45 Postdoctoral Fellowship at Karolinska Institute, Sweden

We are seeking a highly talented, innovative, and enthusiastic researcher who has been awarded a Ph.D. in cognitive neuroscience or a related field within the past two years. The successful candidate will work on projects focused on body representation, bodily illusions, multisensory integration, embodied cognition, or processes related to bodily self-awareness, including the sense of body ownership.

The ideal candidate should possess expertise in experimental psychology or cognitive neuroscience, with a preference for skills in psychophysics and computational modeling, and/or proficiency in neuroimaging methods, especially multivoxel pattern analyses, and/or experience with human electrophysiology (EEG, MEG) or brain stimulation methods (e.g., TMS). We encourage the candidate to creatively explore and propose their own experimental ideas, offering substantial flexibility to shape their project in ways that complement our lab’s research focus (www.ehrssonlab.se) and that align with the scholarship program’s goals of fostering career development and international experience. The ability to work independently, initiate and lead novel research projects, and prepare high-quality draft manuscripts for research articles is crucial. Applicants must demonstrate an excellent academic track record, including high-quality publications in international peer-reviewed journals.

We aim to recruit a highly motivated postdoctoral researcher with a background in intervention development, evaluation and special interest in the social protection for tuberculosis (TB)-affected people. You will support the team in the design of social protection and TB research in Vietnam. The team in Vietnam will co-design implementation and research studies with the team at KI and FIT, as part of the Swedish Research Council funded project: Assessing Social Protection in Vietnam to End catastrophic Costs in Tuberculosis.

In this role, you will help design studies, prepare applications for ethical approval, draft protocols, surveys, topic guides, and standard operating procedures. You will also develop data collection systems that adhere with Vietnamese and Swedish data privacy and protection laws, monitor study implementation, clean and analyze both qualitative and quantitative data and take a leadership role in the development of manuscripts. You will also support team members in preparing existing manuscripts for publication. Furthermore, you will draft and support grant applications.

The Mjösberg group studies the development, regulation and function of innate lymphoid cells (ILCs), in humans, and how these cells contribute to pathology in mucosal organs such as the lung and gut. The studies are translational as they involve advanced basic molecular and cellular immunological investigations of precious human tissue samples to discover novel disease mechanisms, therapy targets and improved strategies for personalized treatment. The Mjösberg group consists of two team leaders, two PhD students, five postdocs and a lab manager working closely together with clinical partners at several Swedish hospitals and laboratory facilities at Science for Life Laboratories (SciLifeLab), Karolinska Institutet and abroad.

The Mjösberg group is internationally recognized as a leader in the field through several high impact publications in recent years (Nat Comm 2020, Cell Res 2021, Sci Imm 2022, Cell Rep Med 2023 etc). In particular, the postdoc will continue the successful line of investigations utilizing single-cell RNA sequencing (scRNA-seq) to dissect human intestinal mucosal lymphocyte biology in health and disease.

The project has already generated scRNA-seq data as well as multicolor flow cytometry data of human intratumoral lymphocytes and stromal cells in colorectal cancer. The postdoc will now analyze these data and perform functional experiments (in vitro differentiation, co-cultures etc) together with another postdoc in the team and gastrosurgeons at Karolinska University Hospital. As this is a team effort, excellent communication skills are essential, as is proven ability to work in multidisciplinary teams. It is expected that the postdoc also supervise students and other researchers if necessary, as well as contribute to common lab duties.

Recognition and fusion of the female and male gametes, egg and sperm, marks the beginning of the life of a new individual. Join the research group of Professor Luca Jovine (http://jovinelab.org) and combine molecular and cell biology, biochemistry and structural biology to shed light on a biological event that is not only fundamental from a basic science point of view but has also major implications for the future of human reproductive medicine!

