19 Postdoctoral Fellowship at Duke University, North Carolina, USA

     The David Lab at Duke University (www.ladlab.org) is recruiting a postdoctoral fellow to join a team of scientists developing and using new DNA sequencing tools to study human diet. We are particularly interested in creating new ways to measure and analyze food intake through the analysis of human waste streams, which could include fecal matter or wastewater. We are developing DNA sequencing-based techniques that allow us to track the dietary plant and animal species that people consume. Our techniques allow us to generate objective data on intakes of over 450 plant and animal species that individuals eat and is robust to differences in memory/recall; the output data are also standardized across languages and cultures using the universal language of DNA. We are applying these tools to biospecimens from populations across North Carolina and the world. Data resulting from these studies will allow us to compare our biomarker of diet to traditional surveys of dietary intake, as well as perform systems biological studies of human food intake. The results of our studies will also allow us to create new models of disease risk and examine geographic, cultural, behavioral, and socioeconomic determinants of diet. These projects are funded by an award from the National Science Foundation for an Engineering Research Center for Precision Microbiome Engineering (PreMiEr). 

Postdoctoral Associate position to conduct studies on the molecular basis of fungal pathogenesis, related to sexual reproduction, functions of mating type loci, calcineurin signaling, or RNAi.

The Surana lab is looking for an energetic and motivated postdoctoral fellow who is interested in elucidating and better understanding causal host–microbiota–immune interactions. The Surana laboratory innovatively integrates gnotobiotic mouse models, microbiology, immunology, and bioinformatics to tackle medically relevant questions. We have recently developed a novel approach of microbe–phenotype triangulation that facilitates the identification of specific bacteria within the microbiota that are causally related to a phenotype of interest (Nature 2017). We interrogate these host–bacterial interactions from both the host (i.e., elucidating the immunological mechanism) and bacterial perspectives (i.e., identifying the necessary bacterial factors). Using our approach of microbe–phenotype triangulation, we identified a new bacterial species, Clostridium immunis, that modulates inflammatory and metabolic phenotypes via regulation of group 3 innate lymphoid cells. Moreover, we have genetically and biochemically characterized the bioactive molecule responsible for these functions. Additional projects focus on two commensal bacteria that protect against enteric infections via induction of host-derived antimicrobial peptides and other commensal bacteria that inhibit HIV pathogenesis. Potential projects include further mechanistic investigations of the above findings. There are also opportunities for translational projects that involve patient samples. 

The position requires some combination of cell biology (including imaging), molecular biology, and biochemistry skills. Experience working in fungal systems is preferred. The ideal candidate will enjoy working in a collaborative, rigorous, scientific environment, be adept at multi-tasking, and be able to work both independently and in a collaborative team environment.  The candidate must have excellent verbal and written communication skills.  This position would be for one year to start with extensions contingent upon funding, performance, and needs of the lab.

Postdoctoral position available immediately for research on genome editing in rare genetic diseases. Genome editing with adeno-associated virus vectors is a major focus of the laboratory. The project will include invivo genome editing to treat glycogen storage disease (GSD), either GSD typeIa or Pompe disease.  A second focus is to develop small molecules to stimulate autophagy and reverse the abnormalities of autophagy in GSD. New drug therapy for GSD will have implications for the treatment of more common conditions, including non-alcoholic fatty liver disease and diabetic nephropathy. Representative publications describe the scope of this project.1-6 Duke University features outstanding clinical and scientific resources with opportunities for local and international collaboration. This position will support an active collaboration with established genome editing, autophagy, andvirology research groups. Candidates with molecular biology experience, and familiarity with viral vectors, immunology, and/or biochemistry are encouraged to apply. Ph.D. and/or M.D. required.  The position is located in Dwight Koeberl’s laboratory in the Department of Pediatrics and Division of Medical Genetics, and the Molecular Genetics and Microbiology Department at Duke University.

The Postdoctoral Appointee holds a PhD or equivalent doctorate (e.g. ScD, MD, DVM). Candidates with non-US degrees may be required to provide proof of degree equivalency. 1. A candidate may also be appointed to a postdoctoral position if the candidate has completed all of the requirements for a degree but the degree has not been formally conferred: in this case, the candidate may present evidence of completion of the degree requirements, together with a statement documenting the date on which the degree is to be conferred. If the degree is not conferred by this projected date, the postdoctoral appointment may be terminated. 2. Note for international candidates: Generally, immigration classifications (e.g., H-1B, J-1, etc.) require that the requisite degree be conferred before a petition can be filed or a visa document issued to sponsor the individual. The term of the appointment is limited (see Section 5 of the Postdoc Policy for length of appointment). The appointment involves substantially full-time research or scholarship, and may include teaching responsibilities. The appointment is generally preparatory for a full time academic or research career. The appointment is not part of a clinical training program, unless research training under the supervision of a senior mentor is the primary purpose of the appointment. The Postdoctoral Appointee functions under the supervision of a mentor or a department at Duke University. The Postdoctoral Appointee is expected to publish the results of his or her research or scholarship during the period of the appointment. EXPECTATION: The conscientious discharge of research or scholarship responsibilities, which may include teaching responsibilities for Postdoctoral Associates Conformance to standards of responsible conduct in research Compliance with good scholarly and research practice Maintenance of a laboratory notebook and/or other comparable records of research activity, which remains the property of Duke University upon termination. Adherence to University standards regarding use of isotopes, chemicals, infectious agents, animals, human subjects, and the like. Open and timely discussion with the mentor regarding all facets of the Postdoctoral Appointee’s research activities. Postdoctoral Appointees are encouraged to consult the AAMC Compact Between Postdoctoral Appointees and Their Mentors for suggested guidelines for the Postdoctoral Appointee-mentor relationship Prompt disclosure to the mentor regarding the possession and desire to distribute materials, reagents, software, copyrightable and potentially patentable discoveries derived from the Postdoctoral Appointee’s research. Collegial conduct towards members of the research group and others as described in the Duke University School of Medicine Honor Code of Professional Conduct and other relevant conduct policies pertaining to other schools at Duke University. Compliance with all applicable University and departmental policies and procedures.

