Postdoctoral Fellowship (28) at Karolinska Institute, Sweden

Research in our lab integrates a variety of approaches, making us open to individuals from diverse backgrounds. A foundation in quantitative fields (e.g., mathematics, engineering, computer science, physics) or prior experience in experimental techniques (e.g., molecular biology, high-channel density silicon probe electrophysiology in vivo or in vitro, advanced animal behavior designs and analysis, miniscope or two-photon imaging) is advantageous. Candidates are expected to demonstrate previous productivity, often by publications, but not exclusively. A combination of at least some of the following skills is essential:

• A high degree of independence
• Ability to construct/maintain and use complex experimental setups
• Proficiency in “big” data analysis (using MATLAB or Python), or

The Department of Laboratory Medicine (Labmed) at Karolinska Institutet conducts research with direct relevance to human health, spanning fundamental biomedical science, biomarker discovery, diagnostic tool development, and advanced treatments such as cell and gene therapy. Labmed integrates patient-oriented clinical questions with technology development and practical implementation across seven divisions, and it also has a major educational mission at Karolinska Institutet.

The research group of Dr. Ping Chen is now recruiting a postdoctoral researcher with expertise in RNA splicing and computational method development. The Chen lab develops data-driven approaches to decipher RNA diversity and its regulatory mechanisms in human metabolic disease. A two-year postdoctoral position is available with a start date as soon as possible (or as agreed).

We are looking for a highly motivated postdoctoral candidate interested in understanding the molecular drivers of metabolic dysfunction. You will join an exciting project aimed at identification and biological validation of key regulatory metabolic pathways that contribute to the interplay between circadian rhythms and changes of insulin resistance in the context of type 2 diabetes. For this project we are looking to recruit a person interested in understanding the role of exercise-responsive metabolites in the regulation of skeletal muscle metabolism, this research project is headed by Professor Juleen R. Zierath, at the Department of Molecular Medicine and Surgery. The research group is interdisciplinary, with expertise spanning clinical physiology and medicine, cell physiology, exercise physiology, molecular biology, and bioinformatics, all focused on the study of metabolic disease.

At the Clinical Epidemiology Division, one of our seven research groups work with clinical epidemiological research on rheumatoid arthritis (RA) and other chronic inflammatory diseases, in close collaboration with translational and clinical researchers. Our work focuses on the aetiology of chronic inflammatory joint diseases such as RA, and personalized approaches to its management. We use a combination of register-, clinical, genetic, serological and lifestyle data, and advanced computational models. We are now recruiting 1-2 postdocs to our team to work with patient stratification and prediction models of clinical outcomes in RA, using various types of data.

Do you want to contribute to better care, support and living conditions for people with developmental, psychiatric and somatic conditions? At the research centre KIND, Karolinska Institutet, we are looking for a postdoctoral researcher who wants to conduct and coordinate research, development and implementation related to the WHO International Classification of Functioning, Disability and Health, ICF. The position combines independent scientific work with coordination of ICF-related projects, development of digital solutions and collaboration with users, clinical services, IT developers and international partners. You will join an internationally recognised research environment in developmental conditions, particularly autism and ADHD, with strong clinical and societal relevance.

As a postdoctoral researcher, you will conduct research in the field of ICF-based assessment, modelling, development and implementation with relevance for people with developmental, psychiatric and somatic conditions. The position includes both independent scientific work and a clear responsibility to contribute to the coordination of research, development and implementation activities within KIND’s ICF programme.

You will work closely with the director of KIND and the research group to drive, coordinate and develop ICF-related activities. This includes scientific studies, methodological development, grant applications, ethical review applications, data collection, analysis, scientific publication, development and testing of ICF-based approaches, and further development of a digital ICF platform.

An important part of the role is to help ensure that research, technical development and practical implementation are connected in a meaningful way. The work therefore involves collaboration with several different stakeholders, including users and family members, clinical services, stakeholder organisations, IT developers, researchers and international collaborators. You need to be comfortable working across academic research, clinical practice, technical development and user-oriented collaboration.

The emphasis of the position is method development. We are seeking a postdoctoral researcher to develop next-generation AI models of cellular dynamics, with a focus on scalable neural network architectures that represent the molecular composition of a single cell in space and time. These models will describe high-dimensional systems with many interacting components and may use multiscale and coarse-grained representations to enable scalability.

The work will draw on concepts from dynamical systems, stochastic processes, and stochastic differential equations (SDEs), including nonequilibrium systems, to model cellular behavior. A central goal is to integrate spatial imaging data with time-resolved molecular measurements, while incorporating physical and biological constraints directly into the model architectures.

The developed methods will form the foundation for future large-scale molecular imaging and modeling efforts within Alpha Cell. The position offers substantial methodological independence.

