Karolinska Institute, Sweden invites online Application for number of Fully Funded PhD Degree at various Departments. We are providing a list of Fully Funded PhD Programs available at Karolinska Institute, Sweden.
Eligible candidate may Apply as soon as possible.
(01) PhD Degree – Fully Funded
PhD position summary/title: Doctoral (PhD) student position in Epigenetics of inflammatory type 2 diabetes
We are seeking a highly motivated and self-driven doctoral student with a keen interest in identifying novel epigenetic mechanisms and alterations linked to inflammation in the context of type 2 diabetes. The doctoral project aims to identify functional alterations of enhancers and silencers (currently understudied) linked to gene expression in human monocytes (a major source of inflammatory mediators). The student will investigate whether the cause of such alterations is genetic (e.g. SNPs), epigenetic (e.g. microenvironment-dependent chromatin modifications and 3D organization), or both (e.g. SNPs affecting a transcription factor or chromatin-modifying cofactor to facilitate genetic-epigenetic crosstalk). The project will apply latest genome and epigenome profiling and editing approaches to human monocytes (obtained from T2D donors via our clinical collaborators) and to human monocyte-derived cell lines.
Deadline : 09.Sep.2024
(02) PhD Degree – Fully Funded
PhD position summary/title: Doctoral (PhD) student position in Functional Genomics/Regulatory Transcriptomics
As a member of the Kutter lab, the successful applicant will apply, optimize and integrate novel transcriptome-wide approaches (based on bulk and single cell RNA-sequencing and epigenome profiling data) to study gene regulation and RNA processing in development and diseases using data obtained from mouse and patients. The post holder will take a strong lead in the project design and management as well as data generation, analyses and interpretation, participate in the general duties of the team and collaborate with other team members. The applicant is expected to report the scientific results leading to scientific manuscripts, attending scientific meetings, and effectively communicate with peers. The ability to work in a highly interdisciplinary and international environment, and to engage in continuous professional development is a must. The student is highly encouraged to apply to the MedBioInfo school.
Deadline : 30.Aug.2024
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(03) PhD Degree – Fully Funded
PhD position summary/title: Doctoral (PhD) student position in oral-systemic health research
Oral health is paramount to overall health and well-being, yet inequities in oral health continue to pose a major global public health threat. This multidisciplinary PhD project aims to explore the connection between “oral-systemic health” to fill the knowledge gap regarding the association between metabolic disorders and oral diseases. The studies are designed using a combination of clinically-based, molecular/biochemical, and registry-based epidemiological methods. The project will be carried out thorough a close collaboration between the Department of Dental Medicine, Sachsska Children’s Hospital, Södersjukhuset and Eastmaninstitutet.
The doctoral student will contribute to development of oral health care policy protocols, synthesizing evidence, analyzing clinical and large-scale national registry datasets, acquiring multi-omics datasets, and engaging in scientific writing. Additionally, the student will actively participate in departmental seminars, present research results at international/national conferences, and attend PhD courses. Furthermore, the student will contribute to the overall management and dynamics of the laboratory.
Deadline : 25.Aug.2024
(04) PhD Degree – Fully Funded
PhD position summary/title: Doctoral (PhD) student position in molecular immunology with a focus on structural and biophysical studies of T cell and NK cell receptors, and their interactions with different MHC/peptide complexes
The overall aims of the project are to assess the molecular bases underlying recognition of MHC class I molecules in complex with different peptides by T cell and NK cell receptors, and the effects of altered peptide ligands on T and NK cell responses. The proposed projects represent a unique opportunity for a PhD student to acquire deep insights into immunology, biochemistry and structural biology using a variety of techniques already well-established within the Achour laboratory and the laboratory of the co-supervisor Professor Hans-Gustaf Ljunggren (Center for Infectious Medicine (CIM), department of medicine Huddinge, Karolinska University Hospital). The duties/tasks and responsibilities of the PhD candidate are to lead the projects under the leadership of the supervisors, and in close collaboration with the colleagues within the research group. By the end of the PhD study period, the candidate should have acquired a deep knowledge in immunology and biochemistry, as well as a broad knowledge in structural biology and biophysical protein-protein affinity measurements. The PhD candidate should demonstrate excellent ability to design, perform, interpret, critically assess and contextualize generated data from experimental work. Furthermore, the PhD candidate should demonstrate aptitude to discuss and spread research results to both the national and international scientific and non-scientific communities.
Deadline : 21.Aug.2024
(05) PhD Degree – Fully Funded
PhD position summary/title: PhD student in Exercise Oncology
In Europe alone, more that 400 000 women are diagnosed with breast cancer yearly. Maintaining a physically active lifestyle after a breast cancer diagnosis is associated with a reduced risk of recurrence and improved cancer specific survival. Exercise induced shifts in immune function has been suggested as a potential mechanism for the beneficial effects and in a recent publication, we showed that the immune system, and especially CD8+ T-cells, are instrumental for the anti-neoplastic effects of exercise. The current project builds on these findings.
