47 Postdoctoral Fellowship at National Institutes of Health (NIH), USA

A postdoctoral position is available in the Inflammation and Tumorigenesis section headed by Yinling Hu Ph.D. in the Cancer Innovation Laboratory, CCR, NCI, Frederick, MD 21701. This research laboratory is studying inflammation- and infection-associated skin, lung, and esophageal cancer by using multidisciplinary approaches including single-cell RNA sequencing, RNA-seq, gene expression regulation, lipidomics, glucose metabolism, tumor-associated microbiota, analysis of human cancer genomic alterations, genetically engineered mouse models, and cellular and biochemical methods (PMID 35121655 PNAS; PMID 28407484 Cell Host Microbe; PMID 23597566 Cancer Cell). This position requires a Ph.D degree and the preferred experience of cancer research, animal work, immunology, and bioinformation. This is a great opportunity to join an exciting basic and translational cancer research.

The Division of Intramural Research (DIR) at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) is seeking to recruit an outstanding Staff Scientist to join The Section on Mammalian Development and Evolution. The candidate should have a strong track record of achievements in molecular/developmental biology, mouse genetics, and genomics. The candidate should have experience with the analysis of next generation sequencing data and possess computer programming skills (including Python, R). The ideal candidate would also have experience with chromatin biology and mammalian germ-line development.

The NIH Department of Bioethics, in collaboration with the National Institute on Minority Health and Health Disparities (NIMHD), welcomes applications for one postdoctoral position in the new focus area of the Department, health disparities and ethics. The postdoctoral fellow will primarily work with Dr. Yukiko Asada conducting research on concepts, measurement, and public dialogues related to health disparities, inequalities, and inequities, through conceptual and empirical analyses. Empirical investigations involve both quantitative and qualitative methods, with a strong emphasis on the intersection between ethics and quantitative methods. The postdoctoral fellow will have opportunities to collaborate with other investigators in the Department of Bioethics and the NIMHD and will be integrated with training offered with in the NIH Bioethics Fellowship program. This is a full-time, annually renewable appointment. The position is open for both domestic and foreign nationals. Salary will be set according to federal agency policies.

The Frank Laboratory in the Clinical Center and National Institute of Biomedical Imaging and Bioengineering, NIH is accepting applications for a two-three-year post-doctoral fellowship position for highly motivated, independent, hands-on innovative Ph.D., M.D., or MD/Ph.D. candidates with Therapeutic Ultrasound (TUS) including focused ultrasound (FUS) and low-intensity pulsed ultrasound (LIPUS), Biomedical Engineering, Cancer Immunotherapy or related backgrounds to enter into an exciting new area of research that enhances cellular therapy by using FUS or LIPUS to alter the tumor microenvironment leading to the treatment cancer. The pre-clinical research focuses on understanding the molecular effects of TUS in tissues and organ systems and combining Cellular Therapies (Stem Cells, Genetically Engineered Cells, T-cells) coupled with TUS approaches serving as an adjuvant to target and treat malignancy. We are exploring several experimental model systems as well as exploring the effects of drug-host interactions on cellular therapy and serving as proof of concept of TUS to facilitate innovative cell therapy strategies.

A postdoctoral fellow position is available in the laboratory of Dr. Yuichi Machida in the Developmental Therapeutics Branch (DTB), NCI-NIH to study DNA repair mechanisms and their effect on anti-cancer drugs. Dr. Machida’s research focuses on proteases involved in the repair of DNA-Protein Crosslink (DPC) damage. The successful candidate will study proteolytic DPC repair mechanisms using molecular and cellular biology techniques as well as mouse genetics. To learn more about the research in the Machida lab,

A postdoctoral fellow position is available in the laboratory of Dr. Chongyi Chen at the National Cancer Institute (NCI), National Institutes of Health (NIH). The potential projects are to investigate the dynamics and regulation of DNA topology upon mitotic chromosome condensation, and to investigate the role of DNA topology in gene expression regulation in human cells. The Chen lab study chromatin structure, DNA topology, and gene expression regulation in human cells, by various genomic technologies and single-cell sequencing assays newly invented in the lab. For more information about the lab and the PI, 

We are recruiting a post-doctoral fellow to join us in our study of adipose tissue physiology in the Diabetes, Endocrinology, and Obesity Branch, NIDDK, NIH, in Bethesda, MD. With the report by our group that human brown adipose tissue (BAT) is a functional organ (NEJM 2009;360:1507), we have built a lab-based platform to understand the underlying human brown and white adipocyte physiology and to translate the discoveries back into clinical trials (JCI 2020;130:2209 and JCI Insight. 2021;6:e139160).

