57 Postdoctoral Fellowship at University of Cambridge, United Kingdom

The Centre for the Study of Existential Risk (CSER) invites applications for a Senior Research Associate to deliver research that maps out environmental issues related to catastrophic risk. This role would suit an experienced researcher who would benefit from a 1-year research-intensive post to make progress on existing interests and opportunities. CSER produces world-leading research on global catastrophic risk topics ranging from pandemics to the impacts of emerging technologies, engaging with policymakers at the national and international level, and launching major research initiatives in Cambridge. The post is funded by the Grantham Foundation for the Protection of the Environment and their mission is to protect and improve the health of the global environment, especially in relation to climate change and carbon removal. To find out more, you can find an infographic under Resources on the Centre’s website, which cover output related to climate change, including cascading risks in agriculture, large-scale technology and biodiversity.

A position exists, for a Senior Research Associate in the Department of Engineering, to work on to work on the Digital Roads of the Future Initiative The post holder will be located in the Civil Engineering Building, 7a JJ Thomson Ave, CB3 0FA, Cambridge, Cambridgeshire, UK. The key responsibilities and duties are to provide technical leadership and coordination to the DRF initiative via research advancement in Data Science within its existing grants; authoring new grant proposals; authoring publications and disseminating the initiative’s outcomes; teaching and learning support; administration, financial management, planning and organisation; staff management, training, and supervising; and internal and external networking, while constantly upholding the university’s values.

The post-holder will lead on archive cataloguing, research and projects relating to the literary, artistic, and other archives. They will research and catalogue archives in line with the Museum’s research projects and priorities, ensuring improved documentation and accessibility of these collections using the Axiell collections database. They will have the opportunity to formulate and contribute to research projects based on the Museum’s archival collections, building partnerships in Cambridge and beyond, undertaking their own – and facilitating others’ – research. We particularly encourage applicants who will seek to bring new perspectives to these collections, including from under-represented audiences and considering collection histories. We are seeking someone who has experience of a wide range of curatorial work in a museum, library or archive, particularly working with literary and artistic archives. The role holder will be someone with excellent interpersonal skills and the ability to develop, establish and utilise internal and external relationships with individuals and institutions. In return we offer an encouraging and supportive environment, an attractive pension scheme, generous holiday allowance and many employee benefits such as a shopping discounts scheme.

We are looking for a highly motivated post-doctoral scientist to join the laboratory of Dr. Sumru Bayin at the Gurdon Institute, University of Cambridge. You will work in the Bayin Lab to explore the molecular mechanisms that regulate the regenerative potential of stem cells in the brain during development and in adulthood using various techniques including but not limited to single cell genomics, and in vivo and in vitro stem cell assays, organoid models and mouse genetics. The Bayin Lab is interested in identifying the molecular mechanisms that regulate self-renewal, differentiation and plasticity of neural stem/progenitor populations during development and homeostasis, in order to discover how to stimulate repair of the brain upon injury. The cerebellum, which is a folded hindbrain structure that is important for skilled motor movements and higher order cognitive functions, has emerged as a powerful system to study the regenerative responses in the brain. We have previously shown that the cerebellum can recover from the loss of at least two types of neurons via distinct regenerative mechanisms (Wojcinski, Nature Neuroscience, 2017; Bayin, eLife, 2018; Bayin, Science Advances, 2021, Bayin and Joyner, Development, 2022). However, the full repertoire of molecular and cellular mechanisms that regulate neonatal cerebellar development and injury response remain to be studied.

We are seeking someone who has extensive track record of will lead on cataloguing the collection of Chinese export paintings, ensuring improved documentation and accessibility of these collections, working closely with our Documentation and Photography teams. They will have the opportunity to formulate new research projects, building partnerships in Cambridge and beyond. We particularly encourage applicants who will seek to bring new perspectives to these collections, including from under-represented audiences and considering collection histories. Furthermore, the postholder will have the opportunity to develop teaching and conceive creative responses to the collection, through engagement with visitors. They will also have the opportunity to contribute to teaching and to help with temporary displays, in the museum and online. They will support the Curator of Chinese Art, including collections enquiries and access, and work with other curators, collections management staff, photographers, documentation experts, conservators, scientists, learning staff and other colleagues across the Museum and the wider University. They will need to maintain strong working relationships with a diverse range of people In return we offer an encouraging and supportive environment, an attractive pension scheme, generous holiday allowance and many employee benefits such as a shopping discounts scheme. To help support our staff to thrive both professionally and personally, we have adopted a system of hybrid working, meaning staff are empowered to split their time between in-person collaboration and remote working. The frequency of remote working may vary due to project needs and will be subject to discussion with your line manager.

The laboratory focuses on studying breast tumour initiation with the aim of developing novel early detection methods and therapeutic interventions. Using single cell genomics, the team has mapped the precancerous cellular changes that occur in BRCA1 mouse and human breast tissue (Bach et al 2017, Bach and Pensa 2021 and Reed and Pensa 2023). This allowed the team to identify 6 drugs that could be used for preventative therapies. In this three-year CRUK funded project the team will test the efficacy of these drugs in preventing tumour development in the mouse and assess their mechanism of action using single cell genomic approaches. The team will also assess the utility of a novel blood biomarker identified in the lab to verify if it could help guide such preventive treatments in the future. At the end of the project, the team aims to be in a position to justify testing some of these drugs in a pilot clinical trial.

We are seeking an enthusiastic Research Associate to study epithelial stem cell fate and tissue regeneration using a tissue engineering-type approach in a collaborative project led by Profs. Maria Alcolea (Cambridge Stem Cell Institute) and Benjamin Simons (Gurdon Institute). The successful candidate will advance a multidisciplinary collaborative programme to i) reconstruct epithelial tissues ex vivo using a state-of-the-art long-term 3D Epithelioid culture method developed recently by Dr. Alcolea, and use this system to ii) study stem cell dynamics by combining fate mapping, live-imaging, and single-cell molecular profiling using quantitative methods pioneered by the Simons lab. The aim will be to unveil the mechanisms governing epithelial stem cell behaviour in human and mouse with the long-term goal to develop strategies to improve tissue repair and prevent regenerative decay in ageing. We welcome applications from candidates with experience in in vitro and/or in vivo experimental models, advanced image analysis, cellular/molecular biology, and interest in the epithelial stem cell field.

