51 Postdoctoral Fellowship at University of Cambridge, United Kingdom

This post represents an excellent opportunity for a medically qualified trainee with an interest in oncology, endocrinology or metabolism to join a multidisciplinary team of clinical and basic scientists investigating the metabolic, neuroendocrine and immunological changes that occur in cancer cachexia. The post-holder will play a key role in undertaking bespoke human phenotyping using facilities on the Cambridge Biomedical Campus. These will include studies of food intake and energy expenditure and fMRI neuroimaging, with involvement in molecular and immunological laboratory analysis.

The Precision Breast Cancer Institute (PBCI, previously the Cambridge Cancer Research Unit) has a vacancy for a clinician with an interest and experience in oncology as a Clinical Research Fellow to support the development of innovative clinical trials in patients with breast cancer, focusing strongly on early breast cancer, and related translational research projects.

The lab of Dr Joo-Hyeon Lee (https://www.stemcells.cam.ac.uk/people/pi/lee) at the Wellcome – Medical Research Council Cambridge Stem Cell Institute is looking for a Postdoctoral Fellow/Research Associate to work on an innovative, multi-disciplinary, and collaborative project that investigates “the mechanisms that lead to cellular reprogramming and lineage plasticity in lung regeneration and disease state.”

The role will involve a substantial amount of in vivo work so prior expertise in using mouse models¿ in either cancer research or neurobiology research, is essential. In addition, expertise in techniques like FACS/flow cytometry, single-cell genomics and epigenomics, mass cytometry, CyTOF and/or proteomics is highly desirable. These techniques will be important for investigating tumour samples of various genotypes composed of heterogeneous populations of cells, with the aim of deconvolving differences in cell type composition and cell state. The work will be supervised by Dr Manav Pathania and will be based at The Milner Institute and the Department of Oncology. The lab is also affiliated with the Cambridge Stem Cell Institute, the CRUK Cambridge Institute and the CRUK Children’s Brain Tumour Centre of Excellence. Paediatric gliomas driven by mutations in histone 3 variants harbour many additional co-segregating partner alterations of unknown functional significance. Our lab developed the first mouse models of this disease (Pathania et al., Cancer Cell, 2017) and since then we have developed many additional models representing distinct tumour subtypes. Importantly, in our prior work we showed that histone mutations are unable to induce transformation alone and that partner mutations are needed for tumourigenesis. This suggests a two-step model of tumour induction, in which first the histone mutations stall the differentiation of specific, spatiotemporally discrete neural progenitors, trapping them in a proliferative state. In a second step, these stalled progenitors accrue additional partner mutations, which then induce transformation. Different partners likely produce transformation through distinct oncogenic mechanisms and co-opt the microenvironment in unique ways, which once identified can serve as the basis for a subtype-specific targeted therapy approach.

Applications are invited for a vacancy in molecular virology to join a dynamic and multi-disciplinary team studying the replication and gene expression strategies of RNA viruses. Our team has pioneered comparative genomic prediction, experimental validation, and characterisation of the physiological role of several novel proteins in different RNA viruses. This project will focus on understanding of the role of accessory proteins in enteric RNA viruses and will be based in the lab of Dr Valeria Lulla (https://www.path.cam.ac.uk/directory/dr-valeria-lulla), working in collaboration with Prof. Andrew Firth and Prof. Matthias Zilbauer.

The University of Cambridge is a world leader in biological research. It provides an unsurpassed environment for both young and established researchers. Scientists are drawn to Cambridge from all over the world, creating a lively international community to exchange ideas to discover and innovate. You will join a pioneering research programme to investigate the underlying principles of immune cell-mediated steroid biosynthesis in regulating cancer inflammation and immunity. The research area offers an excellent opportunity to create a new dimension in cancer immunology, allowing you to develop your unique research niche and academic independence. You will thrive in a highly collaborative and supportive research environment.

The successful candidate will work in the Henderson group to further explore and characterise the genetic and epigenetic control of recombination in Arabidopsis. The scope of the project is flexible, depending on the interests and experience of the applicant and could include, (i) mapping recombination events using long read sequencing, (ii) mapping recombination in plant populations where recombination or epigenetic pathways are altered, and/or (iii) bioinformatics analysis of recombination events in long read data. We are interested to identify candidates with either strong experimental and/or computational backgrounds, or those wishing to combine both approaches.

