Postdoctoral Fellowship (25) at Karolinska Institute, Sweden

Research in our lab integrates a variety of approaches, making us open to individuals from diverse backgrounds. A foundation in quantitative fields (e.g., mathematics, engineering, computer science, physics) or prior experience in experimental techniques (e.g., molecular biology, high-channel density silicon probe electrophysiology in vivo or in vitro, advanced animal behavior designs and analysis, miniscope or two-photon imaging) is advantageous. Candidates are expected to demonstrate previous productivity, often by publications, but not exclusively. A combination of at least some of the following skills is essential:

• A high degree of independence
• Ability to construct/maintain and use complex experimental setups
• Proficiency in “big” data analysis (using MATLAB or Python), or

Candidates with demonstrated expertise in at least one, but ideally more, of the following domains are invited to apply:

• Design of novel, custom behavioral paradigms in mice.
• Use of hardware and (custom) software to interface and synchronize behavioral and neural recording setups.
• Familiarity with Arduino, Bonsai, DataJoint, and/or neural data recording platforms.
• Assembly, maintenance and use of complex electrophysiology or imaging systems.
• Combination of behavior with large-scale neural recordings using silicon probes, miniscope, or 2P imaging.
• Ability to explore and analyze large datasets using modern machine learning methods and a data-centered approach.
• Previous participation in collaborative projects with computational or experimental researchers.
• scRNA sequencing.
• Expertise in non-traditional animal models.

The project will use and develop cell-type specific strategies in mice to image and manipulate neuron subtypes in vivo (e.g. with optogenetics) and sophisticated behavioral paradigms (freely moving and head-fixed) in a state-of-the-art infrastructure. The project will benefit from ongoing projects that have established the identity and connectivity of neuron subtypes in relevant circuits based on single cell RNA-seq and monosynaptic rabies tracing.

The research environment is highly collaborative, and offers many opportunities for career development.

We expect applicants to have a strong determination to reveal the function of neurons and circuits during behavior, with extensive experience and interest in behavior, imaging/optical methods and/or electrophysiology.

We are seeking a postdoctoral researcher to lead a work package in our ERC Synergy grant (D2Smell) with the overall aim to digitalize smell. The aim of this sub-project is to develop and validate a new method to record electrophysiological responses to odor stimuli directly from the human olfactory receptors. Your main tasks will be, with the help of research assistants, to develop the recording setup, design and conduct experiments, analyze collected data, and publish the results in scientific articles. This will be done in direct collaboration with materials scientists in another ERC project with the goal of developing new electrodes. You will also work in close collaboration with other nodes within the ERC project. Beyond working on the ERC project, you will also be able to pursue your own research questions within the framework of our general research program. As a postdoctoral researcher in the group, you get the opportunity to work in a successful and well-funded research group with a number of senior and junior researchers. Our research group collaborates with a number of prominent research groups around the world, which provides an opportunity for international exchanges.

The Department of Neuroscience at Karolinska Institutet hosts ~20 research groups working on fundamental and disease‑related aspects of nervous system function: https://ki.se/en/neuro/research/group-leaders-at-the-department-of-neuroscience

SciLifeLab is a national research infrastructure providing unique technologies and expertise in molecular biosciences, closely integrated with the KI research community and partner universities.

The position is part of a long‑term interdisciplinary collaboration with Dr William Nyberg, Assistant Professor at the Department of Medicine, Huddinge, and SciLifeLab, whose group develops evolved AAV capsids and optically controlled gene‑expression systems for in vivo cell engineering. The successful candidate will help consolidate and expand this joint platform.

The proposed project aims to elucidate the spatiotemporal mechanisms governing basal–apical polarity in epithelial cells and to determine how the establishment and regulation of polarity are coupled to cell fate specification.

The project will rely on ex vivo live cell imaging of esophageal epithelial progenitor cells coupled with genetic manipulation and fate mapping. In addition, we will use spatial proteomics to understand how and when polarity is established.

