47 Postdoctoral Fellowship at Scripps Research, California, United States
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Scripps Research, California, United States invites online Application for various Postdoctoral Fellowship in their different Departments. We are providing a list of Postdoc Fellowship positions available at Scripps Research, California, United States.
Eligible candidate may Apply as soon as possible.
(01) Postdoctoral Fellowship Position
Postdoc Fellowship Position summary/title: Postdoctoral Associate
As a Postdoc, you will play a key role in processing terabytes of data from our partners, developing new AI algorithms and presenting the results in top academic journals. You will collaborate with AI experts and clinical professionals, leading the development of new solutions in Digital Medicine. You will be part of a team of data scientists, AI researchers, clinical and behavioral experts, and UX designers that collaborate on a wide range of innovative projects to improve healthcare.
Our lab is focused on the study of neural circuits and neuroendocrine signaling, with the goal of deciphering mechanisms underlying the bi-directional communication between the brain and the gut, an area with great potential for innovation and discovery. We utilize the C. elegans model system for its powerful molecular genetics and pathway discovery, and unraveled a novel brain-to-gut pathway with profound and unexpected orthology in mammals, which are now pursing in mouse models. We are seeking a motivated postdoctoral fellow to spearhead projects that will investigate the molecular and cellular basis underlying gut-brain signaling, and its impact on whole-body physiology and behavior. Our research program is uniquely juxtaposed at the intersection of molecular neuroscience and metabolism, and offers an exciting new perspective on the integrative biology of the gut-brain axis by leveraging the C. elegans model system.
The Peng lab in the Department of Neuroscience at Scripps Research in La Jolla, California is seeking a postdoctoral research associate. The ideal candidate would be a highly motivated researcher with a quantitative research background. The individuals who are interested in contributing to the following are encouraged to apply: cutting-edge research focusing on the dissection of the complex genetic and epigenetic basis of addiction and related human behaviors utilizing multi-omics data. The fellow will receive professional and career mentorship along with opportunities to advance their own expertise to become an independent investigator.
Postdoc Fellowship Position summary/title: Postdoctoral Fellow – Cline Lab
A Postdoctoral Fellow position is available at the Cline Lab at the Dorris Neuroscience Center at the Scripps Research Institute in La Jolla, CA to conduct cutting edge studies on the roles of EVs in intercellular signaling between neural cells. The Dorris Neuroscience Center at the Scripps Research Institute is a vibrant collaborative neuroscience environment.
An NIH funded Postdoctoral Fellow position is available in a collaborative project involving the Cline, Maximov and Yates Labs at the Scripps Research Institute in La Jolla, CA. The goal of this project is to identify brain cell-type contributions to age- and AD-related synaptic and neuronal decline. We will use state-of-the-art proteomic methods together with diverse genetic, imaging, electrophysiology and behavioral strategies to assess structural and functional aspects of brain function.
The successful applicant is expected to present data at lab and departmental meetings and scientific conferences, prepare manuscripts, mentor junior lab members, and apply for external fellowships. We expect the candidate to be familiar with basic molecular biology, sterile, and cell culture techniques; animal model research; and the operation of standard lab equipment; excellent communication skills and the ability to interact with all levels of lab members and with external contacts in a fast paced and demanding environment. The applicant should have creative problem-solving skills and be able to work independently and as part of a team.
Postdoctoral Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a Scripps Research Faculty member. These appointments are normally not renewed beyond a total of six years. Experience with high-throughput assays, mouse models, mammalian metabolism, and adipose tissue biology preferred. Candidates should be independent, creative. They must have a strong interest and commitment to research, excellent organizational and communication skills, and a knack for teamwork.
