16 Postdoc Positions at Karolinska Institute, Sweden

As a postdoctoral researcher in our group, you will study psoriasis and its consequences for health, quality of life, and costs. Specifically, you will work on structuring and implementing analyses using data from registry-based studies and cohort studies, as well as reporting the results, for example in peer-reviewed publications. You will generate and structure your own code as well as use existing frameworks. Project data include biomarkers, patient-reported data, clinician-reported data, and data from national health registers. You will work independently with study design, programming, analysis, and reporting, with input from experts in clinical, biomedical, and statistical aspects. 

We have an opening for an individual wishing to join a multidisciplinary project aimed to understand the role of lipid mediators in lung disease. The successful candidate will be expected to use and further develop mass spectrometry-based methods for quantification of lipid mediators including eicosanoids and novel octadecanoids. Analyses will involve further development of our novel chromatography approaches including chiral and UPC2 methods for applications in large scale clinical studies as well as experimental models to map the biochemical role of lipid mediators in the pathobiology of lung disease. A particular focus will be on comprehensive profiling of eicosanoids and related oxylipins in respiratory disease, advancing our understanding of how distinct lipid mediator signatures define asthma phenotypes and potential therapeutic targets.

We are seeking an ambitious postdoctoral researcher to map alternative RNA splicing programs in normal and aberrant blood formation. This groundbreaking project will use single-cell full-length transcriptomics to create a comprehensive atlas of alternative splicing in human hematopoiesis. You will cutting-edge technologies for translational research with the opportunity to identify patterns associated with adverse outcomes in myeloproliferative neoplasms. The project is most suitable for a postdoctoral researcher with experience in computational analyses.

As a postdoctoral researcher, you will lead and contribute to projects aimed at:

• Investigating molecular mechanisms of mitochondrial gene expression, and/or
• Dissecting the interplay between mitochondrial function and cellular metabolism in health, disease, and aging.

You will work within a small, interactive team using biochemistry, molecular biology, modern omics approaches, and structural methods. The projects involve in vivo models, including genetically engineered and conditional knockout mouse or fly strains, and may include patient-derived material. You are expected to take an active role in experimental design, data analysis, and dissemination of results.

In this project you will be working in multidisciplinary team to advance personalized therapies for patients with ovarian cancer. The projects focus on drug repositioning for ovarian cancer using patient-derived cell models and the development of new high-content imaging assays to characterize primary patient samples and patient-near disease models.

För att anställas som postdoktor krävs avlagd doktorsexamen eller en utländsk examen som bedöms motsvara en svensk doktorsexamen. Detta behörighetskrav ska vara uppfyllt senast vid tidpunkten då anställningsbeslutet fattas. Det är meriterande om du har avlagt din doktorsexamen inom de tre senaste åren, om det finns särskilda skäl kan din examen ha avlagts tidigare.

Vidare kräver denna tjänst att du har en examen från psykologprogrammet, gärna vara legitimerad psykolog. Du ska ha erfarenhet av internet-baserad KBT. Du ska ha goda kunskaper i svenska då du kommer att ha kontakt med svenska forskningspersoner.  Det är särskilt meriterande om du har erfarenhet av att arbeta med patienter med och forska kring MINOCA och takotsubo syndrom. Du bör ha erfarenhet av att arbeta med registerdata, randomiserade studier samt goda kunskaper inom statistik och psykometri för att kunna bedöma och använda psykologiska mätinstrument.

We are seeking a highly motivated postdoctoral researcher with a strong desire to study principles of immune system functions after vaccination and infection. The candidate applying must have a PhD degree in biomedicine, biophysics, immunology, or a related discipline. Expertise in antibody epitope mapping by electron microscopy is required. Additional assets include experience with studies of genetic evolution of antibody responses. Experience with bioinformatical analyses is required. Emphasis will be placed on personal suitability and compatibility with lab members. Applicants must have good communication skills in English and ability to collaborate and work productively in a team.

Postdoctoral scholarships may be established for foreign researchers who pursue their merit in Sweden. A foreign researcher is a person living in another country who comes to Sweden with the intention of only staying in Sweden for all or part of their postdoctoral education at KI. Persons who are resident in Sweden and/or have carried out all or part of their academic education at KI or some other educational institution in Sweden cannot be considered for scholarships. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.

An important task for the applicant is to contribute to the ongoing research activities in Professor Eric Westman’s research group, both conceptually and methodologically. In particular, the person is expected to take an active role in our research by using imaging methods to study aging and cognitive diseases. It is also expected that you will gradually initiate and run your own research projects, which can be done to some extent based on your own area of ​​interest. The successful candidate should be able to take personal responsibility, work independently and be able to work in a team. In addition, the candidate should have broad knowledge and expertise in brain imaging (MRI), image processing and machine learning. Coordinating projects within the research group, supervising students and writing applications are also included in the role.

Projektet ämnar att utöka förståelsen för arbetsminnet, en central del av flexibel kognition genom att kombinera MEG, eye-tracking och neurala modeller.

Som postdoktor kommer du att:

• Undersöka elektrofysiologiska korrelat till visuospatialt arbetsminne samt dess överlapp med ögonrörelser och spatial uppmärksamhet.
• Designa, genomföra och analysera MEG-experiment med fokus på arbetsminne och uppmärksamhet.
• Utveckla datordrivna hjärnmodeller för att undersöka sambandet mellan insamlad data och underliggande neurala mekanismer.
• Kombinera eye-tracking data med MEG data för att förstå sambandet mellan ögonrörelser och neural dynamik.

