21 Postdoctoral Fellowship at King’s College London, United Kingdom

Applications are invited for a postdoctoral research associate position in Dr. Angika Basant’s group at the Randall Centre for Cell and Molecular Biophysics, King’s College London.

The researcher appointed will focus on candidate phosphatases that have been validated to regulate actin dynamics during infection with the poxvirus Vaccinia. How do these phosphatases function, what are their key interactors, how do they recognise substrates, how do they impact signalling dynamics and outputs? The broader goal is to contextualise these findings in uninfected cells and, with the help of a collaborator, in other viral infections. The researcher appointed will take advantage of, and further develop, a Vaccinia virus-based signalling platform, as well as cutting-edge molecule counting and optogenetics tools available in the lab. Experience in phosphatase biology, microscopy, cell signalling or biochemistry is desirable but not mandatory.

This exciting postdoctoral position is funded by a British Heart Foundation Project grant entitled “Molecular MRI signatures of fibrosis to detect heart failure and response to treatment”.  The research aims to answer the clinically important question whether molecular MR imaging can provide readouts for precision imaging of cardiac fibrosis to detect adverse cardiac remodelling, hearts at risk of failing and monitor therapeutic response. 

The candidate will work in an interdisciplinary team consisting of physicists, imaging biologists, chemists, and clinicians to develop novel MR imaging techniques for the non-invasive detection of cardiac fibrosis using new molecular imaging probes in preclinical models of heart failure. The research team is located at St Thomas´ Hospital in the Research Department of Cardiovascular Imaging which has access to 10 state-of-the-art clinical research scanners with field strengths varying from 0.55T, 1.5T, 3T to 7T. 

This is an exciting new post for a Research Associate (RA) to work on a study funded by the NIHR Programme Development Grants. The study’s focus is to enable delivery of high-quality child-centred care through assessment of complexity and outcomes by health, social care and education providers care for children and young people with life-limiting conditions.

The post holder will be responsible for setting up the study (i.e. obtaining ethical approval) and conducting data review, collection, and evaluation. They will conduct the following tasks:  lead a realist review; recruit for and conduct semi-structured qualitative interviews with children with life-limiting conditions and their parents and health, social care and education professionals; undertake qualitative data analysis; facilitate consensus workshops; support the development of the NIHR Programme Grant application.

The research group of Dr Micaela Matta is seeking to appoint a highly motivated and experienced postdoctoral research associate in computational materials chemistry.

The position is funded by the EPSRC project “Data-driven design of organic mixed conductors”.

Mixed ionic/electronic conducting materials are being developed for applications in bioelectronics, biosensing, energy storage and neuromorphic computing.  However, the lack of general structure-property relationships is a bottleneck for systematic material development. 

In this project, the candidate will conduct a high throughput computational screening of novel organic mixed ionic/electronic conductors leveraging cheminformatics, quantum chemistry, and molecular dynamics simulations. The candidate will work in close collaboration with experimental groups providing validation/testing of novel mixed conducting materials.

Applications are invited for a postdoctoral research position to develop a novel high-speed 3-photon microscopy platform integrating fluorescence lifetime contrast correlated with optical coherence microscopy.

This Wellcome funded project focuses on how metabolism can be investigated using a range of microscopy methods, including fluorescence lifetime imaging (FLIM) and optical coherence techniques for a variety of biological systems. You will work collaboratively as one of five multidisciplinary postdoctoral researchers to develop microscope technology across length-scales from the molecular to whole organ with an emphasis on functional Imaging in three dimensions using a bespoke analysis environment. The successful candidate will assist in the construction of the 3-Photon microscopy system, integrate OCM, and liaise with team members and collaborators to co-create instrumentation, analysis environment and undertake imaging experiments on 3D cell culture models.

The successful applicant must have attained a PhD degree in Physics, Engineering, or related subject and must have extensive prior experience in both optical design and microscopy development. Previous knowledge and experience in the development of bespoke microscopy platforms (i.e. fluorescence light-sheet, confocal or multi-photon) are essential for this position. The candidate will be required to utilise high powered femtosecond laser sources, assist in the design of bespoke optics and incorporate state-of-the-art detector technologies into existing microscope platforms.

As an essential member of the Policy Institute, the Research Assistant will support in the scoping, delivery and research coordination of ongoing and new projects. We have a lot of exciting projects at the moment which you will have the opportunity to get involved in. Current projects include evaluations of: financial education initiatives in primary schools; interventions to aimed at reducing homelessness; programmes that support young people into work; and interventions to reduce youth violence.  

