole Petter Ottersen, who took office in August 2017.

The Karolinska Institute was founded in 1810 on the island of Kungsholmen on the west side of Stockholm; the main campus was relocated decades later to Solna, just outside Stockholm. A second campus was established more recently in Flemingsberg, Huddinge, south of Stockholm.

The Karolinska Institute is Sweden’s third oldest medical school, after Uppsala University (founded in 1477) and Lund University (founded in 1666). It is one of Sweden’s largest centres for training and research, accounting for 30% of the medical training and more than 40% of all academic medical and life science research conducted in Sweden.

The Karolinska University Hospital, located in Solna and Huddinge, is associated with the university as a research and teaching hospital. Together they form an academic health science centre. While most of the medical programs are taught in Swedish, the bulk of the PhD projects are conducted in English. The institute’s name is a reference to the Caroleans.

 

 

 

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