We seek a curious, highly motivated, and creative postdoc with a strong background in cell biology. The ideal candidate should have experience working with epithelial stem cells and live cell imaging. Experience with molecular biology, genetic perturbation strategies and proteomics is a strength. Excellent interpersonal and communication skills (in English written and verbal) is required. Emphasis will be also placed on personal suitability, fitting well into the current research group.

The growing prevalence of obesity is increasing the global burden of metabolic disease. In this position, you will contribute to elucidating cellular and molecular mechanisms underlying obesity and related metabolic disorders, with a primary focus on RNA biology. You will design and perform wet-lab validation of biomarkers and regulatory mechanisms identified through high-throughput transcriptomic data analysis and apply perturbation strategies to link transcriptomic changes to functional phenotypes. You will work with human liver, adipose tissue and blood samples, as well as relevant cellular models. The role also includes maintaining rigorous experimental documentation and reproducible workflows, collaborating with clinical partners, contributing to figures and manuscript preparation, and communicating results through presentations and, where appropriate, through contributions to grant applications.

To be eligible for employment as a postdoctoral researcher, a PhD or a foreign degree deemed to be equivalent to a Swedish PhD is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. Completion of your doctoral degree within the last three years is considered an advantage. If there are special reasons, your degree may have been completed earlier.

We invite applications from outstanding PhD, MD, or MD/PhD candidates with a background in immunology, combined with a strong interest in technology and method development. This position is aimed at candidates who want to work at the interface of immune cell biology and lineage-tracing technologies, and to develop new experimental and computational tools to study immune cell responses at single-cell resolution.

The successful candidate will be highly motivated, technically curious, and creative, with a solid experimental foundation and a clear ambition to grow as an independent researcher. The postdoctoral fellow is expected to contribute equally to biological discovery, and to technology development, including lineage tracing, single-cell workflows, and data-driven analysis. The overarching aim is to generate mechanistic insights with clear relevance for cancer immunotherapy and translational research.

The position is embedded in a highly collaborative environment spanning experimental immunology, quantitative biology, and translational cancer research, with access to world-class infrastructure for single-cell genomics, functional genomics, and computational analysis.

The preferred start date is summer 2026, but the timing and details of the position are open for discussion. The initial appointment is for two years, with the possibility of extension. 

As a postdoctoral researcher you will be working in the research group of professor Ganesh Acharya. You will contribute to the development of pedagogical methods and curricula, as well as pedagogical approaches and educational tools used in simulation based-learning and clinical education. You will take part in the planning, design and conduct of research projects in medical education. The pedagogical research aims to strengthen both clinical and non-clinical competencies among doctors, midwives, nurses and other healthcare professionals.

Special focus will be in areas such as students health, safety and wellbeing, cyber security in medical education and clinical practice, responsible use of artificial intelligence in medical education. The role also includes evaluation of new and emerging teaching and learning methods. The position involves teaching activities, as well as writing research proposals and applying for external research funding. Furthermore, you are expected to author and publish scientific articles and reports in international journals and to present research findings through academic and scientific channels, including conferences.

We are seeking a highly motivated Postdoctoral Researcher to join our team investigating how intracellular cholinergic signaling regulates mitochondrial function, mitochondrial dynamics, and the mitochondrial apoptosis axis in Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), and related neurodegenerative disorders. Our research aims to uncover mechanisms driving cholinergic neuron vulnerability, mitochondrial dysfunction, and progressive neurodegeneration, and to translate these findings into novel therapeutic strategies.

Ideal candidates will have expertise in mitochondrial biology, cellular neuroscience, or neurodegeneration research, with strong interest in disease mechanisms across AD, ALS, and aging. Experience with mitochondrial assays, imaging techniques, or molecular biology is highly advantageous.

