Karolinska Institute, Sweden invites online Application for number of Fully Funded PhD Degree at various Departments. We are providing a list of Fully Funded PhD Programs available at Karolinska Institute, Sweden.
Eligible candidate may Apply as soon as possible.
(01) PhD Degree – Fully Funded
PhD position summary/title: Doctoral (PhD) student position in Functional Genomics/Regulatory Transcriptomics
As a member of the Kutter lab, the successful applicant will apply, optimize and integrate novel transcriptome-wide approaches (based on bulk and single cell RNA-sequencing and epigenome profiling data) to study gene regulation and RNA processing in development and diseases using data obtained from mouse and patients. The post holder will take a strong lead in the project design and management as well as data generation, analyses and interpretation, participate in the general duties of the team and collaborate with other team members. The applicant is expected to report the scientific results leading to scientific manuscripts, attending scientific meetings, and effectively communicate with peers. The ability to work in a highly interdisciplinary and international environment, and to engage in continuous professional development is a must. The student is highly encouraged to apply to the MedBioInfo school.
Deadline : 30.Aug.2024
(02) PhD Degree – Fully Funded
PhD position summary/title: Doctoral (PhD) student position in oral-systemic health research
Oral health is paramount to overall health and well-being, yet inequities in oral health continue to pose a major global public health threat. This multidisciplinary PhD project aims to explore the connection between “oral-systemic health” to fill the knowledge gap regarding the association between metabolic disorders and oral diseases. The studies are designed using a combination of clinically-based, molecular/biochemical, and registry-based epidemiological methods. The project will be carried out thorough a close collaboration between the Department of Dental Medicine, Sachsska Children’s Hospital, Södersjukhuset and Eastmaninstitutet.
The doctoral student will contribute to development of oral health care policy protocols, synthesizing evidence, analyzing clinical and large-scale national registry datasets, acquiring multi-omics datasets, and engaging in scientific writing. Additionally, the student will actively participate in departmental seminars, present research results at international/national conferences, and attend PhD courses. Furthermore, the student will contribute to the overall management and dynamics of the laboratory.
Deadline : 25.Aug.2024
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(03) PhD Degree – Fully Funded
PhD position summary/title: PhD student position in computational developmental biology and stem cell research
The PhD project will aim at integrating single cell clonal, spatial and dissociated cell transcriptomics data for 3D neurodevelopmental reconstruction using a machine learning approach and beyond. Combo of single cell and spatial transcriptomics adds a critical layer of information by mapping gene expression patterns to specific locations within the nervous tissue, revealing how cells interact within their microenvironment. Single cell clonal data tracks the lineage relationships between cells, providing insight into the clonal evolution of neural cells during development and regeneration. This clonal data is crucial for identifying progenitor cells and understanding their role in generating the diverse cell types. The integration of these diverse types of datasets allows for a more comprehensive reconstruction of neurodevelopmental processes, combining insights into what is happening in individual cells (gene expression), where it is happening (spatial context), and how it happened (lineage and clonal history). Also, the combination of these dataset types (cell state, cell place and cell genealogy) is particularly powerful in modeling neurodevelopmental disorders and neurodegenerative diseases, because it enables clonal phenotyping and multiplexing of multiple CRISPR-based perturbation experiments in embryos and human brain organoids. At the level of entry, we expect a good command of Python and R, and also understanding of biology (genomics/transcriptomics).
Deadline : 15.Aug.2024
(04) PhD Degree – Fully Funded
PhD position summary/title: PhD Position in DNA Tools for Spatial Biology
This project is financed by a an ERC Advanced Grant to Björn Högberg with the aim to generate images of RNA distributions in tissue using methods that have become known as DNA Microcsopy. The principle is that by letting barcoded strands of DNA (for example cDNA) interact and concatenate in-situ, it is possible to generate adjacency information from sequence alone, independent from optical microscopy. This adjacency or neighbor-neighbor information can be used generate images in a computer. Today one person can routinely read millions of sequences on a weekly basis. And likely soon, we will be able to read billions of sequences daily in small labs. This outlook together with future increases in power of computational methods will then enable us, and others, to learn the inner secrets of biological system at a significantly faster rate.
The PhD student will need to actively contribute and innovate to the development of this technique and also use the technique to look at tissue samples to elucidate spatial heterogeneity and genetic or epigenetic mosaicism in biology, for example in stem-cell niches and germinal centers. We believe in letting people follow their passions, so the PhD student will have a considerable flexibility in driving his/her project.
Deadline : 04.Aug.2024
(05) PhD Degree – Fully Funded
PhD position summary/title: Doctoral (PhD) student position in Characterization of Mycobacteria host-pathogen interactions using multi-omics approaches
The student will have the gain hands-on experience in mass-spectrometry based proteomics, functional and comparative genomics as well as computational systems biology. They will also enroll in relevant PhD courses at KI, actively participate in MTC’s research, seminars, and educational initiatives.