Our ideal candidate will have formal training in econometrics or quantitative data analysis in R, and experience or an interest in researching effective practices in a range of areas, including but not limited to education, youth work, youth violence reduction, or homelessness.  

The Postdoctoral RA sought for this position will work on South Africa. Preference will be given to candidates with doctorates specialising in legal, political or social questions relating to the rights of South African citizens. Knowledge of South Africa’s judicial and political systems, and familiarity with the social, economic and political issues impacting the population are core requirements.

Candidates should hold a PhD in one of the following disciplines: Politics and International Relations, International Law, or Constitutional Law relating to South Africa, Sociology, Human Geography, Anthropology. Candidates are expected to have experience with at least two of the following qualitative research methods: ethnographic methods, archival research, institutional and discourse analysis, socio-legal methods, and visual methods.

We are seeking a highly motivated and experienced researcher, holding a PhD in biophysics, biochemistry  or related disciplines that has experience and is interested in different aspects of single molecule mechanobiology. The candidate will work with single molecule AFM and magnetic tweezers to study the nanomechanical properties of cell-cell junction proteins.

The project is funded by a BBSRC sLOLA programme. The project will be developed between the Francis Crick Institute and the Department of Physics at King’s College London.

Within King’s, you will be part of the department of Physics, which belongs to the Faculty of Natural, Mathematical & Engineering Sciences (NMES). Supporting our staff is important to us and we offer a range of provision including flexible working, caring support, and training opportunities. The university is making significant investment in the Faculty and both student and staff numbers are growing. Our staff come from over 45 countries and around 56% of our students are from outside the UK.

Applications are invited for a postdoctoral research position to develop a novel microscopy platforms incorporating advanced single photon counting avalanche diode (SPAD) detector arrays for fluorescence lifetime imaging microscopy utilising both super-resolution and light sheet imaging methodologies.

This Wellcome funded project focuses on how metabolism can be investigated using a range of microscopy methods, including fluorescence lifetime imaging (FLIM) and optical coherence techniques for a variety of biological systems. You will work collaboratively as one of five multidisciplinary postdoctoral researchers to develop microscope technology across length-scales from the molecular to whole organ with an emphasis on functional Imaging in three dimensions using a bespoke analysis environment. The successful candidate will be responsible for further development of two microscopy systems, integrating new SPAD sensors, and liaising with team members and collaborators to co-create instrumentation, analysis environments and undertake imaging experiments on single-cell and 3D culture models.

The successful applicant must have attained a PhD degree in Physics, Engineering, or related subject and must have extensive prior experience in both optical design and microscopy development. Previous knowledge and experience in the development of bespoke microscopy platforms (i.e. fluorescence light-sheet, confocal or multi-photon) are essential for this position. The candidate will be required to utilise high powered femtosecond laser sources, assist in the design of bespoke optics and incorporate state-of-the-art detector technologies into existing microscope platforms.

The successful candidate will work with a senior health economist and interdisciplinary teams across three diverse projects in care for people with serious illness and their families: an NIHR-funded national trial in improving care for delirium, a six-country Horizon Europe trial in management of COPD, and as part of an NIHR Policy Research Unit in palliative and end-of-life care. The opportunity is available from January 2025 or as soon as possible thereafter, with a finish date of December 2028.

This is an outstanding opportunity for a capable and ambitious early career health economist.  You will lead in generating and disseminating high-quality scientific findings that aim to impact policy and practice; gain experience in multiple methodologies; engage with diverse stakeholders across research, government and the public; and join a field with a large and growing need for health economics research.

Applications are invited for a talented and enthusiastic postdoctoral scientist to join Prof Bijan Modarai’s laboratory at the School of Cardiovascular and Metabolic Medicine & Sciences at King’s College London. The postholder will be part of a vibrant multi-disciplinary translational research group, working towards developing advanced cell and gene therapies for patients with vascular disease. The research will focus on analysing patient samples that inform disease trajectory in patients with peripheral arterial disease and develop novel therapeutic approaches for these subjects.

The post holder will perform complex cellular and molecular analyses on patient samples (eg complex flow cytometry, RNASeq) and work in close association with Prof Mauro Giacca’s lab to run high throughput screens, aimed at optimising our cell and gene therapy approaches. In addition, the post holder will carry out murine surgery (hindlimb ischaemia model), doppler assessment and histology to validate findings from patient materials. The individual will also collaborate with a highly expert team of scientists in Glasgow and Leicester University as well as a pan-European consortium.