The role holder will focus on RF measurements of medium range coupling between hole spins in quantum dots formed in strained Ge quantum wells. The Cambridge PI Professor Charles G. Smith works in the Semiconductor Physics group on quantum dot research. The material will be provided by Professor Maksym Myronov who is the grant PI at Warwick while devices will be made in the TNI and Professor Sougato Bose at UCL will provide theoretical support. Devices will be fabricated by our partners at the Tyndall National Institute in Ireland. The work is in collaboration with the Hitachi Cambridge Laboratory where Dr Frederico Martins will be working closely on the project. The project has the long-term goal of showing that two Ge Hole dot based qubits can be coupled coherently over distances of about one micron. This would allow cross coupling of the qubits to be extended and open up space for addressing and readout devices which will allow architectures to be designed for future scaling. The role is based in the Cavendish Laboratory which houses the Physics department at the University of Cambridge. Professor Charles G. Smith has access to a BlueFors dilution refrigerator with a bottom sample loader and fitted cryogenic RF amplifier for resonant readout of dot capacitances. This can be used to carry out fast high-fidelity readout of the dot spins. Pulsed RF electric fields applied to the dot gates will be used to control the spins on the dot qubits. The Hitachi Cambridge Laboratory collaborator will be Dr Frederico Martins who has extensive experience with manipulating spins in Ge quantum dot hole devices.

A position exists for a Post Doctoral Research Associate in the Department of Pure Mathematics and Mathematical Statistics. The successful applicant will join the ERC-funded team of Prof. Richard Nickl and work in the project area `Statistical aspects of non-linear inverse problems’, which broadly addresses mathematical and foundational challenges in contemporary data science and the theory of statistical algorithms. Duties include undertaking your own program of research and assisting with ongoing research programmes, using databases, modelling, computation as appropriate; writing up results for publication; and presenting your work to colleagues at conferences or steering groups, both internally and externally. You may also be asked to assist in the supervision of student projects, and/or to provide supervision/instruction to classes or small groups of students. The successful candidate will have completed (or nearly completed) a Ph.D. degree in mathematics and have relevant background knowledge in mathematical statistics and probability theory. Further knowledge of modern techniques in analysis and partial differential equations (PDEs) will strengthen any application but is not strictly necessary. Previous relevant research experience at this level is desirable but not essential.

This project (to commence January 2024) is a major collaborative investigation into the transformation of premodern sacred books and objects. It combines in-depth historical study with scientific and technical analyses. The successful candidate will be responsible for leading on the non-invasive scientific analysis of books and objects using a variety of advanced analytical techniques, including microscopy, various types of spectroscopy, multi-spectral imaging, RTI, and CT-scanning. They will work closely with historians, librarians, museum curators, conservators, scientists and technicians, under the supervision of the PI and Co-Is, to investigate how sacred books were appropriated, modified, mutilated, or used talismanically. The project comprises three themes: books transformed and mutilated in the course of religious reform; books transitioning between Jews and Christians in medieval Europe; talismanic use of Scripture in non-European contexts.

The Centre for the Study of Existential Risk (CSER) invites applications for a Research Associate interested in environmental issues related to catastrophic risk, particularly how to mitigate those issues. This role would suit someone with a PhD in a relevant field, who is developing their research agenda and is interested in spending time connecting their work to previous and existing projects at CSER. CSER produces world-leading research on global catastrophic risk topics ranging from pandemics to the impacts of emerging technologies, engaging with policymakers at the national and international level, and launching major research initiatives in Cambridge. The post is funded by the Grantham Foundation for the Protection of the Environment and their mission is to protect and improve the health of the global environment, especially in relation to climate change and carbon removal. There is a body of previous research and advocacy work at CSER related to extreme risks and the global environment. To find out more, you can find an infographic under Resources on the Centre’s website, which cover output related to climate change, including cascading risks in agriculture, large-scale technology and biodiversity.

Are you passionate about leveraging machine learning to make a profound impact on cancer research? Join the world-leading Ovarian Cancer Programme at the CRUK Cambridge Centre, University of Cambridge as a Postdoctoral Researcher and contribute to cutting-edge advancements in the understanding and treatment of ovarian cancer. These exceptional positions offer a unique opportunity to work with diverse data types, including radiological imaging, genomics, liquid biopsies, and digital pathology. You will work at the forefront of innovation, shaping the future of cancer research.

We are seeking an experienced mechanical/opto-mechanical engineer at the Research Associate/Senior Research Associate level to join our existing multi-disciplinary team. The successful applicant will be expected to provide precision mechanism and opto-mechanical design and construction expertise across our broad portfolio of astronomical instrument projects. These include the delivery of the HARPS3 spectrograph, which will undertake a search for Earth-like planets around nearby Sun-like stars, the Magdalena Ridge Observatory Interferometer, an array of telescopes that will make images at angular resolutions x50 better than the JWST, and ANDES, the high-resolution spectrograph for the European ELT. The postholder will lead the design, construction, assembly and testing of the mechanical, opto-mechanical, and vacuum assemblies for these projects which typically have micron- or sub-micron tolerances. The successful candidate must hold a PhD (or have equivalent experience) in Engineering or a relevant scientific discipline. Candidates must have a proven track record in the computer-aided design, analysis, and FEA modelling of precision mechanical systems and in their procurement, assembly, and testing. Preference will be given to candidates with experience in one or more relevant areas including: (a) the design, fabrication, and assembly of opto-mechanical systems; (b) the design, assembly, and testing of cryogenic (LN2 cooled) instruments; (c) the design and assembly of vacuum and pumping systems for air- and LN2-cooled enclosures; (d) the management of large technical contracts.

