04 Postdoctoral Fellowship at Masaryk University, Czech Republic

Applications are invited for a postdoctoral position in the research group of prof. Martin Lysak to join projects investigating the structure and evolution of crucifer genomes (Brassicaceae). The project aims to establish high-quality chromosome-scale sequence assemblies of several genomes and analyze the process chromosomal and centromere evolution in these plant genomes.

A post-doctoral position is open in the Dr. Dalibor Blažek. Our research team is dedicated to understanding the roles of CDK12, CDK11, and other transcriptional kinases in the regulation of gene expression and their targeting in human diseases, particularly cancer. Our laboratory at CEITEC is international and has numerous collaborations including top bioinformaticians, medicinal chemists, and an innovative biotech company. The post-holder will integrate biochemistry and molecular biochemistry approaches, particularly genomics and proteomics together with bioinformatics analyses to address basic biological questions. We are particularly interested in an individual with strong expertise in molecular biology and biochemistry and expertise/interest in genome-wide bioinformatics analyses.

A post-doctoral position is open in the lab of Dr. Michal Šmída (https://www.ceitec.eu/ceitec-mu/michal-smida-research-group/rg214) to participate in research focused on the identification of novel targets for therapy of leukemias, particularly acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL). The research group is investigating molecular mechanisms essential for malignant cells and/or responsible for developing resistance to current targeted therapies. More importantly, we explore how to exploit the resistance mechanisms for novel personalized therapy. We are seeking a talented person with expertise in cell biology, molecular biology and biochemistry to perform various large-scale drug screens and genome-wide CRISPR/Cas9 cellular screens with following in-depth validation of the screening hits and detailed elucidation of molecular mechanisms. The aim of the project will be to propose novel molecular targets to break the therapy resistance and thereby enhance the success rate of the therapy in CLL or AML patients. The project will include translational research using immortalized cell lines, mouse models and primary patient material. State-of-the-art technologies such as genome-wide CRISPR/Cas9 screening, next-generation sequencing or single-cell sequencing are available in the laboratory and/or local core facilities, and are accessible on a regular basis.

We are seeking a junior post-doc to join the research group of Helene Robert Boisivon – Hormonal Crosstalk in Plant Development (https://boisivonlab.ceitec.cz/). Our team is focused on the role of hormones during the plant embryo and seed development and in the response to warm temperatures. For our studies, we use plant model species Arabidopsis thaliana and oilseed crop Brassica napus. We are looking for a motivated researcher to join us on a project investigating the roles of the BnaTAA1 auxin biosynthetic enzymes in Brassica napus.