22 Postdoctoral Fellowship at University of Pennsylvania, United States
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University of Pennsylvania, United States invites online Application for various Postdoctoral Fellowship in their different Departments. We are providing a list of Postdoc Fellowship positions available at University of Pennsylvania, United States.
Eligible candidate may Apply as soon as possible.
(01) Postdoctoral Fellowship Position
Postdoc Fellowship Position summary/title: Translational Neurosurgical Oncology Postdoctoral Researcher
The focus of our lab’s research is at the intersection of immunology, metabolism, and brain tumor biology. The primary goal of our translational research is to understand mechanisms of immune evasion by primary malignant brain tumors and skull base tumors to generate novel immune-based therapies. We utilize a combination of high-dimensional single cell immune and genomic profiling, metabolomics, and advanced tumor organoid and mouse models, to 1) understand the role of myeloid derived suppressor cells in promoting tumor growth and T cell dysfunction, 2) elucidate the mechanisms of tumor-specific T cell exhaustion and clonal lineage of dysfunction T cells, and 3) understand how metabolic networks control immune cell function within the tumor microenvironment. Finally, our lab is uniquely integrated with the Penn Brain Tumor Center, as such, our lab is involved in evaluating immune responses in brain tumor patients undergoing immunotherapy with the goal of identifying predictors of response and new immune targets. Primary responsibilities include leading the implementation of experimental projects, responsible for the design of the translational/basic science experiments to test hypotheses. The candidate will have a leadership role and will be responsible for the supervision of productivity of other laboratory members, provide training as necessary, and also collaborate with other groups on campus. The candidate will be independent, self-driven, organized, and possess excellent managerial and scientific writing skills. The highly qualified candidate will have excellent opportunities for growth, independence, and teaching in a dynamic lab with the goal to transition to independence. This position is contingent on grant funding.
Postdoc summary/title: Postdoctoral Researcher Positions in Cancer Biology
Our research is dedicated to unraveling the contribution of recurrent genomic alterations, both in protein-coding and non-coding regions, to tumorigenesis. Our primary focus is on identifying therapeutic targets and developing combination strategies for the treatment of cancer. To achieve these goals, we have developed a novel computational approach that integrates large-scale genomic, functionomic, and pharmacologic profiles. This innovative methodology has led to the creation of the Functional Cancer Genome data portal (FCG, http://fcgportal.org/home/), which serves as a comprehensive resource for functionally annotating cancer genomes. The newly funded projects will build upon the novel discoveries generated by the FCG project and will involve in-depth molecular characterization of new epigenetic and immuno-oncology drivers in cancer. We are currently recruiting for three related but independent projects: 1) Epigenetic dysregulation and non-coding RNAs in tumorigenesis, 2) Tumor immunology and immune therapy, and 3) Targeted and epigenetic therapy for cancer treatment. To conduct these projects, we employ cutting-edge technologies such as single-cell and spatial RNA sequencing analysis, as well as CRISPR screen and high-throughput chemical screen technologies. Additionally, our lab’s computational biology team provides a wealth of novel computational biology approaches and resources to support these research projects.
Postdoc Fellowship Position summary/title: Post-doctoral Researcher
Highly motivated applicants with a doctoral degree (PhD or MD/analogue) and strong interests in the areas of tumorigenesis, immunity and inflammation and experience in molecular/cell biology and/or pathology and genetics of mouse disease models are encouraged to apply. This position is supported by NIH grants. The training process is greatly aided by a vibrant, intense, and highly collaborative environment at the campus of the University of Pennsylvania and the charm of Philadelphia, one of America’s most important historical cities.
Postdoc Fellowship Position summary/title: Post-doctoral Researcher
A POSTDOCTORAL POSITION to continue and expand studies into the mechanisms of immuno-suppression in the primary tumor and metastatic microenvironment and importance of these mechanisms in cancer therapies (as described in Cancer Cell 2017 and 2019, Cell Metab 2022, Nat Cancer 2020 and 2022 and J Clin Invest 2021).