Key Responsibilities

• Design and conduct experiments to dissect how intracellular cholinergic signaling modulates mitochondrial metabolism, stress responses, and the mitochondrial apoptosis axis in AD, ALS, and aging.
• Analyze data on mitochondrial respiration, ATP production, ROS generation, and indicators of mitochondrial integrity.
• Use advanced microscopy and imaging approaches to study mitochondrial dynamics, transport, and structural remodeling in vulnerable neuronal populations.
• Collaborate within a multidisciplinary team and contribute to manuscript preparation, data interpretation, and grant development.
• Present research findings at national and international conferences and engage with the scientific community working on AD, ALS, and neurodegenerative disease mechanisms.

Behörig att anställas som postdoktor är den som har avlagt doktorsexamen eller har motsvarande vetenskaplig kompetens. Även sökande som inte avlagt doktorsexamen vid ansökningstidens utgång kan söka under förutsättning att alla krav för fullgjord examen uppfylls innan (avsett) anställningsdatum. Detta ska styrkas av sökandes huvudhandledare, studierektor eller motsvarande.

Vi söker en mycket motiverad person med ett starkt intresse för kvantitativa studier inom området arbetsliv och hälsa. Du skall ha en doktorsexamen inom medicinsk vetenskap, folkhälsovetenskap, arbetslivsvetenskap eller likande. Tidigare erfarenhet av kvantitativ arbetslivsforskning är ett krav, och relevant bakgrund inom folkhälsovetenskaplig eller arbetslivsrelaterad epidemiologi är önskvärt. Goda färdigheter i statistisk mjukvara, till exempel SAS, Stata eller R, förutsätts. God förmåga att uttrycka sig på svenska och engelska, både skriftligt och muntligt, är också ett krav. Undervisningserfarenhet är meriterande. 

We are looking for a highly motivated, driven, enthusiastic person interested in our area of research, and ready to explore new avenues in science. The candidate should have a strong collaborative approach to research, be a team player as capable of contribute independently and contribute to a good social environment in the laboratory. The candidate must have a PhD in medical sciences, biochemistry, molecular biology or equivalent.

The research project aims to understand the underlying molecular details of class F receptor activation for future drug development. The project brings together disciplines such as structural biology (CryoEM), pharmacology, biophysics, molecular biology and oncology. The highly motivated candidate, with a strong background in GPCR structural biology AND pharmacology, is expected to drive the research project, technical development and concept development from idea to publication.

You will participate in the supervision of master’s and doctoral students. In addition to lab work, the applicant is expected to take an active, constructive and developing part in lab management and undergraduate teaching.

As a postdoc, you will study how immunosuppression affects immune functions in the context of viral infections and how that relates to outcome. You will perform integrative multi-omics analyses (including flow cytometry, transcriptomics, proteomics, and metabolomics) on both in vitro systems and ex vivo patient samples. You will receive expert guidance in immunology and virology and access to modern equipment to generate this data.

As a Postdoctoral Researcher in the Systems Virology Lab, your mission is to push the boundaries of viral pathogenesis research using state-of-the-art human organoid models. You will take full ownership of generating, maintaining, and differentiating brain, gut, and placental organoids, optimizing robust protocols that serve as the experimental backbone of the lab’s research programme.

(18) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoktor i human vävnadsimmunologi med fokus på NK-celler

Deadline : 2026-05-07

View details & Apply

The Wredenberg group at Karolinska Institutet is seeking a highly motivated postdoctoral researcher to investigate how mitochondrial function integrates with cellular and organismal metabolism.

Our research focuses on the regulation of mitochondrial function and how its disruption contributes to human disease and ageing. We combine genetic, biochemical, and systems-level approaches alongside in vivo models to define disease mechanisms, with a particular focus on inherited metabolic disorders. A key aim is to understand how mitochondrial pathways influence metabolic adaptation during tissue development and disease.

