33 Postdoctoral Fellowship at Karolinska Institute, Sweden

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

This project is focused on understanding how mRNA translation is altered in cancer. Initially, multimodal data sets from large-scale studies will be used to delineate how mRNA translation is organized and how it interacts with other steps in the gene-expression pathway to control proteome composition. In the second step, the focus will be to identify mechanisms underlying this organization of mRNA translation and how these are altered in cancer. To this end, data sets from both in-vitro models and patient samples will be used.

During the development of obesity and insulin resistance, ectopic lipid accumulation occurs in various organs. In the liver, such condition is called non-alcoholic fatty liver disease (NAFLD), which can progress to more severe stages, such as non-alcoholic steatohepatitis (NASH), cirrhosis, and/or hepatocellular carcinoma. Liver fibrosis is the most important predictor of prognosis in NAFLD patients. In this project, we will focus on NAFLD and develop an innovative non-invasive machine learning model to monitor the real-time disease progression and future risks of NAFLD patients. The tools developed here will allow patient subgroup stratification at a high resolution and further investigate how the immune system is functional in high-risk NAFLD patients during their longitudinal disease progression.

The postdoctoral position will include involvement in projects regarding mitochondrial functions and endoplasmic reticulum-mitochondria interplay in neurodegenerative disorders. The postdoc will be involved in all parts of the projects ranging from planning and performing experimental work to project and data management, and dissemination of results.

The successful candidate will conduct the research with a special focus on deciphering molecular pathways mediating leukemic stem cell interaction with their niche under the supervision of the group leader (Dr. Hong Qian). In addition, the candidate is expected to participate in several collaborated project throughout her/his postdoc training. Further, the candidate is expected to participate in supervision of junior students in the group.

I forskningsprogrammet ”Patienten i förarsätet” på Medical Management Centrum får du en unik möjlighet att samarbeta med forskare inom diverse discipliner (t.ex. implementering, management, hälsoinformatik, patientforskning), samt patienter och närstående som driver hälsoinnovationer (s.k. patientdrivna innovationer). Syftet med forskningsprogrammet är att utifrån fem patientdrivna innovationer studera hur nya samvårdsmodeller (där aktiviteter genomförs i samverkan mellan patienter, närstående och vårdpersonal utifrån patienternas mål och prioriteringar) bäst kan implementeras i rutinsjukvård och i patienternas dagliga liv. I våra forskningsprojekt utvecklar och testar vi även nya rutiner för samskapande forskning mellan individer med olika erfarenheter och kompetenser.   

The Kallioniemi group is a creative and inspiring environment full of expertise and curiosity where each researcher has the possibility to develop individually as well as in a team. Our host university Karolinska Institutet (KI) vision is to pursue the development of knowledge about life and to promote better health for all. At KI, we conduct successful medical research and hold the largest range of medical education in Sweden. KI is a state university, which entitles to several benefits such as extended holidays and a generous occupational pension. Employees also have access to our modern gym for free and receive reimbursements for medical care.

The successful candidate, will together with members of the research group, study and examine how tumour suppressor responses can be activated in healthy and malignant brain stem cells.

The successful candidate will work together with members of the research group and examine how tumour suppressor responses can be activated in healthy and malignant brain stem cells. The work will include molecular analyses of key regulatory networks as well as studies of tumour stem cells both in vitro and in relevant tumour models in mice.

Accumulating evidence reveals that RNA plays a key role in the regulation of DNA repair and genome stability. However, the underlying mechanism(s) remains poorly understood. The postdoc will perform research focused on RNA biology and DNA repair employing human cell lines as model system, including cells from patients with dyskeratosis congenita disorder. This project is designed not only to elucidate novel mechanisms underlying the regulation of genome stability via RNA, but also to provide new insights into the pathogenesis and treatment of associated diseases. A better understanding of the function and regulation of RNA in connection with DNA repair may pave the way for novel anti-cancer therapies based on restoring or blocking specific RNAs.

En kreativ, internationell inspirerande miljö fylld av kompetens och nyfikenhet. Karolinska Institutet är ett av världens ledande medicinska universitet. Här bedriver vi framgångsrik medicinsk forskning och har det största utbudet av medicinska utbildningar i Sverige. På KI får du träffa forskare med olika forskningsinriktningar som jobbar tillsammans. Det är det gränsöverskridande samarbetet som bidrar till KI:s världsledande position inom forskning. Flera av de personer du möter inom vården är utbildade på KI. En nära relationen till hälso- och sjukvården är viktig för att skapa utbildning och forskning av högsta kvalitet. Som universitet är Karolinska Institutet också en statlig myndighet. Det gör att du som anställd får goda förmåner genom vårt kollektivavtal.

Our group combines experimental and computational work, and aims to develop and apply novel genome-wide techniques to address fundamental biological questions with medical implications. We are especially interested in how subtle variations in gene expression can lead to differential cellular phenotypes (http://pelechanolab.com/). You will have the opportunity to work in a highly interdisciplinary and international environment and combine the development of state-of-the art genome-wide approaches with the molecular dissection of fundamental biological problems.

