Many blood cell disorders are driven by mutations in transcription factors and DNA and histone modifiers. Understanding the pathogenic effects of the mutations and the deregulated biological pathways may provide new targets for precision medicine. In this PhD project, we will study how mutations affect chromatin biology and transcription to deregulate cell behaviour, focusing on myeloid malignancies. State-of-the-art models (disorder-specific induced pluripotent stem cells), techniques (CRISPR gene editing, ATAC-, ChIP- and RNA-sequencing and label-free quantitative mass spectrometry) and novel bioinformatics approaches will be used to gain a better insight into the pathogenesis of myeloid malignancies and identify new therapeutic targets for these diseases. As a member of the Martens lab at the Department of Molecular Biology, you will enter our four-year PhD programme at Radboud University. Your teaching load may be up to 10% of your working time.