Our research has shown that approximately 99% of glioblastomas are positive for human cytomegalovirus (HCMV), a virus that enhances tumor aggressiveness. High viral activity in GBM correlates with poor patient outcomes. Importantly, our clinical studies indicate that antiviral therapy combined with standard treatment can extend patient survival by 10–12 months. We have also demonstrated that radiotherapy induces reactivation of HCMV in approximately 50% of patients, placing these patients at particularly high risk for early tumor recurrence.

New data now suggest that a previously unrecognized, HCMV-cancer-associated virus may explain the strong link between HCMV and glioblastoma—and potentially its association with other tumor types. This project aims to characterise this virus, understand its biology, and explore its therapeutic vulnerability.

The primary focus of this project is to characterize this HCMV-cancer-associated virus and understand:

• How it replicates and spreads between cells
• In which tumors and tissues it is active
• How it depends on the rewiring of host cell metabolism
• How it contributes to oncogenic transformation

Our research has demonstrated that approximately 99% of glioblastomas are positive for human cytomegalovirus (HCMV), and that high viral activity strongly correlates with poor patient outcome. Importantly, clinical studies show that antiviral therapy combined with standard treatment provides a significant survival benefit, and that radiotherapy induces viral reactivation in a substantial fraction of patients, placing them at high risk for early tumor recurrence.

New data now indicate the presence of a previously unrecognized, HCMV-cancer-associated virus that may explain the strong association between HCMV and glioblastoma, and potentially its link to other tumor types. The central goal of this project is to identify, sequence, and characterize this virus.

We will generate sequencing data using Oxford Nanopore long-read sequencing and Illumina short-read sequencing, and apply advanced bioinformatic analyses to assemble contigs, reconstruct the viral genome, and define its genetic organization. Identified viral sequences will be systematically searched against established public databases to assess novelty, relatedness, and evolutionary origin.

The postdoctoral bioinformatician will play a central role in viral detection, genome assembly, and sequence annotation, as well as in the integration of sequencing, transcriptomic, proteomic, and metabolic datasets. These analyses will be essential to uncover novel virus–host interactions and to understand how this virus contributes to tumor biology and therapeutic vulnerability.

The Nanoscale Lipid Flux Architecture research group, located in the Department of Medical Biochemistry and Biophysics (MBB) at Karolinska Institutet, led by Assistant Professor Veijo Salo, aims to uncover the molecular logic of lipid flux and organelle biogenesis in metabolic health and disease. We study how cells build, remodel and regulate membrane bound compartments, and how nanoscale structures coordinate the flow of lipids in their native context. Our work integrates cell biology, advanced imaging and in situ cryo-electron tomography (cryo-ET) to reveal membrane architectures and protein assemblies inside intact cells.

In this postdoctoral project you will focus on developing and applying in-cell cryo-ET methodologies to visualise nanoscale lipid handling processes directly inside hepatocytes. This includes building cryo-correlative light and electron microscopy (cryo-CLEM) workflows to identify and target relevant cellular states, and performing cryo-ET to uncover membrane architectures and protein assemblies that determine whether lipids are stored in lipid droplets or secreted through the pathway. The project provides a unique opportunity to create new experimental strategies and to generate mechanistic insight into a central problem in cell biology and metabolic disease.

In this postdoctoral role, you will lead innovative research aimed at deciphering striatal function in genetic models of brain disorders by combining techniques such as patch-clamp electrophysiology, advanced imaging (using confocal and 2-photon microscopy), fiber photometry, and behavioral assays. You will also perform surgical procedures for viral expression and develop data analysis routines using Matlab, Igor Pro, or R. Applicants should have earned a Ph.D. or MD after 2024-2025 and possess a robust publication record with at least two first-author papers, alongside substantial expertise in patch-clamp electrophysiology in brain slices- experience with recordings in freely moving rodents is a plus. Proficiency in computational and statistical programming, coupled with excellent organizational and communication skills in English, is essential. We are looking for enthusiastic researchers with a background in synaptic physiology who are eager to integrate electrophysiology with imaging and molecular studies, and who thrive in a collaborative, team-oriented environment.

Enheten för Arbetsmedicin vid Institutet för miljömedicin (IMM) bedriver forskning inom området arbetsliv och hälsa. Målet med vår forskning är att identifiera och förebygga ergonomiska, psykosociala, kemiska och fysikaliska hälsorisker i arbetsmiljön. Vår verksamhet inkluderar forskning, utbildning och informationsspridning. Enheten är nära knuten till och samlokaliserad med Centrum för Arbets- och miljömedicin, Region Stockholm. Vi erbjuder en kreativ och både tvärprofessionell och tvärvetenskaplig miljö i trevliga lokaler på Torsplan i Stockholm, nära Karolinska Institutet Campus Solna.

Vi söker en postdoktor som vill arbeta med främst kvantitativa studier inom området arbetsliv och hälsa. Personen kommer att vara anställd vid enheten för arbetsmedicin på IMM, Karolinska Institutet. Enheten har fått möjlighet att starta många nya forskningsprojekt de senaste åren. Anställningen är en tvåårig visstidsanställning.