This postdoc position will perform studies to better understand the genetic bases of mycobacterial pathogenesis and host susceptibility to mycobacterial infection, largely using a zebrafish model. We are interested in a creative, collaborative postdoc with previous training and expertise in at least one of the general areas we research/approaches we use, who is excited to expand their training into new areas and perform basic research to understand tuberculosis. Position is one year to start with extensions contingent on funding, performance, and needs of the lab.

The David Lab at Duke University (www.ladlab.org) is recruiting a postdoctoral fellow to join a team of scientists developing and using new DNA sequencing tools to study diet and the gut microbiome. We are particularly interested in creating new ways to measure and analyze food intake, which is essential for monitoring and improving human health. We are developing DNA sequencing-based techniques that allow us to track the dietary plant and animal species that people consume. Our techniques allow us to generate objective data on intakes of over 450 plant and animal species that individuals eat and is robust to differences in memory/recall; the output data are also standardized across languages and cultures using the universal language of DNA. We are applying these tools to biospecimens from populations across North Carolina and the world. Data resulting from these studies will allow us to compare our biomarker of diet to traditional surveys of dietary intake, as well as perform systems biological studies of human food intake. The results of our studies will also allow us to create new models of disease risk and examine geographic, cultural, behavioral, and socioeconomic determinants of diet. These projects are funded by awards from the Chan Zuckerberg Initiative, the National Institutes of Health, the Gerber Foundation, and the Burroughs Wellcome Fund. 

Our lab studies the host and bacterial determinants underlying the variable outcomes of Mycobacterium tuberculosis infection. We leverage genetically diverse mice in conjunction with bacterial genetic technologies to understand the host-pathogen genetics interactions that drive distinct tuberculosis disease states. We seek a post doc with either a strong mammalian genetics background that wants to learn cutting-edge bacterial genetics approaches and novel disease phenotypes OR a bacterial geneticist that is interested in applying their bacterial expertise to novel mouse models of tuberculosis disease and vaccine efficacy. Specific research projects will be determined in conjunction with Dr. Clare Smith and will be shaped by the skills and interests of the selected finalist. Position will be one year to start with extensions contingent on performance, funding, and needs of the lab.

The Heaton Laboratory has an opening for a Postdoctoral Associate at the Duke University School of Medicine. We are seeking a motivated person to take on projects defining host factors that are able to control influenza virus replication, and then determining the mechanisms behind how those factors affect the virus. To address these questions, we will utilize high-throughput genomic screening approaches, primary cell culture systems, and animal models of influenza disease. 

 A postdoctoral position is immediately available in the laboratory of Dr. Ken H. Young in the Department of Pathology at Duke University Medical Center and Duke Cancer Institute. The Young lab focuses on clinical and pathologic translational studies in lymphoma and myeloma and has assessed a number of genetic and epigenetic biomarkers for prognostic and therapeutic importance in blood cancer (examples include PMID 34980601, 30745366, 33148342, 31640780, 31127191, 27760757, 23449635, 23982177, 22955915, etc). The current position is to investigate treatment resistance mechanisms and novel therapeutic approaches in lymphoma using molecular and proteomic technologies. We are seeking a highly motivated postdoctoral candidate with strong background in cellular, molecular and/or immunology for this position. Future promotion is available for those excellent and dedicative individuals.

This postdoctoral position is to support work focused on the development of a cyber-physical system (CPS) framework for monitoring and tracking the location, activity, performance, and health of people working in smart environments. The position will focus on the development of wearable sensing platforms to be worn by human subjects integrated within the broader CPS framework with sensor data processed to extract features for real-time processing. The work will include integration of real-time data with computational services embedded the CPS framework running data-driven models that predict the interaction of people with their environments.

 We seek a highly motivated individual to address how dysregulated immunity drives cognitive deficits after common peripheral surgeries, leveraging various techniques, including advanced genomic, organ-on-chip technologies, animal models, and innovative therapies. The team is highly collaborative and integrated with multiple cores (within Duke) and collaborators across US institutions.

 

(18) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoctoral Associate, Pulmonary and Critical Care Medicine

Deadline : May 31, 2023

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Dr. Sudha Shenoy’s laboratory is seeking a recent PhD graduate interested in the study of signaling and trafficking of seven-transmembrane/G-protein-coupled receptors (7TMR/GPCRs). 7TMRs/GPCRs are the largest and most diverse class of signaling receptors in the mammalian genome and the target of nearly half the drugs currently in use.  We are interested in elucidating the roles of deubiquitinases in the regulation of GPCR and beta-arrestin signaling and trafficking mechanisms using both in vitro and in vivo model systems.  A candidate who is highly motivated and shares a vision of excellence and commitment to research with a recent PhD in Pharmacology, Cell Biology or related discipline is preferred. Prior experience with mouse models is also preferred.