University of Liverpool, Liverpool, England invites online Application for number of Fully Funded PhD Degree at various Departments. We are providing a list of Fully Funded PhD Programs available at University of Liverpool, Liverpool, England.
Eligible candidate may Apply as soon as possible.
(01) PhD Degree – Fully Funded
PhD position summary/title: Accelerating computational materials discovery with diverse toolsets for verification and optimisation
The discovery of new functional materials to drive technologies for the net zero transition, such as batteries, solar absorbers, rare-earth-free magnets for wind power and a myriad of other unmet needs, is a scientific and societal grand challenge. Recent attempts [1-3] show that reliable automated materials discovery is not currently possible.[4]
Two PhD studentships (1 chemistry, 1 computer science) are available that will tackle the challenge to develop and implement an automated robot-based workflow that will accelerate the materials discovery process. They build on our recent physical science progress in automated synthesis of extended inorganic solids [5] and computer science progress in the diffraction data analysis required to define discovery [6]. The two students will work closely together with a multidisciplinary supervisory team to develop and integrate the methods and tools towards an automated high-throughput workflow that will revolutionise the discovery of functional inorganic materials.
Deadline : 31 December 2024
(02) PhD Degree – Fully Funded
PhD position summary/title: An integrated human organ on chip model for the prediction of BBB penetration and CNS exposure.
The development of effective Alzheimer’s disease (AD) therapies continues to be challenging, with 98% of therapies failing in Phase III due to a lack of efficacy (often driven by poor brain exposure). In vitro methodologies to assess CNS disposition are routinely utilised in drug discovery. However, these technologies still fall short of adequately mimicking the human blood-brain barrier (BBB).
To reduce/refine/replace (3R) the use of animal models, the Food and Drug Administration (FDA) has strongly encouraged the use of cell-based assays and computer models in preclinical trials. To that end, specific emphasis has been put on the development of organ-on-chip / microphysiological systems (MPS).
Hypothesis: Innovative chip-based human BBB models will enable improved prediction of CNS drug exposure in healthy volunteers and patients and be applicable to current and novel modalities.
Using cutting edge cell biology tools, this studentship will generate a 3-organ MPS consisting of human brain organoids and liver microtissues separated by a BBB made of brain endothelial-like cells. The successful student will explore and characterize this model to determine if it generates a more physiologically relevant phenotype and increases the accuracy and prediction of exposure for small molecules and new modalities including gene therapy. This is an exciting project at the forefront of science that will provide the student with training and expertise in stem cell biology, BBB, organ-on a chip technologies, and experience in working with an international pharmaceutical partner recognized in the CNS space.
Deadline : 30 September 2024
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(03) PhD Degree – Fully Funded
PhD position summary/title: An international study to investigate and optimise the safety of discontinuing valproate in young men and women with epilepsy
An exciting opportunity has arisen for a PhD student interested in Health Data Science to help us answer a critically important clinical question—probably the most significant one in epilepsy practice this decade.
Sodium valproate is a highly effective medication for controlling seizures in epilepsy. However, its use is restricted in women under 55 because it can harm their unborn child during pregnancy. Recent evidence indicates that valproate can also harm children born to men who take it, so these prescribing restrictions will soon apply to men under 55 as well. This means that many young men on valproate may soon be asked to stop taking it by their doctor, as is already happening for women. As valproate is such an effective antiseizure medication, stopping it could potentially harm these young men and women – but there is currently no evidence available to help counsel them on whether or not that truly is the case, nor to quantify what the level of risk is. Similarly, it is unclear what the safest alternative antiseizure medication is to replace valproate, meaning these young men and women are currently unable to have an informed discussion with their doctor about their options.