Applications are invited for a talented Postdoctoral Research Associate in the newly formed group of Dr Melissa Gammons. This is an exciting opportunity for an experienced protein biochemist/structural biologist to break new scientific ground investigating the molecular mechanisms of Wnt signal transduction pathways and how these are disrupted in disease. The successful candidate will be expected to design, carry out and appropriately analyse experiments encompassing protein purifications, biophysical/biochemical characterisation, structure-function studies and cell-based assays using state-of-the-art tools and resources. The post-holder will be expected to work independently yet collaboratively to achieve the goals of the projects. Good record keeping, high scientific integrity and a friendly, collegial attitude is essential.

 

(18) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Research Associate (Rosenfeld Group) (Fixed Term)

Deadline : 24 October 2023

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We are looking for a post-doctoral scientist to join our collaborative research team investigating transcriptional regulation of lineage fidelity during fate specification and differentiation. Within the laboratory, we use several experimental systems including embryos of the frog Xenopus laevis, as well as mammalian embryonic stem and cancer cell culture. Ongoing projects use Xenopus embryos as a highly versatile model system to uncover epigenetic and co-factor-dependent mechanisms underlying the cellular response to transcription factor reprogramming. We use many techniques including genome-wide analysis of gene expression in single and multiple cells, chromatin binding and accessibility studies, CRISPR genome editing as well as classical embryology and biochemistry. The role holder may take part in our collaboration with Prof. Allon Klein (Harvard Medical School). The successful candidate will have a PhD and be experienced in using molecular biology and genome-wide approaches to probe transcriptional activity. While experience in the use of Xenopus as a model system would be desirable, full training can be provided and an enthusiasm to embrace this model alongside use of cultured cell systems is essential. Evidence of experience in developmental biology, neurobiology, reprogramming or a similar field, and a proven track record in scientific publication are also essential. Experience of bioinformatic analysis of genome-wide, and ideally single cell, data would be highly desirable although we will provide excellent infrastructure and bioinformatic support. Applicants must display an ability to undertake project management, work within a multi-disciplinary team environment, have excellent presentation and communication skills and the ability to contribute to an environment supporting researchers at all stages of their careers.

We are looking for a talented and motivated postdoctoral scientist to join the lab of Professor Sir Steve Jackson (https://www.stevejacksonlab.org/), based in the internationally renowned Cancer Research UK Cambridge Institute https://www.cruk.cam.ac.uk/, located on the Cambridge Biomedical Campus, Cambridge, UK. The successful candidate will join a small GSK-funded team, including two Research Assistants and led by a Senior Postdoctoral Research Associate within the Jackson lab.

We are looking to recruit a postdoctoral Research Associate to join the group of Prof Menna Clatworthy in the Department of Medicine. The post-holder will be involved in supporting projects relating to tissue immunity, particularly with regards to projects interrogating the relationship of immune cells in the gut and central nervous system (CNS) using murine models. The successful applicant will also be required to train other lab members to use relevant in vivo experimental techniques. The appointee will have a PhD in relevant subject (e.g. Immunology, Molecular Biology, or Genomics) with substantial experience in vivo models of gastrointestinal infection and inflammation, as well as meningeal immunity, with a home office personal licence. The successful candidate will also be expected to optimise methods to isolate immune cells from CNS tissues, and to participate in analyses of transcriptomic data (bulk and single cell) generated as part of these projects.

We seek a motivated scholar interested in applied scientific programming and data analysis. Eligible candidates must have a PhD (or equivalent degree) in Climate Physics, Applied Mathematics, Earth Sciences or allied disciplines. A background in paleoclimate modelling and (or) experience in data assimilation is desirable, as is familiarity with interpreting paleoenvironmental proxy data. The candidate must be highly motivated and have excellent time management, organisational and communication skills, and be able to work well as part of a team. The successful candidate will be primarily based in Cambridge, with secondments to Sydney & Hobart, Australia, and (or) Corvallis, Oregon expected over the course of the project to work closely with international collaborators. The candidate will have the opportunity to participate in a wide range of activities within the Centre for Climate Repair and the Department of Geography, including the departmental ‘Climate and Environmental Dynamics’ research group, and reading groups and seminars across the University. The Arnell Post-Doctoral Research Associate will be invited to become a member of Downing College and of its Middle Common Room (MCR) with associated privileges, and it is expected that the candidate will make an active contribution towards College life, educationally and socially.

Applications are invited for a Postdoctoral Research Associate in the McEwan group at the UK Dementia Research Institute, University of Cambridge. The group uses cutting-edge techniques to understand how proteins become misfolded in the brain, and how the immune system can intercept this process. For more information, please visit www.mcewan-lab.com The role will involve the development of new models of Alzheimer’s disease pathology in 3D human cell models. These models will be used to provide a deeper understanding of the molecular mechanisms underlying pathological progression and for testing of new therapeutic approaches. The position is industry funded and will involve close collaboration with the Drug Discovery Unit at the University of Dundee. You will also be working alongside a research assistant whom you will oversee.

Our recent studies identified an extra-organismal RBP in the honeybee jelly secretion, which is somewhat analogous to mammalian milk (Maori et al., Mol Cell, 2019; Maori et al., Cell Reports, 2019). Prompt by this observation, we explored the presence of such RBPs in breast milk. We isolated two secreted milk proteins with robust yet unknown RNA-binding capacity, playing essential metabolic roles. Both factors are conserved across mammals, active in the intestine, and interact with multiple receptors and components of the extracellular matrix. Therefore, our key goals are to define how and why these novel secreted RBPs bind RNA in human milk and the gastrointestinal tract. To achieve these goals, the successful candidate will employ cutting-edge protein and RNA biochemistry techniques, imaging and high-throughput sequencing to assess the impact of RNA binding on protein/RNA stability and function. They will also test whether these secreted RBPs are endocytosed in their ribonucleoprotein forms and deliver their maternal RNA partners into cells. Uncovering the biology of these novel extra-organismal RPBs would provide new knowledge about the bioactivity of breast milk and the healthy digestive process, and what could go wrong during disease. Hence, this research will ultimately contribute towards the development of transformative new research and technology avenues to sustain health and control disease.