We are currently seeking two postdoctoral researchers to develop and apply innovative, robust, and scalable methods for: Visualizing and modelling temporal and spatial high-dimensional single-cell data, Network Analysis in mixtures and Integration of molecular and pathological features to study tumor progression or drug response. However, research topics are not limited to the above, and candidates with different topics of interest are encouraged to apply. We are particularly interested in candidates who are also passionate about systems biological applications, can implement and document these methods following good software engineering practices, benchmark these methods against existing baseline approaches e.g. using simulations, apply these methods to diverse datasets, document and present progress and results in written or oral reports to other lab members or collaborators and prepare manuscripts and external presentations for publication and conferences.

The RNA Viruses Section of the Laboratory of Infectious Diseases, NIAID, has strong basic and translational research programs for pediatric respiratory viruses (human respiratory syncytial virus, human metapneumovirus, and human parainfluenza viruses). Viral biology and host responses are studied in vitro and in animal models (including rodents and nonhuman primates), in pediatric clinical trials of live-attenuated vaccines in collaboration with industry, and in adult controlled-infection studies. We seek a highly motivated postdoctoral researcher interested in molecular virology, live viral vaccine development using “reverse genetics,” and studying the host response to respiratory virus infection and vaccines. The laboratory provides a rich training environment in virology, immunology, molecular and cellular biology, with access to cutting-edge scientific techniques, such as advanced flow cytometry, NextGen and single-cell sequencing.

The Translational Geroproteomics Unit (TGU) is seeking a highly motivated, and enthusiastic postdoctoral fellow to tackle important questions in aging biology using mouse models. This fully funded postdoctoral fellowship will be mentored by Dr. Nathan Basisty, and comes with to a highly interactive, resourceful, and dynamic scientific environment at the NIH, including state-of-the-art mouse facilities, advanced mass spec expertise, and ample opportunities for training and career development. The NIH and the TGU are dedicated to building a diverse community in its training and employment programs and are committed to creating and maintaining an environment that is welcoming, safe, accessible, and uplifting to ALL individuals. We encourage and welcome applications from individuals from underrepresented backgrounds.

A postdoc position is available in the laboratory of Dr. Rodriguez in the Single Cell Dynamics group, Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, NIH in Research Triangle Park, North Carolina. We are interested in eukaryotic gene regulation and how environmental stimuli regulate the single cell estrogen response. Our long-term goal is to understand how heterogeneity in the hormone response contributes to disease. The lab uses a variety of imaging and sequencing approaches including live cell single-molecule microscopy. Projects include understanding how enhancers and promoters regulate estrogen activated transcriptional activity in breast cancer cell lines, organoids and mice.

A postdoctoral position is available in the Cancer Molecular Pathology section headed by Frederic G. Barr, MD PhD in the Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD. This research laboratory uses a multidisciplinary approach involving genomics and bioinformatics along with cell culture and animal models to study genetic and epigenetic alterations in cancer. By initially focusing on specific cancer types, such as the rhabdomyosarcoma family of myogenic soft tissue cancers, this research laboratory is investigating the molecular basis, biological consequences and clinical significance of chromosomal translocations, amplification events, and methylation changes in these cancers. The methodologies, reagents and concepts from these studies are then being applied to address these issues in other relevant cancer categories. This is an exciting opportunity to join a growing and evolving cancer research effort across the basic, translational, and clinical research spectrum. Current projects in the laboratory are in the areas of:

(18) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: INTRACELLULAR SIGNALING

Deadline : Open Until Filled

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A fully funded postdoctoral fellowship is available at the National Institutes of Health in Bethesda, MD in the Nuclear Organization and Gene Expression Section in the Laboratory of Biochemistry and Genetics to study mechanisms by which chromatin and 3D genome organization influences cellular identity and organismal development. We utilize genetic, cell biological, biochemical, and genomics approaches in fruit fly (Drosophila melanogaster), silkworm moth (Bombyx mori), and mouse (Mus musculus) model systems, including cell lines.

The Real-world Assessment, Prediction, and Treatment (RAPT) Unit (https://irp.drugabuse.gov/staff-members/david-epstein/) is part of the National Institute on Drug Abuse (NIDA) Intramural Research Program (IRP), National Institutes of Health (NIH), Department of Health and Human Services (DHHS). We are recruiting a Postdoctoral Fellow. The workplace is the Translational Addiction Medicine Branch (TAMB), NIDA IRP, Baltimore, Maryland.

