36 Postdoctoral Fellowship at University of Pennsylvania, United States
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University of Pennsylvania, United States invites online Application for various Postdoctoral Fellowship in their different Departments. We are providing a list of Postdoc Fellowship positions available at University of Pennsylvania, United States.
Eligible candidate may Apply as soon as possible.
(01) Postdoctoral Fellowship Position
Postdoc Fellowship Position summary/title: Postdoctoral Researcher in Computational Toxicology
The Romano Lab at the University of Pennsylvania is recruiting a postdoctoral researcher to develop and apply new methods in computational toxicology using artificial intelligence and techniques from biomedical informatics. We develop knowledge graphs to computationally predict and explain the downstream clinical effects that arise following exposure to environmental toxicants. This postdoc position will involve extending these knowledge graphs to new biomedical data types, and applying graph machine learning (Graph ML) to detect novel adverse outcome pathways. They will also have the opportunity to interact with real-world observational datasets (e.g., Penn’s Electronic Data Warehouse and Biobank resources) to validate the Graph ML predictions. The postdoctoral researcher will also have the opportunity to participate in clinical and translational informatics projects that arise as the result of new collaborations and departmental initiatives. Furthermore, eligible candidates will have the ability to apply for prestigious training fellowships in environmental health science or genomic medicine.
Postdoc summary/title: Post-transcriptional regulation in Cancer Bio
The Conn Lab is looking for 1-2 postdocs focused on post-transcriptional gene regulation and the roles of RNA-binding proteins, RNA modifications, and signaling that are rewired during cancer progression. One project is focused on identifying regulators of selective translation and spatial RNA interactions in the cell during drug resistance in prostate cancer (more mechanism to move into translational research later). The other project is looking at adaptive stress responses in pancreatic tumors and will require mouse modeling, tissue analysis, and treatments in vivo. The lab has received two awards, over 3 years of DoD funding for project one and has independent funds for project two.
Postdoc Fellowship Position summary/title: POST-DOCTORAL RESEARCHER ON REAL-WORLD EVIDENCE OF THE HEALTH EFFECTS OF THERAPEUTICS
: The postdoctoral researcher will conduct mentored research in pharmacoepidemiology, focusing primarily, but not exclusively, on characterizing the health effects of potential drug-drug interactions. The postdoc will be encouraged to articulate research questions of clinical, population health, and mechanistic importance, design research projects, develop detailed analytic plans, perform analyses, interpret results, effectively communicate results orally and in writing, submit results for publication, and disseminate findings to maximize their impact. The postdoc will be encouraged to work outside of their comfort zone, take on projects that do not have a clear path to completion, and propose solutions to problems encountered. Most postdocs serve as first author of several publications during their time at Penn. About the University of Pennsylvania: The University of Pennsylvania’s Perelman School of Medicine is the oldest medical school in the US. We are rich in tradition and heritage and at the same time consistently at the forefront of new developments and innovations in medical education and research. Since the medical school’s founding in 1765, we have been a strong presence in the community and prided ourselves on educating the leaders of tomorrow in patient care, biomedical research, and medical education. The Perelman School of Medicine consistently ranks among the top research-oriented medical schools. Our mission is to advance knowledge and improve health through research, patient care, and the education of trainees in an inclusive culture that embraces diversity, fosters innovation, stimulates critical thinking, supports lifelong learning, and sustains our legacy of excellence. The Department of Biostatistics, Epidemiology and Informatics is home to more than 100 faculty and the graduate education programs in these three core disciplines. Most faculty are also a member of the Center for Clinical Epidemiology and Biostatistics, an interdisciplinary and inter¬departmental program that links clinical epidemiology and biostatistics within the Perelman School of Medicine, the University of Pennsylvania Health System (i.e., Penn Medicine), and the Penn community.
