16 Postdoctoral Fellowship at Queen Mary University of London, United Kingdom

Applications are invited for a Wellcome Trust-funded Postdoctoral position to join the laboratory of Professor Sussan Nourshargh within the Centre for Microvascular Research at William Harvey Research Institute, Faculty of Medicine, Queen Mary University of London (QMUL). The position offers an exciting opportunity for a motivated postdoctoral fellow to join a dynamic team of researchers investigating neutrophil trafficking. Building on significant recent findings from the team (e.g. Girbl et al., Immunity, 2018; Owen-Woods et al., J Clin Invest., 2020; Reglero-Real et al., Immunity, 2021; Barkaway et al., Immunity, 2021), the focus of the project is to elucidate the molecular basis of remote organ damage as induced by the aberrant response of neutrophil reverse transmigration. To address its objectives, the project will employ highly specialised real-time in vivo microscopy methods, innovative cell culture techniques and single cell spatial transcriptomics.

The role of the Rheumatology Clinical Research Fellow is to provide medical support for the portfolio of commercial and academic rheumatology research studies, including regulated clinical trials (CTIMPs), being undertaken at Mile End Hospital. The post-holder will aid in the identification and recruitment of patients and will perform trial visits and assessments as per trial protocols. The post-holder will also have the opportunity to learn MSK ultrasound techniques and train in performing ultrasound guided synovial biopsies.

We seek an experienced Postdoctoral Research Assistant in cellular and molecular to contribute to the delivery of high-quality research under the supervision of by Prof Costantino Pitzalis in the Centre for Experimental Medicine & Rheumatology (EMR) at Queen Mary University of London (QMUL). The main duty of the post is the co-management, logistical and technical facilitation of European wide projects 3TR initiative (https://www.3tr-imi.eu/) and SQUEEZE. In particular, the applicant will be involved in the Rheumatoid Arthritis (RA) trials and support research investigations/projects. In addition, the post involves supporting other aspects of the EMR centre such as the sample collection/processing, database entry and quality control, auditing, routine technical support, and development/optimisation of protocols. There will also be the opportunity to work and deliver on smaller projects if desired.

Applications are sought for a Postdoctoral Research Assistant (PDRA) to undertake research under the supervision of Dr Roberto Bellelli for a three years MRC-funded research project to study the role of DNA Polymerase Epsilon in genome and epigenome stability. The post will be based at the Barts Cancer Institute (BCI), Queen Mary University of London (QMUL), with potential access to Francis Crick Institute or Great Ormond Street Hospital for some experimental work.

Dr John Riches is seeking a talented and motivated postdoctoral research scientist to understand the interaction between metabolism and epigenetics in lymphoma biology. This project will use a variety of proteomic and metabolomic techniques to investigate the impact of inhibiting metabolism on epigenetics in lymphoma cell lines and primary human cells. In addition, a component of the work will involve the use of murine models of high grade lymphoma with the aim of providing pre-clinical evidence to support the development of metabolic inhibitors as novel treatments for lymphoma, alone or in combination with existing epigenetic therapies.

Applications are sought for a Research Fellow to undertake research investigations in collaboration with and under the supervision of the Principal Investigator (PI) in order to realise the objectives and development of the research programme. The research will be based in the Centre for Haemato-Oncology, Barts Cancer Institute, within the Barts and The London School of Medicine and Dentistry, Queen Mary University of London.

Applications are sought for a Postdoctoral Research Assistant to undertake research investigations in collaboration with and under the supervision of the Principal Investigator (PI) in order to realise the objectives and development of the research programme. The research will be based in the Centre for (Haemato-Oncology), Barts Cancer Institute, within the Barts and The London School of Medicine and Dentistry, Queen Mary University of London.

Bowel cancer is the fourth most common cancer and advanced disease remains very hard to treat. The intestinal epithelium undergoes continuous self-renewal while under constant challenge from tissue damage, inflammation and genotoxic stress, all of which contribute to cancer development. In this MRC funded project we aim to explore the molecular function of a novel colorectal cancer tumour suppressor pathway. This exciting opportunity has huge potential to advance our fundamental understanding of colorectal cancer and to support academic career development.

A Postdoctoral Research Assistant position is available at Queen Mary University of London (QMUL) to work with Professor Richard Pickersgill. This project is in collaboration with Professor Martin Warren and colleagues at the Quadram Institute. We are also in collaboration with Dr Arianna Fornili (QMUL) on the computational aspects of the work. The post-holder will be funded by BBSRC on a project entitled “Vitamin scavenging in the gut: Structure/function of the tight-binding B12 foraging machinery in Bacteroides – and its biotechnological applications”.

Applications are invited for a Postdoctoral Research Associate with experience in machine and deep learning to work on a research project funded by the Precision Health, Cardiovascular Devices and Trials Theme, part of a recent NIHR Biomedical Research Centre Award to Barts Health NHS Trust.

Applications are invited for a Postdoctoral Research Associate with experience/knowledge in machine and deep learning to work on the Precision Musculoskeletal Care Theme of the recent NIHR Biomedical Research Centre Award to Barts Health NHS Trust. This Theme aims to harness this wealth of information to improve healthcare delivery and patient outcomes for musculoskeletal conditions of particularly high burden in the East End of London.

Applications are sought for a Postdoctoral Research Assistant to undertake research in collaboration with and under the supervision of Dr Özgen Deniz to realise the objectives and development of the research programme on “The Roles of Transposable Elements as Oncogenic Regulators in Acute Myeloid Leukaemia”. The research is based in the Centre for Haemato-Oncology, Barts Cancer Institute, The Faculty of Medicine and Dentistry, Queen Mary University of London .

Applications are invited for a Postdoctoral Research Assistant (PDRA) based at the School of Biological and Behavioural Sciences (SBBS), Queen Mary University of London. We are looking for an ambitious candidate to work on an exciting new research area called cell-free synthetic biology, working within the Moore group at SBBS, which is also co-supervised by Prof Tobias von der Haar at the University of Kent (UoK). We have a ~14-month Leverhulme Trust funded PDRA position to study the potential of cell-free synthetic biology in natural product biosynthesis. The PDRA will learn about cell-free gene expression and specifically the study of natural product biosynthetic pathways and their regulation from Streptomyces bacteria. For further information, please read the following:

Oncogene-induced tumour suppression is an important barrier to tumourigenesis driven by oncogene activation. Bypass of tumour suppression is observed in all cancers and understanding the underlying molecular mechanisms will allow for development of novel therapies that can restore tumour suppression in established cancers. Activation of the MYC oncogene leads to activation of the p53 pathway and loss of p53 therefore cooperates with MYC in tumourigenesis. However, the molecular mechanisms underlying MYC-induced p53 activation remain obscure. Through siRNA screening, we have identified an unexpected role for lipid metabolism in this process. The postholder will use molecular biological, biochemical and lipidomic and proteomic techniques to explore how MYC regulates lipid metabolism and how this leads to p53 activation. In addition, they will use genetic and pharmacological tools to assess whether perturbation of lipid metabolism can elicit tumour suppression in mouse models of MYC-induced lymphomagenesis.