Queen’s University Belfast, United Kingdom invites online Application for number of Fully Funded PhD Degree at various Departments. We are providing a list of Fully Funded PhD Programs available at Queen’s University Belfast, United Kingdom.
Eligible candidate may Apply as soon as possible.
(01) PhD Degree – Fully Funded
PhD position summary/title: Retrodirective antenna technology for fast tracking of supersonic platforms
To be able to provide high bit rate comms links between mobile platforms, high gain antennas are needed to provide an increased S/N ratio. In terms of establishing the comms link to a moving target, the disadvantage with high gain antennas is that they are directional, requiring accurate beam tracking. This beam tracking needs to be ultrafast, if tracking platforms moving at pace, making motorised antennas or digitally controlled phased arrays too slow to keep up with the target’s movement. At QUB we have been studying a type of tracking antenna called a retrodirective antenna [1], which is able to track ultrafast targets, as recently demonstrated for space launch vehicles [2-4]. Within this PhD ICASE award, the student will have the exciting opportunity to work in collaboration with Thales Belfast to develop highly compact retrodirective solutions for this use Case. Challenges to be addressed in the PhD will be how to create a directional antenna in a small aperture space that can offer full 360 degrees steerability around the platform. Ultrafast retrodirective tracking circuits will also be studied and demonstrated to be able to track these platforms. Secondary studies will include the resilience of the comms link to interception and jamming.
Deadline : 2 December 2024
(02) PhD Degree – Fully Funded
PhD position summary/title: INTERNATIONAL DFE – What works to mobilise boys’ engagement in sex education and gender equality? A comparison of implementation in Latin America and Sub-Saharan Africa
Working with a UNESCO advisory group, this PhD examines lessons learned from implementing comprehensive sex education targeted to boys and explicitly promoting gender equality for girls in Sub-Saharan Africa and Latin America. The PhD will contribute to UNESCO work on broadening access to high quality comprehensive sexuality education globally.
To investigate what are the incentives and barriers to the delivery of comprehensive sexuality education which is designed to engage boys (alongside girls) and also explicitly promotes gender equality.
Deadline : 1 November 2024
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(03) PhD Degree – Fully Funded
PhD position summary/title: Exploring the mental health needs of patients living with Barrett’s Oesophagus
The All-Ireland Cancer Research Network (AllCaN) programme represents a new, focused effort to implement advances in oesophageal cancer research as rapidly as possible through the creation of a collaborative, translational cancer research network and a series of coordinated work packages. The most talented and promising researchers across Irish institutions will be assembled into an All-Ireland Research Network forming an optimal configuration of expertise needed to solve key problems in Oesophageal Cancer research and positively impact patients in the near future. This network will span multiple disciplines and utilise their expertise to address research questions in a coordinated way.
Deadline : 4 October 2024
(04) PhD Degree – Fully Funded
PhD position summary/title: DfE competition: Enhancing Mother-Baby Attachment: The Role of the Specialist Mental Health Team in Supporting Mothers with Perinatal Mental Health Issues
This research explores how health visitors can support the mother infant attachment relationship for mothers who have been diagnosed as having mental health issues during the perinatal period (from conception to 1 year). The study aims to identify how specialist mental health teams can effectively screen and measure mother-baby attachment relationships to promote secure mother-baby bonds and improve maternal and child mental health outcomes.
Positive parent infant relationships are key to achieving long term child outcomes. Mothers experiencing perinatal mental health issues, such as depression or anxiety, often face challenges in forming secure attachment relationships with their babies. These difficulties can have long-term adverse effects on child development and maternal well-being. Therefore where there are concerns about the mother-infant interaction as a result of maternal mental health problems further support targeting the dyad (mother and infant) should be provided (NICE,2014).
Deadline : 30 September 2024
(05) PhD Degree – Fully Funded
PhD position summary/title: DfE – A community choir intervention to improve well-being for adults with heart failure: A realist evaluation of a co-designed intervention
There is a growing evidence base for the promising use of music as a non-pharmacological intervention for improved health and wellbeing outcomes. Beneficial outcomes have been shown for healthy populations, and also for those with chronic, life-limiting conditions such as heart failure. For example, a recent randomised controlled trial of the benefits of listening to classical music for those with heart failure showed significant improvements in heart failure specific and general quality of life, self-care, sleep quality, depression, anxiety and cognitive functioning1. However, people with heart failure are at a high risk of loneliness2, and as such it is important to consider music-based interventions that have shown promise in addressing the holistic needs of this population, such as the recent cluster randomised trial of a community choir-based intervention with older adults in America which found significant improvements in levels of loneliness and interest in life3.
Deadline : 30 September 2024
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(06) PhD Degree – Fully Funded
PhD position summary/title: Microfluidic technologies applied to respiratory diseases
In Preclinical studies, a large number of molecules and biomolecules, in a very short time, have to be evaluated in terms of efficacy and toxicity. More than 300 compounds are screened per year in order to select the best one for development. In this elusive and chaotic scenario, the in-vitro evaluation of API’s properties and the way to formulate them must be explored. To respond to the urgent demand from regulatory authorities to reduce in-vivo experiments, in vitro – in vivo correlation is such an important field to focus on. With this in mind, the ability to screen in vitro different formulations in order to select only the promising ones to be administered in-vivo, to reach a selected target (e.g., a desired PK profile), should be deeply studied. Therefore, the aim in this project, is the feasibility of nanoparticles by screening their release through an advanced lab-on-a-chip model in order to punctually select best formulations for in-vivo testing.