The National Institute on Minority Health and Health Disparities (NIMHD) Division of Intramural Research (DIR) is committed to supporting the next generation of researchers and diversifying the biomedical research workforce. We are seeking one full-time postdoctoral fellow to join the Health Equity and Decision Sciences (HEADS) research laboratory at DIR. The HEADS research lab strives to improve minority health by using novel quantitative and qualitative methods to support decisions that will lead to equitable health outcomes at individual, interpersonal, community, and societal levels.

The Multiscale Imaging and Integrative Biophysics (MiiB) Unit within the National Institute on Aging’s (NIA’s) Laboratory of Behavioral Neuroscience is offering a postdoctoral position to study Alzheimer’s Disease (AD) and related Dementias. This is a full-time primary research fellowship for postdoctoral scholars, which will be mentored by Dr. Dan Benjamini. The MiiB Unit combines pre-clinical and clinical diffusion-relaxation multidimensional MRI with complementary histological methods to investigate cellular processes that relate to function, microstructure, and chemical composition in normative aging, mild cognitive impairment, and dementia.

The Center for Immuno-Oncology (CIO) Translational Research area at the National Cancer Institute functions as a multidisciplinary and interdisciplinary translational research programmatic effort with the goal of developing novel immunotherapies and immunotherapeutic strategies for cancer. Focus is placed on the development of novel immunotherapeutics, not only as monotherapies, but more importantly, in combination with other immune-mediating modalities, and other conventional or experimental therapies, as part of an immuno-oncology programmatic effort. Within this effort are several research groups which interact closely with the clinical groups of the CIO, and with collaborators within the NCI intramural and extramural programs, and with investigators in the private sector. As Co-Director of the CIO, Dr. Jeffrey Schlom directs the Translational Research area of investigation.

The Postdoctoral Fellow’s primary responsibilities will be to provide skilled expertise in a wide variety of projects involving making, using, and treating animal models of human disease. Specifically, the Postdoctoral Fellow will evaluate models of AKT1-related Proteus syndrome. This will include monitoring animal matings, mouse morphologic phenotyping g, histological and biochemical assessments and implementing small molecule therapeutic interventions. The Postdoctoral fellow will design and optimize assays, design experiments to test hypotheses relevant to clinical questions posed by patients with this disorder. The Postdoctoral fellow will be responsible for acquisition and adaptation, or development and documentation, of data related to these different mouse models. The postdoctoral fellow will be responsible for evaluating the landscape of scientific publications concerning Proteus syndrome and small molecule therapeutics, management of collaborations with other research groups, both inside and outside of NIH, and will also be responsible for training and mentoring of other lab members, including postbacs. 

A postdoctoral position is available to study how human retrotransposon L1 is restricted by factors that defend the genome. Projects also include study of copy number regulation of rDNA repeat sequences.

One postdoctoral fellow position is available in the laboratory of Dr. Paul Liu, National Human Genome Research Institute, NIH, in Bethesda, MD (https://www.genome.gov/10000358/liu–group/). Using genetic and genomic approaches, our lab investigates the molecular mechanisms of leukemia and hematopoiesis. Our long-term goal is to translate our findings to better diagnosis and treatment of leukemia and other blood diseases. Most of our studies have been focused on two transcription factors, RUNX1 and CBFb, which play major roles in leukemia pathogenesis. Using animal models, our lab has illustrated the importance of CBFB-MYH11 for leukemia development, and how this fusion gene works. We have also made important discoveries regarding the normal functions of several important leukemia genes. More recently, our group has focused on clinical studies of familial platelet disorder with associated myeloid malignancy, a rare genetic disease caused by germline mutations in RUNX1.

Our mission and long-term goals focus on understanding the genetic changes that influence the risk of developing complex neurodegenerative diseases, such as Lewy body dementia, Parkinson’s disease, and frontotemporal dementia (see for example Chia R. et al., Nature Genetics, 2021; Dewan R. et al., Neuron, 2021; Kaivola K. et al., Brain, 2021). We also aim to use genetic knowledge for the development of novel ancillary diagnostic tools. We specialize in applying modern gene discovery technologies, including genome-wide association testing, genome sequencing, and functional genomic data integration. 