Postdoc Fellowship Position summary/title: Postdoctoral Fellow in Reproductive and Perinatal Epidemiology
A Postdoctoral Fellow position in Reproductive and Perinatal Epidemiology is available in the Department of Biostatistics, Epidemiology, and Informatics (DBEI) at University of Pennsylvania Perelman School of Medicine. Opportunities currently available involve epidemiologic research which examines an array of exposures and methods in relation to reproductive and perinatal health outcomes as well as Inclusion, Diversity, and Equity in medicine. The candidate will embark on all activities of epidemiologic research with the goal of fostering a future as an independent leader in the field. The candidate will join the collaborative Reproductive and Perinatal Epidemiology research team of Drs. Enrique Schisterman, Sunni Mumford, Stefanie Hinkle, and Ellen Caniglia and will interact with other faculty at DBEI, Perelman School of Medicine. Applicants with related experience are encouraged to apply even if they do not have prior experience in reproductive or perinatal epidemiology. The candidate must have a doctoral degree in Epidemiology, Biostatistics, Nutrition, Environmental Health Sciences, Medicine, Public Health, or related field. Excellent writing and analytic skills are needed for this position. The candidate should send a cover letter, research statement, CV, along with 3 letters of reference for review to Dr. Stefanie Hinkle ([email protected]). Multiple positions available with flexible start dates as soon as Fall 2022 as well as Summer 2023.
Postdoc Fellowship Position summary/title: Postdoctoral Positions – Jain Laboratory
Multiple NIH-funded postdoctoral positions are available in the laboratory of Rajan Jain in the Departments of Medicine and Cell & Developmental Biology at the Perelman School of Medicine at the University of Pennsylvania. Our laboratory uses genetic, biochemical, imaging and genomic approaches to decipher how nuclear architecture governs cell fate decisions. Our laboratory routinely utilizes multiple mouse models and ESC/iPSC differentiation strategies. We are part of a vibrant community at Penn, including the Epigenetics Institute, Institute for Regenerative Medicine, Cardiovascular Institute and Center for Engineering and Mechanobiology. We are a highly collaborative group that routinely works across disciplines.
Postdoc Fellowship Position summary/title: POST-DOCTORAL RESEARCHER ON REAL-WORLD EVIDENCE OF THE HEALTH EFFECTS OF THERAPEUTICS
About the position: The postdoctoral researcher will conduct mentored research in pharmacoepidemiology, focusing primarily, but not exclusively, on characterizing the health effects of potential drug-drug interactions. The postdoc will be encouraged to articulate research questions of clinical, population health, and mechanistic importance, design research projects, develop detailed analytic plans, perform analyses, interpret results, effectively communicate results orally and in writing, submit results for publication, and disseminate findings to maximize their impact. The postdoc will be encouraged to work outside of their comfort zone, take on projects that do not have a clear path to completion, and propose solutions to problems encountered. Most postdocs serve as first author of several publications during their time at Penn. About the University of Pennsylvania: The University of Pennsylvania’s Perelman School of Medicine is the oldest medical school in the US. We are rich in tradition and heritage and at the same time consistently at the forefront of new developments and innovations in medical education and research. Since the medical school’s founding in 1765, we have been a strong presence in the community and prided ourselves on educating the leaders of tomorrow in patient care, biomedical research, and medical education. The Perelman School of Medicine consistently ranks among the top research-oriented medical schools. Our mission is to advance knowledge and improve health through research, patient care, and the education of trainees in an inclusive culture that embraces diversity, fosters innovation, stimulates critical thinking, supports lifelong learning, and sustains our legacy of excellence. The Department of Biostatistics, Epidemiology and Informatics is home to more than 100 faculty and the graduate education programs in these three core disciplines. Most faculty are also a member of the Center for Clinical Epidemiology and Biostatistics, an interdisciplinary and interdepartmental program that links clinical epidemiology and biostatistics within the Perelman School of Medicine, the University of Pennsylvania Health System (i.e., Penn Medicine), and the Penn community.
The Gerson Laboratory in the Center for Reproduction and Women’s Health at the University of Pennsylvania Perelman School of Medicine seeks a postdoctoral fellow for a project investigating microbiome-metabolome interactions governing cervical remodeling in preterm birth. This research will utilize in vitro methodologies to examine the impact of vaginal microbiota and microbial metabolites on epithelial barrier function and host immune response. This work may extend to other areas of the female reproductive tract in an effort to unveil mechanisms through which the metabolome modifies numerous other reproductive outcomes. This work is funded by the Society for Maternal Fetal Medicine and American Association of Obstetricians and Gynecologists Foundation.