The University of Cambridge wishes to appoint a Research Fellow (Research Associate or Research Assistant) at the Centre for Business Research, to work on a project involving statistical analysis of the CBR Leximetric Datasets and other relevant datasets, including rule of law indices, in connection with the rise of populism in Europe.

The University of Cambridge wishes to appoint a Research Fellow (Research Associate or Research Assistant) at the Centre for Business Research, to work on a project exploring employment regulation and the digitalisation of work. The post-holder’s principal role will be to carry out statistical analysis of the CBR Leximetric Datasets. The Datasets provide a unique time series, tracking changes in labour, company and insolvency law over the period since the 1970s, for a large sample of countries. The coding of legal data is carried out using a so-called leximetric methodology developed in the CBR. See https://www.repository.cam.ac.uk/handle/1810/256566.

Applications are invited for a skilled computational biologist/bioinformatician to join the CSCI’s Core Bioinformatics Group (https://www.corebioinf.stemcells.cam.ac.uk/). The group applies and creates state-of-the-art computational methods for the understanding of the biological properties and biomedical potential of stem cells (https://www.corebioinf.stemcells.cam.ac.uk/publications). We process extensive collections of diverse samples generated by CSCI PIs or through collaborations with local and international groups. We contribute to exciting and challenging international projects to systematically disentangle gene-to-gene interactions in stem cells.

A position is available to work on an exciting multi-disciplinary project related to creating adaptive robot social intelligence for wellbeing, with a starting date as soon as possible. The projects aims to (1) equip (humanoid) robots with novel socio-emotional intelligence and adaptation capabilities grounded in the state of the art in affective computing, social signal processing, computer vision and machine learning fields; and (2) deploy these robots as socio-emotionally smart embodied devices to enable their users maintain and improve their health and wellbeing.

A position exists, for a Research Assistant/Associate in the Department of Engineering, University of Cambridge, to undertake research on novel tailored reinforced concrete infrastructure. The project is funded by the EPSRC in collaboration with International Industrial and Academic Partners. Cement production is responsible for 5-7% of man-made CO2 emissions. A promising strategy to mitigate this impact is to use cement more efficiently and thereby reduce the volumes required. The research will include detailed experimental and analytical investigations of the structural behaviour of reinforced concrete and the material properties of concrete, in the context of resilience and resistance to mechanical and environmental loadings. The development of strategies to address manufacturing challenges is also envisaged.

A position is available for Research Assistant/Associate funded by the UK Research and Innovation ExCALIBUR Programme. ExCALIBUR is the UK programme for Exascale computing (https://excalibur.ac.uk/). The post holder will contribute to a collaborative research project on Exascale computing which is led by University of Cambridge (Engineering and Applied Mathematics) and is in collaboration with Imperial College London, University College London and University of Oxford. The collaboration focuses on Exascale computing for problems governed by partial differential equations, with a particular focus of the Cambridge posts being coupled simulation and design optimisation, with application to net-zero future flight concepts. The role offer opportunities to work closely with and visit collaborating partner universities, and to collaborate with overseas Exascale computing partners. There will also be opportunities to contribute to open-source scientific software projects, including the FEniCS Project (https://fenicsproject.org/) and Firedrake (https://www.firedrakeproject.org/).

Applications are invited for a Research Assistant/Associate (Postdoctoral Researcher) in the Department of Engineering, to work on the development of new methods to structure Li-Ion battery electrodes as part of an ERC Consolidator Grant. The post holder will be located at the University of Cambridge in the group of Prof. Michael De Volder (www.nanomanufacturing.eng.cam.ac.uk/).

