26 Postdoctoral Fellowship at Saint Louis University, Missouri, USA

The laboratory of Dr. Liu at the Department of Biology, Saint Louis University, St. Louis, MO, USA, seeks two highly motivated postdoctoral researcher associates to study the structure and function of proteins involved in photophysics and photochemistry in both oxygenic photosynthesis, such as cyanobacteria and higher plants as well as anoxygenic photosynthesis (green sulfur bacteria, GSB). Candidates with training in molecular biology and structural biology, are encouraged to apply. Experience with protein expression and protein purification/isolation are required. Bioinformatics and structural modelling are also desirable. Additional qualifications include effective writing and communication, strong
problem solving and critical thinking, and ability to work both independently and collaboratively within a multidisciplinary and interactive research environment.

This Postdoctoral Fellow position is in the organometallic chemistry research group led by Dr. Malkanthi Karunananda in the Department of Chemistry (Department of Chemistry : SLU). The successful applicant will develop transition-metal-based catalytic systems for applications in polymer upcycling and photocatalytic organic transformations. Additional work duties include design of new molecules, data analysis, analytical characterization, purification, maintaining lab equipment, and mentoring/training graduate and undergraduate student researchers.

The Ferris lab at Saint Louis University in St. Louis, MO, is seeking a full-time postdoctoral research associate in the fields of tumor immunology and autoimmunity. We study the dendritic cells required to mount adaptive T cell responses in the context of tumors and autoimmunity to better understand tumor evolution and identify novel therapeutic strategies that can improve patient outcomes. The successful candidate will be highly motivated and intellectually invested. They will have the opportunity pursue their own ideas that are relevant to the overall goals of the lab and drive their own research projects.

Who is Saint Louis University? Founded in 1818, Saint Louis University is one of the nation’s oldest and most prestigious Catholic universities, with campuses both in St. Louis and Madrid, Spain. SLU is recognized for world-class academics, life-changing research, compassionate health care, and a strong commitment to faith and service.

An immediate postdoctoral position is available in the lab of Gucan (Gabriel) Dai at the Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine. We are seeking candidates with a solid publication record in biophysics and biochemistry, specifically in the field of ion channels or membrane proteins. Prior experience in patch-clamp electrophysiology or fluorescence cell imaging using advanced fluorescence microscopy techniques is highly preferred. The Dai lab focuses on investigating the fundamental mechanisms underlying ion channels of excitable membranes, employing a multidisciplinary approach that combines structural biology, chemical biology, genetics, fluorescence microscopy, and electrophysiology. Notably, our lab is equipped with a state-of-the-art frequency-domain fluorescence lifetime imaging microscopy, which is the only one of its kind in the state of Missouri.

The Taylor Geospatial Institute (TGI), the nation’s leading academic center for geospatial science, is committed to making St Louis a global center of excellence in geospatial science research, education, and innovation. The St. Louis region is well-positioned to become the nation’s geospatial ‘Silicon Valley’ as laid out in the June 2020 “GeoFutures Strategic Roadmap,” a plan for strengthening St. Louis’s competitive advantage in geospatial research and technology. For more information on the Institute please visit www.taylorgeospatial.org. To achieve this goal, the Taylor Geospatial Institute is announcing a Postdoc program that is designed to support local faculty in their research projects in core geospatial science and applied domains (www.taylorgeospatial.org/research/). The Taylor Geospatial Institute envisions building a world-class, interdisciplinary geospatial science research collaborative to address scientific and societal grand challenges (e.g. food security, supply chain resilience, health equity, and national security). The purpose of the Taylor Geospatial Institute postdoctoral program is to bring distinguished researchers in geospatial science core or adjacent fields to the St. Louis region, develop the next generation of scientific leaders, and catalyze regional collaboration to accelerate the St. Louis region’s development as a global geospatial center of excellence. This program is another step to demonstrate our commitment to advancing the geospatial sciences.

NIH funded postdoctoral positions are available to study the structural enzymology of proteins responsible for blood coagulation (https://biochem.slu.edu/faculty/dicerawp/) with the goal of unraveling the molecular architecture and mechanism of the underlying interactions. The approach uses a combination of conventional (rapid kinetics, protein engineering, X-ray crystallography) and innovative (smFRET, cryo-EM) biophysical techniques. Current projects in the lab focus on the interaction of prothrombin with prothrombinase, leading to generation of thrombin and blood clotting, the activation of factor V required for assembly of prothrombinase and the interaction of the thrombin-thrombomodulin complex with protein C that halts the coagulation response. Additional studies focus on factor V short and its interactions with TFPIalpha, protein S and factor Xa and on proteins of the contact pathway like factors IX, XI and XII. Experience in rapid kinetics, smFRET, X-ray crystallography, NMR, or cryoEM is required.

This NIH-funded position focuses on investigating cancer biology. The postdoctoral fellow will be expected to work with cell culture system ; perform animal (mouse) work; contribute to the overall design, implementation, analysis, and presentation/publication(s) of this project with opportunities available to initiate additional research projects as appropriate. 