A postdoctoral position is available to work on a BBSRC-funded project to investigate the molecular mechanisms that regulate mRNA translation in response to stress. The position will be held in the group of Prof. Juan Mata (https://www.bioc.cam.ac.uk/research/mata). The position will be based in the University of Cambridge, Department of Biochemistry, Tennis Court Road, Central Cambridge. The project focuses on the mechanisms by which translation is regulated during elongation, using the fission yeast Schizosaccharomyces pombe as a model system. The project will combine proteomic, metabolomic and genomic approaches to gain a multiomic perspective of how the translatome is remodelled upon stress (see Rubio et al. doi: 10.1093/nar/gkaa1180). Previous experience using these approaches or in any area of RNA biology will be an advantage, but is not absolutely necessary. Prior experience with yeast is not required. Although the project is largely experimental, it will also involve the computational analysis of large-scale datasets generated by the postdoc. Experience with this, or interest in learning, will also be an advantage.

We are seeking an ambitious and motivated individual to contribute to this research. The team has strong collaborations with groups across the Cambridge Biomedical Campus and beyond. Current team members are working on unsupervised, semi-supervised and outcome-guided clustering and integrative clustering, multi-view modelling, multiple kernel learning, Bayesian nonparametrics, and matrix factorisation approaches, across an array of applications. The successful candidate will have a PhD in a strongly quantitative discipline, ideally statistics or probabilistic machine learning. Experience with biomedical applications would be highly advantageous, but not essential. A desire to address questions of substantive biological importance and disease relevance is essential. Good communication skills and an enthusiasm for collaborating with others are also essential. Strong programming ability would be desirable, and experience of Bayesian clustering and variable selection approaches would be advantageous. Experience with clinical and molecular datasets would be highly desirable. The successful applicant will be supported in their career development with a range of formal courses and on-the-job training. The Unit is situated on the Cambridge Biomedical Campus, one of the world’s most vibrant centres of biomedical research, which includes the University of Cambridge’s Clinical School, two major hospitals, the MRC Laboratory of Molecular Biology, and the world headquarters of Astra Zeneca.

This position is to work with Dr Pavel Mozgunov within Efficient Study Design (ESD) research theme of the MRC Biostatistics Unit (BSU) and Dr Nikos Demiris, a lead statistician at Cambridge Clinical Trials Unit – Cancer Theme (CCTU-CT). Half of the post will be spent on developing novel cancer clinical trial designs and another half will take cancer clinical trials from initial ideas and design, through conduct and analysis, to final publication and dissemination of results. The job will involve the development of statistical methodology clinical trials under the guidance of the line managers and implementation of innovative adaptive designs (possibly developed by the successful candidate themselves) in practice. It is expected that the post-holder will take a lead on the direction of the project after the initial period.

These posts will be located in the Bennett Institute for Public Policy, a major, University-wide interdisciplinary institute housed in the Department of Politics and International Studies and supported by the School of the Humanities and Social Sciences. It is led by its inaugural Director Professor Michael Kenny and Professor Diane Coyle, the Bennett Professor of Public Policy. The Research Associate will work on the measurement and analysis of sectoral productivity and related research questions, delivering both academic outputs and policy-relevant outputs and engagement, overseen by Professor Diane Coyle and working alongside other Bennett Institute staff. They will also liaise with other members of The Productivity Institute, for which the Bennett Institute is the Cambridge hub. Candidates for the post of Research Associate should normally have a PhD (submitted or nearly submitted at the time of application) in a relevant field and with experience of the methods required for this project. They should provide evidence of potential for research and publication at the highest level, and a good understanding of the policy process. Further information about the Institute, Department and Faculty can be found at https://www.bennettinstitute.cam.ac.uk/, www.polis.cam.ac.uk and www.hsps.cam.ac.uk

Applications are invited to recruit a postdoctoral scientist to work with Professor Sam J Wilson in a friendly and dynamic research group that aims to understand the molecular details of why viruses can thrive in some situations but are unable to infect or replicate in others. Key processes such as viral transmission, emergence and pathogenesis are underpinned by the ability of viruses to replicate in cells from a certain species, colonize particular tissues or endure in the face of activated antiviral defences. In the future, we believe that understanding antiviral defences will help us predict which viruses are likely to emerge in human populations and inform the design of new therapeutics.

This exciting wet lab-based project aims to elucidate how risks modify molecular pathology and glia-neuron-synapse interactions to inform treatment strategies in Motor Neuron Disease (MND)/Amyotrophic Lateral Sclerosis (ALS). The successful applicant will generate MND/ALS human organoid and other stem cell-based models developed in the laboratory and use genomic and protein perturbations combined with high-resolution imaging and functional assays in mechanistic studies. The post is a unique opportunity for an enthusiastic cell or molecular biologist with an aptitude for semi-independent work, which is well supported by a dynamic team. The Research Associate will also be supported by experts in computational biology in the lab and be expected to interact with collaborating groups at Harvard University, the Wellcome Trust Sanger Institute and the MRC-WT Cambridge Stem Cell Institute. Fellowship applications will be encouraged towards the end of the post.

We seek to recruit a new member to the FlyBase group at the University of Cambridge, UK, subject to confirmation of funding, which extracts biological information from scientific articles about the model organism Drosophila melanogaster and enters this information into the FlyBase database (https://flybase.org). Prior biocuration experience is not required, so this position will suit Drosophila researchers looking for a fulfilling, fly-related career away from the lab and who enjoy the challenge of organizing complex data, as well as experienced biocurators with Drosophila experience. Currently the team members work in a hybrid pattern of office and home working. The phenotype biocurator will focus on research papers that illuminate the function of genes based on their mutant phenotypes and genetic interactions. This work will involve careful reading and interpretation of phenotypic data in published articles, and the annotation of relevant alleles/genotypes using terms from our phenotype and anatomy vocabularies (ontologies). Additional responsibilities include: developing strategies/tools to improve curation; enhancing data display/querying on the website; and interacting with the research community through answering HelpMail and presenting at research conferences. Curators also contribute to FlyBase publications and have the opportunity to develop computational skills (e.g., Unix, scripting, SQL).