Deadline : 9 August 2024
(04) PhD Degree – Fully Funded
PhD position summary/title: Analysis of the role of liver sinusoidal endothelial cells in methotrexate-induced liver toxicity
Liver sinusoidal endothelial cells (LSECs) comprise approximately 50% of the non-parenchymal hepatic cells. They play a vital role in hepatic microcirculation and provide a physiological barrier to the movement of xenobiotics from the bloodstream to hepatic tissue. Methotrexate (MTX) is a chemotherapy and immunosuppressive drug, used at a high dose to treat leukaemia, breast cancer, lung cancer and at a lower dose to manage a variety of autoimmune diseases. The most common adverse effects include hepatotoxicity and blood abnormalities with the mechanism of MTX-induced hepatotoxicity obscure. Our preliminary data from a rat model of MTX injury has shown that MTX can adversely affect liver endothelial cell physiology.
This project will utilise cryopreserved human LSECs to analyse the effect of MTX on endothelial cell physiology, intracellular signalling and gene expression. The project will also utilise a novel 3D multi-cellular liver microtissue composed of primary human hepatocytes, LSECs and human liver fibroblasts to allow analysis of MTX effects on multiple hepatic cells in a more physiologically relevant model.
Deadline : 29 November 2024
(05) PhD Degree – Fully Funded
PhD position summary/title: Bioactive-loaded scaffolds for conjunctiva regeneration
Are you passionate about tissue engineering and regenerative medicine? Join us in undertaking a highly innovative PhD project focused on the conjunctiva, an under-researched yet incredibly vital tissue essential for eye protection and ocular surface homeostasis.
Multiple diseases can impair conjunctival function, often requiring surgical intervention. Our novel approach aims to revolutionise treatment through the development of a biomaterial substrate that supports a stratified epithelium with embedded, mucin-secreting goblet cells.
In our previous studies, we demonstrated electrospun fibres loaded with decellularised tissue matrix significantly enhances the stratification of human conjunctival epithelial cells compared to synthetic fibres alone. These promising matrix-containing scaffolds have the potential to become advanced therapy medicinal products for conjunctival repair and regeneration.
This PhD project offers a unique opportunity to explore the impact of incorporating bioactives, such as powdered decellularised tissue matrix or extracellular vesicles (EVs), sourced from conjunctival tissue and cells into synthetic polymers. You will create bioactive fibre scaffolds and investigate their influence on conjunctival epithelial and goblet cell responses.
Deadline : 31 August 2024
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(06) PhD Degree – Fully Funded
PhD position summary/title: Developing industrial AI support tools for processing legal cases in medical negligence
Two PhD positions are available within a project that is co-created between the University of Liverpool and Fletchers Solicitors, a Law firm specialising in clinical negligence and personal injury law. As one of the UK’s largest firms in the sector, Fletchers have vast experience from handling legal cases over many years. Each one of their cases is made up of thousands of (unstructured) files – primarily word documents, PDFs and emails. As a result, interpreting their historical caseload and extracting new insight is incredibly challenging, which means that despite their vast experience as a firm, their lawyers often only have their past cases and understanding of the law to guide their decision making and work. Additionally, they spend a lot of time reading or reviewing files, writing drafts, or extracting key information from large bodies of text – as a ‘no win, no fee’ business, spending time only in the ‘right’ places is key to their success.
Deadline : 30 September 2024
(07) PhD Degree – Fully Funded
PhD position summary/title: Development of a novel AI model for cardiovascular disease risk prediction by analysing retinal vascular structure and functional changes in blood flow
The Department of Eye and Vision Sciences at the University of Liverpool is inviting PhD candidates who are highly motivated in developing novel risk prediction model of cardiovascular disease (CVD) by analysing retinal images, contributing to a better understanding of relationship between the cardiovascular disease and the functional changes in blood flow.