Postdoc Fellowship Position summary/title:Postdoctoral Associate – Cravatt and Droujinine Labs
We are seeking a highly motivated Postdoctoral Associate to be co-mentored by the labs of Ben Cravatt and Ilia Droujinine. The Droujinine Lab aims to develop novel methods to identify and characterize novel secreted factors that coordinate organ and organism functions in homeostasis and disease in mammalian systems. To that end, we established an in vivo global proteomic platform to investigate secreted protein trafficking between organs. To learn more please visit www.scripps.edu/droujinine. The Cravatt Lab develops activity based protein profiling (ABPP) proteomics methods for basic biology and inhibitor discovery (www.scripps.edu/cravatt/). Ideal candidate will lead their own project, and perform mammalian cell culture, in vivo mouse experiments, quantitative TMT mass spectrometry proteomics, metabolomics, western blot, pulldowns, DNA cloning, immunostaining, confocal microscopy, high throughput screens, and bioinformatic data analysis. Significant emphasis is placed on the professional development of the Postdoctoral Associate. More information on the project will be discussed during the interview process.
The Martin-Fardon lab in the Department of Molecular Medicine at the Scripps Research Institute (La Jolla, CA), is seeking applications for a postdoctoral position. This solicitation seeks applicants who have an interest in alcohol use disorder as well as the interacting effects of alcohol and other abused substances, or who seek to investigate common mechanisms that may contribute to polysubstance abuse. Dr. Martin-Fardon projects are focused on 1) characterization of neural mechanisms of reward, dependence, withdrawal and relapse using pharmacology, in vivo neurochemistry, and molecular approaches; 2) behavioral analyses using animal models of binge-like drug consumption, escalation of drug intake which models compulsive consumption, negative reinforcement of drug taking during dependence, dysregulated stress responsivity and affect control during protracted withdrawal, impaired cognitive function and reinstatement of extinguished drug-seeking behavior.
Postdoc Fellowship Position summary/title:Postdoctoral Associate
Research focuses on the mechanisms of DNA double-strand break (DSB) repair in mammalian cells. DNA double-strand break repair in mammalian cells with focus on both basic mechanisms and translational research We integrate multidisciplinary approaches combining EGFP-based reporter systems and cell-based assays with state-of-the-art technology in genome-wide analysis and mouse models to study DNA DSB repair mechanisms. We also explore synthetic lethality interactions of DNA damage response (DDR) proteins and collaborate with chemistry and structure labs to identify new drug leads for targeted cancer treatment.
Postdoc Fellowship Position summary/title: Postdoctoral Associate – Nakamura Lab
A Postdoctoral Associate position is available in the group of Drs. Lipton and Nakamura at the Neurodegeneration New Medicines Center and the Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California. The successful candidate will join our team to investigate the pathophysiological roles of a posttranslational redox modification known as protein S-nitrosylation in a variety of neurodegenerative diseases. The Postdoctoral Associate will participate in research projects that involve i) a development of biomarkers for neurodegenerative diseases and ii) protein misfolding and spreading of pathology in neurodegenerative diseases.
Successful candidates will contribute to development and application of novel assays to assess impact of genetic diversity for different gene targets. Skill sets of interest include strong experience in tissue culture and the culture of human heterologous and primary cell lines including hiPSCs, familiarity with biochemical tools (SDS-PAGE, ELISA, etc.), knowledge and technical skills required for high-throughput/high content (imaging) screening (HTS/HCS) analyses. Additionally, an interest in the genetic diversity driving the biology of human health and disease with experience in Systems Biology and computational approaches for analysis of large datasets to explore basic mechanism and therapeutics will be helpful.
The selected candidate will plan and conduct novel research projects that involve a significant amount of cell culture, including human induced pluripotent stem cells (hiPSCs). The successful candidate will assist in designing experiments, perform thorough data analyses and interpretation of results, and operate sophisticated scientific lab equipment, including confocal microscope and/or patch-clamp electrophysiology and calcium imaging. Molecular biology and chemical biology knowledge and techniques will be indispensable. The individual will pursue research projects solely and in collaboration with other lab members and supervise or provide work direction and training to other lab members. The individual will also write-up results for publication and attend scientific meetings to present results. The specific research projects will involve investigations of neurodegenerative and neurodevelopmental diseases using hiPSC, cerebral organoid, and rodent model systems.