Postdoc Fellowship Position summary/title: Postdoc Fellow in Machine Learning and Medical Image Analysis
The Department of Radiology at the University of Pennsylvania Perelman School of Medicine seeks candidates for postdoc fellow positions. The main focus of these positions is on the development of biomedical image analysis algorithms with an emphasis on advanced machine learning (deep learning) methods for MRI/CT/PET data analysis. Responsibilities include involvement in various imaging studies of Alzheimer’s disease, aging, brain development, and neuropsychiatric disorders and supervision of junior research investigators for developing algorithms of image segmentation and registration, time-series data modeling, and pattern recognition. The research will be conducted at the Research Laboratory for Machine Learning and Biomedical Data Analytics of the Center for Biomedical Image Computing and Analytics (CBICA), a dynamically growing medical image computing center, involving several laboratories and many collaborators from diverse fields. The position will provide opportunities to participate in collaborative research projects with multidisciplinary research teams of Penn Medicine and the Children’s Hospital of Philadelphia, as well as to launch an independent research career in the area of computational medical imaging analytics.
Postdoc Fellowship Position summary/title: Postdoctoral Fellow
Postdoctoral positions to study the molecular physiologies of InsP3R and MCU Ca2+ ion channels ion channels are available in the laboratory of Kevin Foskett at the Perelman School of Medicine of the University of Pennsylvania in Philadelphia, Pennsylvania. Our focus is on the molecular physiologies of these ion channel families, and their roles in physiology, including bioenergetics, cancer, neurodegeneration and sensory perception. Our research on the IP3R Ca2+ release channel and the mitochondrial Ca2+ uniporter seeks to understand the molecular determinants and physiological functions of endoplasmic reticulum-to-mitochondria Ca2+ transfer. Projects are available to investigate many aspects of channel biophysics, Ca2+ signaling, structural biology, and animal models. Depending upon experience, minimum annual salary will be $67 ,000, plus health benefits.
Postdoc Fellowship Position summary/title: Postdoctoral Fellow
Postdoctoral positions to study the molecular physiologies of InsP3R and MCU Ca2+ ion channels ion channels are available in the laboratory of Kevin Foskett at the Perelman School of Medicine of the University of Pennsylvania in Philadelphia, Pennsylvania. Our focus is on the molecular physiologies of these ion channel families, and their roles in physiology, including bioenergetics, cancer, neurodegeneration and sensory perception. Our research on the IP3R Ca2+ release channel and the mitochondrial Ca2+ uniporter seeks to understand the molecular determinants and physiological functions of endoplasmic reticulum-to-mitochondria Ca2+ transfer. Projects are available to investigate many aspects of channel biophysics, Ca2+ signaling, structural biology, and animal models.
Postdoc Fellowship Position summary/title: Postdoc in computational and systems biology
The Tan research group is interdisciplinary and highly collaborative, utilizing both computational and experimental approaches to study gene regulation. We have pioneered multiple computational algorithms for regulatory genomics, epigenomics, and network biology. Specific projects will be defined by the candidates (and based on the candidates expertise) and with input from Dr. Tan and our close collaborators at the Center for Childhood Cancer Research CHOP and Abramson Cancer Center at the University of Pennsylvania.
Postdoc Fellowship Position summary/title: Postdoc in single-cell cancer genomics
We are seeking a self-motivated and enthusiastic candidate for a postdoctoral scholar position. The postdoc will participate in an exciting project that uses various single-cell technologies to understand tumor clonal evolution, transcriptional and epigenetic heterogeneity and signaling within the tumor microenvironment, during standard and immuno therapeutic responses. The project is funded by a recent NCI center grant to establish the center for pediatric tumor cell atlas as part of the Moonshot initiative (https://humantumoratlas.org/). The project provides an excellent training opportunity in single cell biology and cancer biology.
Postdoc Fellowship Position summary/title: Postdoctoral Researcher in Bioinformatics and Computational Biology
A Postdoctoral Fellow position is available at The Children’s Hospital of Philadelphia Research Institute. The successful candidate will be dedicated and motivated, have creative thinking skills and be a driver of her/his research. This is an exciting opportunity to work with a group of experts on computational genomics to improve algorithms and develop software tools for the long-read sequencing techniques. These technologies, such as Oxford Nanopore and Pacific BioSciences, have significant advantages over conventional short-read Illumina sequencing technologies. We are developing various deep neural network approaches to handle unique challenges in long-read sequencing data, to facilitate novel genetic discoveries and accelerate the implementation of precision medicine.
