18 Postdoctoral Fellowship at Masaryk University, Czech Republic

A post-doctoral position is open in the lab of Dr. Michal Šmída (https://www.ceitec.eu/ceitec-mu/michal-smida-research-group/rg214) to participate in research focused on the identification of novel targets for therapy of leukemias, particularly acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL). The research group is investigating molecular mechanisms essential for malignant cells and/or responsible for developing resistance to current targeted therapies. More importantly, we explore how to exploit the resistance mechanisms for novel personalized therapy. We are seeking a talented person with expertise in cell biology, molecular biology and biochemistry to perform various large-scale drug screens and genome-wide CRISPR/Cas9 cellular screens with following in-depth validation of the screening hits and detailed elucidation of molecular mechanisms. The aim of the project will be to propose novel molecular targets to break the therapy resistance and thereby enhance the success rate of the therapy in CLL or AML patients. The project will include translational research using immortalized cell lines, mouse models and primary patient material. State-of-the-art technologies such as genome-wide CRISPR/Cas9 screening, next-generation sequencing or single-cell sequencing are available in the laboratory and/or local core facilities, and are accessible on a regular basis.

A post-doctoral position is open in the Dr. Dalibor Blažek. Our research team is dedicated to understanding the roles of CDK12, CDK11, and other transcriptional kinases in the regulation of gene expression and their targeting in human diseases, particularly cancer. Our laboratory at CEITEC is international and has numerous collaborations including top bioinformaticians, medicinal chemists, and an innovative biotech company. The post-holder will integrate biochemistry and molecular biochemistry approaches, particularly genomics and proteomics together with bioinformatics analyses to address basic biological questions. We are particularly interested in an individual with strong expertise in molecular biology and biochemistry and expertise/interest in genome-wide bioinformatics analyses.

Postdoctoral position is available in laboratory of Pavel Krejci, to study various aspects of Fibroblast Growth Factor (FGF) signaling in disease. Current focus is on non-canonical FGF signaling pathways, differential signaling of FGF-receptors, and development of treatment for skeletal dysplasias caused by aberrant FGFR signaling. While our primary interest is the FGF pathway, projects on the entire RTK family are also running in the lab.

We are looking for a motivated and enthusiastic postdoc to join Stjepan Uldrijan Research Group and decipher the molecular mechanisms controlling the oncogenic RAS/RAF/MEK/ERK signaling in malignant melanoma cells under metabolic stress, particularly the crosstalk between the AMPK and ERK signaling pathways. The ambitious project builds partly on our previously published findings (Verlande et al. EMBO Rep. 2018 Feb;19(2):320-336) and more recent unpublished discoveries. The successful applicant will use various molecular and cell biology techniques – e.g., confocal microscopy, molecular cloning, flow cytometry, site-directed mutagenesis, expression profiling, proteomics, and immunoprecipitations.

The Sumbalova Koledova Lab at Masaryk University in Brno, Czech Republic, is looking for a passionate, intellectually curious postdoctoral scientist with an interest in developmental and cancer biology. Potential projects focus on the role of fibroblasts in mammary gland development and breast cancer. The experimental approaches of our interdisciplinary team include mouse models, organoids, biosensors, state-of-the-art imaging techniques, single-cell RNA sequencing, and mathematical modelling. We are closely affiliated with the Central European Institute of Technology, which offers excellent facilities, opportunities for training and cross-disciplinary collaborations. We have active international collaborations with top experts in their field at several excellent international institutions.

The Sumbalova Koledova Lab at Masaryk University in Brno, Czech Republic, is looking for a passionate, intellectually curious postdoctoral scientist with an interest in developmental and cancer biology. Potential projects focus on the role of fibroblasts in mammary gland development and breast cancer. The experimental approaches of our interdisciplinary team include mouse models, organoids, biosensors, state-of-the-art imaging techniques, single-cell RNA sequencing, and mathematical modelling. We are closely affiliated with the Central European Institute of Technology, which offers excellent facilities, opportunities for training and cross-disciplinary collaborations. We have active international collaborations with top experts in their field at several excellent international institutions.