A postdoctoral position is available in the Encalada Laboratory in the areas of neurodegeneration, aging, and intracellular endolysosomal trafficking. Our lab is interested in characterizing the mechanisms of regulation of molecular motor-driven transport in neurons, the role that defective transport and endolysosomal pathways play in neurodegeneration and aging, and the mechanisms of spreading of misfolded proteins involved in prion diseases, Alzheimer’s disease, and other tauopathies. The project will be the choice of the postdoctoral fellow, and could include mechanisms of aggregate spread in prion and tau models, mechanisms of formation of liquid-liquid phase separations in mouse and/or human neuronal disease models, mechanisms of neuronal toxicity in models of mechanisms of molecular motor regulation in neurons, and others. You will have the opportunity to do research in a superb intellectual setting at Scripps Research, by applying a combination of cell biology, genetics, biochemistry, and high-resolution quantitative light, super-resolution, and EM microscopy to your research in various model systems including mammalian neurons, mice, C. elegans, and/or in vitro reconstituted systems.
Scripps Research is seeking a Postdoctoral Associate in the Molecular Medicine Department. This opportunity will study the function of the novel plasminogen receptor, Plg-RKT, in pulmonary immunology and asthma using new mouse models. In addition, cell biology approaches and single cell RNA Sequencing will be used to study the function of Plg-RKT in intracellular signaling.
The Molecular Medicine Department at Scripps Research is seeking a Postdoctoral Associate to support the Dr. Lotz lab. The candidate is expected to have knowledge and technical expertise in cell and molecular biology, cell culture, RNA isolation and analysis, protein isolation and analysis, statistics and basic knowledge in bioinformatics. The Lotz Laboratory is studying mechanisms and treatments of intervertebral disc degeneration (IDD) which affects a large population of older individuals and represents the major cause of back pain. The research on disease mechanisms uses human spines and genetic mouse models to investigate changes in cells, genes and proteins that develop during the aging process and the development of IDD. These studies examine cell function, RNA expression patterns using RNA sequencing and single cell RNA sequencing. The studies on treatments of IDD are using viral gene transfer of protective genes in rat models of IDD.
The Molecular Medicine Department at Scripps Research is seeking a Postdoctoral Associate with experience on chemical biology, cell biology, immunology and experiences with murine models. Training in multi-color flow cytometry, fluorescent imaging, T-cell or cancer immunology is a plus.
The Molecular Medicine Department at Scripps Research is seeking a Postdoctoral Associate. The lab focuses on the discovery of molecular and cellular mechanisms that are dysfunctional in musculoskeletal tissues during early stages of pathogenesis to create a foundation for therapeutic interventions to prevent disease onset and slow progression. The successful candidate will have a solid background in cell and molecular biology, with previous experience in target identification and validation. The candidate will lead in vitro and in vivo studies to identify and validate molecular targets that are essential for intervertebral disc homeostasis or that contribute to spine pathology, as part of a newly funded program in spine aging. Promising targets will be used in drug screening assays and/or gene therapy approaches. The candidate will work as part of a multidisciplinary and dynamic group with extensive experience with preclinical models for proof of concept validation of drug targets and drug candidates.
Postdoc Fellowship Position summary/title: Postdoctoral Associate – Wilson Lab
Fully-funded postdoctoral positions are available in the laboratory of Prof. Ian Wilson at Scripps Research (http://wilson.scripps.edu) for highly motivated candidates who are interested in immune recognition and inhibition of microbial pathogens. Specifically, we are looking for candidates interested in working on projects focused on structure-based design of vaccine candidates, as well as antibody and small molecule therapeutics against microbial pathogens. Candidates with prior experience in structural biology with interests in virology, immunology, infectious disease, antibody and antigen characterization, and design/development of vaccines and therapeutics, are encouraged to apply.
Fully-funded postdoctoral in chemical biology position is available in the laboratory of Prof. Ian Wilson at Scripps Research (http://wilson.scripps.edu) for highly motivated and skilled chemical biologist. Specifically, we are looking for candidates interested in working on projects focused on developing, synthesizing, and screening biological probes and therapeutics against microbial pathogens. Candidates with prior experience in organic chemistry, chemical biology including peptide and small molecule synthesis, drug development and HT screening and protein production are encouraged to apply. The candidate will be part of a multidisciplinary team of investigators with expertise in structural biology, biochemistry, chemistry, virology and immunology.
