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11 Postdoctoral Fellowship at University of Pennsylvania, United States

University of Pennsylvania, United States invites online Application for various Postdoctoral Fellowship in their different Departments. We are providing a list of Postdoc Fellowship positions available at University of Pennsylvania, United States.

Eligible candidate may Apply as soon as possible.

 

(01) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoctoral position in Cardiovascular Research

A postdoctoral fellow position is available in the Cardiovascular Institute of the University of Pennsylvania Perelman School of Medicine to perform basic-translational research focused on the coronary microvasculature. Coronary Microvascular Disease (CMVD) accounts for 30-50% of ischemic heart disease yet has been understudied in the past. We have developed novel methods to image the coronary microcirculation and uncover novel mechanisms of CMVD. This position focuses on using genomics, mouse models, novel mouse imaging, and cell and molecular studies on gene regulation to understand the pathogenesis of CMVD and develop novel therapeutic approaches.

Deadline : Open until Filled

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(02) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoctoral position in Cardiovascular Research

A postdoctoral fellow position is available in the Cardiovascular Institute of the University of Pennsylvania Perelman School of Medicine to perform basic-translational research focused on the coronary microvasculature. Coronary Microvascular Disease (CMVD) accounts for 30-50% of ischemic heart disease yet has been understudied in the past. We have developed novel methods to image the coronary microcirculation and uncover novel mechanisms of CMVD. This position focuses on using genomics, mouse models, novel mouse imaging, and cell and molecular studies on gene regulation to understand the pathogenesis of CMVD and develop novel therapeutic approaches.

Deadline : Open until Filled

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(03) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoctoral Fellow

The Penn Image Computing and Science Laboratory (PICSL) and the Penn Alzheimer’s Disease Research Center (ADRC) are seeking to recruit a postdoctoral fellow to engage in computational image analysis research focused on studying variability of imaging-based biomarkers of Alzheimer’s disease. The postdoctoral fellow will be working with ADRC faculty to analyze unique in vivo and postmortem imaging datasets using novel image registration, segmenta-tion, morphometry, and machine learning techniques. Candidates should have completed (or be about to complete) a Ph.D. in a relevant field of study and have a strong interest in neurodegenerative disease research. In particular, the candidates should have

Deadline : Open until Filled

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(04) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoctoral Fellow

Postdoctoral positions to study the molecular physiologies of InsP3R and MCU Ca2+ ion channels and CALHM ion channels are available in the laboratory of Kevin Foskett at the Perelman School of Medicine of the University of Pennsylvania in Philadelphia, Pennsylvania.
Our focus is on the molecular physiologies of three ion channel families, and their roles in physiology, including bioenergetics, cancer, neurodegeneration and sensory perception. Our research on the IP3R Ca2+ release channel and the mitochondrial Ca2+ uniporter seeks to understand the molecular determinants and physiological functions of endoplasmic reticulum-to-mitochondria Ca2+ transfer. Our research on CALHM ion channels centers on their roles in taste perception and the elucidation of the functional roles of different CALHM family members. Projects are available to investigate many aspects of channel biophysics, Ca2+ signaling, structural biology, and animal models.

Deadline : Open until Filled

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(05) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoctoral Researchers

Two postdoctoral researcher positions are available in the laboratory of Dr. Xiaolu Yang at the Perelman School of Medicine at the University of Pennsylvania. Our lab is interested in cancer, stemness, and neurodegeneration. The current projects focus on two areas:

(1) The tumor suppressor p53, metabolism, and autophagy. We are interested in the regulation and functions of the preeminent tumor suppressor p53. Our results have revealed an important role for p53 in modulating metabolic pathways that are critical for biosynthesis and redox balance. We are investigating the function of p53 as both a sentinel and a regulator for metabolic activities. Furthermore, we are identifying and characterizing metabolic alterations that drive tumor initiation and progression. A recent extension of this research area is to define the role of metabolism and autophagy in stem cells, including embryonic stem cells and cancer stem cells.