(18) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Research Assistant/Associate in Nuclear Engineering of Sodium-Cooled Fast Reactors (Fixed Term)

Deadline : 7 October 2022

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We are looking to appoint a Research Associate within the economics and policy subject group at Cambridge Judge Business School. The Research Associate will support a research project funded by UK Research and Innovation (UKRI) called HUMAN (Hydrogen infrastructure Uncertainty MANagement for heat decarbonisation) and contribute to our wider research agenda. The successful candidate will be based within the Energy Policy Research Group (EPRG) at the Business School. Our research team have broad expertise in economics, technology policy and political science. Through our publications and via our Energy Policy Forum (EPF), the group offers rigorous independent research output that informs public and private sector decision making in the energy sector. EPRG is the leading academic energy economics and policy research group in Europe as judged by citations in RePEC. This project will complement other EPRG research into deep decarbonisation in energy-intensive industry, electricity, heat, and transport.

A position exists for a Research Assistant/Associate to design, fabricate and validate implantable bioelectronic devices as part of a NIHR funded project to develop a minimally invasive spinal cord stimulator system.

Background to the Project Our ability to interface with the central nervous system is currently constrained by the absence of minimally invasive tools that can provide adequate access to select nerve tracts. This post will explore a new solution to this problem: a shape-actuated bioelectronic implant that can be implanted percutaneously in a rolled state and then unrolled inside the body to cover a large area. The primary aim of the project will be to finalize a functional prototype in partnership with an external manufacturer. The realization of this tool will enable wider spread use of spinal cord stimulation for pain management.

The postholder will play a significant role in conducting a programme of research within the Faculty of Education developing and leading research on HE in crisis and states of conflict in at least two of the four case studies: Turkey, Hungary, UK and South Africa. They will play a leading role in ensuring that high impact writing, publications and events are developed from this large ESRC research programme on Higher Education and Crisis, and associated activities. The postholder will also play a role in overseeing part of the research grant portfolio and will provide some research support to group leaders, research committee meetings, research activity and case study planning.

The Biffi Laboratory at the CRUK Cambridge Institute (part of the University of Cambridge) is seeking to hire an experienced and motivated Research Associate (post-doctoral level) with a background in cancer research and strong skills in cell biology, tissue culture, and mouse work to join a team working on studying and targeting cancer-associated cachexia and the tumour microenvironment of pancreatic cancer. The team combines ex vivo human and murine pancreatic tumour organoid/fibroblast co-cultures with murine in vivo models to study and target the interactions between pancreatic cancer cells and the surrounding microenvironment. Common techniques used in the laboratory are generation of orthotopic transplantation models of pancreatic cancer, flow cytometry and sorting, single-cell and bulk RNA-sequencing, multiplexed immunohistochemistry, RNA in situ hybridization, microscopy, drug and CRISPR strategies in both organoids and fibroblasts, pre-clinical studies in genetically engineered mouse models of pancreatic cancer, and analysis of human pancreatic tissues.

We have an exciting opportunity for a postdoctoral Research Associate to join our team studying the molecular mechanisms linking lysosomal dysfunction to neurodegenerative diseases. This is a Wellcome Trust-funded post in the laboratory of Dr Janet Deane at the Cambridge Institute for Medical Research. We encourage applications from scientists with a background in protein biochemistry and/or structural biology who have a keen interest in developing cell-based discoveries into molecular insights.

Applications are invited for a postdoctoral research associate position within the Williams-Gray/Barker lab (with possible extension subject to funding). The lab works at the interface of clinical and laboratory science, aiming to better understand the clinical heterogeneity of Parkinson’s disease and the underlying biological basis of this, with a view to developing more targeted and personalized therapies. The successful candidate will contribute to an expanding programme of research investigating how immune activation and protein aggregation interact to drive the progression of Parkinson’s disease. The role will focus particularly on using PET and MR neuroimaging to investigate these mechanisms. The post holder will play an integral role in a major established longitudinal study using neuroimaging measures of inflammation and tau deposition, alongside blood and cerebrospinal fluid markers, to investigate the basis of cognitive decline and dementia in Parkinson’s. In addition, they will have the opportunity to contribute to related projects running within the lab, including neuropathological studies, immunophenotyping and biomarker studies, mechanistic in-vitro studies, and an ongoing clinical trial of an immunosuppressant drug in Parkinson’s disease.

Professor James B. Rowe and Dr Annelies Quaegebeur are looking for an experienced post-doctoral scientist to join the Cambridge Centre for Parkinson-Plus and its partnership with the Cambridge Centre for Frontotemporal Dementia.