Postdoc Fellowship Position summary/title: Postdoctoral Researcher in Spatial Omics
We are looking for an exceptionally creative and self-motivated postdoctoral fellow to join us in developing new technologies for spatial omics profiling at the cellular level. The successful candidate will collaborate with internal and external groups to solve challenging biological problems. The work will be multi-disciplinary, combining microchip, microscopy, genomics, and computational analysis to profile genome, epigenome, transcriptome, and proteome within the spatial context of tissues and cells. These novel technologies will greatly improve our ability to study tissue complexity and reveal the salient features of tissue architecture in physiology and disease.
Postdoc Fellowship Position summary/title: Postdoctoral Researcher in Genomics
A post-doctoral position in human genetics and genomics is immediately available. Research in our group focuses on the development of genomics and bioinformatics methods to analyze sequencing data, and to enable the implementation of genomic medicine in clinical settings. The successful candidate will work on developing novel genomic methods to study human diseases that are related to genomic repeats. Example projects include the use of Illumina sequencing, optical mapping or long-read sequencing to assay human genomes, transcriptomes and epigenomes from patients with undiagnosed diseases, and to understand how repetitive elements and structural variants in complex genomic regions cause human diseases. More information about current research can be found at https://wglab.org.
Postdoc Fellowship Position summary/title: Postdoctoral Researcher in Genomics
A post-doctoral position in human genetics and genomics is immediately available. Research in our group focuses on the development of genomics and bioinformatics methods to analyze sequencing data, and to enable the implementation of genomic medicine in clinical settings. The successful candidate will work on developing novel genomic methods to study human diseases that are related to genomic repeats. Example projects include the use of Illumina sequencing, optical mapping or long-read sequencing to assay human genomes, transcriptomes and epigenomes from patients with undiagnosed diseases, and to understand how repetitive elements and structural variants in complex genomic regions cause human diseases. More information about current research can be found at https://wglab.org.
Postdoc Fellowship Position summary/title: Postdoctoral Researcher
We are a multi-disciplinary and collaborative research group seeking highly-motivated investigators to join our program studying rare genetic human diseases of extra-skeletal (heterotopic) bone formation. Inactivating mutations in the human GNAS gene cause POH; heterotopic bone in POH initiates within subcutaneous adipose tissue and is preceded by depletion of the adipose tissue and lipid content. Activating mutations in ACVR1, a BMP type I receptor, cause FOP; in skeletal muscle heterotopic ossification is preceded by an altered immune response and changes in the tissue microenvironment. Opportunities are available to conduct research investigating stem cells in muscle and adipose tissues, tissue regeneration and repair, genetic and epigenetic regulation, chromatin organization, biomechanical signaling, transcriptional regulation, and/or cell/tissue energy metabolism.
Postdoc Fellowship Position summary/title: Postdoctoral fellow
A Postdoctoral Researcher position is available for a highly motivated applicant in the laboratory of Dr. Fiona Simpkins at the University of Pennsylvania. Our focuses are to understand resistance mechanisms to targeted therapies such as DNA Damage Repair inhibitors (DDRi), to sequence DDRi with Immuno-Oncology (IO) drugs, and to identify biomarkers or response to these agents. We have developed a preclinical drug development program in the Ovarian Cancer Research Center with the goal of moving novel laboratory therapeutic discoveries into the clinic. We have developed >150 patient derived xenografts (PDX) models, patient-derived organoids, and primary tumor cultures from ovarian and endometrial cancers. These PDX models mimic the original tumors, thereby accelerating the translation of preclinical study results into clinical trials for patients. Also, we are “humanizing” our models by autologous tumor infiltrating lymphocyte (TIL) and macrophage (TAM) transfer, creating an autologous in vivo model system. Our laboratory has close collaborations with pharmaceutical companies including AstraZeneca, Merck, REPAIR, Zentalis. Based on preclinical studies from our lab, novel combination therapies have moved to phase 1/2 clinical trials led by Dr Simpkins (e.g. ClinicalTrials.gov Identifier: NCT03462342 and GY031). We have another two drug combinations also moving into clinical trials. Dr. Simpkins strongly supports career development of postdocs, either developing an independent laboratory in academia or finding a position in industry. We provide a rich multi-disciplinary training environment in animal modeling, molecular biology, genomics, cancer biology, and immunology, and we have sufficient fundings from various sources, including NIH funding to support this. Previous trainees have been awarded with multiple grants including NIH career development K12 grant, OCRA early career grant, AACR fellowship, Rivkin award, OCRA mentored award, FWC grant, KOH grant and Harrison award.