The retina is one of the most metabolically active organs in the body critically supported by ocular blood flow, while CVD is a leading cause of morbidity and mortality worldwide. We aim to develop advanced AI models for analysing the dynamic retinal function, providing a comprehensive analysis of blood flow changes. Multi-modality data will be employed in this project, including imaging data (e.g., color fundus photography, fundus fluorescein angiography) and non-imaging data (e.g., electronic health records). The research will delve into the intersection between AI and healthcare, developing new approaches to revolutionise our understanding of the relationship between retinal vascular structure, blood flow dynamics, and CVD.
Deadline : 31 August 2024
(08) PhD Degree – Fully Funded
PhD position summary/title: Discovery of Functional Inorganic Materials for Net Zero Applications using High-Throughput Synthesis
This project will use high-throughput solid state synthesis methods developed in the group (Hampson 2023) to accelerate the discovery of new functional inorganic (oxide) materials for applications towards net zero technologies e.g. ionic conductors, catalysts for electrochemical hydrogen production, transparent conductors. These high-throughput methods will be applied to a variety of materials functionalities depending on the interests of the student and emerging technologies from our industrial collaborators.
The project will involve the preparation of precursor slurries and solutions for dispensing and mixing on robotic platforms before reacting at high temperatures for characterisation on high-throughput powder X-ray diffractometers and other analytical techniques. The project will involve close collaboration with computational chemists to suggest compositional spaces to explore, to predict new structures and aid in the understanding of the properties of the new materials discovered in the arrays using tools developed in the multi-disciplinary EPSRC Programme Grant: “Digital Navigation of Chemical Space for Function” and the Leverhulme Research Centre for Functional Materials Design, that seek to develop a new approach to materials design and discovery, exploiting machine learning and symbolic artificial intelligence, demonstrated by the realisation of new functional inorganic materials. You will thus gain understanding of how the artificial intelligence methods developed in the team accelerate materials discovery, and be able to contribute to the development of these models, which are designed to incorporate human expertise.
Deadline : 31 December 2024
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(09) PhD Degree – Fully Funded
PhD position summary/title: Electrochemically switchable materials down to the single molecule level
This project will study the electrochemical properties of materials down to the single molecule level and it will investigate how electrochemical (redox state) switching of the molecules can change useful materials properties. This studentship is part of £7.1 million EPSRC-funded Programme grant “Quantum engineering of energy-efficient molecular materials (QMol)”, https://gow.epsrc.ukri.org/NGBOViewGrant.aspx?GrantRef=EP/X026876/1 , which involves the Universities of Lancaster, Liverpool, Oxford and Imperial College, and the group of Professor Richard Nichols at the Department of Chemistry, The University of Liverpool. This PhD project at Liverpool University (Department of Chemistry) will focus on electrochemistry for molecular/organic electronics and thermoelectrics and will include the measurement of the electrochemical and electrical properties of molecular materials from single molecules to self-assembled monolayers and bulk multilayer structures. Techniques to be used in the project include electrochemical methods, scanning tunnelling and atomic force microscopy (STM and AFM), surface spectroscopies and nanofabrication. The QMol Programme Grant aims to realise a new generation of switchable organic/organometallic compounds, with the potential to fulfil societal needs for flexible energy harvesting materials, low-power neuromorphic computing, smart textiles and self-powered patches for healthcare.
Deadline : 30 September 2024
(10) PhD Degree – Fully Funded
PhD position summary/title: High-throughput exploration of multicomponent metal organic frameworks (MOFs)
New porous materials are important for advances in key technologies such as carbon dioxide sequestration and storage or catalysts for clean manufacturing. The assembly of multiple metal and organic linkers in the well-defined and complex crystal structures of multicomponent metal organic frameworks (MOFs) will deliver materials with enhanced properties. However, at present we do not have the experimental tools with the scale and speed to efficiently explore the vast chemical space available. This project will harness recent advances in robotics to efficiently explore the discovery of new multicomponent MOFs. The student will design and execute experiments on state-of-the-art robotic synthesis platforms, develop the required measurement approaches to extract and analyse data from the arrays of materials.