Postdoc Fellowship Position summary/title: Postdoc Position to identify neurodevelopmental syndrome mechanisms and therapies
A postdoctoral fellow position is available in the Lefebvre laboratory at the Children’s Hospital of Philadelphia (CHOP) Abramson Research Institute. The fellow will elucidate cellular and molecular mechanisms underlying Lamb-Shaffer syndrome, a neurodevelopmental disorder due to SOX5 inactivating variants, and will also seek to develop gene therapy approaches to improve the condition of affected individuals. The fellow will use cutting-edge approaches in vivo and in vitro, including mouse models and human iPSC-derived brain organoid models, high-throughput ‘omics’, and AAV-mediated gene therapy approaches. Successful accomplishment of this research is anticipated to deepen fundamental scientific knowledge and have major translational impact in addition to helping the fellow launch a promising career as an independent research investigator.
Postdoc Fellowship Position summary/title: Postdoctoral Fellow Position in Genetic Regulation of Skeletal Growth and Adult Maintenance
A postdoctoral fellow position is available in the Lefebvre laboratory in the Translational Research Program in Pediatric Orthopaedics at the Children’s Hospital of Philadelphia (CHOP) Abramson Research Institute. The fellow will elucidate genetic mechanisms whereby specific growth factor signaling pathways interact with transcription factors to control the commitment of mesenchymal progenitor/stem cells to skeletal lineages and the multi-step programs of osteoblast and chondrocyte differentiation. The fellows will use cutting-edge approaches in vivo and in vitro, including mouse models, high-throughput ‘omics’, and AAV-mediated gene therapy approaches. Successful accomplishment of this research is anticipated to deepen fundamental scientific knowledge, increase understanding of mechanisms underlying skeleton malformation and degenerative diseases, and help the fellow launch a promising career as an independent research investigator.
Postdoc Fellowship Position summary/title: Post-doctoral Researcher
A POSTDOCTORAL POSITION to continue and expand studies into the mechanisms of immuno-suppression in the primary tumor and metastatic microenvironment and importance of these mechanisms in cancer therapies (as described in Cancer Cell 2017 and 2019, Cell Metab 2022, Nat Cancer 2020 and 2022 and J Clin Invest 2021).
Postdoc Fellowship Position summary/title: Postdoctoral Researcher
Postdoctoral position is immediately available for NIH funded research projects to study the biological role of protein modifications and protein isoform diversity in actin cytoskeleton functioning and mouse development. Approaches involving biochemistry, molecular biology, cell biology, live cell imaging, and mouse genetics are used separately and in combination to uncover new pathways regulating intracellular protein targets, with focus on cytoskeleton, cell motility, and signaling.
Postdoc Fellowship Position summary/title: Postdoc-bioengineer, chemist or cell biologist
We seek highly motivated researchers who enjoy working in a team while concomitantly desiring to pursue their own ideas in a supportive environment. Desired expertise includes, but is not limited to biophysics, atomic force microscopy, confocal microscopy, mathematical modeling, and evolutionary biology in the context of biofilm research.
Postdoc Fellowship Position summary/title: postdoctoral fellow
One postdoctoral fellow position is available in the laboratory of Dr. Anh Le/Dr. Zhang. We are seeking a highly motivated, independent, and collaborative scientist to study immunoregulatory mechanisms under dental stem cell-based tissue regeneration or head & neck tumor microenvironment settings. The position is supported by federal and internal funding. There are multiple basic and translational research projects available for consideration. The laboratory is a highly collaborative and supportive training environment in which successful candidates will be given the opportunity to mentor and train junior lab members, develop new methodologies, and enhance professional development skills. The candidate’s responsibilities will include experimental design, execution, data analysis, data presentation, and manuscript preparation. The position is contingent on continued funding.