We are recruiting one highly motivated Postdoctoral Bioinformatician to join King’s College London in a new collaborative research programme. Through comprehensive genomic research that utilises large-scale multi-omics and clinical datasets (including WGS, SNP arrays, Methylation, RNAseq for tens of thousands of individuals), this programme aims to develop and validate machine learning solutions for precision medicine approaches and the early diagnosis of Motor Neurone Disease (MND).

The successful candidate will join a team of neuroscientists and computational experts at the King’s MND Care and Research Centre, where they will have a leading role in developing computational analysis methods and analysing large-scale multi-omics datasets comprising thousands of samples. These posts will be based in Dr Iacoangeli’s bioinformatics team at the Department of Biostatistics and Health Informatics but given the collaborative and multi-disciplinary nature of the programme, the expectation is that they will work closely with other members of the King’s MND Care and Research Centre (Professor Al-Chalabi lead) and Health Informatics unit (Professor Richard Dobson lead).

This role offers a unique opportunity to contribute to innovative research at the forefront of systems medicine, focusing on the progression of Metabolic Associated Steatotic Liver Disease (MASLD). The successful candidate will work within a multidisciplinary team to unravel the metabolic drivers of MASLD through cutting-edge spatial multi-omics and computational metabolic modeling.

The role involves developing and implementing computational methods to integrate genome-scale metabolic models (GEMs) with single-cell and spatial transcriptomics data. Using advanced techniques such as MALDI-MSI metabolic profiling and enzyme-constrained GEMs, the candidate will generate region-specific models to predict metabolic fluxes associated with liver disease. This research will provide key insights into the metabolic alterations driving MASLD progression, with the ultimate goal of contributing to the development of novel diagnostic and therapeutic strategies.

The post is based at the James Black Center, Denmark Hill campus, and the candidate will report directly to Dr. Cheng Zhang. The successful candidate will collaborate closely with clinicians, computational biologists, and experimentalists, ensuring that computational models are seamlessly integrated with experimental data. Responsibilities also include the supervision of junior researchers and the preparation of high-impact research publications.

As a Data Scientist in Population Health & Clinical Pathways, you will be fulfilling a crucial role within the London SDE programme, translating cutting edge data infrastructure into insights, research, and predictive models. You will be responsible for building analytics pipelines across some of the most complete primary and secondary care data in the NHS, independently implementing data science projects (including predictive analytics using machine learning) that will inform population health and clinical decision-making, and measure real-world impacts on outcomes and health equity. You will work across NHS health data environments across London, including (but not limited to) Guy’s and St. Thomas’ Hospital, King’s College Hospital, and linked primary care data on a London-wide cloud data platform.

(18) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Post-Doctoral Research Associate in Cardiovascular Virtual Twins II

Deadline : 27 October 2024.

View details & Apply

Professor Jernje Ule is seeking to appoint two enthusiastic and organised research associates to his research group working on the mechanisms of amyotrophic lateral sclerosis caused by mutations in RNA binding proteins. The group focuses on transcriptomic approaches to study RNP assembly and its defects in disease.You will contribute to the project by studying RNA condensates that contribute to the regulation of gene expression by;

• Using methods such as transcriptomics, proteomics and imaging
• Establishing new techniques
• Producing relevant publications.

This exciting and demanding senior research role will be responsible for continuing the successful delivery and future development of an ongoing set of projects, using Natural Language Processing and other AI methods, to interrogate a very large sample of electronic health records from people with epilepsy and develop models to predict clinical outcomes. Deep familiarity with current methods in this area is essential, as is the ability and knowledge to develop new methods. The postholder will be expected to develop research funding proposals, and expected to take a lead on networking internally within KCL and externally with world-leading researchers in this area. The postholder will supervise junior researchers and students.

We are seeking someone committed to developing their career in diabetes distress research in the UK by enrolling in a part-time PhD at King’s (https://www.kcl.ac.uk/nmpc/postgraduate-research) alongside their research assistant role on the programme. The post is funded 100% FTE of which a 30% contribution of time will be allocated to the conduct of a part-time PhD. It is expected the D-stress programme and the PhD will align to maximise the value of the award to the funder and opportunity for the doctoral candidate. Part-time tuition fees are NOT included in the package. Applicants must assume they will be responsible for self-funding doctoral tuition fees https://www.kcl.ac.uk/study/postgraduate-research/areas/nursing-research-with-option-of-joint-phd-with-hku-or-nus or be bringing funding with them to the application. Tuition fees contributions may be available to the post holder from year to year depending on subsequent collaborative research award opportunities and funding success developed between the post holder and academic members of the D-stress programme team. Funding for PhD-related conferences, research costs and research training is competitively available within the Division and the Faculty.