09 Postdoctoral Fellowship at National Jewish Health, Denver, United States

The Dooms laboratory in the Department of Immunology and Genomic Medicine at National Jewish Health, Denver, Colorado is seeking to recruit a highly motivated and skilled Postdoctoral Research Fellow to study the role of T cells in autoimmune diseases. Our laboratory is interested in understanding how T cells become dysregulated and cause autoimmunity. We are specifically investigating how T cell exhaustion, caused by chronic antigen exposure, may play protective or pathogenic roles in autoimmune diseases, and how this mechanism can be exploited for therapeutic intervention. We are currently using samples from Systemic Sclerosis patients and the NOD mouse model of Type 1 Diabetes to answer these questions.

The Numata-Nakamura Lab at National Jewish Health is seeking a highly motivated and skilled Postdoctoral Research Associate to join our team. Our lab is studying innate immunity of the lung, focusing on anti-viral effects of pulmonary surfactant phospholipids against respiratory viruses (e.g., Respiratory syncytial virus (RSV), Influenza A, Rhinovirus and SARS-CoV-2) using primary human airway epithelial cells and immune cells. Techniques used in the lab include, human primary cell cultures maintained in air-liquid interface cultures, fluorescence microscopy, flow cytometry, ELISA, molecular biology (DNA/RNA isolation, PCR), viral replication to make recombinant viruses and in vivo animal models. Training on specific techniques used in the laboratory will be provided. Significant experience with bacterial culture and molecular biology and/or mammalian cells is strongly preferred. 

The Seibold Laboratory is a cutting-edge, NIH funded, laboratory focused on elucidating the pathobiological basis of asthma and other complex lung and allergic diseases. Our goal is to discover pathobiological subgroups of disease (termed disease endotypes) and the genetic, environmental, and immune factors driving their development. We are accomplishing these goals through the integration of genomic endotyping studies of large patient cohorts with in vitro mechanistic studies of human organoid culture models. Ultimately, we will leverage the information gained from our research to develop precision medicine approaches for the diagnosis, management, and treatment of these diseases. The Seibold Laboratory is composed of a multi-disciplinary team of “wet lab” cell, airway, and molecular biologists integrated with “dry lab” computational biologists, bioinformaticians, and statistical geneticists.

To perform, on a very independent basis, all phases of experimental investigations and to collaborate with Principal Investigators and senior researchers in the progress of major research projects.  To act as technical advisor to laboratory technical, support and auxiliary staff.

Our research focuses on mechanisms of lung injury and repair in the pathogenesis of lung diseases. Our goal is to identify therapeutic targets for diseases caused by exposures to cigarette smoke, vaping, and respiratory viral infections, such as COPD/emphysema, pulmonary hypertension, and ARDS. Our research projects employ complementary approaches including molecular and cellular biology, biochemistry, pulmonary patho-physiological assessment of small animal models of disease, and translational approaches using human cohorts. Postdoctoral fellows in our laboratory are encouraged and mentored to apply for extramural funding and provided with opportunity to teach, write manuscripts, and present data at international conferences. 

The Majka Lab at National Jewish Health and is seeking a Postdoctoral Research Fellow to join their innovative team studying lung stem cell fate and function. 

Our lab has discovered and characterized a novel population of resident lung mesenchymal stem cells (MSC) in murine and human systems. Research efforts are focused on understanding how these stem cells regulate tissue homeostasis as well as remodeling at the expense of repair during chronic lung disease.

Training on specific techniques used in the laboratory will be provided. General techniques utilized in the lab include:  in vivo and in vitro modeling of stem cell fate and function, flow cytometry, cell culture, measuring physiology, confocal & 2-photon microscopy and molecular biology (PCR, Western blots, transfections, etc.)

The goals of the lab are to define maternal information that is gained and transmitted to offspring or lost and not transferred to offspring, elucidate routes of information transfer (placenta, breast milk, gametes), delineate offspring cells and pathways that are programmed by this information, and study how these cells and pathways contribute to the development of asthma. The lab has particular interest in cells and pathways of the immune system. The translational goals are to identify early-life biomarkers of predisposition to asthma in humans and define molecular targets for development of preventive drugs. 

To perform, on a very independent basis, all phases of experimental investigations and to collaborate with Principal Investigators and senior researchers in the progress of major research projects.  To act as technical advisor to laboratory technical, support and auxiliary staff.