Postdoc Fellowship Position summary/title: Postdoc in Human Tumor immunology
We are seeking a highly devoted and enthusiastic PhD or MD/PhD scientist to join our group as a postdoctoral research fellow. He/She will be involved in investigating the role of the inflammatory myeloid cells in the tumor microenvironment and the cellular and molecular mechanisms by which tumor modulates their immune functions in cancer patients. Specifically, the researcher will investigate the role of the tumor-infiltrating macrophages and neutrophils in the regulation of tumor-specific T cell and NK cell responses in lung cancer patients. Also, He/She will investigate the ability of tumor-associated neutrophils and macrophages to regulate anti-tumor antibody-triggered immune responses. He/she need to be able to perform the flow cytometry-based assays, tissue culturing, processing human specimens, cytokine multi-plex assay, ELISA, ELISpot. Skills in a molecular biology such as DNA/RNA extraction and analysis, standard and quantitative PCR, conventional and next-generation sequencing are desired. The postdoctoral fellow is expected to participate in design and performing experiments, data analysis and presentation. The candidate will work independently to manage daily research projects, data collection and organization of the laboratory. He/she must be able to identify and resolve technical problems, and use analytical and decision-making skills to implement assigned projects. He/she will be required to write up the manuscripts.
Postdoc Fellowship Position summary/title: Postdoc Fellow in Machine Learning and Medical Image Analysis
The Department of Radiology at the University of Pennsylvania Perelman School of Medicine seeks candidates for postdoc fellow positions. The main focus of these positions is on the development of biomedical image analysis algorithms with an emphasis on advanced machine learning (deep learning) methods for MRI/CT/PET data analysis. Responsibilities include involvement in various imaging studies of Alzheimer’s disease, aging, brain development, and neuropsychiatric disorders and supervision of junior research investigators for developing algorithms of image segmentation and registration, time-series data modeling, and pattern recognition. The research will be conducted at the Research Laboratory for Machine Learning and Biomedical Data Analytics of the Center for Biomedical Image Computing and Analytics (CBICA), a dynamically growing medical image computing center, involving several laboratories and many collaborators from diverse fields. The position will provide opportunities to participate in collaborative research projects with multidisciplinary research teams of Penn Medicine and the Children’s Hospital of Philadelphia, as well as to launch an independent research career in the area of computational medical imaging analytics.
Postdoc Fellowship Position summary/title: Postdoctoral Researcher in Psychiatric Genetics
A postdoctoral researcher position is available in the Department of Psychiatry, University of Pennsylvania. The selected applicant will work under the direct supervision of Dr. Rachel Kember, a computational geneticist with expertise in biomedical informatics and psychiatric disorders. The postdoc will also have the opportunity to work with collaborators both at Penn and other institutions on multiple studies involving large-scale datasets. Current projects in the lab focus on understanding the genetic underpinnings of psychiatric and substance use disorders using genetic and phenotypic data from electronic health records with linked biobanks. Datasets include the Million Veteran Program, a large dataset of over 850,000 veterans with genetic data currently available for 650,000 individuals; the Penn Medicine Biobank, which includes 190,000 patients, 45,000 with genetic data; and the Yale-Penn study, which includes 12,000 individuals with an in-depth substance use and psychiatric assessment. Dr. Kember is co-chair of the PsycheMERGE Diversity Initiative, a collaboration across multiple biobanks formed to address inequity in psychiatric genetics research.
Postdoc Fellowship Position summary/title: Postdoctoral Researcher for revolutionizing patient-clinician interaction
The Kevin Johnson Lab is seeking a highly motivated and talented Postdoctoral Researcher to join our team in revolutionizing patient-clinician interaction using multimodal video/audio learning techniques. As a member of our multidisciplinary research team, you will be responsible for developing innovative solutions that enhance the quality, efficiency, and effectiveness of patient-clinician communication. This position offers an excellent opportunity to contribute to cutting-edge research and shape the future of healthcare technology.