(2) Protein quality control, aging, and neurodegeneration. Our lab recently identified two protein quality control (PQC) systems, which consist of tripartite motif (TRIM) proteins and poly-Asp/Glu (polyD/E) proteins, respectively. Unlike canonical PQC systems, these new systems are independent of ATP. They are multifunctional and highly effective in suppressing protein misfolding and aggregation. We are investigating their mechanisms of action; their roles in aging and neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and polyglutamine diseases; and their utility in treating these diseases.

Deadline : Open until Filled

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(06) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoctoral Position in Tumor & Radiation Oncology

The Koumenis and Minn labs in the Department of Radiation Oncology at the Perelman School of Medicine at the University of Pennsylvania in Philadelphia, PA seek qualified and self-motivated candidates for a joint Postdoctoral Fellow position available immediately to study the molecular mechanisms underlying an exciting new radiation modality (“FLASH radiotherapy”). Our groups are well funded by large NIH grant and Foundation grants and by industry sponsored agreements.
The two labs are part of a large Research Division comprised of 10 faculty and is well integrated within the Abramson Cancer Center. There are ample opportunities for training and career development, including mentoring on grant writing, career advice, networking and attendance and presentations national and international scientific meetings and symposia. Former graduate students and postdoctoral fellows trained in our labs currently hold faculty positions in academia and scientist positions in industry and in government agencies.
This appointment will be for a maximum of three (3) years pending satisfactory performance. Competitive salary and benefits will be provided.

Deadline : Open until Filled

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(07) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Regenerative Medicine in Hematology

A full-time postdoctoral position is available in the Chou Lab in the Division of Hematology at the Children’s Hospital of Philadelphia and the University of Pennsylvania for an NIH-funded project to study and enhance in vitro generation of red blood cells from induced pluripotent stem cells (iPSCs) for transfusion medicine.

Deadline : Open until Filled

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(08) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Cancer Genetics Postdoctoral Position

The Maxwell Laboratory is seeking a highly motivated and creative postdoctoral fellow to understand the role of inherited TP53 mutations and interactions with the immune system in breast tumor development. The PI, Dr. Kara Maxwell, runs the Li Fraumeni Syndrome (LFS) Biobank at Penn Medicine, which ascertains patients with inherited mutations in the tumor suppressor TP53. The LFS biobank contains extensive clinical information, germline and tissue samples, peripheral blood mononuclear cells, and lymphoblastoid cell lines created from patients. Our studies have shown that certain hypomorphic TP53 mutations lead to high risks of breast cancer. Using knock-in breast cancer cell lines and patient derived lymphoblastoid cell lines, the postdoctoral fellow will characterize p53 pathway defects associated with these alleles. The fellow will utilize mouse models to study breast tumor development due to these TP53 mutations, both xenograft models and CRISPR knock-in models. Finally, the fellow will investigate the humoral and cellular responses to breast cancer development in our patient samples.

Deadline : Open until Filled

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(09) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Cancer Genetics Postdoctoral Position

The Maxwell Laboratory is seeking a highly motivated and creative postdoctoral fellow to understand the role of inherited TP53 mutations and interactions with the immune system in breast tumor development. The PI, Dr. Kara Maxwell, runs the Li Fraumeni Syndrome (LFS) Biobank at Penn Medicine, which ascertains patients with inherited mutations in the tumor suppressor TP53. The LFS biobank contains extensive clinical information, germline and tissue samples, peripheral blood mononuclear cells, and lymphoblastoid cell lines created from patients. Our studies have shown that certain hypomorphic TP53 mutations lead to high risks of breast cancer. Using knock-in breast cancer cell lines and patient derived lymphoblastoid cell lines, the postdoctoral fellow will characterize p53 pathway defects associated with these alleles. The fellow will utilize mouse models to study breast tumor development due to these TP53 mutations, both xenograft models and CRISPR knock-in models. Finally, the fellow will investigate the humoral and cellular responses to breast cancer development in our patient samples.