This new Wellcome Trust funded post will characterise the neuropathological processes of frontotemporal lobar degeneration, in human post mortem brain tissue, focusing on the relationships between synapse loss, tau pathology and neuroinflammation.

Our centre of excellence is a vibrant and diverse environment. The post exten

The successful candidate will work on cutting edge neural scene representation technologies including geometry and appearance capture, lighting estimation, neural and differentiable rendering, generative machine learning.

Our research group develops algorithms and systems in the fields of computer vision, graphics, and applied machine learning for creating new forms of 3D digital reality.

Applications are invited from an enthusiastic and motivated Post-doctoral Research Associate to join Prof Martin Bennett’s group, based within the Department of Medicine at Cambridge University, UK. The post is funded by a British Heart Foundation Project Grant for up to 3 years, and will investigate the mechanisms underlying vascular disease, the commonest cause of death in the world (https://www.cardiovascular.cam.ac.uk/directory/mbennett).

We are seeking a motivated and experienced Research Associate to join a collaborative research team led by Professor Andres Floto in the Department of Medicine, University of Cambridge.

You will be working on a project co-led by Professor Floto and Dr Josie Bryant, and the position will be based mainly in Dr Bryant’s lab at the Wellcome Sanger Institute (https://www.sanger.ac.uk/group/bryant-group/). You will be required to hold a Visiting Worker Agreement with the Sanger Institute.

Applications are invited for a Research Associate to join the group of Dr Matt Hoare within the new Early Cancer Institute on the Cambridge Biomedical Campus. Our group is interested in why patients with chronic liver disease develop liver cancer. This is an exciting opportunity to join a CRUK-funded 5-year project, based on previous findings from the group (Brunner et al, Nature, 2019; Ng et al, Nature, 2021) and will further define how acquired somatic mutations impact on cell survival, liver cancer development and systemic metabolic dysfunction.

The successful candidate will join the laboratories of Dr. Katerina Artavanis-Tsakonas and Dr. Andrew Blagborough to investigate the fundamental cell biology of Plasmodium parasites and, more specifically, the role of the ubiquitin pathway in parasite development and malarial transmission. The post will be within the Division of Microbiology & Parasitology, Department of Pathology, University of Cambridge.

We are looking for a highly motivated, proactive and enthusiastic postdoc to work on a BBSRC funded project within the recently founded Galliano Laboratory (https://gallianolab.org) in the Department of Physiology, Development and Neuroscience. This project aims to elucidate the role of morphologically and developmentally diverse dopaminergic neurons in olfactory processing. This project will combine timed stereotaxic injections of opto- and chemogenetic effectors and automated olfactory behavioural testing with whole-cell electrophysiology. By integrating these approaches, you will provide a multi-level synthesis of how developmentally-defined neurons of the same class differentially contribute to sensory processing.

The Department of Pure Mathematics and Mathematical Statistics invites applications for the position of Postdoctoral Research Associate funded by the ‘Homotopy Theory of Moduli Spaces’ grant, which is held by Prof Oscar Randal-Williams. The post holder would work in the Topology group (faculty members include Prof Gabriel Paternain, Prof Ivan Smith, Dr Ailsa Keating, and Prof Jake Rasmussen) on projects in algebraic and geometric topology, on topics such as: moduli spaces, cobordism categories, spaces of manifolds, configuration spaces, mapping class groups, surgery, characteristic classes, K-theory, applications of homotopy theory to geometry, and related research areas.

We are seeking applications for this exciting joint post between the Cambridge Cancer Trials Centre (CCTC) and the MRC Biostatistics Unit (MRC-BSU). This position is part of a pan-European consortium (Cancer Core Europe) to improve the design and implementation of clinical trials. We seek a statistician interested in developing novel, more efficient clinical trial designs. Particular focus will be on the design of adaptive clinical trial arms, and clinical trials which incorporate novel biomarker endpoints (eg. liquid biopsy or imaging). The vacancy provides an exciting opportunity to make important contributions to clinical research, working with fellow statisticians and with clinical and translational researchers in Cambridge and across the Cancer Core Europe Centres (see below).