We employ genetically engineered mouse models, Drosophila, and patient-derived material, combined with molecular biology, biochemistry, and multi-omics approaches. The work is embedded in a collaborative and multidisciplinary environment that links experimental model systems with clinical data.

Do you want to contribute to top-quality medical research and build a strong foundation for a future academic career? The Romeo research group (Human Translational Genetics Group) at Karolinska Institutet is recruiting 2 motivated and dedicated postdoctoral researchers to join exciting projects aimed at uncovering the molecular and cellular mechanisms driving fibrosis and metabolic disease.

The Romeo group works at the intersection of genetics, metabolism, and clinical medicine. We combine state-of-the-art experimental models with patient-oriented translational research and strong collaborations across KI, Swedish healthcare, and leading international research environments. We offer a stimulating workplace with excellent opportunities for collaboration, high scientific ambition, and strong potential for a bright academic future.

We are looking for a motivated and ambitious postdoctoral researcher to coordinate and evaluate an intervention study starting in 2026. The study focuses on lifestyle habits and will, among other things, explore how AI can be part of lifestyle support. The study will be conducted in Swedish. The duties include:

• Design the intervention study based on your preparatory co-creation work with various stakeholders prior to its start
• Conduct data collection, data processing, and data analysis in collaboration with internal and external partners
• Provide practical supervision to bachelor’s and master’s students
• Actively participate in research discussions, contribute to a dynamic and collaborative research environment, and mentor junior colleagues
• Prepare scientific presentations, contribute to research funding applications, and participate in scientific publications
• Engage with the local community and collaborate with other researchers nationally and internationally

The Nanoscale Lipid Flux Architecture research group, located in the Department of Medical Biochemistry and Biophysics (MBB) at Karolinska Institutet, led by Assistant Professor Veijo Salo, aims to uncover the molecular logic of lipid flux and organelle biogenesis in metabolic health and disease. We study how cells build, remodel and regulate membrane bound compartments, and how nanoscale structures coordinate the flow of lipids in their native context. Our work integrates cell biology, advanced imaging and in situ cryo-electron tomography (cryo-ET) to reveal membrane architectures and protein assemblies inside intact cells.

In this postdoctoral project you will focus on developing and applying in-cell cryo-ET methodologies to visualise nanoscale lipid handling processes directly inside hepatocytes. This includes building cryo-correlative light and electron microscopy (cryo-CLEM) workflows to identify and target relevant cellular states, and performing cryo-ET to uncover membrane architectures and protein assemblies that determine whether lipids are stored in lipid droplets or secreted through the VLDL pathway. The project provides a unique opportunity to create new experimental strategies and to generate mechanistic insight into a central problem in cell biology and metabolic disease.

As a postdoctoral researcher, you will lead innovative research projects to elucidate the role of brain cholesterol metabolism and transport in male and female mouse models of Alzheimer’s disease pathology. Your work will involve both pharmacological and genetic manipulations, including surgical procedures for viral vector-mediated gene expression, behavioral assays (both standard and automated, such as Intellicage systems), immunohistochemistry, molecular techniques, and analysis of transcriptomic and lipidomic data. In-depth molecular mechanisms will also be studied in in vitro systems.

We are looking for a postdoctoral candidate that will work on advanced reconstitution methods, primary human immune cells and advanced imaging methods to quantitatively investigate immune responses to foreign antigens.

The project will be performed at the Cell Signalling, Immunity and Nanoimaging (CSI:Nano) Lab (https://www.csi-nano.org/SciLifeLab (www.scilifelab.se) and Karolinska Institute (https://ki.se)), led by Assoc. Prof. Erdinc Sezgin.

SciLifeLab and KI are excellent places to carry out basic biomedical research with clinical potential. Our lab is in the intersection of biology, chemistry, physics and engineering, aiming to reveal the molecular codes of cellular physiology and diseases. The candidate will greatly benefit from this interdisciplinary environment and unique infrastructure.