Mohammadi lab at Scripps Research is looking for highly motivated postdocs/senior scientists interested in genomic data analysis to join ongoing projects analyzing variation in non-coding genome, identifying genetic variation that contributes to disease, and combining multiple omics datasets. For more information, visit our lab website: http://pejlab.scripps.edu or contact Dr. Mohammadi directly via email [email protected].
A postdoctoral position is available in Dr. Lisa Racki’s Lab at the Scripps Research Institute in La Jolla, CA (rackilab.org) for a highly motivated scientist interested in bacterial chromatin and the role of chromatin in regulating bacterial phages. Specifically, this project will use phage and phage-derived tools to characterize the organization, structure, and dynamics of bacterial chromatin in the opportunistic human pathogen Pseudomonas aeruginosa. This project uses an integrative approach to study bacterial chromatin structure at multiple scales, from in vitro biochemistry, to quantitative single cell timelapse imaging using microfluidics, to macroscopic studies of biofilm communities. This project is supported by an NIH New Innovator Award: https://commonfund.nih.gov/newinnovator/AwardRecipients20
This technical position supports a research laboratory, and it will require regular usage of existing procedures for the experimental use of small animal models of disease, tissue culture, flow cytometry, cellular and molecular biology, biochemistry, genetics, microscopy and histology. The successful candidate will be detail oriented, self-motivated, a fast learner and possess excellent time management, organizational, written and verbal communication skills. The ability to take direction and use independent judgment to meet multiple deadlines is required. Occasional evening and weekend work is required. Willingness to perform BSL-2 work upon completion of required training is required.
We are seeking a self-motivated Postdoctoral Associate with prior experience in molecular biology, biochemistry, immunology, and/or virology. The successful candidate will do interdisciplinary research in HIV vaccine development involving the following,
recombinant DNA cloning and mutagenesis
assays of antibody responses to vaccines in animal models
cell culture; production of recombinant glycoproteins and antibodies
operation of lab instruments; analysis, interpretation, and presentation of results
other responsibilities may include single cell and NGS analyses of B cell lineages, mRNA-LNP production, or other tasks as required
The research project will focus on NK cell-based vaccination protocols and immunotherapies to prevent HIV infection, or attack latently HIV infected cells in models of humanized mice that harbor a functional human immune system. The work will be performed using in-house generated mice and humanized mice and requires expertise in the generation and experimental use of mice and humanized mice, cancer immunology, tissue culture, in vitro cellular assays such as quantitative PCR, killing assays, proliferation assays, flow cytometry, cellular and molecular biology. Positions require successful completion of required training courses (i.e. animal use, radioisotope training, BL-2 safety and general lab and chemical safety training).
The laboratory specifically focuses on immunologic mechanisms of ischemia-induced tissue injury with a particular interest in the innate immune system in kidney ischemia/reperfusion injury (IRI). The overall focus is to extend our understanding of the innate immune system as a key initiator of tissue injury after kidney ischemia and our work is aimed to provide new knowledge about how activation of both membrane-bound and intracellular PRRs contribute to ischemic kidney damage.
Hepatocellular carcinoma (HCC) is a major cause of cancer death worldwide, accounting for over half a million deaths per year. Chronic infections with hepatitis B (HBV) and C (HCV) viruses have been recognized as main human liver carcinogens. Multiple non-viral factors have also been implicated in the development of HCC. The development of non-alcoholic steatohepatitis (NASH) and liver fibrosis represent high risk factors for HCC. Remarkably, we recently found that cyclophilin inhibitors suppress the development of viral-induced and non-viral-induced liver fibrosis and HCC in mouse models. However, their mechanisms of action are totally unknown.
SARS-CoV-2 is currently a major cause of death worldwide. Although vaccines are emerging, new therapies are urgently required. We recently developed a novel approach that permits the killing of SARS-CoV-2-infected cells while preserving non-infected cells. This new approach exploits the viral replication machinery (specifically the SARS-CoV-2 polymerase) to induce the expression of killer genes (diphtheria toxin fragment A) which triggers a rapid specific death of viral-infected cells, but not non-infected cells.