We are looking for two Postdoctoral fellows to join Professor Luca Jovine´s research group at the department of Biosciences and Nutrition in Campus Flemingsberg. The department resides in Neo, a biomedical research building, aimed at being a creative and open environment that enables meetings, synergies, and exploration of areas of mutual interest across disciplines. For more information, see department of Biosciences and Nutrition

As a postdoctoral researcher you will be involved in researching maternal and infant health effects of high temperature. Your role will include coordination and epidemiological research output for an EU financed project: HIGH Horizons (Heat Indicators in Global Health; https://www.high-horizons.eu) which is a multi-country and multi-institutional collaboration project that includes several workstream to assess the impact of heat on maternal and infant health and health worker performance as well as a mitigation package of interventions. Your area of responsibility includes assessing the impact of heat on maternal, perinatal and neonatal adverse outcomes using the national Swedish pregnancy register and other data sources in Europe and Africa. The work will include, linkage of climate and health outcome data, data analyses and manuscript preparation in collaboration with other researchers across the relevant work package. The postdoctoral researcher is also expected to undertake a limited amount of teaching and supervise students.

We are looking for a highly motivated post-doctoral fellow to strengthen our team. You should have a broad knowledge and experience in experimental work, data analysis and processing of data, preferably in the cardiovascular field. You will work closely in a team with molecular biologists, laboratory technicians, clinicians, PhD-students and bioinformaticians where your role will be to lead and perform experimental work using molecular and cellular biology technique such as siRNA, histology and microscopy, next generation sequencing and cell culture models, conduct data analysis, but also participate in the collection and handling of surgical biopsies. You will also participate in supervising doctoral and master/undergraduate students. We expect you to work in a diligent and responsible way, generating properly controlled scientific data of high quality.

A postdoctoral fellowship is available in the laboratory of Carl M. Sellgren at the department of Physiology and Pharmacology at Karolinska Institutet. The group focus on identifying mechanisms that govern neurodevelopment and are disrupted in various neurodevelopmental disorders. The models are based on induced pluripotent stem cells collected from patients in the clinic and used to generate brain organoid models. We model both genetic and environmental risk factors and apply different molecular biology techniques and single cell omics for characterizations. The group also consists of a clinical unit that performs skin biopsies for generation of induced pluripotent stem cells as well as collection of tissue and brain imaging for in vivo validations. We are involved in several international and national collaborations on multiple levels. The group is supported by several funding agencies and for the specific fellowship the Swedish Society for Medical Research will provide the financial support.

The Baranello Lab- Drawing from our expertise in the fields of topoisomerase and cancer biology, we aim to answer fundamental questions about how transcription, replication and DNA topology are functionally coordinated in human cells. We use state-of-the-art approaches to assess transcriptomic, epigenomic and replisomic profiles, as well as advanced microscopy and drug screens to understand how topoisomerase regulation affects fundamental nuclear processes (key lab references: Baranello et al. Cell 2016; Wiegard et al. Molecular Cell 2021; Das et al. Molecular Cell 2022; Cameron et al. Science Advances 2023). The overall aim is to reveal novel cancer therapy targets and improved strategies for personalized treatment.

We are looking for an ambitious postdoctoral candidate that will contribute to advancing our understanding of how the oncoprotein MYC controls lymphocytes development through the regulation of topoisomerase activity, with the aim of developing strategies to hijacking MYC-driven lymphomas.

The project will be performed collaboratively between Laura Baranello Lab (Department of Cell and Molecular Biology) and Lisa Westerberg Lab (Department of Microbiology, Tumor and Cell Biology). The postdoctoral fellow will be located at Biomedicum, a top modern research building with a large repertoire of researchers and access to state-of-the-art infrastructure and facilities.

The successful candidate will apply and develop protocols including in vitro and ex vivo culture, size exclusion chromatography, nanoparticle tracking analysis, flow cytometry, super-resolution microscopy, ex vivo organ culture, histological and histochemical staining, immunofluoresence, electron microscopy and other relevant technologies, as applicable.

The research groups of Jonathan Coquet and Benedict Chambers are looking for a postdoctoral candidate excited by cancer immunology. The project examines the expression of adhesion molecules on tumor infiltrating T cells, NK cells and dendritic cells and immune exhaustion. Experience with mouse tumor models including xenograft models, spectral flow cytometry, 10X or similar single cell genomic techniques would be beneficial. The research groups have backgrounds in innate lymphocytes and T cells and publish cutting edge research. We are imbedded in a broader environment with complimentary immunology groups in cancer and infection.