A postdoctoral position is available in the RNA Biology Laboratory, Center for Cancer Research – Frederick, MD, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS). The candidate will perform basic research on small RNA functions. MicroRNAs (miRNAs) play critical roles in both mammalian development and human diseases such as cancer. The goal of our program is to study how miRNAs themselves are regulated, and to apply gained insights into developing effective treatments for cancer. Using genetic studies in living cells and animals, together with biochemical and next-generation sequencing (NGS) approaches, our laboratory focuses on elucidating mechanisms of miRNA biogenesis and the roles which miRNAs play in tumorigenesis.

The Constrained Statistical Inference (CSI) group, led by Dr. Shyamal Peddada (https://www.niehs.nih.gov/research/atniehs/labs/bb/staff/peddada/index.cfm), in the Biostatistics and Computational Biology Branch (BCBB) at the National Institute of Environmental Health Sciences, Research Triangle Park, NC, is seeking applications for a post-doctoral fellow who is interested in developing methods for analysis of complex high dimensional data with applications to biomedical research. The post-doctoral fellow will primarily work with Dr. Peddada on his research but will have the opportunity to initiate and develop independent research projects of their interest. Some areas of Dr. Peddada’s current interests include constrained inference-based methods in a variety of contexts including, the analysis of temporal and multi-group non-normal multivariate data, climate change related data, microbiome and metabolomics data. NIEHS is a highly collaborative and a data rich environment for a post-doctoral fellow to broaden their research interests and experiences.

The National Cancer Institute is one of the world’s top biomedical research institutions. Investigators at NCI run some of the world’s largest and most cutting-edge biomedical studies. Our postdocs analyze data from these studies and publish high-impact papers that help springboard them to success in academia, government, or industry. NCI takes mentoring seriously and has a proven track record in promoting its fellows. Learn more about DCEG fellowships, advantages, and what current fellows are doing.

A postdoctoral fellowship is available to study the molecular basis of how the centrosome is organized in a 3D space and how HIV and other virus-encoded proteins hijack the centrosome duplication machinery and induce aneuploidy and cancer development. The primary focus will be on determining the structures of multiple complexes that we have identified from our recent unpublished studies. The ultimate goal of this research is to investigate the etiology of centrosome abnormality–associated cancers or other human disorders and to design novel strategies to tackle them. Related to this project, we are also taking biochemical and cell biological approaches, including super-resolution imaging, single molecule tracking, and in vitro reconstitution, to delineate the mechanisms governing Polo-like kinase 4 and 1 (Plk4/Plk1)’s functionality on the centrosomal architecture, the deregulation of which can lead to the development of various human diseases, including cancers. 

A fully funded postdoctoral position is available in Dr. Traci Hall’s lab at the NIEHS/NIH in North Carolina. We are looking for people who are excited to use structural biology to discover how genes are regulated at the RNA level. We combine molecular, biochemical, and structural approaches to determine how RNA regulatory proteins/enzymes select specific targets and what happens when they engage their targets. Better yet, what happens when multiple proteins work together on RNA targets? We are seeking a postdoctoral fellow who has demonstrated success in structural biology (X-ray crystallography, NMR, cryo-electron microscopy) or a biochemist/biophysicist whose background is in RNA biology, enzymology, and macromolecular complex formation. Please see our recent publications for examples of our approaches: Molecular Cell 82:4049, Nucleic Acids Research 50:536).

A postdoctoral position is available in the Section on Microbial Pathogenesis, Division of Molecular and Cellular Biology, NICHD, to investigate host-pathogen interactions during Legionella infection. The project will focus on exploring how L. pneumophila madulates host cell signaling and trafficking pathways to promote virulence.

Multiple Postdoctoral Fellowships are immediately available in the Jothi Lab at the National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH) to study transcriptional and epigenetic control of cell fate decisions.The Jothi Lab investigates how transcription regulators and chromatin modifications regulate gene expression programs during cellular development and differentiation.

A postdoctoral position is available in the Sadhu lab at the US National Institutes of Health. The Sadhu lab’s focus is on genome functionalization: understanding how genetic differences across the genome affects phenotypes. To tackle this question, we are developing and applying new high-throughput methods. This includes harnessing the strengths of CRISPR, large scale oligo synthesis, and yeast genetics. Research in the Sadhu lab involves both wet lab and dry lab components, giving postdocs the opportunity to develop and sharpen skills in either.