Deadline : 20.Jul.2024
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(06) PhD Degree – Fully Funded
PhD position summary/title: Doctoral (PhD) position in genetics
The doctoral student will conduct experimental research and perform analyses of medical genetics, archaic DNA, and population-scale biobanks. This includes challenging tasks in computational biology, bioinformatics, and wet-lab work including molecular biology and pharmacology. Overall, the project strives to leverage combined insights in genetics with medical knowledge to gain insights of pathophysiological and pharmacological relevance.
Deadline : 19.Jul.2024
(07) PhD Degree – Fully Funded
PhD position summary/title: Doctoral (PhD) student position in Mucosal Immunology and Intestinal Diseases
The aim of the PhD project is to characterize the cell circuit of the colonic tissue from healthy, IBD, and colorectal (CRC) patients, as well as in experimental models of colitis and CRC. This will be done using established methodologies, like multiplex staining platforms and novel, non-commercially available Spatial metaTranscriptomics (SmT) for the identification of the host and microbiome signal in situ (SmT; Saarenpää S., et al., BioRxiv, 2022). The study plan will be establishing a spatial transcriptomic reference atlases of healthy and diseases intestinal tissues and functional characterize host-microbiome interactions involved in health and diseases. The project will be in collaboration with the laboratories of, Camilla Engblom (KI), Julio Saez-Rodriguez (EMBL), Joakim Lundberg and Dr. Stefania Giacomello (KTH, and SciLifeLab). In brief the PhD student will be exposed to experimental models of intestinal disease, human material, spatial proteotranscriptomics, organoid culture, and bioinformatic analysis.
Deadline : 15.Jul.2024
(08) PhD Degree – Fully Funded
PhD position summary/title: Doctoral (PhD) student position in spatial transcriptomics and cancer immunology
The Engblom lab recently developed a new method to study B cells and B cell receptors within their tissue microenvironment using spatial transcriptomics. The candidate will contribute to cutting-edge research in spatially resolving immune responses during tumor progression and anti-cancer therapy.
The PhD projects will be focused on adapting and using the spatial vdj method to pre-clinical studies, analyze B cell clonal dynamics using spatial transcriptomics, and develop new tools to study and analyze these interactions.
The candidate is expected to learn to develop research questions and hypothesis, design experiments, analyze data, take courses, write scientific manuscripts, communicate science to their peers and the general public, and to critically engage with the scientific community.
The applicant will work in close collaboration with other PhD students, postdocs, and researchers. The applicant is expected to actively perform analysis of spatial transcriptomics and immune clone data, and present results to general and specialized audiences.
Deadline : 11.Jul.2024
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(09) PhD Degree – Fully Funded
PhD position summary/title: Doctoral (PhD) student position in colon cancer and the microbiome
You will work on an exciting project on understanding how the gut microbiome and its metabolites promote colon cancer. Our team has a solid background in proteomics, bioinformatics and biochemistry. You will combine versatile methods including mass spectrometry-based proteomics, cell-based techniques, molecular biology and biochemistry to identify the targets and mechanism of metabolites that modulate cancer growth. Our new multidimensional proteomics technique called PISA-REX will be one of the exemplary tools that will be exploited (Saei et al. BioRxiv, 2023). Intermediate levels of bioinformatics will be required in the project. We aim to validate the most essential targets and elucidate their mechanism of tumorigenicity. The project will be in collaboration with Prof. Yihai Cao and Dr. Sylvain Peuget’s groups. If you would enjoy making original fundamental discoveries in cancer research, this position is for you.
Deadline : 10.Jul.2024
(10) PhD Degree – Fully Funded
PhD position summary/title: Doktorandplats inom malaria och subkliniska infektioner
Syftet med detta doktorandprojekt är att öka förståelsen för subkliniska malariainfektioner och bäraraskap av parasiter. Projektet omfattar kliniska, diagnostiska och immunologiska studier och innefattar att undersöka nya molekylära verktyg, antikroppssvar och proteinbiomarkörer för detektion av asymtomatiska infektioner hos migranter och individer i malaria endemiska områden. Som doktorand kommer du att delta i alla olika delar av projektet med inklusion av studiedeltagare, insamling av data i frågeformulär samt laborativa analyser. Du kommer att optimera molekylära och immunologiska analyser, analysera olika typer av data och utföra statiska analyser samt författa artiklar och presentera forskningsresultat.
Deadline : 2024-07-08
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(11) PhD Degree – Fully Funded
PhD position summary/title: Doktorandplats inom Nutritionsepidemiologi
Vi söker en driven och ansvarstagande person för avhandlingsprojekt med fokus på levnadsvanor och njurcancer. Projektet innebär epidemiologisk forskning och statistiska analyser av kohortdata för att undersöka samband mellan kost och fysisk aktivitet och risk för njurcancer, samt kvalitativa studier där patienter med njurcancer intervjuas om sina upplevelser efter diagnos. Doktoranden kommer att lära sig behärska både kvantitativa och kvalitativa forskningsmetoder. Doktorandprojekt kommer att inkludera samarbete med internationella forskargrupper och patientföreningar. Utöver att sammanställa resultat från ingående studier i vetenskapliga manuskript för publicering inkluderar doktorandutbildningen kurser, seminarier och presentationer av vetenskapliga resultat vid möten och konferenser. Doktoranden förväntas också närvara på arbetsplatsen samt diskutera och presentera vid gruppmöten och journal clubs.