The MRC Epidemiology Unit is offering an exciting opportunity for an enthusiastic and talented post-doctoral scientist with an interest in the relationship between children’s environmental contexts and their travel and physical activity patterns. The post will be situated in the Population Health Interventions (PHI) programme, which investigates the potential for shifting population patterns of diet and physical activity by altering fiscal, physical or social environments. The successful applicant will lead the collection and analysis of qualitative interviews within a sample of children from the CHILL cohort living in London as well as teachers from participating schools. CHILL is a cohort study funded by NIHR and aims to evaluate the impact of the ultra-low emission zone in London on children’s health. The Unit currently leads the processing of the physical activity data collected as part of the study, but is also leading this qualitative sub-study.

The University of Cambridge wishes to appoint a Postdoctoral Research Associate to join the research group of Prof. Edmund Kunji at the MRC Mitochondrial Biology Unit.

The post holder will work within a programme focused on mitochondrial transport proteins. Transport processes are crucial for the functioning of mammalian mitochondria and cells. Mutations in transport proteins cause a wide range of metabolic, neuromuscular and developmental diseases.

Applications are invited for the positions of Research Associate to join the group of Dr Elisa Laurenti within The Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute and Department of Haematology on the Cambridge Biomedical Campus. This project will focus on understanding the heterogeneity of behaviours of human blood stem cells and their relevance to blood formation and human health. In recent years, work from many groups, including that of Dr Laurenti, has shown that there are different blood stem cell subtypes. Some of these subtypes are “atypical” because they do not possess all of the classical features of a blood stem cell. Specifically, this Wellcome sponsored project will study how these “atypical” blood stem cells are formed and to what extent they contribute to stress responses. The project will predominantly use single cell technologies (functional assays and single cell -omics) on primary patient samples. Key biological questions will centre around the molecular regulation of lineage decisions under healthy, stressed and diseased conditions.

Applications are invited for a post-doctoral Research Associate position in the group of Dr Sarah Robinson at the Sainsbury Laboratory Cambridge University (SLCU). The aim of the Robinson lab is to investigate plant development, particularly from a mechanical point of view. We are looking for someone who is excited about plant development and interested in generating mechanical models of plant tissues.

The University of Cambridge Institute for Sustainability Leadership (CISL) is seeking to appoint a Fellow (0.8 FTE – full-time, 18 months) in sustainable finance under The Prince of Wales Global Sustainability Fellowship Programme. Funding for the Fellowship has been secured through a philanthropic donation from Heathrow Airport LtD but academic stewardship of the Programme lies with CISL. The successful candidate will work on integrating transition and physical risks for the UK aviation industry.

This role will be based in the AI: Futures and Responsibility (AI:FAR) team. Previous work includes: identifying underexplored AI risk scenarios, such as those arising from malicious uses of AI; developing new methodologies for foresight and scenarios relating to the long-term impacts of transformative AI; and developing recommendations and best practices for responsible, safe and inclusive AI development. The AI:FAR team includes researchers from our sister centre the Leverhulme Centre for the Future of Intelligence. More here: https://www.ai-far.org/

The Simons Observatory:UK (SO:UK) collaboration seeks five Post-Doctoral Research Associates (PDRAs) to work on the Simons Observatory (SO). SO is a next-generation Cosmic Microwave Background observatory currently under construction in the Atacama Desert in Chile and due to begin early science operations in early 2023. The positions will be based at The University of Manchester (two positions), The University of Cambridge (one position), The University of Oxford (one position) and Imperial College London (one position). The successful candidates will work with the local SO:UK Investigators at each institute on the development of the SO data processing pipeline and on the preparation and delivery of the Science Ready Data Products (SRDPs) for SO.

This is an opportunity ideally suited to a postdoc data scientist interested in developing machine learning tools in mental health. We are a multi-disciplinary team based at University of Cambridge, spanning the departments of Psychiatry, Psychology, Computing and Mathematics, and working with a number of charity and industry partners (e.g. Anna Freud National Centre for Children and Families and Bitfount plc).

