03 Postdoctoral Fellowship at European Molecular Biology Laboratory (EMBL), Germany, Germany

We are looking for a postdoctoral researcher to work on a project related to EMBL’s Human Ecosystems Transversal Theme, where the focus will be using human organoid models to understand how environmental exposures and genetic perturbations influence airway plasticity and susceptibility to cancer. The project will involve collaboration with the Cortes-Ciriano group at EMBL-EBI as well as additional collaborations with clinicians and environmental epidemiologists. Within this framework, the specific project can be tailored to fit the candidate’s particular expertise and interests. This specific position is for a 2-year appointment with the possibility and expectation for renewal. The successful candidate will be intrinsically motivated, and will lead their own project, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and may guide PhD and Masters students in their research. Importantly, the candidate will contribute to shaping the environment and research of a young and growing research team.

We are looking for a computational biologist / bioinformatician / biostatistician who combines data-driven biological discovery research, requisite computational or statistical method development, and central management and integrative analysis of the research data. The position provides excellent opportunities for complementing your existing skills with new ones, building up your research profile in computational biology and biomedicine, and making a real contribution to improving patient outcomes. The research group of Wolfgang Huber at EMBL develops statistical data analysis and machine learning methods for modern biotechnologies, applies them to biological and biomedical discovery, and translates them into reusable tools by engaging in open source software communities. The interdisciplinary and international team has strong collaborations with researchers in cancer and developmental biology. They use cutting edge experimental data to discover and understand biological processes and to develop new biomedical applications.

You will embark on an exciting journey to decipher the structures of selected reconstituted complexes and macromolecular condensates using an integrative structural biology approach, which encompasses molecular biophysics characterisation, combined with small angles X-ray scattering, macromolecular crystallography, and cryo-electron microscopy/tomography, depending on their size and dynamics. As a team member, you will play a crucial role in uncovering the detailed biophysical and structural principles that regulate complex assembly. Joining collaborative efforts, you will contribute to the generation of a 4D multiscale integrative molecular model.