Training in robotics, chemistry and structural characterisation will be given. The project will develop protocols to identify materials with potential application gas separation (focusing on capturing carbon dioxide from flue gas and challenging separations of hydrocarbons) and catalysis (transformation of biomass for next-generation clean manufacturing) applications that will focus the large numbers of new materials identified for further detailed exploration. The project is driven by a vision of a future where research scientists will make routine, broad use of robotics as part of the discovery of advanced materials, and thus the project will prepare the student for a wide range of industrial and academic career opportunities.
Deadline : 31 December 2024
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(11) PhD Degree – Fully Funded
PhD position summary/title: High power laser development
This PhD project will contribute to a major Ministry of Defence (MoD) research programme intended to develop generation after next technologies for applications in defence and security, and is co-funded by Qinetiq.
The project will focus on creating high-energy, high-repetition-rate lasers. It will involve the student working with optical fibre lasers operating at 1mm and combining the output of these systems using polarisation combination to create one output beam. The project aims to harness the major advantages of chirped pulsed amplifier Yb fibre lasers over other solid-state systems by using combination technologies to increase the low (nJ – mJ) energy output into J level pulses at kHz repetition rates. This performance is unobtainable with current systems and the project involves working at the forefront of laser technology to drive innovative development and performance.
We wish to recruit a PhD candidate to undertake this project and be part of a new MoD/EPSRC Energy Transfer Technology Skills and Training Hub (STH). The main aim of the STH is to train the next generation of leaders in energy transfer technologies relevant for defence and other related applications. The Hub is supported by MoD, Dstl, and UK companies working in the defence and security sector. Each student funded by the Hub will have an industrial partner and have opportunities to work with and train alongside experts from industry. The Hub offers individuals training for both research and industrial career paths.
Deadline : 30 September 2024
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(12) PhD Degree – Fully Funded
PhD position summary/title: Investigating the Local Mode of Action of Anti-Perspirants using model systems and advanced probing techniques
This EPSRC Case PhD studentship is a collaboration between the University of Liverpool and Unilever to understand the action of personal care products on skin at the localised chemical level.
Personal care products represent a £multi-billion global industry. Such products often require high level chemistry to work synergistically within a complex biological environment. However, the actual action of such products is not understood well due to the difficulty of tracking events within a living system. This project will aim to create a step-change in this field by utilising advanced fabrication to mimic biological systems and then deploying sophisticated techniques to understand the action of anti-perspirants with high chemical and spatial resolution.
The project will fabricate model sweat gland platforms based on recent biological and in-vivo measurement results. The effect of anti-perspirant actives within these mimic systems will be characterised with the advanced surface measurement methods including Atomic Force Microscopy (AFM), Electron Microscopies and localised vibrational techniques of IR and Raman microscopy.
Deadline : 15 June 2025
(13) PhD Degree – Fully Funded
PhD position summary/title: Knowledge-based Design of Dental Surfaces to combat Oral Biofilms
This 4-year BBSRC PhD studentship is a collaboration between University of Liverpool & Unilever R&D.
Oral diseases are among the most common noncommunicable diseases worldwide, affecting an estimated 3.5 billion people. There are major scientific challenges in understanding how protective technologies can be designed and fabricated so that oral biofilms can be controlled to prevent oral diseases. This interdisciplinary project will investigate the protective effect of natural materials that have gained increasing interest, due to their abundant availability and environmentally friendly and biodegradable characteristics. This project will aim to advance this technology by combining advanced imaging and spectroscopic techniques in both Physical Sciences and Life Sciences to understand the how modifications of dental surfaces can be created with precision control on model tooth surfaces and how bacteria and model oral biofilms interact and behave at these surfaces so that their efficacy and mode of action can be understood.