As a research specialist in Lanner lab, you will have a leading role in an integrated team with members from several different labs at Karolinska Institutet with diversified expertise in stem cell-based regenerative medicine, large-scale cell production, advanced biomaterials, animal models and beta cell signaling. In this team, you will work on optimizing robust differentiation protocols for functional insulin-producing islets for clinical transplantation.

The Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching within immunology, infection biology, cell biology and cancer.  Our key words are multidisciplinary, bridging, national and international collaborations.

The Cancer–stroma crosstalk team led by Kaisa Lehti (within the research group of Margareta Wilhelm) studies the properties and functions of a cellular and cellular components of the tumour microenvironment, with a focus on both general and context-dependent mechanisms controlling the cancer phenotypes and outcomes. Embedded in a dynamic, multicultural environment at the Division of Tumor Biology, and with strong Nordic and international collaborations, our team provides an inspiring and highly interactive research setting. You will be supported to grow scientifically and creatively, contributing to ambitious efforts to understand and activate extracellular matrix related tissue surveillance pathways for improved cancer treatments.

Differentiation therapy induces cancer cells into terminally differentiated, non-proliferating state, and has revolutionized the treatment of the once deadly acute promyeloid leukemia (APML). Nevertheless, identifying and mechanistic deciphering of factors controlling differentiation therapy response remains critical for 1) treating resistant/refectory APML, 2) individualized treatment regimen design to mitigate excessive side effects, and 3) sensitizing non-APML cancer to differentiation therapy. Here we are seeking a highly motivated postdoctoral researcher to join our team to identify and develop approaches to improve differentiation therapy, in the disease context of acute myeloid leukemia and beyond.

As a postdoctoral researcher you will work in our team to establish a method for differentiation of pluripotent stem cells into retinal cells and tissues. The work will specifically employ scalable culture modalities and bioreactors. This work will be undertaken in close collaboration with industrial partners and will involve culturing and differentiating pluripotent stem cells, cell isolation, genetic analysis and microscopy. Produced retinal cells and microtissues will be tested in animal models together with Professor Anders Kvanta and Dr. Filippo Locri. Once functionality has been demonstrated in animal models, the work will focus on making the method clinically compatible for future clinical trials, which may include the use of a bioreactor.

(18) Postdoctoral Fellowship Position

Postdoc Fellowship Position summary/title: Postdoctoral Researcher in Nuclear Organization and Mammalian Embryo Development

Deadline : 24.Jul.2026

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In this position, you will take on a broad and responsible role covering the full research process, from idea generation to publication. This includes data management and curation, data extraction, study design, statistical analyses, interpretation, and dissemination. You will play a key role in developing and leading independent, innovative projects on sex differences in social health trajectories and their impact on cognitive functioning and resilience in later life. Your responsibilities will include:

• Develop and refine research questions, conduct literature reviews, and manage and process non-imaging data.
• Perform advanced longitudinal statistical models (e.g., mixed-effects models, splines, growth models) to estimate social health and cognitive trajectories, including interaction analyses to assess synergistic or additive effects.
• Interpret results and prepare manuscripts for publication in peer-reviewed journals; writing lay summaries for broader audiences is optional but encouraged.
• Present research findings at seminars, conferences, and other professional forums.
• Participate in regular meetings and engage in collaborations.

You are expected to gradually initiate and lead your own research projects, potentially aligned with your own research interests. Coordinating projects within the research group, supervising students, participating in teaching activities, and writing and contributing to funding applications are also part of the role.

We are looking for an ambitious postdoctoral fellow with a strong background in T cell immunology and vaccine responses to join our highly accomplished team. The successful candidate will lead studies of yellow fever virus (YFV)-specific CD4+ T cell immunity in a unique longitudinal cohort of monozygotic and dizygotic twins. The project will determine how inherited and non-inherited factors shape CD4+ T cell responses and how these responses coordinate with CD8+ T cell memory and antibody immunity.

To be eligible for employment as a postdoctoral researcher, a PhD or a foreign degree deemed to be equivalent to a Swedish PhD is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. Completion of your doctoral degree within the last three years is considered an advantage. If there are special reasons, your degree may have been completed earlier.

Ditt arbete kommer att utgöras av arbetsuppgifter på postdoktoral nivå såsom projektkoordinering, datainsamling, analys, skrivande av vetenskapliga artiklar samt kommunikation av forskningsresultat i olika sammanhang. Anställningen är organisatoriskt förlagd till avdelningen för allmänmedicin och primärvård, Lena von Kochs forskargrupp för hälso- och sjukvård och socialt arbete och du kommer där att ingå i ett forskningsprojekt som arbetar med att utveckla ett utbildningsprogram för att förbättra kommunikation med personer med afasi.

