18 Postdoctoral Fellowship at Saint Louis University, Missouri, USA

The Post Doc Researcher will participate in the generation and analysis of quantitative maps of transcription start sites for a large number of fungal species. This includes CAGE sequencing library preparation and sequencing data analysis, molecular genetic analysis, etc.

The laboratory of Dr. Angel Baldan in the Department of Biochemistry and Molecular Biology at Saint Louis University has an immediate opening for a junior postdoctoral fellow with proven expertise in lipid/sterol metabolism, ncRNAs, RNA-seq, and/or molecular mechanisms of diet-induced diseases (CVD, NAFLD, obesity). The Baldan laboratory has ongoing research programs related to lipid droplet-associated proteins, sterol-regulated ncRNAs, and liver/adipose/intestinal/lipoprotein lipid homeostasis. An independent and highly motivated candidate with a recent Ph.D. degree and rigorous training in molecular/cell biology is required for the position. Competitive candidates have two or more first-author publications and are experienced and comfortable working with mice. Candidates with research experience in bioinformatics and next-generation sequencing are preferred but not required.

NIH-funded postdoctoral positions are available for highly motivated postdoctoral fellows to join the laboratory of Dr. Aubin Moutal, in the Department of Pharmacology and Physiology at St Louis university to study novel proteins involved in chronic pain in the context of autoimmunity. Our work focuses on first identifying determinants of the transition from acute to chronic pain by reverse translating clinical findings to then perform a complete mechanistic characterization of how these new factors influence chronic vs physiological pain. The PI has a strong record of high impact papers with multiple recent publications in Science Translational Medicine, Pain, and PNAS. Through the active external collaborations with the New York University (Dr. Rajesh Khanna), the University of Arizona (Dr. Frank Porreca) and with the Institut neuromyogene in France the candidate will also grow an interest in ion channel regulation, central mechanisms of pain and paraneoplastic syndromes, respectively.

NIH-funded postdoctoral positions are available for highly motivated postdoctoral fellows to join the laboratory of Dr. Aubin Moutal, in the Department of Pharmacology and Physiology at St Louis university to study novel proteins involved in chronic pain in the context of autoimmunity. Our work focuses on first identifying determinants of the transition from acute to chronic pain by reverse translating clinical findings to then perform a complete mechanistic characterization of how these new factors influence chronic vs physiological pain. The PI has a strong record of high impact papers with multiple recent publications in Science Translational Medicine, Pain, and PNAS. Through the active external collaborations with the New York University (Dr. Rajesh Khanna), the University of Arizona (Dr. Frank Porreca) and with the Institut neuromyogene (Dr. Jérôme Honnorat) in France, the candidate will also grow an interest in ion channel regulation, central mechanisms of pain and paraneoplastic syndromes, respectively. 

The candidate will join a dynamic, interdisciplinary team that uses cell biology, protein engineering, biochemistry, human immunology and molecular biology techniques to understand lysosomal dysfunction in rare genetic disorders. The successful candidate must be highly motivated with extensive experience within one or more of the following areas: single cell sequencing, cell culture, pharmacokinetics, pharmacodynamics, organelle, and cell/molecular biology, while experience with advanced imaging techniques is advantageous. We are particularly interested in candidates with experience in lysosomal biology.  The candidate is expected to conduct independent lab work and have a strong record of scientific productivity.   He or she should be able to think critically about complex problems and contribute to a team-working environment to advance research projects.

Our NIH-funded laboratory is seeking an enthusiastic postdoctoral fellow to study the immunological response and pathogenesis of viral infections. Laboratory studies are focused on the understanding of the antigen specific B cell response to infection and vaccination and how this B cell response is reflected in the polyclonal antibody response. Our laboratory uses in vitro and in vivo approaches to understand infection and disease.  Techniques include cloning and molecular biology, biochemistry, cell/tissue culture, flow cytometry, transcriptomics, and mouse models of infection. Experience in one or more of these techniques and areas is strongly preferred. You will be provided with the mentorship and resources to be successful.

A postdoctoral position is immediately available for exceptionally motivated and creative individuals in the laboratory of Dr. Anutosh Chakraborty at Saint Louis University, Missouri. Using a system biology approach, the Chakraborty lab aims to understand molecular mechanisms that regulate development and progression of obesity, insulin resistance and NAFLD/NASH. Prior work from the lab established that the enzyme inositol hexakisphosphate kinase-1 is a target in metabolic diseases. The current focus is to define functions of a novel ubiquitin ligase in these diseases using knockout mouse models and pharmacologic tools. The postdoc will be primarily responsible to determine role of this ligase in lipid accumulation, endoplasmic reticulum stress, metabolism, and survival of hepatocytes in vitro and in vivo. He/she will also be engaged in identifying/validating ubiquitination targets of this ligase in these processes. Candidates with a solid background in ubiquitination, molecular/cellular biology and biochemistry and a strong publication record in the areas of ubiquitination, obesity, and/or NAFLD/NASH are encouraged to apply.

Projects include studying the genetic, metabolic and epigenetic mechanisms leading to alterations in iron homeostasis, inflammation and anti-oxidative pathways during diabetic retinopathy, and the characterization of novel preventive/therapeutic targets for neuronal cell loss and vascular changes in diabetic retinopathy.

A postdoctoral position is available immediately in the lab of Gucan “Gabriel” Dai at the Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine. Candidates with a strong publication record in biophysics and biochemistry in ion channels or membrane proteins are encouraged to apply. Past experiences in patch-clamp electrophysiology or fluorescence cell imaging using advanced microscopy are preferred but not required. The Dai lab combines structural biology, chemical biology, genetics, fluorescence microscopy and electrophysiological methods to understand the fundamental mechanisms underlying ion channels of excitable membranes. The candidate is expected to publish high-impact papers as a lead author and apply for academic faculty positions or leadership positions in industry after receiving this training. The research directions in the lab are summarized in below. Applicants who are interested in this position should contact: [email protected] 

This is a grant supported position focused on the study of “Metabolic Control of T Cell Senescence in Pathogenesis and Immunotherapy of Alzheimer’s Disease.” The Peng laboratory has been performing the translational studies to dissect molecular mechanisms responsible for the senescence and dysfunction of T cells in different diseases, including cancer and age-related neurological disorder (Alzheimer’s Disease), and then to develop effective strategies for molecular and metabolic control of T cell fate and function for disease prevention and immunotherapy.

A postdoctoral researcher interested in pursuing computational policy research into urban development and sustainable geodesign as it relates to contemporary pollution problems is sought. The position involves developing decision-making and sensor fusion algorithms and using existing deep-learning frameworks. The successful candidate is expected to have a strong background in applied (spatial) statistics and high-performance computing. A recent Ph.D. in Earth Sciences, Ecology, Computer Science, or a related discipline is required. ABD candidates expecting to graduate in the next six months will be considered. The position is initially a one-year appointment renewable up to three years, depending on performance. Questions about the positions can be directed to [email protected]. Review of applications will begin immediately and continue until the position is filled.

This is a grant supported position focused on the study of “Metabolic Control of T Cell Senescence in Pathogenesis and Immunotherapy of Alzheimer’s Disease.” The Peng laboratory has been performing the translational studies to dissect molecular mechanisms responsible for the senescence and dysfunction of T cells in different diseases, including cancer and age-related neurological disorder (Alzheimer’s Disease), and then to develop effective strategies for molecular and metabolic control of T cell fate and function for disease prevention and immunotherapy.

(18) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title:    Post-Doctoral Fellow

Deadline : Open Until Filled

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