The selected researcher will contribute conceptually as well as methodologically to several registry-based, big-data and clinical studies investigating the status of and barriers to the implementation of guideline directed medical therapies on heart failure in clinical practice, as well as the design of clinical studies testing implementation strategies.  The selected research will work in the team and under the supervision of Assoc. Professor Gianluigi Savarese. The candidate will work on performing statistical analyses and writing reports or manuscripts for submission to peer-reviewed journals. The candidate will be also engaged in teaching and supervising PhD and MD students, as well as in writing applications for funding. 

The applicant will work in close collaboration with PhD students, postdocs, and researchers. The applicant is expected to develop and analyze animal models and human samples of cancer, and present results to general and specialized audiences. The applicant is expected to be highly engaged, curious, and a team player.

A postdoc position for understanding the molecular mechanisms underlying the development of chronic pain is available in the laboratory of Saida Hadjab. The research spans from delineating the (epi)genetic of cell state changes associated with pain disorders to ultimately be able to find new targets for treatment and reshape healthy cell state from pain disorders.

(18) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoctoral Researcher within Systemic Lupus Erythematosus

Deadline : 06.Mar.2024

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Your role in the team will be to specialize in the curation and processing of large-scale real-world observational data, including longitudinal MRI, neurologic, treatment and lifestyle registry-based information. Your mission is to take the lead in refining and maintaining post-processing pipelines on our Dockerized server. This involves optimizing data storage, pseudonymization streams, and implementing advanced analysis techniques in collaboration with clinical experts. Your commitment to structuring and meticulously documenting your work will serve as the foundation for high-quality scientific publications, showcasing the innovative strides made in the field. In our dynamic work environment, you’ll have the flexibility to contribute remotely, fostering a convenient work arrangement. Your contributions will help advance the field of medical imaging and improve patient outcomes.

The position will be placed in the Cancer proteomics Mass spectrometry research group headed by Professor Janne Lehtiö at Science for Life Laboratory (SciLifeLab). The Lehtiö group is a translational group aiming to improve cancer treatment using multi-omics tumor data analysis. The group members are from various disciplines working as a team to study genes and proteins in the context of biological networks, understand how tumor molecular changes impact the proteome and discover new disease biomarkers to be exploited therapeutically. Scientists and engineers in our group work closely together using a variety of technologies to generate novel knowledge about the biology of the disease and implement tools to support the clinical-decision making in the oncology setting. The position is funded by and will involve collaboration within the RESCUER consortium, which consists of fifteen organizations from ten different countries.

We are seeking a highly motivated and enthusiastic postdoctoral fellow to join our research team. The ideal candidate should possess a critical mind and a passion for advancing scientific knowledge. The successful candidate will actively engage in scientific discussions, fostering a collaborative environment with other team members. Strong communication skills are essential, as the role involves not only contributing to cutting-edge research but also sharing insights and discoveries with colleagues. The ability to supervise and mentor master’s and Ph.D. students is a key aspect of this position, making it an excellent opportunity for individuals eager to contribute to both their academic growth and the development of emerging researchers. If you are a dedicated researcher with a commitment to excellence, innovation, and collaboration, we invite you to apply and be part of our scientific journey.

The project combines basic research with method development and will be centered around creating a unified diagnostic method based on joint genomic/mRNA sequencing and physical cell interaction (see: Zachariadis et al. Mol. Cell 2020, Andrews et al. Nat. Methods 2021, Enge et al. Cell 2017), and to use this method to better understand cancer evolution and how subclones persist treatment and cause relapse. It is a strictly data driven approach, and your main role will be to develop the computational methods involved. The project involves working closely with clinical collaborators, and directly contribute to improving future precision medicine.

We are looking for a highly motivated person with a strong background in immunology and tumor biology. The projects involve the development of human T cell technologies and evaluation of T cells from blood/tumor tissue from cancer patients, T cell repertoires and T cell function. The overall aim of the projects is to develop novel immunotherapies against cancer. Your daily work would include, primary cell culture, FACS analysis, functional T cell assays, sample collection etc.