Postdoc Fellowship Position summary/title: Postdoctoral Fellow in Cardiovascular Disease and Cancer
The Ky lab is a National Institutes of Health-and American Heart Association-funded internationally recognized program that focuses on advancing the cardiovascular health of patients living with and beyond cancer through clinical science. The Ky Lab has a postdoctoral position in the field of cardiovascular and cancer clinical epidemiology and data science. This position for a clinical researcher involves the use of large datasets comprised of biomarker, echocardiography, genomic, clinical, social determinants of health and other “-omic” data to understand individual patient risk. The ideal candidate will have a Ph.D. or M.D. with strong experience in epidemiology, data science, and computational and data analysis. The ideal candidate must also have strong written and oral communication skills, and be able to effectively design an epidemiologic study and develop and execute an analytic plan with close mentorship. The Ky lab operates within the Thalheimer Center for Cardio-Oncology, in which the mission is to relentlessly advance the cardiovascular health in our cancer patients and survivors, and envision a world of longer, healthier lives. The Thalheimer Center strives to lead and shape the field of cardio-oncology clinical care, science, and education. Members of the Ky lab collaborate with a broad range of investigators with diverse expertise in order to advance rigorous, impactful and actionable science. Competitive compensation for appropriate expertise. The Ky lab values the mentor-mentee relationship and is highly invested in the academic and professional development of lab members. This is a two-year position with the opportunity to renew for multiple years.
Postdoc Fellowship Position summary/title: Post Doctoral Researcher
The Volk laboratory invites applications for a postdoctoral position in our comparative breast cancer program at the School of Veterinary Medicine, University of Pennsylvania. The goals of our laboratory are to understand regulatory mechanisms governing dynamic interactions between cells and their surrounding extracellular matrix in the wound healing-fibrosis-cancer progression triad and to apply this knowledge to develop innovative regenerative and oncologic therapies for veterinary and human patients. One-year positions are available immediately with the option to extend an additional 1-3 years. Using a combination of in vitro and mouse models, as well as human, feline and canine breast cancer biopsy samples, we have initiated multiple lines of investigation that will provide insight into how regulation of the collagen fibrillar matrix and its components, specifically type III collagen, inhibits formation of a tumor-permissive microenvironment. This project capitalizes on our studies using spontaneous naturally occurring large animal models of mammary tumors. Future work will characterize drivers of tumor-permissive and suppressive collagen signatures and investigate the use of a novel tissue engineering strategy to control tumor growth and metastasis following tumor resection to improve clinical outcome in veterinary and human breast cancer patients.
Postdoc Fellowship Position summary/title: Postdoctoral Fellow: Mechanics of liver cirrhosis and hepatocellular carcinoma
The goal is to the study the mechanics of liver fibrosis, cirrhosis, and hepatocellular carcinoma, in particular the role of stiffness, compressive forces, and solid stress on hepatocyte behavior and dysfunction. Potential approaches will include the use of animal models and cutting-edge imaging approaches to measure forces and define complex collagen organization. The postdoc will be a participant in the NSF Center for Engineering MechanoBiology, which provides a variety of career development opportunities.