Postdoc Fellowship Position summary/title: Postdoctoral Fellow in AI/ML for Biomedical Data Science
Applications are invited for Postdoc Positions in the Shen Lab (https://www.med.upenn.edu/shenlab/) at the Perelman School of Medicine (PSOM) at the University of Pennsylvania. These positions will offer opportunities to develop and apply advanced artificial intelligence (AI) and machine learning (ML) strategies for integrative analysis of multidimensional imaging, omics, biomarker and clinical data, with applications to the study of complex disorders such as Alzheimer’s disease (AD) and AD related dementia (ADRD). The following research areas are of particular interest: 1) development of fair and interpretable AI/ML methods for AD/ADRD diagnosis and care management through mining EHR and clinical data; 2) development of transformative AI approaches for high throughput analysis of next generation sequencing and related AD biomarker and cognitive data in landmark AD biobanks for prediction of disease risk, prognosis and progression, identification of disease subtypes, and better understanding of disease mechanism; 3) development of innovative translational big data analytic methods to systematically integrate AD biomarker research and systems medicine study, and to identify novel promising targets and drugs for repositioning against AD; 4) integration of automated machine learning, knowledge database and informatics to advance AD research; 5) identifying novel technology for monitoring aging adults and those with AD/ADRD in their home environment and the AI methods and software for analyzing data generated by those technologies; and 6) methods and applications on natural language processing, large language models and trustworthy AI.
Postdoc Fellowship Position summary/title: Postdoc in computational and systems biology
The Tan research group is interdisciplinary and highly collaborative, utilizing both computational and experimental approaches to study gene regulation. We have pioneered multiple computational algorithms for regulatory genomics, epigenomics, and network biology. Specific projects will be defined by the candidates (and based on the candidates expertise) and with input from Dr. Tan and our close collaborators at the Center for Childhood Cancer Research CHOP and Abramson Cancer Center at the University of Pennsylvania.
Postdoc Fellowship Position summary/title: Postdoc in single-cell cancer genomics
We are seeking a self-motivated and enthusiastic candidate for a postdoctoral scholar position. The postdoc will participate in an exciting project that uses various single-cell technologies to understand tumor clonal evolution, transcriptional and epigenetic heterogeneity and signaling within the tumor microenvironment, during standard and immuno therapeutic responses. The project is funded by a recent NCI center grant to establish the center for pediatric tumor cell atlas as part of the Moonshot initiative (https://humantumoratlas.org/). The project provides an excellent training opportunity in single cell biology and cancer biology.
Postdoc Fellowship Position summary/title: Postdoctoral Fellow
The Wilson laboratory in the Division of Diagnostic Innovation in the Department of Pathology and Laboratory Medicine at Penn is hiring a postdoctoral fellow to work on an established project focused on single cell and spatial analysis of human diabetic kidney disease. This position involves both dry lab and wet lab responsibilities and will consider applicants with experience in either area. The fellow will conduct single cell analysis of human donor specimens from patients with diabetic kidney disease under the supervision of Dr. Wilson. We have already sequenced a large number of single cell libraries in collaboration with Novo Nordisk and preprocessed our dataset for downstream analysis. We are looking for a motivated individual who can work together with our research team to complete any necessary validation studies and move this project to publication. Prior coding experience is not required and the position can be tailored to the applicant skillset. Applicants with bioinformatics experience may be interested in single cell or spatial analysis techniques whereas applicants with molecular biology experience could focus on assay development and cell culture models of diabetic kidney injury. You can find links to our prior publications and GitHub repositories on the laboratory website. In addition, there are a wide variety of opportunities in the Wilson lab for building independent projects. Please send Dr. Wilson an email with your CV if you are interested in pursuing this opportunity.
Postdoc Fellowship Position summary/title: Postdoctoral Researcher in Bioinformatics and Computational Biology
A Postdoctoral Fellow position is available at The Children’s Hospital of Philadelphia Research Institute. The successful candidate will be dedicated and motivated, have creative thinking skills and be a driver of her/his research. This is an exciting opportunity to work with a group of experts on computational genomics to improve algorithms and develop software tools for the long-read sequencing techniques. These technologies, such as Oxford Nanopore and Pacific BioSciences, have significant advantages over conventional short-read Illumina sequencing technologies. We are developing various deep neural network approaches to handle unique challenges in long-read sequencing data, to facilitate novel genetic discoveries and accelerate the implementation of precision medicine.