The project combines basic research with method development and will be centered around creating a unified diagnostic method based on joint genomic/mRNA sequencing and physical cell interaction (see: Zachariadis et al. Mol. Cell 2020, Andrews et al. Nat. Methods 2021, Enge et al. Cell 2017), and to use this method to better understand cancer evolution and how subclones persist treatment and cause relapse. It is a strictly data driven approach, and your main role will be to develop the computational methods involved. The project involves working closely with clinical collaborators, and directly contribute to improving future precision medicine.

We look for a researcher interested in stem cell biology, midbrain development, dopaminergic neurons and Parkinson’s disease. The successful candidate will work with human pluripotent stem cells and human tissue, and will perform amongst others, single cell omics, cell engineering and functional genomics experiments.

The project is based on previous and ongoing work from the lab aiming at defining human midbrain dopaminergic neuron development (La Mano et al., Cell, 2016; Braun et al., Science, 2023), human adult dopaminergic neurons (Siletti et al., Science, 2023) and Parkinson’s disease (Bryois et al., Nature Genetics, 2020) at the single cell level. This knowledge has helped to develop improved protocols for the generation of DA neurons from pluripotent stem cells (Nishimura, Stem Cell reports, 2022). We are now looking for postdoctorals interested in studying the function of genes involved in human DA neuron development, and in the degeneration of DA neurons in PD. Our goal is to develop novel cell replacement approaches for PD and strategies for interfering with pathogenic mechanisms of PD. This work is being supported by an ERC Advanced Grant aiming at developing precision cell replacement strategies for Parkinson’s disease (PreciseCell PD), the Wallenberg Foundation, an EU collaborative project (Neurostemcell-reconstruct), and an international ASAP (Aligning Science Across Parkinson’s) project to understand the underlying causes of PD.

We are looking for a postdoc to the research group EPiCSS with an interest in and expertise in psychiatric epidemiology, to work within a FORTE-financed project focusing on how migration affects compulsory psychiatric care using regional and national registers.

The aim is to study why compulsory psychiatric care is more common amongst migrants than the Swedish-born population and examine possible explanations as to why it differs. This will be done using register based epidemiology.

The main task is the production of scientific articles for publication. The applicant is expected to plan and perform statistical analyzes, present at conferences and participate in writing research applications. Furthermore, the applicant is expected to conduct some teaching and supervision.

The research group of Principal Researcher Rongrong Fan at the department of Biosciences and Nutrition is looking for a highly motivated research assistant. The Rongrong Fan lab locates in the south campus of Karolinska Institutet in Flemingsberg. Our main interest is studying liver and cardiometabolic disorders. We are using multi-OMICs approaches to understand how those diseases initiate and develop. We aim to better understand the molecular mechanisms and identify potential therapeutic targets.

As a research specialist, you will coordinate the development and clinical implementation of methods for extracellular vesicle purification and analysis of their content. Your tasks will be to assist in the preparation of ethical approvals, address regulatory barriers and assist in the optimization and characterization of the methods developed for EV enrichment. Most of the work will be performed with clinical samples obtained through various collaborations with Karolinska University Hospital. The projects will be highly innovative and require up-to-date knowledge in the field as well as an excellent ability to integrate and apply advanced technologies to develop innovative technical methods. In your role as a researcher, you will work hands-on in the laboratory, interpret and write legal documentation, participate in the conception and design of new projects and take on supervisory responsibilities.

The research focus of the team is the study of the neurobiology of stress sensitivity, anxiety disorders, stress-induced long-lasting brain states (Calvigioni et al., Nature Neuroscience, 2023) and maladaptive neurodevelopment, with a specific focus on sex differences and critical windows (i.e adolescence). We aim to identify the cellular and molecular state transition in projection-defined and genetically identified sensitive brain network, causal to stress-induced long-lasting disorders, as to the increased sensitivity in women and adolescence.