The Alspach lab at Saint Louis University in St. Louis, MO, is seeking a full-time postdoctoral research associate in the fields of tumor immunology and sex disparities. We study the impacts of biologic sex on anti-tumor T cell responses to better understand tumor evolution and identify novel therapeutic strategies that can improve patient outcomes. The successful candidate will be highly motivated and intellectually invested. They will have the opportunity pursue their own ideas that are relevant to the overall goals of the lab and drive their own research projects. Dr. Alspach is an Assistant Professor in the Department of Molecular Microbiology and Immunology. MMI houses a diverse variety of research groups studying virology and innate and adaptive immune responses in the context of viral infection, cancer, and autoimmunity. MMI is a highly collaborative community, meaning the successful candidate will have the opportunity to form relationships with many different laboratory groups and faculty members.

A postdoctoral position is available immediately in the laboratory of Dr. Amina Mohammadalipour at Saint Louis University, St. Louis, MO. Alipour lab combines biophysics, mechanobiology, structural biology, membrane proteins, and genetics to understand the fundamental mechanisms underlying cancer cells’ rheological properties. Past experiences with cell culture, flow cytometry, fluorescence microscopy, and live imaging are required. Experiences in micropipette aspiration, AFM, flow chambers/microfluidic devices, Western blotting, and PCR are preferred but not required. Applicants should apply through the Saint Louis University website or directly contact Dr. Alipour at [email protected], submitting a single PDF consisting of a cover letter, a CV, and the contact information of two references. Review of applications will begin immediately and continue until the position is filled.

The Cifarelli Lab at SLU School of Medicine is seeking a motivated postdoc to work on a NIH funded project examining the role of lipids in vascular and lymphatic endothelial cell biology and its connection to gastrointestinal health and inflammation. Candidates must have a PhD or MD with an interest in cellular/molecular cardiovascular or gut research. Eligible candidates should email a CV including publications and the names of 3 professional references, and a brief statement of research with career plan to [email protected]

A postdoctoral position is immediately available for an exceptionally motivated and creative individual in the laboratory of Dr. Anutosh Chakraborty at Saint Louis University, Missouri. Using a system biology approach, the Chakraborty lab aims to understand molecular mechanisms that regulate the development and progression of obesity, insulin resistance, and NAFLD/NASH. Prior work from the lab established that the enzyme inositol hexakisphosphate kinase-1 is a target in metabolic diseases. The current focus is to define the functions of a novel ubiquitin ligase, Ube4A, in these diseases, using knockout mouse models and pharmacologic tools. The postdoc will be primarily responsible to perform various injection procedures and perfusion in mice and collect tissues from those animals. Moreover, he/she will be determining the impact of deletion and overexpression of Ube4A on the metabolism and survival of hepatocytes and identifying/validating ubiquitination targets of this ligase in these processes. The person will also be expected to work with the lab manager to maintain mouse colonies and develop mouse models of obesity and NAFLD/NASH. Candidates with a solid background in mouse models of obesity/NASH, cell biology, molecular biology, and biochemistry, evidenced by a strong publication record in these areas, are encouraged to apply. The position is supported by a recently funded NIH-R01 grant.

The Postdoctoral Fellow will assist the Principal Investigator. The incumbent will conduct research and ensure that all experiments are appropriately conducted following the policies and procedures of Saint Louis University. Dr. Ranjit Ray’s laboratory conducts basic science research on Hepatitis C virus. A PhD in immunology or related field is required.

Saint Louis University, dedicated to student learning, research, health care, and service, is seeking applicants for a Postdoctoral Fellow in Dr. Jianguo Liu’s lab in the Departments of Internal Medicine and Molecular Microbiology and Immunology. Tuberculosis (TB) remains a leading health problem worldwide. The lack of highly effective preventive vaccine, the emergence of drug-resistant strains, and an epidemic in HIV patients make TB a worsening threat. Host-directed therapy (HDT) is a promising approach for treating drug-resistant TB. This NIH-funded position is to investigate the host protective immune mechanisms and develop new HDT against Mycobacterium tuberculosis infection. Postdoctoral position is available immediately for researchers (Ph.D., D.V.M. or M.D.) with strong background in molecular biology and immunology. Previous experience in TB research is desired.  

 

(18) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoctoral Research Associate

Deadline : Open Until Filled

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NIH-funded postdoctoral positions are available for highly motivated postdoctoral fellows to join the laboratory of Dr. Aubin Moutal, in the Department of Pharmacology and Physiology at St Louis university to study novel proteins involved in chronic pain in the context of autoimmunity. Our work focuses on first identifying determinants of the transition from acute to chronic pain by reverse translating clinical findings to then perform a complete mechanistic characterization of how these new factors influence chronic vs physiological pain. The PI has a strong record of high impact papers with multiple recent publications in Science Translational Medicine, Pain, and PNAS. Through the active external collaborations with the New York University (Dr. Rajesh Khanna), the University of Arizona (Dr. Frank Porreca) and with the Institut neuromyogene (Dr. Jérôme Honnorat) in France, the candidate will also grow an interest in ion channel regulation, central mechanisms of pain and paraneoplastic syndromes, respectively. 