The successful candidate for this position will be mentored by investigators from REB. Depending on one’s interest, projects may include the collaboration on radiation epidemiologic studies that require assessment of doses in studies as a prelude to risk evaluation and non-standard modeling of the dose-response relationship between radiation and cancer risk. There is particular interest in application of machine learning methods and measurement error models to these areas. The candidate will also be given flexibility to pursue research in broader statistical areas, such as machine learning methods and measurement error, that have applications beyond radiation epidemiologic studies.

The Ribonucleoprotein Assembly Section within the Laboratory of Biochemistry and Genetics in NIDDK (Rodgers lab) is seeking a Postdoctoral Fellow to investigate the molecular mechanisms guiding ribonucleoprotein assembly during transcription. This position provides:

• Fully-funded postdoctoral training for up to 5 years including health and other benefits
• Access to a wide range of core facilities and resources across NIH campuses, including high-throughput sequencing, cryo-EM, advanced microscopy, flow cytometry, and mass spectrometry
• Support for career development, networking, and additional training through the NIH Office of Intramural Training and Education
• Integration into a dynamic and interdisciplinary RNA biology community at NIH
• Opportunity to develop new research avenues for independent careers

Emily Vogtmann, Ph.D., M.P.H., an Earl Stadtman investigator in the Metabolic Epidemiology Branch (MEB), is seeking a postdoctoral fellow with interest in conducting research to understand the potential association between the human microbiome and cancer starting in spring or summer of 2022. The human microbiome is garnering significant interest in relation to health but is still relatively understudied in relation to cancer. Specific areas of Dr. Vogtmann’s research include:

• Determining the association between the human microbiome and cancer risk with a particular focus on cancers of the lung, colorectum, head/neck, and breast;
• Considering the association between the human microbiome and cancer risk factors;
• Evaluating methods for the collection, storage, and processing of samples and data for the study of the human microbiome.

The Hogg Lab within the Biochemistry and Biophysics Center (BBC) at the National Heart, Lung, and Blood Institute is seeking a Postdoctoral Fellow to explore the biochemistry and cell biology of the nonsense-mediated mRNA decay (NMD) pathway. We investigate how RNA-protein complexes are built and destroyed at levels spanning from single molecules to whole transcriptomes. This position offers the opportunity for postdoctoral fellows to develop independent research programs with the scientific and career development support of the Hogg laboratory, the BBC, and the resources of the NIH Intramural Research Program. This includes:

The Bell laboratory is seeking a highly motivated Postdoctoral candidate committed to research into the molecular underpinnings of uterine cancer. The overarching goal of the laboratory is to identify pathogenic driver genes that underlie the development of the most clinically aggressive forms of endometrial cancer. Our research entails the functional annotation of somatic mutations in candidate driver genes previously identified by next generation sequencing of endometrial tumor tissues. Specifically, the successful applicant will apply detailed molecular, biochemical, and cellular approaches to functionally evaluate somatic mutations in the ALK2 (ACVR1) receptor tyrosine kinase; the goals are to discriminate driver mutations from passenger mutations and to assess the potential druggability of driver mutations. Access to extensive core facilities including cores in bioinformatics, microarrays, copy number analysis, flow cytometry, cytogenetics, and a transgenic mouse core, offers the trainee wide latitude in the design and pursuit of their research questions. Extensive career development opportunities are available through the NHGRI Intramural Training Office and the NIH Office of Intramural Training and Education. The Intramural Research Program is on the Bethesda campus and offers a wide array of training opportunities for scientists early in their careers. The NIH is dedicated to building a diverse community in its training and employment programs.

The Bell laboratory is seeking a highly motivated Postdoctoral candidate committed to research into the molecular underpinnings of uterine cancer. The overarching goal of the laboratory is to identify pathogenic driver genes that underlie the development of the most clinically aggressive forms of endometrial cancer. Our research entails the functional annotation of somatic mutations in candidate driver genes previously identified by next generation sequencing of endometrial tumor tissues. Specifically, the successful applicant will apply detailed molecular, biochemical, and cellular approaches to functionally evaluate somatic mutations in SMAD2, within the TGF-b pathway; the goal is to discriminate driver mutations from passenger mutations. Access to extensive core facilities including cores in bioinformatics, microarrays, copy number analysis, flow cytometry, cytogenetics, and a transgenic mouse core, offers the trainee wide latitude in the design and pursuit of their research questions. Extensive career development opportunities are available through the NHGRI Intramural Training Office and the NIH Office of Intramural Training and Education. The Intramural Research Program is on the Bethesda campus and offers a wide array of training opportunities for scientists early in their careers. The NIH is dedicated to building a diverse community in its training and employment programs.