We seek to recruit a new member to the FlyBase group at the University of Cambridge, UK, which extracts biological information from scientific articles about the model organism Drosophila melanogaster and enters this information into the FlyBase database (https://flybase.org). Prior biocuration experience is not required, so this position will suit Drosophila researchers looking for a fulfilling, fly-related career away from the lab and who enjoy the challenge of organizing complex data, as well as experienced biocurators with Drosophila experience. Currently the team members work in a hybrid pattern of office and home working. The metabolic pathway biocurator will focus on the functional annotation of metabolic enzymes and transporters using the Gene Ontology (GO), with the aim of generating diagrams of Drosophila metabolic pathways as GO-causal activity models. This work will involve direct curation of metabolic data from the literature, assessment and integration of computationally predicted pathways, and interactions with collaborators generating data through genetic and metabolomic approaches.

This is an exciting opportunity for an ambitious data scientist to work within the Cambridge Astronomical Survey Unit (CASU) at the Institute of Astronomy (IoA) at West Cambridge site as part of the IMAXT Cancer Research UK Grand Challenge Project and Precision Breast Cancer Institute (PBCI) (https://www.cambridgecancer.org.uk/our-research/precision-medicine-institute/) teams. The post is located at the Institute of Astronomy, but the successful candidate will be expected to spend time at Precision Breast Cancer Institute situated on the Addenbrooke’s Biomedical Campus in Cambridge (West Cambridge). The Imaging and Molecular Annotation of Xenografts (IMAXT: see http://imaxt.cruk.cam.ac.uk) project is taking an integrated approach in producing faithful three-dimensional maps of tumours and their host environment, wherein each cell is identified and molecularly annotated. These maps will be accessed in an interactive, virtual reality framework. This will provide an entirely new way for scientists and physicians to understand how cancer develops and predict its clinical behaviour. CASU undertakes a range of activities in wide field astronomy including: developing and operating pipeline processing and analysis systems for optical and near-infrared mosaic imaging and spectroscopic surveys; together with various space mission projects including PLATO and Euclid, and manages a data processing and archive centre. Within IMAXT, CASU is responsible for developing high throughput pipelines to segment and align the various IMAXT imaging datasets. CASU is also managing the flow of reduced data, both images and catalogues into the central IMAXT database, and defines the structure of this database. Within the PBCI, the focus is on developing novel algorithms for high throughput analysis of digitised histopathology imaging data, automated scoring methodology for pathology-related biomarkers and use of this data in multi-modal data integration.

We are seeking a Computational Biologist to work in a multi-disciplinary team focused on studying epithelial cell fate reprogramming and plasticity during ageing. The ultimate aim of this research programme is to identify potential targets to partially reduce/reverse age-related complications. This Computational Biologist/Research Associate position will be based in the group of Dr Maria P. Alcolea (Wellcome ¿ MRC Cambridge Stem Cell Institute; CSCI). This represents a collaborative effort with Prof. Steffen Rulands at Faculty of Physics, Ludwig-Maximilians, University of Munich. We welcome applications from candidates with experience analysing genomics and sequencing-based data with a particular focus on single-cell RNA sequencing. The role holder will have a key position in analysing existing as well as newly generated single-cell RNA sequencing datasets, including multi-omics. There will be opportunity to develop other quantitative skills, as well as establish collaborative projects with experimental scientists in the lab.

We are looking to appoint a Research Assistant or Research Associate on a Fixed Term contract ending November 2026to support a variety of novel translational clinical projects being undertaken within the Cambridge NIHR Biomedical Research Centre. You will be based within Professor O’Brien’s research group, a vibrant interdisciplinary group of basic and clinical scientists in the Department of Psychiatry at the University of Cambridge undertaking clinical and biomarker studies seeking to understand the causes of and improve interventions for those with and at risk of dementia. See http://www.psychiatry.cam.ac.uk/oap The BRC studies are primarily directed by Professors John O’Brien (Professor of Old Age Psychiatry) and James Rowe (Professor of Cognitive Neurology and BRC Theme Lead) and involve investigators and teams both in the Dept of Psychiatry and the Dept of Clinical Neurosciences. They involve the recruitment and follow-up of participants with degenerative dementias and at prodromal stages, including Alzheimer’s disease, dementia with Lewy bodies, fronto-temporal dementia and related disorders as well as those “at risk” and healthy controls. Participants, often recruited from local memory and cognitive clinics, undergo comprehensive assessments including cognitive testing, biosample (blood, saliva, CSF) collection and MRI and PET brain imaging. This post would be central to the co-ordination of activities, recruiting participants, administering standardised cognitive and clinical scales, accompanying participants for brain scans and associated tests and maintaining study databases and assisting with statistical analysis. Study administration, including obtaining and maintaining ethical, HRA and other governance approvals and writing study reports, would also be part of the duties required.

We are looking for an enthusiastic candidate to be involved in a new strand of research resulting from an ERC/UKRI award competition, which aims to understand the long-term fates and migration trajectories of innate immune cells after inflammatory challenge. The research will involve molecular and cell biology techniques, animal work and live microscopy. The successful candidate will also be expected to take on laboratory management tasks, such as the maintenance of lab resources (including equipment and animal stocks), updating of health and safety protocols and the training and induction of new lab members.