Postdoc Fellowship Position summary/title: Postdoc in genomics of neurodegenerative diseases
A postdoctoral position is immediately available in the laboratory of Dr. Alessandra Chesi at the University of Pennsylvania with a focus on discovering and functionally characterizing novel genes for Alzheimer’s, Parkinson’s and other neurodegenerative diseases in human brain relevant cell types. Dr. Chesi has a long-standing interest in genomics and neurodegenerative diseases; she has developed Capture C based approaches to map GWAS signals to their effector genes (see some examples in linked publications) and is applying them to brain-related disorders. Main areas of research in our lab are 3D genomics and epigenomics techniques (such as Hi-C, ATAC-seq, ChIP-seq and RNA-seq), CRISPR/Cas9 editing, pooled CRISPRi/a screens with scRNA-seq readout, plus development of iPSC-based models for neurodegenerative and neurodevelopmental diseases (2D neuronal/glial differentiation, co-cultures, 3D brain organoids).
Postdoc Fellowship Position summary/title: Postdoctoral Researcher in Spatial Omics
We are looking for an exceptionally creative and self-motivated postdoctoral fellow to join us in developing new technologies for spatial omics profiling at the cellular level. The successful candidate will collaborate with internal and external groups to solve challenging biological problems. The work will be multi-disciplinary, combining microchip, microscopy, genomics, and computational analysis to profile genome, epigenome, transcriptome, and proteome within the spatial context of tissues and cells. These novel technologies will greatly improve our ability to study tissue complexity and reveal the salient features of tissue architecture in physiology and disease.
Postdoc Fellowship Position summary/title: Postdoctoral Researcher in Genomics
A post-doctoral position in human genetics and genomics is immediately available. Research in our group focuses on the development of genomics and bioinformatics methods to analyze sequencing data, and to enable the implementation of genomic medicine in clinical settings. The successful candidate will work on developing novel genomic methods to study human diseases that are related to genomic repeats. Example projects include the use of Illumina sequencing, optical mapping or long-read sequencing to assay human genomes, transcriptomes and epigenomes from patients with undiagnosed diseases, and to understand how repetitive elements and structural variants in complex genomic regions cause human diseases. More information about current research can be found at https://wglab.org.
Postdoc Fellowship Position summary/title: Postdoctoral fellow
A Postdoctoral Researcher position is available for a highly motivated applicant in the laboratory of Dr. Fiona Simpkins at the University of Pennsylvania. Our focuses are to understand resistance mechanisms to targeted therapies such as DNA Damage Repair inhibitors (DDRi), to sequence DDRi with Immuno-Oncology (IO) drugs, and to identify biomarkers or response to these agents. We have developed a preclinical drug development program in the Ovarian Cancer Research Center with the goal of moving novel laboratory therapeutic discoveries into the clinic. We have developed >150 patient derived xenografts (PDX) models, patient-derived organoids, and primary tumor cultures from ovarian and endometrial cancers. These PDX models mimic the original tumors, thereby accelerating the translation of preclinical study results into clinical trials for patients. Also, we are “humanizing” our models by autologous tumor infiltrating lymphocyte (TIL) and macrophage (TAM) transfer, creating an autologous in vivo model system. Our laboratory has close collaborations with pharmaceutical companies including AstraZeneca, Merck, REPAIR, Zentalis. Based on preclinical studies from our lab, novel combination therapies have moved to phase 1/2 clinical trials led by Dr Simpkins (e.g. ClinicalTrials.gov Identifier: NCT03462342 and GY031). We have another two drug combinations also moving into clinical trials. Dr. Simpkins strongly supports career development of postdocs, either developing an independent laboratory in academia or finding a position in industry. We provide a rich multi-disciplinary training environment in animal modeling, molecular biology, genomics, cancer biology, and immunology, and we have sufficient fundings from various sources, including NIH funding to support this. Previous trainees have been awarded with multiple grants including NIH career development K12 grant, OCRA early career grant, AACR fellowship, Rivkin award, OCRA mentored award, FWC grant, KOH grant and Harrison award.