A Postdoctoral Associate position is available immediately at Scripps Research in the Zwick lab.The successful candidate will contribute to the design of HIV vaccine candidates based on the envelope glycoprotein trimeric spike, identification of broadly neutralizing antibodies (bnAbs) from HIV-seropositive humans, and assessment of vaccine-induced bnAb responses in animal models. The candidate will be required to learn quickly and apply cutting-edge technologies to address critical problems in vaccine design. Candidate must be self-motivated, able to manage deadlines and solve problems. Excellent communication skills are essential. Candidate must work well independently and as part of a team. There will be opportunities to interact with experts in immunology, virology, bioinformatics, clinical researchers, and structural biologists. Additional training opportunities exist at Scripps in science writing and career development.
We are seeking a talented self-driven Postdoctoral Associate with strong expertise in molecular biology, immunology, virology and biochemistry. The successful candidate is expected to perform a variety of scientific tasks directed at HIV vaccine development including the following
Recombinant DNA technology; mutagenesis; cell culture
Recombinant glycoprotein and antibody production
Evaluation of vaccine candidates in various animal models
Set up and operate standard lab equipment of moderate complexity
Record data providing basic analyses and interpretations
Perform other related duties, tasks and responsibilities as required
The Postdoctoral Research Associate will join the Law laboratory to manage and execute the recently funded NIH P01 Program “Broadly Effective HCV Vaccine”. The goal of this research program is to develop a vaccine candidate that can elicit potent and broad immune responses against the antigenically variable hepatitis C virus (HCV). The research program involves several laboratories at Scripps Research and the Southwest National Primate Research Center at San Antonio.
Postdoc Fellowship Position summary/title: Postdoctoral Associate – Immunology and Microbiology – Dr. Sumit K. Chanda Lab
A Postdoctoral Associate position is immediately available in the Immunology and Microbiology Department in the laboratory of Dr. Sumit K. Chanda as part of a multi-disciplinary program focused on using a systems-level understanding of innate immunity, T cell immunology, and virus-host interactions. The person filling this position will play an important intellectual, technical, and scientific role in leading projects.
Scripps Research is currently seeking a Postdoctoral Associate to join the Immunology and Microbiology Department of its La Jolla, California facility. The ideal candidate will have extensive experience in synaptic plasticity, field electrophysiology, and/or patch whole cell in brain slices and neuronal cells.
We are looking for talented, highly motivated post-doctoral candidates with a strong interest in virology and drug development. The successful candidate will join a team investigating mechanisms of viral latency and developing novel antiviral treatment strategies. The project is part of the Martin Delaney Collaboratory for HIV Cure Research, a flagship NIH program that brings together a broad range of collaborators from academia and industry (ridhiv.org). The work will be highly translational, bridging mechanistic studies and drug discovery to develop immune restorative treatments and latency reversal strategies to cure HIV infection. The person filling this position is expected to play an important intellectual, technical, and scientific role in projects. The candidate will also assist with the preparation of grant applications and manuscripts, and contribute to additional projects in the lab.
We are looking for talented, highly motivated post-doctoral candidates with a strong interest in basic virology and immunology. The successful candidate will join a team investigating mechanisms of virus-host interactions, with a focus on identifying cellular antiviral responses and molecular signatures linked to severe disease. These studies will utilize systems biology, including large-scale technologies (CRISPR/RNAi, proteomics/ chemoproteomics, chemical biology, NextGen Sequencing, etc.), as well as fundamental virology and more traditional cellular/molecular biology and biochemistry-based approaches. The person filling this position is expected to play an important intellectual, technical, and scientific role in projects. The candidate will also assist with the preparation of grant applications and manuscripts, and contribute to additional projects in the lab. (Position supported by NIH funding.)
A Postdoctoral Associate position is immediately available in the Immunology and Microbiology Department in the laboratory of Dr. Sumit K. Chanda as part of a multi-disciplinary program focused on using a systems-level understanding of innate immunity, immunology, and virus-host interactions. The successful candidate will join a team investigating mechanisms of virus-host interactions, with a focus on utilizing chemical biology and chemoproteomics tools to identify novel host-pathogen interactions that underlie viral infection and to develop novel therapeutic strategies to facilitate pandemic preparedness. Studies will focus on RNA viruses of pandemic potential, including influenza virus, coronavirus, flaviviruses, and filoviruses. The person filling this position will play an important intellectual, technical, and scientific role in leading projects. The candidate will also assist with the preparation of grant applications and manuscripts, and contribute to additional projects in the lab. (Position supported by NIH funding.)