Därutöver kommer du även att arbeta inom forskningsprogrammet Framtidens hälsosamma åldrande, som ingår i forskargruppen HELD (Hälsa i vardagen) vid avdelningen för arbetsterapi. Programmet finansieras av FORTE, och arbetsuppgifterna kommer främst att omfatta datainsamling inom projektet ASSIST 2.0 samt analys och vetenskapligt skrivande.

Inom rollen ingår också 20% undervisning på logopedprogrammet som omfattar såväl planering och administration av kurser som direkt undervisning och examination. Området för utbildningsuppdraget omfattar tal- och språkstörning hos vuxna, vetenskaplig metod, statistik och vil/vfu inom logopedisk verksamhet.

We are seeking a highly motivated and enthusiastic postdoctoral fellow to apply and develop advanced computational methods to cutting-edge single-cell and spatial genomics approaches to uncover mechanisms of neural circuit repair and regeneration. The candidate will integrate large-scale transcriptomic and epigenomic datasets across species with state-of-the-art deep learning models to link sequence to function, supporting the design of regenerative therapies in the nervous system. The successful candidate will interact with experimentalists to combine data-driven analysis with subsequent in vivo perturbations.

The successful candidate will employ proteomics-based methods to uncover novel interaction partners in alphavirus infections and in infection-related cellular conditions. Screening methods, using CRISPR and siRNA as well as drug libraries will be used to identify novel cellular players in viral infection. In addition, hypothesis-driven investigations should reveal mechanisms of importance in viral infection and host responses. The postdoctoral fellow will have or will develop expertise with classical virology and cell biology methods as well as to contribute to the development of new techniques and methods to study cell biology of viral infection. The work will be presented in prominent academic journals and at international conferences. The successful candidate will contribute to the day- to-day supervision and training of project students and junior staff.

The project combines expertise in structural biology, mitochondrial biology, molecular biology, and disease modelling to understand how mitochondrial proteins regulate gene expression and contribute to mitochondrial disease. The successful candidate will use detailed molecular and structural approaches to uncover new insights into mitochondrial protein function and disease pathophysiology.

As a postdoctoral researcher, you will work in a project aimed at characterising a TLR7-driven macrophage–complement axis in lupus nephritis. The project combines experimental mouse models with analyses of human kidney biopsies to understand how local inflammation and complement activation contribute to renal tissue injury.

Your responsibilities will include:

• establishing and analysing an imiquimod-induced model of lupus-like autoimmunity and lupus nephritis
• investigating intrarenal macrophage accumulation and activation
• assessing local complement activation and the expression of complement-related markers
• evaluating how therapeutic intervention affects disease manifestations and the proposed macrophage–complement axis
• analysing human kidney biopsies from patients with lupus nephritis using spatial tissue profiling approaches
• integrating experimental and clinically relevant data and contributing to manuscripts, conference presentations and scientific reporting.

I rollen som postdoktor kommer du att arbeta med forskning och undervisning inom arbets- och miljömedicin, med särskilt fokus på företagshälsovård och arbetsinriktad rehabilitering. Du förväntas bedriva internationellt konkurrenskraftig forskning och aktivt bidra till utvecklingen av nya kunskaper och metoder som främjar återgång i arbete och ett hållbart arbetsliv. Undervisningen omfattar både deltagande i magisterprogrammet i arbete och hälsa och vidareutbildning för företagshälsovårdens professioner.

Samverkan med det omgivande samhället ingår i tjänsten, med fokus på kompetensförsörjning och implementering av arbetsinriktad rehabilitering. Du kommer också arbeta med att stödja Region Stockholms involvering FINSAM inom ramen för ett ESF-finansierat projekt om återgång i arbete för personer som står långt från arbetsmarknaden

Du får också möjlighet att handleda magisterstudenter. Dessutom finns utrymme att söka egna forskningsmedel och utveckla en självständig forskningslinje inom ditt intresseområde.

Genom att kombinera forskning, undervisning och samverkan får du möjlighet att påverka både policy och praktik, och bidra till att skapa en bättre arbetsmiljö och hälsa för alla.

The successful applicant will perform his/her tasks in the experimental research group of Associate Prof. Piotr Nowak and Team Leader Shilpa Ray, part of Anders Sönnerborgs research group. The postdoctoral project will focus on investigating the effects of antiretroviral therapy (ART) on gut barrier function, metabolism, immune responses, and microbiome interactions in people living with HIV. The candidate will work with advanced gut-on-chip models and clinical samples to study host-microbiome interactions and mechanisms underlying metabolic and inflammatory changes associated with long-term HIV treatment. The project combines experimental and translational approaches, including microbiome research, molecular profiling, and immune characterization, in close connection with existing clinical cohorts. The applicant will work within the projects of Dr. Piotr Nowak and Dr. Shilpa Ray and contribute to both scientific and administrative activities within the research group.