To study the role of mitochondrial dysfunction in Parkinson’s disease (PD). PD is a common neurodegenerative disorder caused by the preferential loss of dopamine-producing neurons in the Substantia nigra of the midbrain. Growing evidence indicates that mitochondrial dysfunction is heavily implicated in both sporadic and familial forms of the disease, although the underlying molecular mechanisms remain unclear. Our research aims to unravel how mitochondrial fitness is involved in PD pathophysiology and in the maintenance of dopamine neurons by employing a broad set of biochemical and molecular analyses, cutting-edge technologies, and genetically modified mouse models.

 

(18) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title:    Postdoctoral Researcher in molecular infection biology

Deadline :  09.Mar.2023

View details & Apply

 

Our research group has enrolled in an academia-industry collaboration with government-operated gambling provider Norsk Tipping – a gambling monopoly with approx. 2 million customers, offering both online and traditional gambling – to do independent research on how gambling habits changed during the COVID-19 pandemic. Researchers at the University of Bergen and at Stockholm University are additional academic partners. We are now looking for a postdoctoral researcher for this two-year project, with the possibility of an extension. As a postdoc, you are expected to plan and take primary responsibility for carrying out five-six planned studies on this topic. This includes:

Documented experience of epidemiological studies is required for the position. Experience of working with large databases of register and/or survey data as well as analyses in, e.g., SAS, STATA, SPSS, or R, are meriting for the position. Experience of working with nationwide Swedish registers and research within the insurance medicine area are particularly meriting. Good knowledge of spoken and written English is essential, and knowledge of Swedish is meriting. The applicant should show a high degree of conscientiousness, initiative, and independence. The work will be conducted in collaboration with the PI and other project members, and places high demands on flexibility and good collaborative abilities.

Anställningen är placerad i Yvonne Wengströms forskargrupp i olika kliniska interventionsstudier som syftar till att förstå effekterna av träning på hälsa för patienter med olika cancerdiagnoser. Forskargruppen har omfattande nationella och internationella samarbeten. Under perioden som postdoktor ingår arbetsuppgifter såsom studiedesign, rekrytering av studiedeltagare, att genomföra träningsutvärdering/testning, insamling av data, datahantering och analys samt att rapportera resultat av studierna. Ansvar ingår även för att skriva etikansökningar, manuskript och projektansökningar, att handleda forskarstudenter samt samarbete och deltagande i nätverk inom och utanför akademin. Anställningen avser två år motsvarande 100 % av heltidsanställning, med eventuell möjlighet till ett års förlängning. För sökande med intresse för undervisning på grund- och avancerad nivå och med relevant kompetens finns möjlighet att kombinera anställningen som postdoktor med adjunktstjänst på Avdelningen för omvårdnad eller med kliniskt arbete i Tema Cancer, Karolinska Universitetssjukhuset.

En kreativ och inspirerande miljö fylld av kompetens och nyfikenhet. Karolinska Institutet är ett av världens ledande medicinska universitet. Vår vision är att driva utvecklingen av kunskap om livet och verka för en bättre hälsa för alla. Här bedriver vi framgångsrik medicinsk forskning och har det största utbudet av medicinska utbildningar i Sverige. Som universitet är Karolinska Institutet även en statlig myndighet. Det innebär att du får goda förmåner genom vårt kollektivavtal, generös semester och en bra tjänstepension. Du får träna fritt i våra moderna friskvårdsanläggningar och får ersättning för läkarvård.

The postdoc will be placed in the Lung Cancer team headed by Associate Professor Lukas Orre. The team is embedded in the larger research group Cancer Proteomics Mass Spectrometry led by Professor Janne Lehtiö and located at Science for Life Laboratory (SciLifeLab). The overall aim of this research group is to generate and investigate multi-omics tumor data in a translational setting to improve cancer treatment. The group members are from various disciplines working as a team to study genes and proteins in the context of biological networks. The generated knowledge is used to improve our understanding of how molecular changes in a tumor impact the proteome, and to discover new disease biomarkers for prediction of therapy response.

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

The postdoc education will focus on applying experimental methods on biologically/clinically relevant research questions and on analyzing the acquired data followed by validation and expansion on the findings using public domain data. The research will include mechanistic investigation of the biology behind different lung cancer subgroups, experimental testing of the predicted novel therapeutic strategies in model systems, and the development of strategies to use the generated information to guide future therapy selection in lung cancer. The PostDoc/s will, together with a multi-disciplinary team of scientists, plan, perform and analyze proteomics and molecular biology experiments, with the aim to understand the biology of lung cancer subgroups in context of improving lung cancer treatment. More specifically, this includes both applying our in-house developed proteomics methods as well as setting up targeted molecular biology methods for mechanistic investigation and validation of specific findings. Targeted investigations will include both generation and application of genetic models, e.g., through knock-out/silencing or overexpression of genes, as well as drug sensitivity testing. Experimental design and statistical analysis of the quantitative data are important components of the work, and it is expected that the applicant is acquainted with software related to omics data analysis.  