Deadline : 15 June 2025
(14) PhD Degree – Fully Funded
PhD position summary/title: Microbial Induced Electrochemistry at the Local Site and Single Cell Level
Microbial Induced Corrosion (MIC) is a serious economic problem with an estimate worldwide cost of $113 Bn every year. MIC impacts a very wide range of industries, from power plants to construction, and even the health of humans with implants or protheses. While modern research has realised and demonstrated the relevance of microbial corrosion, the processes involved are still poorly understood, and mitigating strategies are still inadequate.
This is not surprising given the variety of electrochemical processes at work in biofilms.
This PhD project brings together expertise in nanoscale surface science and local scale electrochemistry, cell-surface interaction probes, microbiology and imaging across physical and biological sciences to study the electrochemical process that occurs both at the local site and single cell level and at the population level.
The appointed student will gain multidisciplinary skills and expertise in advanced characterisation techniques, including surface spectroscopy, scanning probe microscopy, local electrochemistry and bio-imaging approach, leveraging the unique capabilities at our Open Innovation Hub for Antimicrobial Surfaces, Surface Science Research Centre and the Centre of Cell Imaging, both equipped with state-of-the-art techniques.
Deadline : 15 June 2025
(15) PhD Degree – Fully Funded
PhD position summary/title: Non-thermal plasma as a chemical reagent: elucidating mechanism and exploring NTP for pharmaceutically relevant electroreductive reactions
Chemistry depends on electrons, but we cannot yet fully control electrons to deliver precise reactivity. Controlled high-energy electron sources—such as non-thermal plasma (NTP)—could unlock new and selective chemical transformations, but little is known about these states of matter when mixed with reaction media.
We have developed a prototype plasma-microfluidic testing chip and a batch NTP reactor for benchmarking1 and used these to deliver rapid and efficient synthesis of imine macrocycles and metal-organic frameworks. Now, further research is needed to 1) develop the on-chip analysis methods needed to achieve the full potential of these exciting early results and 2) translate this into transformative control of chemical reactivity.
A key missing piece is mechanistic investigations; our prototype has the advantage of minimal evaporation and ready customisation to include analytical equipment. In this PhD, the student will be co-supervised by Prof Anna Slater (flow and supramolecular materials) and Dr Christophe Aissa (organic chemistry, University of Liverpool) and collaborate with Prof James Walsh (plasma physics, University of York), and Dr Timothy Easun (ultrafast vibrational spectroscopy, University of Birmingham) to:
- elucidate the mechanism of the imine condensations that we have established proceed cleanly in 5 minutes under NTP conditions;
- investigate the potential of NTP in electroreductive organic chemistry, focusing initially on reactions important for the pharma industry
- develop methods to probe reaction rates (e.g., radical clock), and hence produce a framework by which NTP reactions can be mechanistically understood, benchmarked against photocatalytic and electrosynthetic methods, and optimized.
Deadline :10 January 2025
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(16) PhD Degree – Fully Funded
PhD position summary/title: Understanding interactions between chronic kidney disease and mental health to improve holistic, intelligence-led care
Individually, CKD and mental health conditions account for a significant burden of ill health. The global CKD prevalence was approximately 9%, with regional variations. In the UK around 3 million people in England were living with CKD. In the UK around 20% of UK adults experienced depression or anxiety symptoms. It is predictable to expect a high prevalence of the combination of both chronic conditions. Individuals with CKD are at an increased risk of experiencing mental health conditions compared to the general population. Studies have shown a higher prevalence of conditions such as depression, anxiety, cognitive impairment, and sleep disorders among CKD patients. There is an increasing recognition of the need to consider the mental health implications of CKD and to incorporate mental health screening, assessment, and interventions into the care of CKD patients as a way for healthcare providers to improve the wellbeing and outcomes of individuals living with CKD, with integrated care and tailored interventions. We currently do not know the prevalence of the co-occurrence of specific mental health conditions and CKD, their spatial variation and stratification by different population groups (e.g. socioeconomic). There is a paucity of longitudinal multidimensional data resources that can describe the temporal aspects of disease progression, onset of comorbidities and frequency of interaction with services.