The post-holder will work with Dr Sarah Lloyd-Fox and international collaborators to use these datasets (i.e. fNIRS/EEG/neurocognitive eye-tracking markers/language, motor and developmental assessments) in models of exposure, for example, to predict the contribution of exposure phenotypes (i.e. undernutrition / caregiving context) to the substantive variation in developmental outcomes seen in infants born into a low income setting in The Gambia. They will be supported by a team of established research academics both at the University of Cambridge and across the collaborating institutes (UCL, KCL, MRC Unit The Gambia at the London School of Hygiene and Tropical Medicine, the University of Oxford, Radboud University, University of British Columbia, University of Greenwich and Queen Mary, University of London) . As part of this collaborative team, the postholder will also contribute to identifying primary targets of intervention and the delivery of a scalable developmental toolkit (including optimized designs for accessible lower-density NIRS and EEG systems and a battery of cognitive behavioural tasks)

The Research Assistant/Associate will join the Integrated Quantum Photonics group, based in the Nanoscience Centre at the University of Cambridge, a newly founded research group that works on simulation, nanofabrication and optical characterisation of nano- and quantum photonic devices, integrating quantum light emitters. They will work on a research project focused on the development of aperiodic photonic devices embedding light emitter for fundamental quantum optics experiments and for the realisation of single-photon devices and novel nano-lasers with enhanced performances for quantum technology applications.

A position exists, for a Research Assistant/Associate in the Department of Engineering to work on developing novel algorithms for multi-target tracking and intent prediction for complex dynamically changing environments, degraded sensor accuracy (for example, due to countermeasures employed by the tracked objects) and evasive targets that undertake manoeuvres to undermine the tracking performance or mask malicious intent. This is part of a project funded by the Defence Science and Technology Laboratory (Dstl) through the MOD WSRF framework.

The Research Associate / Research Assistant will work together with a team of students and research collaborators on the development of learning-based control policies that facilitate the coordination of large-scale robot systems (ground and aerial). The ideal candidate will possess hands-on experience with designing and implementing reinforcement learning algorithms, and deploying them onto real robots. They will be working with a team composed of PhD students, Research Assistants and Postdocs that is developing novel multi-robot architectures for practical, real-world settings. Current solutions to many of the coordination challenges use simplifying assumptions and simulated operational environments to achieve success. Our team is pushing these assumptions to their limits, with the aim to break the barrier to real-world and outdoor deployments with large robot teams. As a result, we need to design systems and algorithms that are robust and resilient, while also offering scalability to larger swarms and highly dynamic environments. The RA will also lead in-field testing and deployments. Therefore, we require someone with excellent implementation skills, and substantial experience with real robot deployments.

Applications are invited for a Research Assistant/Associate (Postdoctoral Researcher) in the Department of Engineering, to work on the development of a new lithography and laser processing techniques to integrate carbon nanotubes (CNTs) into microdevices. Applications of this process includes microsensors, microbatteries and microthrusters. The post holder will be located at the University of Cambridge in the group of Prof. Michael De Volder (www.nanomanufacturing.eng.cam.ac.uk/) and collaborate with project partners at UCL (Prof Buddha Deka Boruah https://profiles.ucl.ac.uk/87661) and Cambridge (Prof Adam Boies https://cambridgenanoaerosol.com/). CNTs are one of the most widely studied, and most attractive nanomaterials with off-the-chart mechanical and electrical properties. However, these off-the-chart properties only apply to high quality individual nanotubes whereas most commercial applications require tens to millions of carbon nanoparticles to be assembled into one device. Unfortunately, the mechanical and electronic figures of merit of CNTs typically drop by at least an order of magnitude in comparison to the constituent nanoparticles once integrated into a device. In this project, we will build on lithographic and laser processing as well as self-assembly techniques developed in the host group to control the morphology of CNTs at multiple lengthscales and improve the performance of CNT devices. This project requires knowledge of lithography and/or laser processing and/or CNT synthesis. In collaboration with our project partners, these structures will find applications in microsensors, microbatteries and thrusters.

We are looking to appoint a Research Associate within the economics and policy subject group at Cambridge Judge Business School. The Research Associate will support a Horizon Europe research project called AURORA on industrial decarbonisation and contribute to our wider research agenda on energy and climate policy research. The successful candidate will be based within the Energy Policy Research Group (EPRG) at Judge Business School. Our research team have broad expertise in economics, technology policy and political science. Through our publications and via our Energy Policy Forum (EPF), the group offers rigorous independent research output that informs public and private sector decision making in the energy sector. EPRG is the leading academic energy economics and policy research group in Europe as judged by citations in RePEC. This project will complement other EPRG research into deep decarbonisation in the power sector, heat, transport, and energy-intensive industry. The AURORA project seeks to make a significant contribution to the decarbonisation of industry by demonstrating and qualifying large scale cost-efficient integration in at least three CO2-intensive industries: refining, cement, and materials recycling as sectors where other ready alternatives towards climate neutrality do not exist yet. The AURORA project partners bring together the depth of technical and industrial experience and expertise that can successfully accomplish such an ambitious programme. Cambridge EPRG leads the social science components of the project. We will carry out interviews, workshops, and public surveys to better understand the political economy of industrial decarbonisation. The person will focus on the decarbonisation of industrial clusters and should ideally be an expert in at least one of economic geography, energy or applied economics, industrial or technology policy, or geographic information systems. More information about the project and the role can be found in the Further Particulars.

We are looking for a full-time Research Assistant/Associate to undertake the creation of a number of large datasets on public investment in water and sanitation projects in Britain c.1800 ¿ 1910. These datasets will be used in conjunction with demographic data to evaluate whether investments in water and sanitation were associated with improvements in population health and longevity. The appointee will work closely with Dr Toke Aidt (Faculty of Economics, Cambridge) and Prof. Bernard Harris (Dept of Social Work and Social Policy, Strathclyde). The Research Assistant/Associate will undertake primary archival work to extract data on loans undertaken by Scottish municipal authorities and by rural local authorities in England and Wales, and will collate previously collected loans data from diverse sources into consistent series for English and Welsh towns. They will also work with Dr Aidt to oversee the transcription of the Local Taxation Returns for Scotland, to clean and assemble the data by town, and to assist in generating contextual variables for regression modelling. The Research Assistant/Associate will be involved in preliminary drafting of a research article and will be a co-author. This post is based in Cambridge because the Local Acts and other archival materials are available there and because the post involves close work with Dr Aidt. However the post may include two short stays in Strathclyde in order to work with Prof. Harris, and further supervision by Prof. Harris will be provided remotely.