The present position is based on a project aiming to increase our knowledge concerning the dietary determinants of geriatric syndromes. Geriatric syndromes (e.g. multimorbidity, frailty, malnutrition, pain,) are one of the major contributors to ill health among older adults. Contrary to what is the case for most pharmacological interventions, key health-related behaviours, such as maintaining adequate nutrition, could potentially exert powerful influences on these conditions and reduce the risk of death. Nevertheless, the dietary determinants of geriatric syndromes have seldom been researched in depth, which precludes the design of interventions to palliate the expected increase in age-associated health and social needs in the coming decades. Taking advantage of the well-characterized population-based Swedish National Study on Aging and Care in Kungsholmen (SNAC-K), we aim to fill some of these knowledge gaps putting geriatric syndromes and the biological mechanisms of aging at the centre, and studying them through the lens of dietary patterns, foods and nutrients.

We will employ studies involving in-vitro experimentation, enzyme kinetics, and ex-vivo set-up to study the effect of certain modulators on NGF activity and stability. Using preclinical animal models of AD, we will assess the effect of different therapies targeted to treat AD and evaluate NGF related parameters to evaluate its potential as a biomarker. We will also evaluate the effect of AD treatment on NGF status using clinical samples to evaluate the accuracy of our preclinical data. We also have ongoing interest in developing nano-systems for drug delivery and diagnostics. 

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

We have an opening for 1-2 postdoctoral scholarships to this translational and multidisciplinary research team with the overarching aim to understand the role of oxylipin lipid mediators in the health-to-disease transition. Focus will be placed upon oxylipins produced from polyunsaturated fatty acids, including octadecanoids, eicosanoids, and docosanoids in atherosclerotic cardiovascular disease. The research scope will include applying existing mass spectrometry-based methods as well as developing new protocols to quantify specialized pro-resolving lipid mediators (SPMs) and related molecules. Analyses will involve applying these methods in both clinical samples and experimental models to map the biochemical role of oxylipins in health and disease. These data will be used in the overall project aim to draw a personalized blueprint of chronic inflammation in the health-to-disease transition, map the lipid immune landscape, and understand the role of lipids in maintaining an individual’s cardiovascular health.

We have an opening for 1-2 individuals wishing to join this translational and multidisciplinary research team with the overarching aim to understand the role of oxylipin lipid mediators in the health-to-disease transition. Focus will be placed upon oxylipins produced from polyunsaturated fatty acids, including octadecanoids, eicosanoids, and docosanoids in atherosclerotic cardiovascular disease. The research scope will include applying existing mass spectrometry-based methods as well as developing new protocols to quantify specialized pro-resolving lipid mediators (SPMs) and related molecules. Analyses will involve applying these methods in both clinical samples and experimental models to map the biochemical role of oxylipins in health and disease. These data will be used in the overall project aim to draw a personalized blueprint of chronic inflammation in the health-to-disease transition, map the lipid immune landscape, and understand the role of lipids in maintaining an individual’s cardiovascular health.

The ideal candidate is highly motivated, with an outstanding completed PhD thesis (or equivalent) and a strong drive for a future career in research. The candidate should be capable of generating novel ideas, acquire knowledge independently and have a strong background in molecular biology. Experience in RNA-biology, mRNA translation or similar subjects is an advantage. Fluency in spoken and written English is required. At least one published paper in a high quality international peer-reviewed journal is necessary to be considered and additional academic merits are also considered. In addition, personal suitability will be a factor in the selection process.

We look for two postdoctoral fellows interested in developing precision cell replacement strategies for Parkinson’s disease based on cell engineering. Our laboratory has previously provided proof of concept that the conversion of somatic cells into midbrain dopamine neurons in vivo can rescue motor deficits in a mouse model of PD (Rivetti di val Cervo, 2017, Nature Biotechnology). Expanding on our previous single cell RNA-seqeuncing analysis of the developing human midbrain (La Manno et al., 2016, Cell), we have recently identified a number of factors important for the development and maintenance of adult DA neuron subtype identity (bioRxiv 2022.10.24.513487 and 2022.10.12.511898). We now aim at engineering somatic cells into subtype-specific DA neurons in order to develop more precise cell replacement strategies for Parkinson’s disease.  

The advent of high-throughput technologies has produced an avalanche of omics data and revolutionized medical research. Our research aims at developing and applying computational and statistical methodologies for analyses of multi-omics data from complex human diseases. The successful postdoctoral candidate will collaborate closely with our team members and external collaborators to analyze different omics-data for discoveries of biomarkers in cancers and rare diseases using statistical methodologies and bioinformatics tools. The candidate will be a part of the Department of Medical Epidemiology and Biostatistics (MEB), which is among the largest departments of epidemiology in Europe. The candidate will work with Dr. Trung Nghia Vu and Professor Yudi Pawitan on the research projects.