17 Postdoctoral Fellowship at Queen Mary University of London, United Kingdom

You will join a 60 strong research team of scientists and clinicians dedicated to understanding the disease pathogenesis and improve the treatment of several musculoskeletal diseases including Rheumatoid Arthritis, Sjogren’s syndrome and Osteoarthritis at the Centre for Experimental Medicine & Rheumatology (EMR). EMR is part of the newly awarded Biomedical Research Centre (BRC). The Centre is located at the Charterhouse square campus in the heart of the City of London in close proximity to the Barbican Arts and Music Centre

The ideal candidate has extensive experience of human tissue culture, preferably including PDO culture or cellular immunology assays. First author publications are essential to demonstrate experience in taking a project to publication. Experience in the analysis of large-scale datasets or bioinformatics would be desirable. Good organisation, record keeping and communication skills are essential. The candidate will have a PhD in biology, immunology or a related relevant subject.

The position is at the Centre for Biochemical Pharmacolgy which brings together a group of leading clinical and non-clinical scientists researching the cellular and molecular basis of inflammation, rheumatic, and cardiovascular diseases. The Centre is based within the picturesque Charterhouse Square Campus in the heart of the City of London and within the world-renowned William Harvey Research Institute at Barts and The London School of Medicine, Queen Mary University of London (QMUL).

We are seeking a highly motivated postdoctoral fellow to join our leukaemia biology team at Barts Cancer Institute. The successful candidate will explore novel molecular techniques to monitor ALL resistance and relapse using both bulk and single cell sequencing technologies, applying these tools to both experimental models of ALL resistance/relapse as well as human samples. The successful candidate will work within an integrated programme of ALL research at Barts Cancer Institute and alongside NHS teams in the Molecular Diagnostic Services at St Barts Hospital. The position will be a unique opportunity for those considering a future career in academic research or an onward career in cancer genomics within the NHS. Potential candidates must have practical experience in molecular biology. Practical knowledge in flow cytometry and bioinformatics data mining is a plus.

The WIPH harnesses expertise across a wide range of population-based research and education activities and is an internationally recognised centre of excellence in population health and preventive medicine.  The WIPH comprises five separate research centres, one of which, the CPDD, is at the national and international forefront of research into the prevention, detection and control of cancer.  We have particularly active research programmes investigating prevention, screening, awareness and early diagnosis of a range of cancers including breast, cervical, colorectal, lung, pancreatic and prostate cancer, and utilising a range of research methods.

The candidate will be working in the area of mechanics of materials with focus on (1) the interaction events between materials and biological system (such as cells & tissues – substrate interactions) and (2) mechanics of bio-inspired composites. The researcher is expected to develop the validated numerical modelling on the relevant complex physical phenomena. The researcher will work closely with team members with different research expertise. The candidate is expected to disseminate research outcomes in relevant conferences and renowned international journals and involve in supervision of PhD students and development of new research ideas.

The successful candidate should have a PhD in Biophysics, Cell Biology, Bioengineering, Mechanobiology or a related field of science or engineering. They should have sound experience in experimental cell biology and imaging, as well as strong computational skills. Knowledge of cellular senescence, ageing, or skin biology is highly advantageous. The PDRA will also prepare manuscripts using high-quality data, make oral presentations and help supervise postgraduate students. 

The ideal candidate has extensive experience of human tissue culture, preferably including PDO culture or cellular immunology assays. First author publications are essential to demonstrate experience in taking a project to publication. Experience in single cell sequencing and/or the analysis of large-scale datasets or bioinformatics would be desirable. Good organisation, record keeping and communication skills are essential. The candidate will have a PhD in biology, immunology or a related relevant subject.

Our CRUK/Barts Charity funded team (https://www.bartscancer.london/staff/dr-paolo-gallipoli/) uses a multidisciplinary approach and complementary models to study how rewired metabolism contributes to leukaemic transformation and AML cells ability to withstand therapeutic pressure with the aim to identify novel therapeutic targets in AML (Woodley et al., BioRxiv, 2022, Dembitz et al., Blood, 2022&Gallipoli et al., Blood, 2018). The candidate will gain experience in characterisation of leukaemia models in vitro and in vivo, metabolic profiling and big-omics data analysis. Active research themes in the lab are studying the role of mannose and fatty acid metabolism in AML, the metabolic interplay between AML and microenvironment and the role of dietary intervention to enhance metabolic inhibitors efficacy. We enjoy close links with Barts Hospital and have a strong translational focus with excellent prospects for developing new therapies and making a significant contribution to our field. The candidate will enjoy a vibrant multidisciplinary environment at BCI, take advantage of our ongoing collaborations with the partner institutions within the CRUK City of London (Crick, Kings and UCL) and be provided with significant opportunities for excellent career development.

We are looking for outstanding, self-motivated and independent candidates committed to a scientific career with interest in pulmonary hypertension, cardiovascular and/or vascular biology. Technical expertise in in vivo (induction and monitoring of pulmonary hypertension, echocardiography, blood pressure telemetry, isolated heart perfusion, arterial myography), molecular (redox biochemistry, cell culture, proteomics) methodologies would be advantageous. The ability to work in a team is essential. The successful candidate requires a PhD degree in a biological, medical, or chemical sciences discipline, with a good track record in publishing their work in leading journals using some of the methods and skills listed above.

The project is focused on the molecular mechanism of DNA replication initiation in bacteria. Together with the laboratory of Prof. Heath Murray at Newcastle University, this work is aimed at unravelling the sequence of events that lead to helicase loading during initiation and restart. This structural biology project will take advantage of the expertise in the lab working with nucleoprotein complexes aided by dedicated cryo-EM and X-ray crystallography facilities. The group has routine access to the Titan Krios microscopes at LonCEM and eBIC and an in-house computing infrastructure for data processing.

Applicants should have an excellent academic record, proven academic writing ability and problem-solving capability. We are looking for an organised and motivated researcher. You will have a PhD or equivalent in a relevant discipline in healthcare research, a sound knowledge of quantitative research methods and experience in the analysis of large healthcare datasets. You will have experience in, or an interest in gaining experience in, prediction model development and/or machine learning techniques.

Applications are sought for a Postdoctoral Research Assistant (PDRA) to undertake research in collaboration with and under the supervision of Dr Faraz Mardakheh (Barts Cancer Institute), and Dr Paola Scaffidi (Francis Crick Institute) for a BBSRC funded research project to study the role of RNA in chromatin regulation. The post will be based in the Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London (QMUL), with access to Francis Crick Institute also provided to the PDRA for some of the experimental works.

Applicants should have or be about to complete a PhD in Chemistry, Material Science, Physics, or equivalent. Experience of photoelectrochemical measurements is essential. Applications should also have experience of materials synthesis (ideally via solution processing) and characterisation techniques. Knowledge and experience of ferroelectric materials is also desirable, as is experience of setting up and carrying out opto-electronic measurements.