We are seeking a talented bioinformatician to contribute to an exciting new grant on endometrial cancer prevention and early detection, led by Dr Xin Yang and Professor Antonis Antoniou. The postholder will lead the bioinformatic analysis of large-scale sequencing studies, such as the UK Biobank, the Cancer Genome Atlas, and the 100,000 genomes project, and contribute to the development of personalized endometrial cancer risk prediction models. Applicants should have a Master’s or PhD in bioinformatics, statistics or a related scientific discipline or have an equivalent level of professional qualifications or experience. Previous experience of working with next generation sequence data would be a strong advantage. Experience of programming in R, and a sound knowledge of Perl or Python, would also be desirable. The ability to work well in a team environment will be essential. Appointment at Research Associate level is dependent on having a PhD (or equivalent experience), including those who have submitted but not received their PhD. Where a PhD is to be, awarded appointment will initially be made at research assistant, amended to research associate when PhD is awarded (PhD needs to be awarded within 6 months of start date). If an individual has not submitted a PhD or is not working towards one they maybe appointed as Research Assistant if they have a degree (and/or Master’s) in a relevant area or equivalent experience.

We have an exciting opportunity for a postdoctoral research scientist* to study the physical properties of viral enzymes that allow them to evolve resistance to anti-viral drugs. This project will use advanced computation biology approaches, enzymology and structural biology to define structurally invariant regions of the SARS-CoV-2 MPro protease. This will inform the design of future therapies that reduce/prevent the evolution of drug resistance and may illuminate how evolution of resistance mutations will affect the potency of Mpro drugs already in clinical trials. This project is funded by the Novo Nordisk Foundation as part of the Pandemic Antiviral Discovery (PAD) initiative (https://padinitiative.com/) and is a collaboration between Profs. Stephen Graham and Ian Goodfellow (University of Cambridge, UK) and Prof. Özlem Tastan Bishop (Rhodes University, South Africa). The post holder must possess a PhD in Biochemistry or a related area, have a strong track record of generating publication-quality experimental data, and have demonstrated experience of recombinant protein expression and purification using FPLC systems. Experience in either enzyme kinetic analysis using purified proteins or in solving protein structures using X-ray crystallography is also essential. Prior experience in virology, molecular dynamics analysis or structural pharmacology is desirable. The post holder must have good interpersonal skills as well as the ability to communicate their work clearly in both formal and informal settings, with great attention to detail and excellent record keeping.

A position exists for a Post Doctoral Research Associate in the Department of Pure Mathematics and Mathematical Statistics to work on topics in mathematical statistics (Bayesian inverse problems, stochastic PDEs and SDEs) with Dr Randolf Altmeyer. Duties include developing and conducting individual and collaborative research projects. The role holders will be expected to plan and manage their own research and administration, with guidance if required. They must be able to communicate material of a technical nature and be able to build internal and external contacts. The successful candidates may be asked to provide teaching support to other members within the Statistical Laboratory (e.g. examples classes). They may be asked to assist in the supervision of student projects, and the development of student research skills, provide instruction or plan/deliver seminars relating to their research area.

Applications are invited for a postdoctoral research associate position in the lab of Dr. Sepiedeh Keshavarzi at the Department of Physiology, Development and Neuroscience (https://www.pdn.cam.ac.uk/), University of Cambridge. The position involves investigating the neural circuits underlying spatial orientation and is funded by the Wellcome Trust. The project provides the opportunity to combine behaviour, electrophysiology, calcium imaging, and circuit manipulation across the thalamic and cortical networks involved in navigation, using the mouse as an animal model. Further information about our research questions and approaches can be found on our lab website at https://www.keshavarzilab.com/.

Applications are invited for a Postdoctoral Research Associate in Bioengineering to join an international team in the Department of Genetics in central Cambridge. The project will explore the connection between metabolism, biomechanics and signalling during axis specification in vertebrate embryos. It will make use of a combination of zebrafish embryos and explants, as well as embryonic organoids derived from mouse embryonic stem cells. We are looking for a highly motivated and well-organised person, with a PhD in Developmental Biology.

The beneficial interaction of plants with endomycorrhizal fungi commences via mutual recognition in the rhizosphere. We recently identified a half-size ABCG transporter protein that conditions fungal invasion of the host root. Preliminary data suggest that the transproter is involved with modulating critical root exudates. However, as half-size ABCG transporters are known to homo- or heterodimerise, this project seeks to identify the transport partner or complex that mediates exudate release, and to determine its transport substrate. The projected work will involve biochemical and genetic approaches for transport partner identification and metabolomics to determine the bioactive exudate component. Applicants must have a solid background in plant biochemistry; available knowledge in plant metabolism and plant molecular genetics would be advantageous.

Applications are invited for a Postdoctoral Research Associate in the Department of Applied Mathematics and Theoretical Physics to work on the Aeroacoustics of Dynamic Stall with Professor Nigel Peake. The position is part of a joint research project between University of Cambridge, University of Bristol and Queen Mary University of London, funded by EPSRC and working with several industrial partners, with the aim of developing improved understanding of, and reduction strategies for, noise pollution by large wind turbines. The post holder will be responsible for developing mathematical and physical models of the fluid mechanics and acoustics of dynamic stall, using a blend of advanced techniques in applied mathematics and fluid mechanics, and will be expected to liaise and collaborate closely with colleagues based in the other partner universities who are responsible for experimental and computational investigations of dynamic stall. The successful candidate will have a PhD in applied mathematics and experience in physical modelling. Familiarity with the use of asymptotic methods is highly desirable. They will: be required to develop and conduct their individual and collaborative research objectives within the overall project; write scientific publications for peer review; plan and manage their own research and administration; be able to communicate material of a technical nature to a range of audiences; and be able to build internal and external contacts relating to the research area.