Postdoc Fellowship Position summary/title: Postdoctoral Researcher Positions in Cancer Biology
Our research is dedicated to unraveling the contribution of recurrent genomic alterations, both in protein-coding and non-coding regions, to tumorigenesis. Our primary focus is on identifying therapeutic targets and developing combination strategies for the treatment of cancer. To achieve these goals, we have developed a novel computational approach that integrates large-scale genomic, functionomic, and pharmacologic profiles. This innovative methodology has led to the creation of the Functional Cancer Genome data portal (FCG, http://fcgportal.org/home/), which serves as a comprehensive resource for functionally annotating cancer genomes. The newly funded projects will build upon the novel discoveries generated by the FCG project and will involve in-depth molecular characterization of new epigenetic and immuno-oncology drivers in cancer. We are currently recruiting for three related but independent projects: 1) Epigenetic dysregulation and non-coding RNAs in tumorigenesis, 2) Tumor immunology and immune therapy, and 3) Targeted and epigenetic therapy for cancer treatment. To conduct these projects, we employ cutting-edge technologies such as single-cell and spatial RNA sequencing analysis, as well as CRISPR screen and high-throughput chemical screen technologies. Additionally, our lab’s computational biology team provides a wealth of novel computational biology approaches and resources to support these research projects.
Postdoc Fellowship Position summary/title: Post-doctoral fellow
The Wexler Lab at the Department of Medical Ethics & Health Policy at the Perelman School of Medicine at the University of Pennsylvania is seeking a full-time postdoctoral fellow. The Wexler Lab is an exciting, highly collaborative, and interdisciplinary research lab focused on the ethical, legal, and social implications of emerging technologies. We are particularly interested in ethical issues arising from novel neurotechnologies, direct-to-consumer healthcare, and digital medicine. Ongoing research activities in our group involve active collaborations across the Perelman School of Medicine, the larger Penn community, and external institutions.
Postdoc Fellowship Position summary/title: Post-doctoral position
Our research topics are focused on nuclear mechano-sensing of cells that grow and move within dense microenvironments in both homeostasis and disease. We recently found that the nucleus ruptures when cells experience physical confinement, exposing nuclear DNA to damage from cytosolic nucleases generating changes in gene expression and cellular behavior (Nader et al., 2021, Cell). Our lab combines fluorescence microscopy techniques with novel microfabricated and organ-on-a chip devices to mimic crowded spaces such as the tumor microenvironment, interstitial space or a densely packed tissue. We propose to better understand how cell and nuclear confinement influences transcriptional programs in cells experiencing mechanical stress imposed by the surrounding microenvironment. Additionally, my lab seeks to understand the molecular mechanisms underlying cell motility and invasion following repeated nuclear rupture and chronic DNA damage.
Postdoc Fellowship Position summary/title: Postdoctoral Fellow in Cardiovascular Disease and Cancer
The Ky lab is a National Institutes of Health-and American Heart Association-funded internationally recognized program that focuses on advancing the cardiovascular health of patients living with and beyond cancer through clinical science. The Ky Lab has a postdoctoral position in the field of cardiovascular and cancer clinical epidemiology and data science. This position for a clinical researcher involves the use of large datasets comprised of biomarker, echocardiography, genomic, clinical, social determinants of health and other “-omic” data to understand individual patient risk. The ideal candidate will have a Ph.D. or M.D. with strong experience in epidemiology, data science, and computational and data analysis. The ideal candidate must also have strong written and oral communication skills, and be able to effectively design an epidemiologic study and develop and execute an analytic plan with close mentorship. The Ky lab operates within the Thalheimer Center for Cardio-Oncology, in which the mission is to relentlessly advance the cardiovascular health in our cancer patients and survivors, and envision a world of longer, healthier lives. The Thalheimer Center strives to lead and shape the field of cardio-oncology clinical care, science, and education. Members of the Ky lab collaborate with a broad range of investigators with diverse expertise in order to advance rigorous, impactful and actionable science. Competitive compensation for appropriate expertise. The Ky lab values the mentor-mentee relationship and is highly invested in the academic and professional development of lab members. This is a two-year position with the opportunity to renew for multiple years.
Postdoc Fellowship Position summary/title: Post Doctoral Researcher
The Volk laboratory invites applications for a postdoctoral position in our comparative breast cancer program at the School of Veterinary Medicine, University of Pennsylvania. The goals of our laboratory are to understand regulatory mechanisms governing dynamic interactions between cells and their surrounding extracellular matrix in the wound healing-fibrosis-cancer progression triad and to apply this knowledge to develop innovative regenerative and oncologic therapies for veterinary and human patients. One-year positions are available immediately with the option to extend an additional 1-3 years. Using a combination of in vitro and mouse models, as well as human, feline and canine breast cancer biopsy samples, we have initiated multiple lines of investigation that will provide insight into how regulation of the collagen fibrillar matrix and its components, specifically type III collagen, inhibits formation of a tumor-permissive microenvironment. This project capitalizes on our studies using spontaneous naturally occurring large animal models of mammary tumors. Future work will characterize drivers of tumor-permissive and suppressive collagen signatures and investigate the use of a novel tissue engineering strategy to control tumor growth and metastasis following tumor resection to improve clinical outcome in veterinary and human breast cancer patients.