We are seeking a talented and motivated candidate to join our team to pursue the mechanisms and functions of primary cilia. The primary cilium is an antenna-like organelle that has emerged as a fundamental regulator of embryonic development as well as tissue homeostasis. Consequently, the deregulation of its assembly, maintenance, or function leads to numerous human diseases, collectively termed ciliopathies. It has been estimated that cilia dysfunctions are responsible for as many as 100 human diseases. However, the mechanistic explanation of primary cilia assembly and function, crucial for the understanding of cilia-related defects and their therapeutic targeting, is insufficient.   

Adequate excitability is a basic parameter determining the physiological activity of the nervous tissue. Increased and decreased neuronal excitability can thus have a significant impact on the function of the nervous tissue and is the basis of a number of neuropsychiatric diseases including epilepsy, schizophrenia, and neurodegenerative diseases. Our research group is working at the Department of Physiology, Faculty of Medicine, Masaryk University (Brno, Czech Republic; https://www.med.muni.cz/o-fakulte/organizacni-struktura/pracoviste/fyziologicky-ustav/vyzkumna-skupina-markety-bebarove) and is currently explicitly focused on the Alzheimer´s disease and epilepsy (including the role of miRNA in its pathogenesis). For the study of changes in neuronal excitability, functional analysis of various nerve tissue preparations will be performed (especially 2D neuronal cultures, patient-specific hiPSC-derived neuronal organoids, or human/rat brain slices, including those coming from the extirpated brain samples of patients during neurosurgical therapeutic interventions) using multielectrode array and whole cell patch clamp techniques.

Jan Krivanek’s ‘Dental Development and Regeneration Research group’ focuses on fundamental aspects of developmental biology and its connection with regenerative medicine. We reveal the mechanisms involved in maintaining stem cell niche homeostasis, stem cell activation after injury, and the processes controlling cell differentiation at the molecular level. We are currently looking for a postdoc with experience in stem cell biology, developmental biology or dental research. We offer to work on an exciting and funded research project focused on deciphering the plasticity and function of the dental stem cell niche in vivo, using state-of-the-art methodologies. We offer competitive salary and international collaborations.

The Laboratory of Materials in Medicine at Medical Faculty of Masaryk University, led by Prof Monika Pavkova Goldbergova, provide a multi-disciplinary team that is focused on basic and applied research in the field of metals used in implantology and nanostructures (nanoparticles and nanostructured surfaces) and their effect on the organism, especially at the cellular and tissue levels. The fellows’ responsibility would include the analysis and interpretation of data from multiple assays, including genomics, methylomics, proteomics data, and data on toxicity. The overarching goal is the elucidation of the biological mechanisms driving healing and immune processes to improve metal incorporation.

The Department of Economics at the Masaryk University, Faculty of Economics and Administration, is looking for a highly motivated and productive post-doctoral researcher in the field of macroeconomics. The position is funded for 3 years.

Our postdoctoral programme will enable you to participate in one of many exciting scientific projects addressing current global issues related to health and the quality of human life. You will have the opportunity to discuss and develop ideas and train your ability to reason in a scientific manner, formulate hypotheses independently, to innovate, and to perform independent research. It is an excellent opportunity to fully develop the skills acquired throughout your PhD studies. You will have access to a professional administration supporting you with grant preparation and administration, with technology transfer, science communication and with other areas of modern research management. You will have the chance to participate in a wide range of scientific and career development events and become a valued member of our vibrant multinational scientific community.

Excellent background in the latest empirical methods, as well as a desire to apply the research of innovation and/or tourism to the context of regional economics and development, is expected. The candidate should be an independent researcher with a promising research agenda. The selected postdoc’s candidate will conduct research at the department and cooperate with other members of the team. The candidate is expected to acquire external research grants on relevant topics. The position involves a reduced teaching load (up to 4 hours per week).

We are looking for a motivated postdoc, biologist, to work on the project focused on deciphering stem cell niche dynamics in vivo. The project is based on a new concept of stemness in homeostasis and after injury and has direct implications for understanding the processes of development, repair and regeneration. In our research we take advantage of unique model of continuously growing teeth. We use variety of genetically modified mouse strains and state-of-the-art techniques including single-cell and spatial transcriptomics, advanced imaging techniques or others.

 

(18) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoc in sociology / social anthropology / migration studies

Deadline : 10 Jan 2023

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