Research in the Voss laboratory is centered on the development of engineered B cell therapies to achieve an HIV functional cure. A position is immediately available for a highly motivated individual who is interested in improving B cell genome-editing approaches and characterizing the function of engineered cells in vivo in the mouse and non-human primate (NHP) animal models. The successful candidate will join a small team that will include doctoral students and research assistants who will work together to accomplish experimental goals. The applicant should have expert knowledge in immunology, relevant lab experience, and a track record of successful completion of work leading to high quality, peer-reviewed publication in scientific journals as first author. The candidate should enjoy participating in mentorship, have excellent experimental design, troubleshooting, communication, interpersonal, and organizational skills. A strong commitment to experimental goals, career goals and deadlines is required. Prior post-doctoral experience is not required for this position.
A funded postdoctoral position is available in the Laboratories of Jeffery Kelly and Kristen Johnson at The Scripps Research Institute in La Jolla, California, USA, to work on the role of proteostasis in diseases of aging and neurodegeneration. Our lab has performed HT screens in collaboration with Calibr, the drug discovery arm of TSRI, using lipid droplet clearance to identify small molecules that activate autophagy, and we are now characterizing their mechanisms of action and cellular targets in the context of disease-relevant models of neurodegeneration. We are committed to the development of new therapeutic strategies and to educating graduate students and postdoctoral associates to become successful, independent scientists in both academia and biotech/pharmaceutical research. We provide a diverse and collaborative research environment where scientists with distinct backgrounds can come together and share their collective expertise and experiences to drive forward both individual and team-based scientific projects. The postdoctoral associate will have full access to the extensive imaging and screening infrastructure, capabilities, and expertise available at Calibr.
Dr. Ahmed H. Badran’s laboratory at Scripps Research seeks to hire 3-4 highly motivated Postdoctoral Associates to start in 2021-2022. The Badran Lab aims to address technical shortcomings in conserved cellular processes through innovative synthetic/chemical biology, directed evolution, genome editing and bioengineering approaches. Specifically, we aspire to develop tools for accelerating the evolution of macromolecular biosynthetic machinery and whole organisms.
Dr. Shannon Miller’s laboratory at Scripps Research is currently seeking talented Postoctoral Associate candidates. The Miller Lab uses directed evolution and engineering to develop novel technologies for biomolecule delivery, with a focus on improving in vivo delivery of genome editing agents. Areas of exploration encompass non-viral and viral approaches, including engineering viral payload (RNA/DNA/protein), increasing viral packaging limit, exploring natural diversity for new evolutionary starting points, and improving in vivo biomolecule stability. The candidate would lead efforts towards the creation of bacterial circuits for the improved activity of viral packaging proteins, development of technologies that enable packaging of non-canonical materials, and development and implementation of assays to evaluate the properties of the resulting biomolecules and vectors.
Multiple fully funded positions for post-doctoral fellows are currently available in the Erb laboratory (Department of Chemistry, The Scripps Research Institute, La Jolla, CA). Our chemical biology group uses discovery chemistry, CRISPR/Cas9-based functional genetic screens, and advanced transcriptional genomics approaches to discover and study drug-like small molecules that therapeutically modulate chromatin regulation and mRNA transcription (see: https://www.erblab.scripps.edu/publications). We are seeking to hire multiple post-doctoral fellows to lead projects in ligand discovery, chromatin regulation, and cancer biology. Successful candidates will have laboratory experience in biology, chemistry, or computer science and be committed to working in a collaborative, multidisciplinary group with the goal of advancing new chemical tools, genetic insights, and therapeutic hypotheses.