Postdoc Fellowship Position summary/title: Lung Epithelial Cell Biology Post-Doctoral Position
The Beers’ Lab has an existing program funded by NIH, the Department of Veterans Affairs, private foundations, and industry to study the molecular mechanisms that regulate tissue injury and repair in focused on discovery, target ID, target validation, and proof or principal studies aimed at uncovering and exploiting novel pathways to treat fibrotic lung diseases. The postdoctoral fellow can focus the project in any of several related areas (epithelial biology, immunological networks, metabolomics, epithelial-mesenchymal crosstalk, and/or transcriptomics/proteomics) using 2 novel published models of lung injury and fibrosis (see https://www.ncbi.nlm.nih.gov/pubmed/29920187; https://www.ncbi.nlm.nih.gov/pubmed/30910861; https://www.ncbi.nlm.nih.gov/pubmed/30721158 . In addition to the unique mouse reagents, the successful candidate will have access to a variety of cutting edge technologies including RNAseq, single cell and ATAC RNAseq, high resolution proteomics, CRISPR mediated screens, lineage tracing, organoid assays, and iPS cells to identify pathways critical for lung tissue repair and regeneration. The ideal candidate will have an M.D., Ph.D. or MD/PhD with a strong background in basic molecular and cell biology skills. Experience utilizing mouse models and primary cell culture systems is required for the success of this position. The PPCLBI is an interdisciplinary center that combines basic, clinical and translational research being conducted by Pulmonary faculty, both at UPenn (adult patients) and at Children’s Hospital of Philadelphia (neonatal and pediatric patients). The LBI is housed in a completely renovated, state of the art research space in Stemmler Hall with more than 12,000 square feet of newly designed open concept lab space, offices and support areas. In addition to the research lab space, the PLBI houses the Human Lung Biology Core (HLB), which provides support in the design and implementation of experiments involving the use of human lung samples. The HLB Core has developed optimized protocols for the isolation and generation of high quality, reproducible human primary cells and organoids. The PCLBI houses eight core research labs with a wide range of basic and translational research including developmental biology, tissue regeneration, oncology, immunology, and inflammation. This new major investment of resources will facilitate a rich interdisciplinary environment and markedly benefit the field of lung biology.
Postdoc Fellowship Position summary/title: Postdoctoral Positions (immunology, virology, cancer)
The Miner laboratory studies the role of cytosolic nucleic acid sensors in rare diseases, antiviral immunity, autoimmunity, neurodegeneration, and DNA damage responses. In our laboratory, rare disease research is a starting point to define fundamental biological mechanisms. We also prioritize development of novel therapies for patients with rare monogenic diseases. We have 2 new R01s as well as private funding to support multiple new postdocs. We have discovered several new mechanisms of autoimmunity, antiviral immunity, neurodegeneration, and autoinflammation. We have numerous, unique animal models available in the laboratory. We are currently recruiting postdocs, who would join us to pursue projects related to immunology, virology, gene therapy, advancement of small molecular inhibitors as therapies, or fundamental mechanisms related to DNA damage responses, as well as other fundamental questions related to autoimmunity or microbiology.
Postdoc Fellowship Position summary/title: Postdoctoral Researcher in Tumor Virology and Cancer Immunotherapy
A Postdoctoral Researcher position is available in the laboratory of Dr. Jianxin You at the University of Pennsylvania Perelman School of Medicine. The laboratory investigates how the molecular interplay between oncogenic viruses and their host cells leads to cancer (Cell 117:349-360, Cell Host Microbe 19:775-87). We are also developing nanotechnology-based immunotherapy for eliciting antiviral and antitumor immunity against human cancers induced by tumor viruses (Proc Natl Acad Sci U S A. 2020;117:13730-13739). We are seeking enthusiastic and highly motivated Postdoctoral fellows to join our effort in building innovative therapeutic strategies for blocking oncogenic viral infection and associated tumorigenesis.
Postdoc Fellowship Position summary/title: Postdoc Researcher in Bacterial Pathogenesis
A postdoctoral position is available immediately in the Zhu laboratory in the Microbiology Department of the School of Medicine. We are studying pathogen-host-microbiome and antibiotic resistance mechanisms, including Vibrio cholerae and multi-drug resistant enterobacteria.
About The University of Pennsylvania, United States – Official Website
The University of Pennsylvania is a private Ivy League research university in Philadelphia, Pennsylvania. The university claims a founding date of 1740 and is one of the nine colonial colleges chartered prior to the U.S. Declaration of Independence. Benjamin Franklin, Penn’s founder and first president, advocated an educational program that trained leaders in commerce, government, and public service, similar to a modern liberal arts curriculum with a practical perspective.
Penn has four undergraduate schools as well as twelve graduate and professional schools. Schools enrolling undergraduates include the College of Arts and Sciences, the School of Engineering and Applied Science, the Wharton School, and the School of Nursing. Penn’s “One University Policy” allows students to enroll in classes in any of Penn’s twelve schools. Among its highly ranked graduate and professional schools are a law school whose first professor wrote the first draft of the United States Constitution, the first school of medicine in North America (Perelman School of Medicine, 1765), and the first collegiate business school (Wharton School, 1881).
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