Deadline : Open until filled
(07) PhD Degree – Fully Funded
PhD position summary/title: Investigation of novel protease-antiprotease imbalances associated with chronic airways disease.
COPD is an umbrella terms for a range of conditions to include chronic bronchitis (inflammation) and emphysema. A protease-antiprotease imbalance associated with chronic inflammation and neutrophilic infiltration is well established in COPD. To date, however, most attention has focussed on the neutrophil serine protease, neutrophil elastase and its endogenous inhibitor, alpha1 antitrypsin (AAT), also known as serine protease inhibitor A1 (serpinA1). Indeed, a genetic deficiency of AAT is a risk factor for the development of early onset COPD giving rise to aberrant levels of elastase activity which can inflict significant damage to the aveolar tissue impairing gas exchange (emphysema).
Recent work in our lab has shown that in addition to serpinA1, a number of other serpins are expressed which can inhibit a range of physiologically relevant proteases in the airways. This project will thereore progress these studies to yield valuable insight into as yet undisclosed functions of these serpins in the airways. These serpins have the potential to be critical regulators of protease activity in the lungs, down-regulation of which would contribute the protease-antiprotease imbalance which plays a significant role in the progressive destruction of lung tissue.
Deadline : Open until filled
(08) PhD Degree – Fully Funded
PhD position summary/title: Novel strategies and innovative technologies to produce amorphous solid dispersion
Poor drug solubility presents a major challenge in drug product development of oral solid dosage (OSD) forms. However, many new development compounds exhibit poor solubility and only a few of them reach market approval. Therefore, several formulation strategies are being explored to overcome solubility issues, with solid dispersion technology being of particular importance. Hot-melt extrusion is one of the key technologies for the production of amorphous solid dispersions (ASDs) and presents several advantages such as continuous and solvent-free processing, versatility and the capability to produce high-drug loaded formulations. Especially, high dose formulations are often required to reduce the pill burden of the patient, but the development of high dose formulation can also be challenging in terms of ASD stability and processability. Lately, novel manufacturing techniques emerge having the potential to revolutionize future pharmaceutical manufacturing. One of these techniques is additive manufacturing or 3D Printing, which enables dose personalization as well as the production advanced dosage forms. Coupling of solubility enhancement strategies and novel manufacturing techniques has a high potential and offers new opportunities in future drug product development.
Deadline : Open until filled
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(09) PhD Degree – Fully Funded
PhD position summary/title: Microfluidic Encapsulation of biologics into Nanomedicines
Progress in drug design has led to the development of new peptides, proteins, and drug molecules. However, the limited ability to deliver selectively these molecules at well-defined dosing regimens and without invoking drug-resistance remains a significant challenge. Another challenging aspect of some smaller sized biologics is the clearance rate. Certain modifications are required to enable effective residency time in the body. Therefore, the development of effective therapies relies on the development of effective carriers that can mitigate these challenges. Historically, lipid encapsulation of an API has led to the protection of bio-sensitive APIs, such as biologics. Evidence of this is well documented in literature. The use of carriers such as liposomes, prevents a variety of proteases from early degradation of the protein-based molecules. The initial step of encapsulation within a liposome also provides the opportunity for future membrane modification, for example with PEGylated phospholipids. This would open the door to a higher capacity for targeted delivery or altering pharmacokinetic parameters such as residence time. The confined volumetric environment provided by the Microfluidic (MF) environment coerces the self-assembly process during encapsulation to be performed in a controlled and reproducible manner. MFs can be considered as a far greener process compared to other methods currently used by companies, not only by the reduced number of materials, but also the time (and hence subsequent energy exposure) taken for formulation. The system allows the production of encapsulated NPs with predictable sizes and PDI with the need for minimal post processing. This aspect means that a pharmacopoeia grade formulation can be produced in a short and economically viable way. The aim of this Ph.D. project, which includes formulation, scalability of the MF platform, computational modelling, in vitro and (potentially) in vivo studies, is the development of formulations for the successful delivery of biologics, which could be subject to extensive metabolism or clearance post-administration, which highlights the need for alternative formulation suing MFs. The goal is to develop and optimise a method to successfully delivering a range of biopharmaceutical molecules.
Deadline : Open until filled
About Queen’s University Belfast, United Kingdom: Official website
Queen’s University Belfast (informally Queen’s or QUB) is a public research university in Belfast, Northern Ireland, United Kingdom. The university received its charter in 1845 as “Queen’s College, Belfast” and opened four years later.
Queen’s offers academic degrees at various levels, with approximately 300 degree programmes available. The current president and vice-chancellor is Ian Greer. The annual income of the institution for 2019–20 was £400 million of which £88.7 million was from research grants and contracts, with an expenditure of £372.7 million.
Queen’s is a member of the Russell Group of research intensive universities, the Association of Commonwealth Universities, the European University Association, Universities UK and Universities Ireland. The university is associated with two Nobel laureates and one Turing Award laureate.
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