The lab is developing new, general approaches to control the site and timing of enzyme activity. Enzymes have great potential as therapeutic and diagnostic agents due to their high specificity and catalytic activity, but the ability to better control the timing and location of enzyme function would enable the use of a wider variety of enzymes for therapeutic purposes. Our approach for enzyme programming relies on attaching an enzyme to its small-molecule inhibitor through an allosteric DNA tether. Upon interaction of the DNA tether with its complement strand, the ensuing conformational change activates the enzyme by dislodging the inhibitor from its active site. We have established the utility of DNA-programmed intrasterically-regulated enzymes in developing constructs for fast, sensitive, and PCR-independent isothermal detection of label-free nucleic acid sequences; carrying out complex logic operations; programming the activity of streptokinase, a clinically-used fibrinogen activator; and specifically killing targeted cancer cells. We are seeking qualified candidates who can join our multidisciplinary team of scientists to lead this broad research effort.
The laboratory of Professor CH Wong in the Department of Chemistry at Scripps Research has postdoctoral positions available in the following areas: chemoenzymatic synthesis of glycans and glycoproteins, glycosylation pathway engineering using CRISPR, development of glycan sequencing method with mass spectrometry, glycan-protein interaction in immunology. Postdoctoral Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a Scripps Research Faculty member. These appointments are normally not renewed beyond a total of five years. Postdoctoral Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair.
Calibr is seeking a talented Research Scientist in the area of Pharmacology. Will be part of Calibr Pharmacology group to provide much needed in vivo support for multiple drug discovery projects and in vitro needs (assay development, cell culture and/or Flow cytometry). Calibr’s open lab space design and collaborative environment encourages the seamless flow of ideas within and between research groups. This position will receive hands on training in translational research and is expected to bring the basic scientific proficiencies listed below at the start. This position offers significant growth opportunity through promotion structures designed to retain exceptional talent within the Calibr team.
Calibr is seeking a talented Research Associate or Assistant in the area of Immuno-Oncology. This position will work as part of a small team of interdisciplinary scientists to translate novel cell and protein therapies for the treatment of cancer into first in human clinical trials. Specifically, projects will be focused on the development of a gene therapy referred to as chimeric antigen receptor T (CAR-T cell) and in the development of immunotherapies known as CD3 T cell recruiting bispecific antibody platforms. Both platform technologies have the potential to have curative responses in the clinic for cancer patients. While working within the scope of these projects, this position will also have the unique opportunity to be exposed to a wide range of other projects at Calibr covering infectious and neglected tropical diseases, metabolic disorders, autoimmunity, and others. Calibr’s open lab space design and collaborative environment encourages the seamless flow of ideas within and between research groups. Publication in high impact journals and conference/meeting attendance will be highly encouraged as part of this position. This position will receive hands on training in translational research and is expected to bring the basic scientific proficiencies listed below at the start.
The Calibr global health team is seeking a highly motivated individual to support antiviral drug discovery. Under this role, the ideal candidate will work in an interdisciplinary team environment to support the execution of key high-throughput assays and develop new assays to enable drug discovery flowcharts for BSL2 and BSL3-level pathogens
The Young Group at Calibr is seeking exceptionally talented postdoc candidates who are interested in working in a highly resourced research environment to develop novel biologics that have the potential to be paradigm changing medicines in the areas of oncology, autoimmune, and metabolic diseases. This includes gene and cell therapy programs leveraging Calibr’s unique switchable CAR-T cell platform, the discovery of novel immuno-oncology targets, and the use of Calibr’s proprietary protein engineering technologies to create multi-specific antibodies. The position will both lead programs and work as part of a larger team of interdisciplinary scientists to profile promising candidates, select leads, and translate selected candidates into first in human clinical trials.
Scripps Research, previously known as The Scripps Research Institute (TSRI), is a nonprofit American medical research facility that focuses on research and education in the biomedical sciences. Headquartered in San Diego, California, with a sister facility in Jupiter, Florida, the institute has over 200 laboratories employing 2,400 scientists, technicians, graduate students, and administrative and other staff, making it the largest private, non-profit biomedical research organization in the United States and among the largest in the world.
The institute holds nearly 1,000 patents, produced 9 FDA-approved therapeutics, and has generated over 50 spin-off companies. According to the 2017 Nature Innovation Index, Scripps Research is the #1 most influential research institution in the world. The Scripps Research graduate program is ranked 10th nationally in the biological sciences, 5th for organic chemistry, and 2nd for biochemistry.
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