Deadline : 1 September 2024
(17) PhD Degree – Fully Funded
PhD position summary/title: Using AI to dissect the shape of cells in response to biological and chemical threat agents for hazard identification
The project will utilise high resolution images of cells that have been exposed to a variety of biological and chemical threat agents. These include lethal viruses such as MERS-coronavirus, SARS-CoV-2 and chemical and biological agents such as chlorine and ricin. The focus of the project is to identify whether there are characteristic cellular morphological (shape) changes in response to these agents.
Our bodies are made up of millions of cells that have different functions, whether these be in the respiratory system, liver, neurological/brain functions etc. The functioning of these cells can be perturbed and destroyed by either virus infection or exposure to toxic agents. This can result in debilitating disease and death or long-term health consequences.
One of the complications in exposure to threat agents is identification of the agent itself (attribution), understanding the mechanism of action and mounting effective medical countermeasures. These factors underscore the philosophy of the PhD project.
We would like the student to use AI and machine learning approaches to understand how cells change shape in response to a threat agent and align this with high resolution data of host transcriptome and proteome changes. This will build a complex picture of function and mechanism.
Deadline : 16 August 2024
(18) PhD Degree – Fully Funded
PhD position summary/title: A multidisciplinary approach using 3D Gastruloids to understand the role of Glycosaminoglycans (GAGs) in early mammalian development
A fully-funded, multidisciplinary PhD studentship position in quantitative stem cell and developmental biology and proteomics is available in the labs of Dr David Turner and Prof. Claire Eyers in the University of Liverpool to support our recently awarded BBSRC strategic Longer and Larger project, GlycoWeb.
This multi-partner project includes research groups from The University of Nottingham, the University Liverpool, Manchester University, and the Francis Crick Institute, and we additionally have international (USA and Denmark) and commercial partners as part of the team. We value diversity and welcome applications from people who are part of groups typically under-represented in academic research. Our labs are built to be inclusive, with modifications that will support researchers with physical disabilities.
We are interested in taking quantitative fixed and live-cell approaches, coupled with state-of-the-art quantitative proteomic approaches to understand cell decision-making processes during early development. This exciting, multidisciplinary project aims to understand how glycosaminoglycans (GAGs) regulate biological function, using our cutting-edge in vitro model system: Gastruloids. Gastruloids are aggregates of mouse embryonic stem cells (mESCs) generated in non-adherent culture, which are able to effectively recapitulate many of the processes of early mammalian development such as symmetry-breaking, polarisation, gastrulation-like movements and the development of the three embryonic axes.
Deadline : 9 August 2024
About The University of Liverpool, Liverpool, England –Official Website
The University of Liverpool (abbreviated UOL; locally known as The Uni of) is a public research university in Liverpool, England. Founded as a college in 1881, it gained its Royal Charter in 1903 with the ability to award degrees, and is also known to be one of the six ‘red brick’ civic universities, the first to be referred to as The Original Red Brick. It comprises three faculties organised into 35 departments and schools. It is a founding member of the Russell Group, the N8 Group for research collaboration and the university management school is triple crown accredited.
Ten Nobel Prize winners are amongst its alumni and past faculty and the university offers more than 230 first degree courses across 103 subjects. Its alumni include the CEOs of GlobalFoundries, ARM Holdings, Tesco, Motorola and The Coca-Cola Company. It was the UK’s first university to establish departments in oceanography, civic design, architecture, and biochemistry (at the Johnston Laboratories). In 2006 the university became the first in the UK to establish an independent university in China, Xi’an Jiaotong-Liverpool University, making it the world’s first Sino-British university. For 2021–22, Liverpool had a turnover of £612.6 million, including £113.6 million from research grants and contracts. It has the seventh-largest endowment of any university in England. Graduates of the university are styled with the post-nominal letters Lpool, to indicate the institution.
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