17 Postdoctoral Fellowship at University of Pennsylvania, United States
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University of Pennsylvania, United States invites online Application for various Postdoctoral Fellowship in their different Departments. We are providing a list of Postdoc Fellowship positions available at University of Pennsylvania, United States.
Eligible candidate may Apply as soon as possible.
(01) Postdoctoral Fellowship Position
Postdoc Fellowship Position summary/title: Postdoctoral Researcher in Computational Toxicology
The Romano Lab at the University of Pennsylvania is recruiting a postdoctoral researcher to develop and apply new methods in computational toxicology using artificial intelligence and techniques from biomedical informatics. We develop knowledge graphs to computationally predict and explain the downstream clinical effects that arise following exposure to environmental toxicants. This postdoc position will involve extending these knowledge graphs to new biomedical data types, and applying graph machine learning (Graph ML) to detect novel adverse outcome pathways. They will also have the opportunity to interact with real-world observational datasets (e.g., Penn’s Electronic Data Warehouse and Biobank resources) to validate the Graph ML predictions. The postdoctoral researcher will also have the opportunity to participate in clinical and translational informatics projects that arise as the result of new collaborations and departmental initiatives. Furthermore, eligible candidates will have the ability to apply for prestigious training fellowships in environmental health science or genomic medicine.
Postdoc summary/title: Post-doctoral Fellowship in Cancer Genetics
The Nathanson laboratory invites applications for Post-Doctoral positions at the Perelman School of Medicine, University of Pennsylvania. We focus on cutting-edge translational research in cancer genetics, both in the inherited and somatic genetics of cancer (example publications include Hu et al., NEJM 2021; Maxwell et al., JCO Pres Onc, 2020; Kraya et al., Clin Cancer Res 2019). Expertise and interest in both wet bench studies and bioinformatics is preferred, however applicants with only expertise in bioinformatics would be welcome. The laboratory is highly collaborative and investigates several cancers, among which are hereditary breast cancer (due to BRCA1/2 and non-BRCA1/2 mutations), melanoma, testicular germ cell tumors, and neuroendocrine tumors. Applications for postdoctoral positions are invited across all areas of research, all of which are funded by multiple NIH grants and foundation funding. Potential projects include research to identify novel susceptibility variants through whole exome sequencing in men with testicular germ cell tumors, on the inherited and somatic genetics of breast cancer, including identification of novel susceptibility genes, characterization of moderate penetrance genes, and somatic studies of breast and other cancers in BRCA1/2 mutation carriers (with bulk and single cell RNA/DNA sequencing, and immunophenotyping), with the opportunity to perform correlative studies in relationship to therapeutic response, both targeted and immunotherapies. Further, we have access to the Penn Medicine Biobank with over 45K individuals with whole exome sequencing available for multiple genetic studies in cancer. The laboratory is located with the Institute for Immunology at Penn, and there are multiple opportunities for local collaboration. Applicants also will have the opportunity to engage in collaborative efforts at the national and international stage.
Postdoc Fellowship Position summary/title: Postdoc in human tumor immunology
We are seeking a highly devoted and enthusiastic PhD or MD/PhD scientist to join our group as a postdoctoral research fellow. He/She will be involved in investigating the role of the inflammatory myeloid cells in the tumor microenvironment and the cellular and molecular mechanisms by which tumor modulates their immune functions in cancer patients. Specifically, the researcher will investigate the role of the tumor-infiltrating macrophages and neutrophils in the regulation of tumor-specific T cell and NK cell responses in lung cancer patients. Also, He/She will investigate the ability of tumor-associated neutrophils and macrophages to regulate anti-tumor antibody-triggered immune responses.
Postdoc Fellowship Position summary/title: 2023 Postdoctoral Position
The Heller Lab studies the mechanisms by which epigenetic remodeling regulates gene function, in the context of neuropsychiatric diseases such as addiction and depression. To approach this problem, we directly manipulate histone and DNA modifications at specific genes in vivo, using viral delivery of novel epigenetic editing tools, such as CRISPR/dCas9-fusion proteins. This ‘bottom-up’ approach allows direct elucidation of the causal relevance of epigenetic remodeling in the brain. Because addiction and depression persist long after cessation of the harmful experience, epigenetic remodeling is an attractive underlying mechanism and presents an intriguing target for therapeutic intervention. For further information see http://www.med.upenn.edu/hellerlab/.