CSER produces world-leading research on global catastrophic risk topics ranging from pandemics to the impacts of emerging technologies, engaging with policymakers at the national and international level, and launching major research initiatives in Cambridge.

Applications are invited for a full-time post-doctoral position to develop functional nanoparticles. The project will build nanoparticle-based biological reactors capable of concentrating targets and effectors to accelerate intracellular reactions. The properties of the nanoparticles (size, shape, intrinsic structure, ligand functionalisation) will be manipulated to control the proximity effect, and the reactors so-designed will drive target protein degradation via the ubiquitin-proteasome system as well as lysosomal pathways.

Cambridge Public Health (CPH) has been awarded funding to support approaches to better measurement of the interactions of business, environment and population health and better alignment of these for global societies than has been possible to date. This work aligns with, and is linked to, the aspirations of Business for Health (www.businessforhealth.org/ ) and Reform for Resilience (www.r4rx.org/ ) The overall purpose of this role is to provide public health and statistical expertise to develop the framework, approach and content of indices that capture whether regions/nations/localities have resilience regarding improvement in health of populations as well as sustainability and economic resilience. Working with multidisciplinary teams, within and beyond the University the post holder will be expected to engage actively across Cambridge Public Health. They will be expected to contribute to the conduct, analysis and implementation of the approach with partners outside the University such as mayors and corporate sectors and to support evaluation and reporting.

The successful candidate will work within CASU’s Gaia and PLATO software development teams. The main tasks will be in data analysis and development of novel scientific algorithms and applications in the areas of photometric and spectrophotometric processing (Gaia) and photometric light curve analysis (PLATO). The role will also involve: contributions to the software infrastructure, liaising with the wider PLATO and Gaia project teams and external science users; contributing to the documentation and user manuals; and collaborating in the Gaia and PLATO exoplanet related research programs to optimise interpretation and use of such Gaia and PLATO data. The role will include opportunities to interact with the wider CASU team.

We are looking for an energetic and enthusiastic colleague to work with Professor Stephen Barclay, Professor of Palliative Care, and colleagues on a programme of national research that is now in its second year of the three-year initial funding period. We are looking for someone with qualitative/mixed methods research skills, an interest in Palliative and End of Life Care or related research and an interest in the current landscape of UK Palliative and End of Life Care, health and social care services and policy.

A postdoctoral position is available to conduct cutting edge neuroscience to isolate the mechanisms underlying adaptive forgetting. The postdoctoral fellow would contribute to work that integrates cognitive theory concerning memory, cognitive control, and affect with the neurobiological research at the systems and circuit levels, using advanced imaging methods as well as advanced connectivity and multivariate methods. The long-term aim is to understand how people regulate intrusive memories, thoughts, and feelings at multiple levels of analysis and to identify how those mechanisms break down in psychiatric disorders. The research thus lies at the interface of cognitive control, memory, and affect regulation and candidates with interest in any of these areas will be considered. Applicants with experience in functional or structural imaging are strongly encouraged to apply.

The University of Cambridge Institute for Sustainability Leadership (CISL) is seeking to appoint a Fellow (0.8 FTE – full-time, 18 months) in sustainable consumption under The Prince of Wales Global Sustainability Fellowship Programme. Funding for the Fellowship has been secured through a philanthropic donation from Sainsbury’s plc but academic stewardship of the Programme lies with CISL.

The successful candidate will explore how supermarkets can enable sustainable consumption through the effective design and use environmental measures of food products (e.g. carbon footprints), drawing conclusions about how such information could impact consumer and industry behaviour.

A position exists for the Tencent Post-Doctoral Research Fellowship, which is at Senior Research Associate grade, in the Department of Engineering, to work on Quantum Technology.

The post holder will be located in the Electrical Engineering Building on the West Cambridge Site, Cambridge, UK.

The key responsibilities and duties are to act to facilitate bringing together research in Quantum Technologies across the University and to build up links with Tencent in the field of Quantum Computing. This will involve liaising with research groups across the departments of Engineering, Physics, Applied Maths and Theoretical Physics and Computer Science and Technology. In addition, the successful candidate will be expected to develop and execute a programme of research in an aspect of Quantum Technologies.