Our approach, long-term vision and methodology strive to ultimately uncover how single neurons encode stimuli of emotional valence in vivo in the healthy brain and identify the causality between activity modes/genetic cell states and behavioral transition to anxiety disorders.

We are looking for a motivated, skilled and committed researcher to take part in several projects in childhood cancer. The employment will focus on how MYC/N regulates gene expression programs that are essential for tumor development and resistance to therapy, as well as using hiPSCs to model neuroblastoma development. The researcher is expected to have a leading role in experimental design, experimental performance, data analysis and representation, and presentation/publication of the results. The successful candidate will also help to write scientific articles and grant applications, and to supervise Bachelor and Master students.

Asthma is among the most common chronic diseases with an estimated 339 million cases worldwide, resulting in over 250,000 deaths each year. A major challenge is that “asthma” is an umbrella diagnosis for obstructive airway diseases with variable clinical presentations (phenotypes) and distinct mechanistic pathways (endotypes). Research in the Unit of Integrative Metabolomics in the Institute of Environmental Medicine (IMM) is focused on identifying the fundamental biochemical dysregulations (metabotypes) associated with the etiology and pathophysiology of asthma. The successful candidate will fill an important role in our efforts to improve quality of life for individuals with asthma.

The selected candidate will play an important role in the development and management of scientific projects. Projects within the group collectively focus on understanding the contribution of fat cells to promoting disease progression in obesity in humans. An ability to drive projects, experimentally and intellectually is required. The successful candidate will be expected to assist doctoral and postdoctoral researchers with their projects, providing seniority and expertise to the group, as well as pursue an independent line of research.

Somatic cells accumulate thousands of mutations during development and aging. However, detailed analysis and insight into the extent of somatic variance in the vascular tissue is lacking. You will study the clonality of the vascular wall in human tissue samples and generate advanced mouse models based on lineage tracing to follow the fate of mutated cells. The aim is to define functional implications of somatic mutations in relation to aging and age-associated cardiovascular disease. The research work includes standard molecular biological techniques, mouse phenotyping and modern omics-approaches. You are expected to be part of the group and to develop in accordance with the common group goals and research interests.

The research program in our group is focused on understating the role of MYC family of oncogenes in the biology and therapy of childhood tumors including neuroblastoma, medulloblastoma, and sarcoma. One part is focused on uncovering how MYC oncoproteins regulate several biological processes such as metabolic reprograming, cell differentiation, cell proliferation and death. Another major theme of the research is focused on assessing the therapeutic potential of MYC as well as down-stream effector proteins in these tumors by pharmacological approach utilizing small molecule inhibitors. Furthermore, the Arsenian-Henriksson’s Lab is interesting in understating the development and cell of origin of neuroblastoma using induced pluripotent stem cell (hiPSCs) models. Thus, the project will include experiments to be carried out on human cancer cell lines, hiPSCs, and animal models of neuroblastoma, medulloblastoma and sarcoma.

Asthma is among the most common chronic diseases with an estimated 339 million cases worldwide, resulting in over 250,000 deaths each year. A major challenge is that “asthma” is an umbrella diagnosis for obstructive airway diseases with variable clinical presentations (phenotypes) and distinct mechanistic pathways (endotypes). Research in the Unit of Integrative Metabolomics in the Institute of Environmental Medicine (IMM) is focused on identifying the fundamental biochemical dysregulations (metabotypes) associated with the etiology and pathophysiology of asthma. The successful candidate will fill an important role in our efforts to improve quality of life for individuals with asthma.

The selected candidate will play an important role in the development and management of scientific projects. Projects within the group collectively focus on understanding the contribution of fat cells to promoting disease progression in obesity in humans. An ability to drive projects, experimentally and intellectually is required. The successful candidate will be expected to assist doctoral and postdoctoral researchers with their projects, providing seniority and expertise to the group, as well as pursue an independent line of research.