Deadline : Open until Filled

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(10) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoctoral Researcher in Pharmacoepidemiology

The postdoctoral researcher will primarily work on the following pharmacoepidemiology-focused studies, each led by a faculty member in the Division of Epidemiology.

Dr. Sean Hennessy, a clinical pharmacist and pharmacoepidemiologist, is PI of a National Institute on Drug Abuse-funded study entitled “Drug-Drug Interactions Involving Methadone and Buprenorphine”. This study will: i) perform high-throughput physiologically-based pharmacokinetic screening to predict the degree to which two-drug and three-drug combinations that include methadone or buprenorphine increase biological exposure to those agents; ii) perform high-throughput pharmacoepidemiologic screening of two-drug and three-drug combinations that include methadone or buprenorphine with regard to rate of emergency department presentation or hospitalization for opioid overdose and poisoning, opioid adverse effects, and cardiac arrest; iii) convene an independent multidisciplinary Expert Panel to review screening results and prioritize potential drug interaction pairs and triads for further investigation; and iv) conduct a series of rigorous pharmacoepidemiologic studies to inform causal inferences and thereby generate clinically-actionable evidence on prioritized methadone and buprenorphine drug-drug interactions. This rigorous, innovative study will produce actionable results that will guide the selection of drug therapy in the growing population of persons using methadone or buprenorphine who have comorbidities necessitating treatment. The postdoctoral researcher should anticipate leading aspects of study components ii–iv.

Deadline : Open until Filled

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(11) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoc –CRISPR screen in hematopoietic stem cells to study ribosome biogenesis /ubiquitin signaling

A postdoctoral fellow position is available at the University of Pennsylvania School of Medicine and the Children’s Hospital of Philadelphia, to perform state-of-the-art CRISPR/Cas9 screens to identify novel therapeutic targets for treating hematopoietic stem cell diseases. Hematopoietic stem cells give rise to all circulating blood cells throughout life. Maintenance of stem cell self-renewal, proliferation and differentiation is regulated by complex signaling pathways. Aberrant regulation leads to bone marrow failure or leukemia. Dr. Tong’s laboratory studies various signaling pathways in hematopoietic stem cells, bone marrow failure, and leukemia. Her laboratory recently identified a novel E3 ubiquitin ligase that plays a critical role in ribosome assembly and thereby controls hematopoietic stem cell regeneration. This postdoctoral fellow position will focus on studying the mechanisms by which ubiquitin-dependent signaling and ribosome biogenesis in regulating stem cells and investigating how failures in these processes impact hematopoietic stem cell function that leads to bone marrow failure and/or leukemia. Furthermore, this postdoctoral fellow will perform state-of-the-art CRISPR/Cas9 screens to identify novel therapeutic targets for treating hematopoietic stem cell diseases.

Deadline : Open until Filled

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About The University of Pennsylvania, United States – Official Website

The University of Pennsylvania is a private Ivy League research university in Philadelphia, Pennsylvania. The university claims a founding date of 1740 and is one of the nine colonial colleges chartered prior to the U.S. Declaration of Independence. Benjamin Franklin, Penn’s founder and first president, advocated an educational program that trained leaders in commerce, government, and public service, similar to a modern liberal arts curriculum with a practical perspective.

Penn has four undergraduate schools as well as twelve graduate and professional schools. Schools enrolling undergraduates include the College of Arts and Sciences, the School of Engineering and Applied Science, the Wharton School, and the School of Nursing. Penn’s “One University Policy” allows students to enroll in classes in any of Penn’s twelve schools. Among its highly ranked graduate and professional schools are a law school whose first professor wrote the first draft of the United States Constitution, the first school of medicine in North America (Perelman School of Medicine, 1765), and the first collegiate business school (Wharton School, 1881).

 

 

 

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