Saint Louis University, a Catholic, Jesuit institution dedicated to student learning, research, health care, and service is seeking applicants for a postdoctoral fellow position in the Department of Pediatrics, Division of Medical Genetics.  The candidate will join a dynamic, interdisciplinary team that uses cell biology, protein engineering, biochemistry, human immunology and molecular biology techniques to understand lysosomal dysfunction in rare genetic disorders. The successful candidate must be highly motivated with extensive experience within one or more of the following areas: single cell sequencing, cell culture, pharmacokinetics, pharmacodynamics, organelle, and cell/molecular biology, while experience with advanced imaging techniques is advantageous. We are particularly interested in candidates with experience in lysosomal biology.  The candidate is expected to conduct independent lab work and have a strong record of scientific productivity.   He or she should be able to think critically about complex problems and contribute to a team-working environment to advance research projects.

The Postdoctoral Fellow will assist the Principal Investigator. The incumbent will conduct research and ensure that all experiments are appropriately conducted following the policies and procedures of Saint Louis University. Our lab has had continuous NIH funding and we also collaborate with industry partners and foundations. Using a highly translatable short bowel syndrome (SBS) model, our lab is advancing strategies to mitigate serious complications and provide key insights into drivers of injury in SBS and its mitigation with a novel system. We are investigating key pathways along the gut-systemic signaling axis. We have also developed a novel machine to keep alive livers and are using this system to interrogate underlying biology of ischemia-reperfusion (IR) and to test therapeutic targets to mitigate IR mediated injury. Our other projects involve developing an organoid model system to test FXR and TGR5 signaling pathways, modulation of the gut-microbiota to assess its impact on systemic signaling, evaluating non-invasive biomarkers for liver transplant rejection and several lipidomic, metabolomic and transcriptomic based approaches.

The Postdoctoral Fellow will be expected to pursue high quality scholarship and collaborate with faculty in economics, finance, and other disciplines across campus to conduct research in areas related to urban economics, regional economics, transportation economics, economic development, economics of education, or public policy. This will involve data preparation and cleaning, spatial econometric data analysis and related programming, co-authorship of scholarly research papers. Through the newly established Taylor Geospatial Institute, Saint Louis University is currently building an ambitious research agenda in Geospatial Science. The Sinquefield Center for Applied Economic Research (SCAER) is an integral partner in this university-wide strategic plan. Researchers associated with the Center are making extensive use of large spatial datasets for economic, business, and public policy research.

A postdoctoral position is available immediately in the lab of Gucan “Gabriel” Dai at the Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine. Candidates with a strong publication record in biophysics and biochemistry in ion channels or membrane proteins are encouraged to apply. Past experiences in patch-clamp electrophysiology or fluorescence cell imaging using advanced microscopy are preferred but not required. The Dai lab combines structural biology, chemical biology, genetics, fluorescence microscopy and electrophysiological methods to understand the fundamental mechanisms underlying ion channels of excitable membranes. The candidate is expected to publish high-impact papers as a lead author and apply for academic faculty positions or leadership positions in industry after receiving this training. The research directions in the lab are summarized in below. Applicants who are interested in this position should contact: [email protected] 

Our NIH-funded laboratory is seeking an enthusiastic postdoctoral fellow to study the immunological response and pathogenesis of viral infections. Laboratory studies are focused on the understanding of the antigen specific B cell response to infection and vaccination and how this B cell response is reflected in the polyclonal antibody response. Our laboratory uses in vitro and in vivo approaches to understand infection and disease.  Techniques include cloning and molecular biology, biochemistry, cell/tissue culture, flow cytometry, transcriptomics, and mouse models of infection. Experience in one or more of these techniques and areas is strongly preferred. You will be provided with the mentorship and resources to be successful.

Saint Louis University, a Catholic, Jesuit institution dedicated to student learning, research, health care, and service, is seeking applicants for a postdoctoral fellow in the Edward A. Doisy Department of Biochemistry and Molecular Biology, beginning in the spring of 2020.  A postdoctoral position is now available in the laboratory of Dr. Kyle McCommis. Successful candidates are expected to have a doctoral degree in a life sciences-related field, with research experience in molecular biology and/or animal physiology. The laboratory of Dr. Kyle McCommis focuses on the importance of mitochondrial metabolism in the pathogenesis and treatment of metabolic diseases such as heart failure and nonalcoholic fatty liver disease. Projects will combine in vivo animal physiology and pathology, isolated primary cell and immortalized cell cultures, as well as biochemical and molecular biology techniques. Applicants should be highly motivated, be able to think critically, and demonstrate productivity throughout previous research experiences.Compensation will be based on experience, according to the NIH pay scale. Interested candidates must submit a cover letter, application and current curriculum vitae to http://jobs.slu.edu. Saint Louis University is an Affirmative Action, Equal Opportunity Employer and encourages nominations of an application from women and minorities.