The project is translational and will comprise exercise interventions in animal models, healthy human subjects and primary and metastatic breast cancer patients. Specifically, the focus of the project will be on understanding how exercise induced changes in immune function, including mobilization during exercise and subsequent homing to distant tissues, contributes to disease progression and therapeutic response.
Deadline : 16.Aug.2024
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(06) PhD Degree – Fully Funded
PhD position summary/title: 1-2 doctoral (PhD) student position on computational analysis of and/or development of single-cell/spatial transcriptomics/epigenomics technologies
Our research group has performed single-cell/spatial omics studies, identifying for instance several cell states within the oligodendrocyte lineage in development and disease (Science 2016, Dev Cell 2018, 2022, Nature Medicine 2018, Nature 2019, 2023 Nature Biotechnology 2021, 2022, Neuron 2022, Cell 2024,among others). Our recent findings suggest that oligodendrocyte lineage cells might present other functional properties than previously thought, transitioning for instance to disease-associated states. The PhD student projects will focus on the development and/or computational analysis of spatial transcriptomic and epigenomic technologies, and application to multiple sclerosis. The successful candidate(s) will be integrated in a multidisciplinary team comprising computational, molecular and cellular biologists and neuroimmunologists.
Deadline :16 .Aug.2024
(07) PhD Degree – Fully Funded
PhD position summary/title: Doctoral (PhD) student position in Neurobiology of Stress and Treatment Response
We are looking for a highly motivated doctoral student who is interested in studying the molecular mechanisms and behavioral correlates, associated with stress-related psychiatric disorders and their treatments. You will gain experience in the areas of molecular biology, functional genomics, pharmacology, behavioral neuroscience, and bioinformatics. You will perform experiments using novel automatic behavioral tracking systems, activity-dependent labelling techniques, and single-cell methods to identify the genes and brain circuits engaged during treatment response. You are expected to play a leading role in experimental design, execution of experiments, analysis of data, writing research findings, as well as presentation and publication of results. You will work with collaborating laboratories (locally and internationally) to learn and adapt new techniques, in case you do not have experience with a particular method. You will also have a chance to work closely and collaborate with the scientists who are pioneers in their fields.
Deadline : 15 .Aug.2024
(08) PhD Degree – Fully Funded
PhD position summary/title: PhD student position in computational developmental biology and stem cell research
The PhD project will aim at integrating single cell clonal, spatial and dissociated cell transcriptomics data for 3D neurodevelopmental reconstruction using a machine learning approach and beyond. Combo of single cell and spatial transcriptomics adds a critical layer of information by mapping gene expression patterns to specific locations within the nervous tissue, revealing how cells interact within their microenvironment. Single cell clonal data tracks the lineage relationships between cells, providing insight into the clonal evolution of neural cells during development and regeneration. This clonal data is crucial for identifying progenitor cells and understanding their role in generating the diverse cell types. The integration of these diverse types of datasets allows for a more comprehensive reconstruction of neurodevelopmental processes, combining insights into what is happening in individual cells (gene expression), where it is happening (spatial context), and how it happened (lineage and clonal history). Also, the combination of these dataset types (cell state, cell place and cell genealogy) is particularly powerful in modeling neurodevelopmental disorders and neurodegenerative diseases, because it enables clonal phenotyping and multiplexing of multiple CRISPR-based perturbation experiments in embryos and human brain organoids. At the level of entry, we expect a good command of Python and R, and also understanding of biology (genomics/transcriptomics).
Deadline : 15.Aug.2024
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About The Karolinska Institute, Sweden – Official Website
The Karolinska Institute sometimes known as the (Royal) Caroline Institute in English is a research-led medical university in Solna within the Stockholm urban area of Sweden. The Nobel Assembly at the Karolinska Institute awards the Nobel Prize in Physiology or Medicine. The assembly consists of fifty professors from various medical disciplines at the university. The current rector of Karolinska Institute is Ole Petter Ottersen, who took office in August 2017.
The Karolinska Institute was founded in 1810 on the island of Kungsholmen on the west side of Stockholm; the main campus was relocated decades later to Solna, just outside Stockholm. A second campus was established more recently in Flemingsberg, Huddinge, south of Stockholm.
The Karolinska Institute is Sweden’s third oldest medical school, after Uppsala University (founded in 1477) and Lund University (founded in 1666). It is one of Sweden’s largest centres for training and research, accounting for 30% of the medical training and more than 40% of all academic medical and life science research conducted in Sweden.
The Karolinska University Hospital, located in Solna and Huddinge, is associated with the university as a research and teaching hospital. Together they form an academic health science centre. While most of the medical programs are taught in Swedish, the bulk of the PhD projects are conducted in English. The institute’s name is a reference to the Caroleans.
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