Postdoc Fellowship Position summary/title: Neonatal Resuscitation Postdoctoral Position
This postdoctoral position is embedded within the Delivery Room of the Future Frontier Program at CHOP. Principal Investigator Elizabeth Foglia, MD, MSCE leads an NIH-funded multidisciplinary research team focused on developing an evidence base for neonatal resuscitation for high-risk infants. The postdoctorate investigator will have full access to all Delivery Room of the Future resources, including a longitudinal multimodal registry of physiologic, clinical, and follow up data (including neurodevelopment) for newborns born at CHOP. Postdocs will receive support from existing Delivery Room of the Future research infrastructure, including project management, research coordinators, computational and IS resources, and a data science and statistical team.
Postdoc Fellowship Position summary/title: Postdoctoral Fellow Positions in Genetic Regulation of Skeletal Cells
Two postdoctoral fellow positions are available in the Lefebvre laboratory in the Translational Research Program in Pediatric Orthopaedics at the Children’s Hospital of Philadelphia (CHOP) Abramson Research Institute. The fellows will elucidate specific genetic and epigenetic mechanisms whereby SOX and other transcription factors interact with one another and with growth factor signaling pathways to govern the commitment of mesenchymal progenitor/stem cells to skeletal lineages and the multi-step programs of osteoblast and chondrocyte differentiation. The fellows will use cutting-edge approaches in vivo and in vitro, including mouse models and high-throughput ‘omics’ approaches. Successful accomplishment of this research is anticipated to deepen fundamental scientific knowledge, increase understanding of mechanisms underlying skeleton malformation and degenerative diseases, and help the fellows launch promising careers as independent research investigators.
Postdoc Fellowship Position summary/title: Postdoctoral Fellow
A position is available in the Khurana laboratory at The Department of Physiology & Pennsylvania Muscle Institute to conduct basic and translational research on muscular dystrophy; specifically to develop Utrophin Gene Editing for Duchenne’s Muscular Dystrophy Therapy. We use a combination of physiological, molecular, biochemical and genetic approaches to understand the basic biology of muscle, and develop therapies for the muscular dystrophies.
Postdoc Fellowship Position summary/title: Postdoctoral fellowship in human immunology and bioinformatics
A postdoctoral position in human immunology and/or bioinformatics is available immediately in the laboratory of Dr. Michael R. Betts at the University of Pennsylvania Perelman School of Medicine. Our group studies human immunology in the context of various human diseases including HIV, SIV, type I diabetes, and others. With our unique access to human samples, we are using high-parameter flow cytometry and next-generation techniques at single-cell resolution to parse through cellular heterogeneity and understand the roles of various rare cell populations in their contribution to human disease. The successful candidate will work on developing computational pipelines in the context of human immunology and viral infection, as well as working with other members in the group to analyze high dimensional data generated in the lab from various projects. These may include but are not limited to experiments that include high-parameter (25+ color) flow cytometry, single-cell CITEseq, single-cell ATACseq, and additional genomic profiling methods. More information about current research can be found at https://bettslab.org
Postdoc Fellowship Position summary/title: Postdoctoral Fellow in Biomedical Informatics (Cellular Immunotherapy) A postdoctoral position for a computational biologist is available in the interdisciplinary Human Genome Editing and Translational and Correlative Sciences Laboratories. We are part of the Department of Microbiology within the University of Pennsylvania Perelman School of Medicine. We are also a member of the Center for Cellular Immunotherapies and Abramson Cancer Center. Our group is multidisciplinary, integrating computational and experimental approaches to develop a single to collective cell understanding of gene regulation in engineered immune cells and their interaction with tumor cells. We blend transcriptomics, epigenomics, gene editing, immunology, immunotherapy and computational biology to pursue a new understanding of gene regulation in the immune system. We use bulk assays including ChIP-seq, ATAC-seq, and spatial transcriptomics, in addition to cutting-edge single-cell assays such as single-cell (sc)ATAC-seq, scRNA-seq and spatial molecular imaging. Project goals will involve understanding disease mechanisms and/or efficacy of novel therapeutic approaches (e.g., CAR T cells) using patient data from clinical cell therapy trials. Under the guidance of Dr. Friederike Herbst and Dr. Joseph Fraietta, the successful applicant will be primarily responsible for detailed data analysis of medium and large-scale data sets derived from high-throughput sequencing or other single-cell technologies. The candidate should be willing to work as part of a team, but also individually in order to develop a high level of independence. If interested, the selected postdoc will also have opportunities to gain experience in supervising students, grant writing, and/or teaching. The position is available immediately and can be renewed annually.