Deadline : 2024-07-07
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(12) PhD Degree – Fully Funded
PhD position summary/title: Doktorandplats inom rektalcancerforskning
Doktorandplatsen innefattar arbete kopplat till lärandemål som inkluderar hantering av nationella registerdata, analys av observationella data m.h.a avancerade statistiska metoder och en klinisk prövning. Syftet med doktorandprojektet är att undersöka olika aspekter av funktionella biverkningar och komplikationer efter rektalcancerbehandling.
Doktorandstudierna motsvarar 4 års heltidsstudier och ska kunna kombineras med klinisk tjänstgöring. Detta inkluderar vetenskapligt arbete, kurser, seminarier och konferenser. Doktoranden kommer att få göra omfattande dataanalyser samt noggrant läsa den litteratur som finns inom ämnet. Doktoranden kommer även att utföra avancerade statistiska analyser för varje delstudie som ska ingå i avhandlingen under handledning av en statistiker. Under handledning och med stöd från handledare ska doktoranden förbereda de vetenskapliga manuskripten som första författare.
Deadline : 2024-07-04
(13) PhD Degree – Fully Funded
PhD position summary/title: Doktorandplats inom nanoteknologi och metabolism
We have previously shown that the levels of activation of the insulin receptor can be controlled by the valency and spatial organization of engineered insulin nanoclusters (Spratt, Dias et al., 2023). This PhD project will build on this work to understand the effects of multivalent insulin nanoclusters in different cell types using in vitro models and diabetes models of zebrafish and mice.
Deadline : 04.Jul.2024
(14) PhD Degree – Fully Funded
PhD position summary/title: Doctoral (PhD) student position in health data science
Hydroclimate extremes (e.g. floods, droughts and heatwaves) negatively affect both human and natural systems, having led to over 2 million deaths worldwide over the last 50 years. Climate change increases the frequency and severity of such events, notably of floods and heatwaves. For instance, in 2022, amid a drought, Italy’s river Misa overflowed, devastating agriculture, while Europe faced simultaneous heatwaves and droughts. In the spring of 2023, the Po Valley in Italy experienced flooding following a prolonged drought, concurrently with Spain undergoing a heatwave-drought. This points to the urgency of reducing the impacts on the most vulnerable societal groups by developing new recommendations and long-term mitigation strategies.
The goal of this PhD project is to develop a novel modelling framework to quantify the societal and health impacts of hydroclimate extremes also considering adaptation actions. The specific aims are to:
- quantify the societal and health impacts of hydroclimate extremes;
- develop system dynamic models of the societal and health impacts of hydroclimate extremes to inform sustainable development pathways.
Deadline : 02.Jul.2024
(15) PhD Degree – Fully Funded
PhD position summary/title: Doctoral (PhD) student position in cardiovascular magnetic resonance imaging research
The doctoral project will investigate the impact of systemic diseases on myocardial perfusion using cardiac magnetic resonance imaging. By comparing myocardial blood flow and perfusion reserves in patients with various systemic conditions, the study aims to enhance our understanding of the underlying pathophysiological processes and to identify early imaging markers of cardiac involvement. The ultimate goal is to improve diagnosis and management strategies of myocardial involvement in systemic diseases. The PhD student will participate in patient inclusion and study design, and will be responsible for data acquisition, image and data analysis. Additionally, the PhD student will communicate research findings through scientific presentations and publications, with guidance from supervisors.
Deadline : 02.Jul.2024
About The Karolinska Institute, Sweden – Official Website
The Karolinska Institute sometimes known as the (Royal) Caroline Institute in English is a research-led medical university in Solna within the Stockholm urban area of Sweden. The Nobel Assembly at the Karolinska Institute awards the Nobel Prize in Physiology or Medicine. The assembly consists of fifty professors from various medical disciplines at the university. The current rector of Karolinska Institute is Ole Petter Ottersen, who took office in August 2017.
The Karolinska Institute was founded in 1810 on the island of Kungsholmen on the west side of Stockholm; the main campus was relocated decades later to Solna, just outside Stockholm. A second campus was established more recently in Flemingsberg, Huddinge, south of Stockholm.
The Karolinska Institute is Sweden’s third oldest medical school, after Uppsala University (founded in 1477) and Lund University (founded in 1666). It is one of Sweden’s largest centres for training and research, accounting for 30% of the medical training and more than 40% of all academic medical and life science research conducted in Sweden.
The Karolinska University Hospital, located in Solna and Huddinge, is associated with the university as a research and teaching hospital. Together they form an academic health science centre. While most of the medical programs are taught in Swedish, the bulk of the PhD projects are conducted in English. The institute’s name is a reference to the Caroleans.
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