Somatic cells accumulate thousands of mutations during development and aging. However, detailed analysis and insight into the extent of somatic variance in the vascular tissue is lacking. You will study the clonality of the vascular wall in human tissue samples and generate advanced mouse models based on lineage tracing to follow the fate of mutated cells. The aim is to define functional implications of somatic mutations in relation to aging and age-associated cardiovascular disease. The research work includes standard molecular biological techniques, mouse phenotyping and modern omics-approaches. You are expected to be part of the group and to develop in accordance with the common group goals and research interests.

The Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching within immunology, infection biology, cell biology and cancer. MTC have about 40 research groups and our key words are multidisciplinary, bridging, national and international collaborations.

The Arsenian Henriksson Lab conducts research on the MYC family of oncoproteins and network, to uncover their contribution to tumorigenesis, differentiation, metabolism, and apoptosis in different types of cancer. We are a multicultural and dynamic group with many national and international collaborators.

We are looking for 1-2 highly motivated person(s) with a strong background in immunology and tumor biology. The projects involve the development of human T cell technologies and evaluation of T cells from blood/tumor tissue from cancer patients, T cell repertoires and T cell function. The overall aim of the projects is to develop novel immunotherapies against cancer. Your daily work would include, primary cell culture, FACS analysis, functional T cell assays, sample collection etc.

We are seeking a highly motivated and dedicated researcher to carry out an exciting endeavor aiming to elucidate the mechanisms of interaction of the p53 tumor suppressor with immune system. You will take part in a highly collaborative and multidisciplinary research programme involving cancer and cell biology and immunology.

We are focusing on several endocrinological and reproductive diseases such as polycystic ovary syndrome (PCOS), obesity and type I diabetes (T1D) and aiming to investigate how the germline and maternal condition play role in fetal programming and epigenetic inheritance of disease. Our research aims to achieve in-depth knowledge of maternal-fetal interactions, transcriptional and metabolic regulations of key organ functions with link to offspring phenotypes. To achieve this, we use in vitro differentiation of germ cells from pluripotent stem cells, primary trophoblast organoids, genetic and non-genetic mouse modeling and phenotypic analyses, and single-cell sequencing

We are looking for an ambitious, highly motivated individual. Requirements for the position include a master’s degree in toxicology, cell biology or similar, hands-on experience of working with 2D cell cultures as well as performing toxicity assessment with such cultures, including different cell viability and cytotoxicity assays, ELISA, and gene expression analysis is required. Practical experience in working with epithelial organoids or other advanced 3D cell cultures as experimental models is considered advantageous.

We seek a motivated and innovative postdoc to join our leading team at Karolinska Institute. This individual should be passionately committed to furthering the knowledge to improve young people’s mental health.

Research at KI, as part of the SISU consortium, will specifically examine the impact of individual characteristics on the mental health, education, and well-being outcomes of young individuals, with a particular emphasis on vulnerable populations.

SISU builds on exceptional opportunities for Nordic countries with extensive longitudinal data sets, including school and municipality surveys, prospective cohort studies with genetic data, and population-based registries providing comprehensive information on all levels of bio-ecological influences. Methods will include a wide range of genetically informative and quasi-experimental study designs.

We are seeking a highly skilled and motivated post-doctoral research fellow in protein production/structural biology, to join an international open science project in translational medical research. The project aims to investigate under-studied human genes as potential drug targets through generation of open-access knowledge and high-quality research tools. This is an exciting opportunity to work on producing and characterizing novel human proteins as well as recombinant antibodies to human targets as part of the EUbOPEN project, using a combination of molecular biology, biochemistry and structural biology. We offer a multi-national and collaborative research environment with partners in academia and the biomedical industry worldwide.

The major goal is to explore the importance and interplay of the rich variety of cell types and states in the skin. For example, how do the various skin cell types regulate epidermal turnover and differentiation, and what are key-regulatory molecular processes that maintain health and trigger disease? The successful candidate will explore human and mouse skin using a wide variety of state-or-the-art technologies such single-cell RNA sequencing, in vivo lineage tracing and targeted cell ablation, confocal microscopy, organoid culture, and tissue engineering. The successful candidate is expected to independently plan and coordinate scientific projects, actively engage in writing grant applications and in supervising students within the Kasper lab.