Postdoc Fellowship Position summary/title: Postdoc fellow to study DNA replication regulation in hematopoietic stem cells
A postdoctoral fellow position is available at the University of Pennsylvania School of Medicine and the Children’s Hospital of Philadelphia, to perform state-of-the-art CRISPR/Cas9 screens to identify novel therapeutic targets for treating hematopoietic stem cell diseases. Hematopoietic stem cells give rise to all circulating blood cells throughout life. Maintenance of stem cell self-renewal, proliferation and differentiation is regulated by complex signaling pathways. Aberrant regulation leads to bone marrow failure or leukemia. Genome integrity plays a critical role in the prevention of leukemia, ageing, and blood development. This postdoctoral fellow position will focus on studying the DNA replication and DNA repair mechanisms that safeguard the genome during DNA replication and investigating how failures in these processes impact hematopoietic stem cell function that leads to bone marrow failure and/or leukemia. Furthermore, this postdoctoral fellow will perform state-of-the-art CRISPR/Cas9 screens to identify novel therapeutic targets for treating hematopoietic stem cell diseases.
Postdoc Fellowship Position summary/title: Postdoc fellow to study DNA replication regulation in hematopoietic stem cells
A postdoctoral fellow position is available at the University of Pennsylvania School of Medicine and the Children’s Hospital of Philadelphia, to perform state-of-the-art CRISPR/Cas9 screens to identify novel therapeutic targets for treating hematopoietic stem cell diseases. Hematopoietic stem cells give rise to all circulating blood cells throughout life. Maintenance of stem cell self-renewal, proliferation and differentiation is regulated by complex signaling pathways. Aberrant regulation leads to bone marrow failure or leukemia. Genome integrity plays a critical role in the prevention of leukemia, ageing, and blood development. This postdoctoral fellow position will focus on studying the DNA replication and DNA repair mechanisms that safeguard the genome during DNA replication and investigating how failures in these processes impact hematopoietic stem cell function that leads to bone marrow failure and/or leukemia. Furthermore, this postdoctoral fellow will perform state-of-the-art CRISPR/Cas9 screens to identify novel therapeutic targets for treating hematopoietic stem cell diseases.
Postdoc Fellowship Position summary/title: Postdoctoral position in Cardiovascular Research
A postdoctoral fellow position is available in the Cardiovascular Institute of the University of Pennsylvania Perelman School of Medicine to perform basic-translational research focused on the coronary microvasculature. Coronary Microvascular Disease (CMVD) accounts for 30-50% of ischemic heart disease yet has been understudied in the past. We have developed novel methods to image the coronary microcirculation and uncover novel mechanisms of CMVD. This position focuses on using genomics, mouse models, novel mouse imaging, and cell and molecular studies on gene regulation to understand the pathogenesis of CMVD and develop novel therapeutic approaches.
Postdoc Fellowship Position summary/title: Post-doctoral position
Our research topics are focused on nuclear mechano-sensing of cells that grow and move within dense microenvironments in both homeostasis and disease. We recently found that the nucleus ruptures when cells experience physical confinement, exposing nuclear DNA to damage from cytosolic nucleases generating changes in gene expression and cellular behavior (Nader et al., 2021, Cell). Our lab combines fluorescence microscopy techniques with novel microfabricated and organ-on-a chip devices to mimic crowded spaces such as the tumor microenvironment, interstitial space or a densely packed tissue. We propose to better understand how cell and nuclear confinement influences transcriptional programs in cells experiencing mechanical stress imposed by the surrounding microenvironment. Additionally, my lab seeks to understand the molecular mechanisms underlying cell motility and invasion following repeated nuclear rupture and chronic DNA damage.