The overarching aim of the post-doctoral position is to develop and apply computational approaches that enable an accurate description of interfacial and nano-confined water to be obtained. The project builds upon recent work in the group (see e.g. Nature 609, 512 (2022); ACS Nano 16, 10775 (2022); Science 372, 1444 (2021); Proc. Nat. Acad. Sci. 118 (38), e2110077118 (2021)) and will be carried out in collaboration with experimental groups in ENS Paris and the Max Planck Institute for Polymer Research in Mainz. Day to day, the project will involve development and application of a range of theoretical and simulaton approaches. This will include, but is not limited to: electronic structure methods, classical atomistic, and machine learning methods. The duties/responsibilities of this post include developing and driving research objectives, writing up work for presentation and publication, collaborating with experimental partners, assisting in the supervision of student research projects, and delivering seminars and occasional talks. The successful candidate will have a strong background in the treatment of complex materials interface systems with electronic structure and/or machine learning methods, including (or be about to obtain) a PhD in a relevant area. Experience in theory and modelling of interfacial water is highly desirable, as is a track-record of successful collaborative work. The ability to work both as part of a team, and independently, coupled with excellent communication, organisational and problem-solving skills are required.

We are looking for individuals who are committed to fostering a positive and inclusive research environment. The candidate should also have good interpersonal and organizational skills, the ability to work with limited supervision and exercise initiative, the ability to prioritize his/her own work in response to deadlines, and experience in making effective presentations and writing scientific manuscripts. The Department of Pathology is a very active research and teaching department in the School of Biological Sciences. We offer modern laboratory spaces, flow cytometry, imaging, histology, proteomics and sequencing facilities in the centre of Cambridge. We host an external seminar series as well as internal talks, journal clubs, and a Department annual symposium. There are approximately 40 research groups spanning a wide array of disciplines, including infectious and genetic diseases, immunology and cancer biology. Additional information can be found here; www.path.cam.ac.uk/research

The Research Associate will be an integral member of the CGHR team and will be expected to pursue an independent but related applied research agenda (60%) as well as to work with the co-directors on convening scholar-practitioner events and networks related to the technology, human rights and democracy theme and to collaborate on practitioner-related outputs (40%). The RA’s research agenda will be expected to align with the technology, human rights and democracy theme. Applicants should furthermore have experience with applied research in this area, whether this is action research, design-led research, or another type of applied research. Candidates should hold a PhD in a relevant social science discipline, or computer science with a strong interdisciplinary social science element, and should have a research record in line with their career stage. They should also have excellent communication skills and experience working in a team as well as independently. Past participation in strategic development of applied research is desirable.

The Department of Biochemistry provides enthusiastic support for early career scientists who wish to establish their own research programmes and labs through career development fellowships. Synergy with our current research groups is important to us. We are particularly interested in recruiting in the following research areas: Computational biology/AI, DNA and chromatin biology, RNA biology, molecular microbiology, plant biochemistry and bioenergy, synthetic biology/Bioengineering. The Department and School of Biological Sciences offer a dynamic environment where our research programmes benefit from state-of-the-art facilities. If you are interested in obtaining the Department’s support for application to granting agencies, you must discuss your potential application with current members of the Department. If you are unsure who to contact, please email our Research Fellowships Team at [email protected], who will identify a faculty member for you to discuss your potential application.

Are you planning to submit a senior research fellowship* application from April 2024? The Department of Zoology at the University of Cambridge seeks Expressions of Interest from early career researchers who wish to be sponsored for externally funded fellowships that will allow them to start an independent research group in our Department. We offer a programme of support that will help you to establish your independence as an academic researcher, including assistance with your fellowship application and setting up your lab, as well as mentoring and training to help you develop your career. Research fellows will also have access to the comprehensive package of ongoing support available from the School of Biological Sciences https://www.bio.cam.ac.uk/research/research-fellowships. During the past 10 years, every one of our Senior Research Fellows has secured a lectureship or equivalent position at leading international universities and research institutes.

We are seeking a Clinical Research Associate to contribute to the conduct of Phase 1b, 2 and Phase 3 clinical trials as well as experimental medicine studies in patients with severe obesity and patients with fatty liver disease. The successful applicant will join an internationally recognised team led by Professor Sadaf Farooqi and will be based in the Institute of Metabolic Science on the Addenbrooke’s Hospital campus, Cambridge. The team are playing a leading role in trialling new weight loss medications in patients with severe obesity due to genetic causes and performing experimental medicine studies in people with extreme metabolic phenotypes supported by the Botnar Fondation. Possession of MRCP (UK) or its recognised equivalent is essential. Given the complex medical needs of the patient groups, advanced postgraduate training in adult Endocrinology / Diabetes, Hepatology or a closely related medical specialty such as Chemical Pathology or Metabolic Medicine, is essential (ST5 or above).

Cambridge University Engineering Department is seeking applicants for the “Ashby Postdoctoral Fellowship in Mechanics and Materials”. This Fellowship has recently been established in honour of the pioneering research by Prof M F Ashby CBE, FRS, FREng. The Fellowship is normally of 3 years duration. The post holder will be located in Central Cambridge, Cambridgeshire, UK. The Ashby Postdoctoral Fellow will be given the opportunity to pursue independent research in the general area of mechanics and materials, as well as to contribute to ongoing research in the Mechanics and/or Materials Groups. Research activities in mechanics and materials are broadly interpreted. The candidate should be broadly aligned with interests in the groups. Areas of current research include additive manufacturing, micro- and nano-mechanics, coupled phenomena of direct relevance to mechanical engineering such as performance and failure of electro-chemical devices, statistical theory of vibration, and data-based computational methods, but applicants are not limited to these example topics.