Postdoc Fellowship Position summary/title: Postdoctoral fellowship in mucosal injury, inflammation and cancer
A postdoctoral researcher position is available in the laboratory of Dr. Nicole Maloney Belle at the University of Pennsylvania Perelman School of Medicine. The laboratory investigates how the intestinal epithelial layer repairs itself, how injured epithelial cells protect themselves from changes that lead to tumorigenesis and how epithelial cells modulate immune responses. We are particularly interested in understanding how these pathways are dysregulated in patients with inflammatory bowel disease with the ultimate goal of developing novel therapeutics.
Postdoc Fellowship Position summary/title: Postdoctoral Fellow Opportunities: Miner Lab
The Miner laboratory studies the role of cytosolic nucleic acid sensors in rare diseases, antiviral immunity, autoimmunity, neurodegeneration, and DNA damage responses. In our laboratory, rare disease research is a starting point to define fundamental biological mechanisms. We also prioritize development of novel therapies for patients with rare monogenic diseases. We have 2 new R01s as well as private funding to support multiple new postdocs. We have discovered several new mechanisms of autoimmunity, antiviral immunity, neurodegeneration, and autoinflammation. We have numerous, unique animal models available in the laboratory.
Postdoc Fellowship Position summary/title: Postdoc Researcher in Bacterial Pathogenesis
A postdoctoral position is available immediately in the Zhu laboratory in the Microbiology Department of the School of Medicine. We are studying pathogen-host-microbiome and antibiotic resistance mechanisms, including Vibrio cholerae and multi-drug resistant enterobacteria.
Postdoc Fellowship Position summary/title: Postdoctoral Researcher in Tumor Virology and Cancer Immunotherapy
A Postdoctoral Researcher position is available in the laboratory of Dr. Jianxin You at the University of Pennsylvania Perelman School of Medicine. The laboratory investigates how the molecular interplay between oncogenic viruses and their host cells leads to cancer (Cell 117:349-360, Cell Host Microbe 19:775-87). We are also developing nanotechnology-based immunotherapy for eliciting antiviral and antitumor immunity against human cancers induced by tumor viruses (Proc Natl Acad Sci U S A. 2020;117:13730-13739). We are seeking enthusiastic and highly motivated Postdoctoral fellows to join our effort in building innovative therapeutic strategies for blocking oncogenic viral infection and associated tumorigenesis.
Postdoc Fellowship Position summary/title: Postdoctoral Fellow – Computational
The Bowman Laboratory is seeking to fill a postdoctoral fellow position to study clonal evolution in leukemia. Applicants with a recent PhD or MD/PhD with experience in animal modeling of disease or computational modeling of system dynamics are invited to apply. Further details about the lab can be found at: www.bowmanlab.org Interested applicants should forward their cover letter and CV to: [email protected]
The University of Pennsylvania is a private Ivy League research university in Philadelphia, Pennsylvania. The university claims a founding date of 1740 and is one of the nine colonial colleges chartered prior to the U.S. Declaration of Independence. Benjamin Franklin, Penn’s founder and first president, advocated an educational program that trained leaders in commerce, government, and public service, similar to a modern liberal arts curriculum with a practical perspective.
Penn has four undergraduate schools as well as twelve graduate and professional schools. Schools enrolling undergraduates include the College of Arts and Sciences, the School of Engineering and Applied Science, the Wharton School, and the School of Nursing. Penn’s “One University Policy” allows students to enroll in classes in any of Penn’s twelve schools. Among its highly ranked graduate and professional schools are a law school whose first professor wrote the first draft of the United States Constitution, the first school of medicine in North America (Perelman School of Medicine, 1765), and the first collegiate business school (Wharton School, 1881).
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