Postdoc Fellowship Position summary/title: Post-doctoral position
Our research topics are focused on nuclear mechano-sensing of cells that grow and move within dense microenvironments in both homeostasis and disease. We recently found that the nucleus ruptures when cells experience physical confinement, exposing nuclear DNA to damage from cytosolic nucleases generating changes in gene expression and cellular behavior (Nader et al., 2021, Cell). Our lab combines fluorescence microscopy techniques with novel microfabricated and organ-on-a chip devices to mimic crowded spaces such as the tumor microenvironment, interstitial space or a densely packed tissue. We propose to better understand how cell and nuclear confinement influences transcriptional programs in cells experiencing mechanical stress imposed by the surrounding microenvironment. Additionally, my lab seeks to understand the molecular mechanisms underlying cell motility and invasion following repeated nuclear rupture and chronic DNA damage.
Postdoc Fellowship Position summary/title: Post-doctoral position
Our research topics are focused on nuclear mechano-sensing of cells that grow and move within dense microenvironments in both homeostasis and disease. We recently found that the nucleus ruptures when cells experience physical confinement, exposing nuclear DNA to damage from cytosolic nucleases generating changes in gene expression and cellular behavior (Nader et al., 2021, Cell). Our lab combines fluorescence microscopy techniques with novel microfabricated and organ-on-a chip devices to mimic crowded spaces such as the tumor microenvironment, interstitial space or a densely packed tissue. We propose to better understand how cell and nuclear confinement influences transcriptional programs in cells experiencing mechanical stress imposed by the surrounding microenvironment. Additionally, my lab seeks to understand the molecular mechanisms underlying cell motility and invasion following repeated nuclear rupture and chronic DNA damage.
Postdoc Fellowship Position summary/title: Postdoctoral Fellow (Penn Autism Spectrum Program of Excellence)
The Fuccillo lab is seeking a Postdoctoral Researcher that is interested in being an integral member of an interdisciplinary program across human and model systems, the Autism Spectrum Program of Excellence (ASPE), which looks to shed new light on autism pathophysiology and treatment. Specifically, the postdoctoral researcher will perform whole cell electrophysiology recordings from visualized neurons in various cortical, striatal and midbrain acute slices. Applicants are expected to have some experience using whole cell voltage and current clamp recordings to assess the synaptic connectivity of specific neural circuits. The researcher will also perform stereotaxic delivery of viruses into brain and perform basic immunohistochemical assays on recorded tissues. The candidate will work closely with Dr. Fuccillo, ASPE principal investigators and a broader leadership team to develop a rigorous and cutting-edge research agenda that prepares the Postdoctoral Researcher for his/her next career steps. Joining ASPE affords you with a unique cross-disciplinary training experience in collaborative science and access to a wide range of professional development activities.
Postdoc Fellowship Position summary/title: Postdoctoral Researcher
We are a multi-disciplinary and collaborative research group seeking highly-motivated investigators to join our program studying rare genetic human diseases of de novo extra-skeletal bone formation. Inactivating mutations in the human GNAS gene cause POH; heterotopic bone in POH initiates within subcutaneous adipose tissue and is preceded by depletion of the adipose tissue and lipid content. Activating mutations in ACVR1, a BMP type I receptor, cause FOP; in skeletal muscle heterotopic ossification is preceded by an altered immune response and changes in the tissue microenvironment. Opportunities are available to conduct research investigating stem cells in muscle and adipose tissues, tissue regeneration and repair, genetic and epigenetic regulation, chromatin organization, biomechanical signaling, transcriptional regulation, and/or cell/tissue energy metabolism.
About The University of Pennsylvania, United States – Official Website
The University of Pennsylvania is a private Ivy League research university in Philadelphia, Pennsylvania. The university claims a founding date of 1740 and is one of the nine colonial colleges chartered prior to the U.S. Declaration of Independence. Benjamin Franklin, Penn’s founder and first president, advocated an educational program that trained leaders in commerce, government, and public service, similar to a modern liberal arts curriculum with a practical perspective.
Penn has four undergraduate schools as well as twelve graduate and professional schools. Schools enrolling undergraduates include the College of Arts and Sciences, the School of Engineering and Applied Science, the Wharton School, and the School of Nursing. Penn’s “One University Policy” allows students to enroll in classes in any of Penn’s twelve schools. Among its highly ranked graduate and professional schools are a law school whose first professor wrote the first draft of the United States Constitution, the first school of medicine in North America (Perelman School of Medicine, 1765), and the first collegiate business school (Wharton School, 1881).
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